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Text of the page (random words):
ne half is technically correct though highly misleading the reported annual incidence of coronary events was 37 people in 10 000 controls and 17 people in 10 000 treated similar results were reported for risk of stroke when expressed as a proportion a 46 improvement 17 37 sounds large however an improvement of 20 events 37 17 in 10 000 people known to be at risk is less impressive such an improvement means that 500 people 10 000 20 with this increased risk would need to take the tablet daily for a year to prevent one person suffering an event the paper does not explicitly report deaths one reason for this may be that if a person on statins suffered a heart attack that person was about three times more likely to die than a control who was not on statins the cost of rosuvastatin per person is approximately 1000 per year so treating enough people to prevent one heart attack costs 500 000 per year since about 70 of the heart attacks were not fatal prevention of a single death from heart attack would cost even more approximately 1 700 000 giving the benefit of the doubt we may allow for a similar reduction in stroke and say that only 250 000 is needed to protect one person from a stroke or heart attack it is hardly surprising that astra zeneca s share price increased by 1 3 billion dollars on release of this paper and the corresponding media hype 2 the media suggested millions of healthy people could cut their risk of heart disease by taking statins 3 they also claimed that statins could cut the risk of heart attack for everyone 4 this is inaccurate and incorrect the study did not include normal healthy people only a sample of a relatively small number of people suffering from inflammation increased c reactive protein a known cause of heart disease and stroke out of 89 890 people considered for inclusion 17 802 people 19 8 met the specific criteria of poor health for the study widespread prescription of statins to healthy people is not supported by these findings the fact that statins produce a modest improvement is unsurprising since they are known to lower inflammation as do many nutritional supplements it has pointed out that crestor lowered c reactive protein by 37 but vitamin e lowers it c reactive protein by 32 5 and vitamin c by 25 3 6 7 these effects are similar to those of statins and would be expected to provide comparable benefits without side effects and at a lower cost crestor and other statin drugs have serious side effects the incidence of established side effects such as rhabdomyolysis 0 3 per 10 000 per year myopathy 1 1 per 10 000 and peripheral neuropathy 1 2 per 10 000 per year seems low 8 but may be underestimated as it takes time to establish long term side effects the depletion of coenzyme q10 by statins is a particular concern the figures imply that for every ten people who avoid a cardiovascular event at least one previously healthy person will suffer a non trivial side effect of the statin drug the doctors reported a statistically significant increase 270 in diabetes in the statin group compared to the placebo group 216 over the course of the study this corresponds to an increased risk of approximately 61 in 10 000 people so the number of people on statins reported to become diabetic was greater than the number that avoided a heart attack these people might have shorter lives and be at greater risk of heart disease in the long term notably the jupiter study was stopped early which the authors admit prevents assessment of how side effects might outweigh reported benefits in the longer term the study was to last 3 5 years and the criteria for stopping were not included in the original published design 9 the paper claims that when the study was stopped these diabetic events were not adjudicated by the end point committee the committee either knew about the diabetes in which case it was considered or it did not and the committee was not doing its job properly the jupiter name stands for justification for the use of statins in prevention an intervention trial evaluating rosuvastatin the reader might think this justification sounds more like a marketing plan than a scientific endeavor the researchers did not address the underlying cause of the inflammation and increased c reactive protein they simply treated the condition with drugs in many cases raised c reactive protein is a result of nutritional deficiency 10 it is worth mentioning that several nutritional supplements inhibit inflammation and lower c reactive protein without causing known side effects deficiency in vitamins a 11 b6 c e a folate carotenoids and lycopene 12 and selenium for example is associated with raised c reactive protein 13 14 15 we suggest that the 250 000 cost of preventing a single cardiovascular event with rosuvastatin might be better spent funding a study of such inexpensive alternatives the deficiency of which may be the cause of the problem the people at risk could be encouraged to supplement their diet and restore their health without using these expensive drugs to conceal their underlying sickness stick with the supplements references 1 ridker p m danielson e fonseca f a h genest j gotto a m kastelein j j p koenig w libby p lorenzatti a j macfadyen j g nordestgaard b g shepherd j willerson j t glynn r j for the jupiter study group 2008 rosuvastatin to prevent vascular events in men and women with elevated c reactive protein nejm 359 21 2195 2207 2 mail online 2008 crestor news helps astrazeneca market value leap by more than 1 3bn 9 25 pm 10th nov 3 smith r 2008 millions could cut heart attack risk by taking statins study finds telegraph co uk 7 55am gmt 10 nov 4 hope j 2008 the new statin drug that cuts the risk of heart attacks and strokes for everyone daily mail 11th nov 5 devaraj s tang r adams huet b harris a seenivasan t de lemos j a jialal i 2007 effect of high dose alpha tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease am j clin nutr 86 5 1392 1398 6 block g jensen c d dalvi t b norkus e p hudes m crawford p b holland n fung e b schumacher l harmatz p 2008 vitamin c treatment reduces elevated c reactive protein free radic biol med oct 10 epub 7 sardi b 2008 the headline you should be reading statin drugs don t save lives and may increase your risk for diabetes knowledge of health report nov 11 8 law m rudnicka a r statin safety a systematic review the american journal of cardiology 97 8 suppl 1 s52 s60 9 ridker p m jupiter study group 2003 rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low density lipoprotein cholesterol and elevated high sensitivity c reactive protein rationale and design of the jupiter trial circulation 108 19 2292 2297 10 ford e s liu s mannino d m giles w h smith s j 2003 c reactive protein concentration and concentrations of blood vitamins carotenoids and selenium among united states adults european journal of clinical nutrition 57 1157 1163 11 root m m hu j stephenson l s parker r s campbell t c 1999 determinants of plasma retinol concentrations of middle aged women in rural china nutrition 15 101 107 12 boosalis m g snowdon d a tully c l gross m d 1996 acute phase response and plasma carotenoid concentrations in older women findings from the nun study nutrition 12 475 478 13 friso s jacques p f wilson p w rosenberg i h selhub j 2001 low circulating vitamin b 6 is associated with elevation of the inflammation marker c reactive protein independently of plasma homocysteine levels circulation 103 23 2788 2791 14 devaraja s jialal i 2000 alpha tocopherol supplementation decreases serum c reactive protein and monocyte interleukin 6 levels in normal volunteers and type 2 diabetic patients free radical biology and medicine 29 8 790 792 15 upritchard j e sutherland w h mann j i 2000 effect of supplementation with tomato juice vitamin e and vitamin c on ldl oxidation and products of inflammatory activity in type 2 diabetes diabetes care 23 733 738 nutritional medicine is orthomolecular medicine posted by unknown at 4 55 pm no comments email this blogthis share to x share to facebook share to pinterest labels cholesterol crestor health news natural health news natural news niacin nutrition supplements vitamin c vitamin e low cholesterol risks professionals only supplements resources that i rely on in my clinical work usually publish reports on studies of natural supplements that help health concerns while most hear about how high cholesterol is so bad and how many risky drugs you need often you don t hear that low cholesterol can impair your immune function or defer review of other more risky markers triglycerides included i ve educated on triglyceride issues for so long it seems funny to me that its just hitting headlines still its not prominent in the media to equal the risk to your health the real warning should be that yes high triglycerides will kill you the deadly truth about low cholesterol it s a common misconception with fatal consequences many people still believe that low total cholesterol levels mean you re not at risk for stroke heart attack or any of the other deadly risks that come with cardiovascular disease but in reality nothing could be further from the truth and unless you re paying close attention to one particular group of fats called triglycerides your heart could be a ticking time bomb no matter how healthy your cholesterol might look triglycerides are naturally manufactured and stored by both your liver and fat cells at normal levels they re a crucial source of energy for your body but start producing more than you can store and those excess triglycerides will be dumped into your bloodstream where they can wreak havoc on your arteries heart pancreas and liver 1 studies have shown that abnormally high triglyceride levels raise your risk of heart attack threefold and when accompanied by low levels of high density lipoproteins hdl or good cholesterol your risk jumps a staggering 16 times higher in fact this ratio is one of the single strongest predictors of heart attack risk even more accurate than the better known ldl low density lipoprotein or bad cholesterol to hdl ratio 2 and it isn t just your heart that suffers studies show that risk of stroke obesity diabetes and liver disease are all linked to these dangerous fats 3 5 keeping triglycerides in check is absolutely critical to your health and a simple combination of omega 3 fatty acids niacin and a supplement blend can make all the difference one recent trial showed that supplementing with fish oil daily slashed triglyceride levels by 46 percent in as little as eight weeks 6 and niacin boasts nearly five decades of research demonstrating that it not only reduces triglycerides and ldl cholesterol but also increases hdl levels by up to 29 percent 7 8 finally be wary of your blood sugar numerous clinical trials have shown that refined carbs and sugar can actually double triglyceride production 9 10 tossing sugary sodas and boosting protein intake can help 11 so can supplementing with natural blood sugar managing agents like bitter melon goat s rue and quercetin 12 13a comprehensive formulas like some we use in our work contain these ingredients along with several others including cinnamon clinical trials reveal that this popular spice can reduce triglycerides by 23 to 30 percent 14 references 1 webster s new world medical dictionary 3rd edition william schiel jr md author 2008 webster publishing 2 gaziano jm hennekens ch fasting triglycerides high density lipoprotein and the risk of myocardial infarction circulation 1997 oct 21 96 8 2520 5 3 grundy sm cleeman ji merz cn brewer hb jr clark lt implications of recent clinical trials for the national cholesterol education program adult treatment panel iii guidelines circulation 2004 jul 13 110 2 227 39 review erratum in circulation 2004 aug 10 110 6 763 4 tanne d koren morag n graff e blood lipids and first ever ischemic stroke transient ischemic attack in the bezafibrate infarction prevention bip registry high triglycerides constitute an independent risk factor circulation 2001 dec 11 104 24 2892 7 5 kadikoylu g yavasoglu i bolaman z plasma exchange in severe hypertriglyceridemia a clinical study transfus apher sci 2006 jun 3 253 7 6 vega gl chandalia m szczepaniak ls grundy sm effects of n 3 fatty acids on hepatic triglyceride content in humans j investig med 2008 jun 56 5 780 5 7 crouse jr 3rd new developments in the use of niacin for treatment of hyperlipidemia new considerations for use of an old drug coron artery dis 1996 apr 7 4 321 6 8 drexel h nicotinic acid in the treatment of hyperlipidaemia fundam clin pharmacol 2007 nov 21 suppl 2 5 6 9 teff kl elliott ss tschop m dietary fructose reduces circulating insulin and leptin attenuates postprandial suppression of ghrelin and increases in triglycerides in women j clin endocrinol metab 2004 jun 89 6 2963 72 10 furtado jd campos h appel lj miler er effects of protein unsaturated fat and carbohydrate intakes on plasma apolipoprotein b and vldl and ldl containing apolipoprotein c iii results from the omniheart trial am j clin nutr 2008 jun 87 6 1623 30 11 parks ej skokan le timlin dingfelder cs dietary sugars stimulate fatty acid synthesis in adults j nutr 2008 jun 138 6 1039 46 12 sridhar mg vinayagamoorthi r arul suyambunathan v bobby z selvaraj n bitter gourd momordica charantia improves insulin sensitivity by increasing skeletal muscle insulin stimulated irs 1 tyrosine phosphorylation in high fat fed rats br j nutr 2008 apr 99 4 806 12 13 rivera l morón r sánchez m zarzuelo a galisteo m quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese zucker rats obesity silver spring 2008 sep 16 9 2081 7 14 anderson ra chromium and polyphenols from cinnamon improve insulin sensitivity proc nutr soc 2008 feb 67 1 48 53 posted by unknown at 12 58 pm no comments email this blogthis share to x share to facebook share to pinterest labels cholesterol health news inflammation ldl natural health news natural news triglycerides unwarranted and unwise mandatory hpv vaccination for well over a year we have been alerting readers of natural health news to the risks of the hpv vaccines the problematic side effects and the fact that for the most part it is unproven and that hpv more often than not clears on its own we also believe it should not be mandatory that there are no studies of long term effects and several natural therapy approaches are available you can locate our prior posts on vaccines and gardasil via the search function on natural health news now we find that a number of experts agree mandatory hpv vaccination is unwarranted and unwise according to experts sciencedaily 2008 11 12 a new article in the journal of law medicine ethics suggests that it is premature for states to currently mandate the hpv vaccine as a condition for school attendance gardasi...
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