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the number of people exposed to dangerously high particulate matter concentrations between 2003 to 2007 and 2018 to 2022 and 151 million more people experiencing moderate to severe food insecurity across 124 countries in 2022 meanwhile 61 of the global land area saw an increase in extreme precipitation events from 2014 to 2023 compared with the average from 1961 to 1990 increasing the risk for infectious diseases flooding and water contamination worsening climate change has also had a significant impact on the spread of infectious diseases in particular the transmission risk for dengue by aedes albopictus and aedes aegypti mosquitoes saw marked increases overall an all time high of over 5 million cases of dengue were reported across 80 countries and territories in 2023 the researchers underlined that prioritization of and financial investments into health systems are needed to better protect people from the prevalent and extreme effects of climate change amidst global turmoil the powerful and trusted leadership of the health community could hold the key to reversing these concerning trends and harnessing new opportunities to put the protection and promotion of health and survival at the center of political agendas anthony costello co chair of the lancet countdown said in the release for successful reform people s health must be put front and center of climate change policy to ensure the funding mechanisms protect wellbeing reduce health inequities and maximize health gains especially for the countries and communities that need it most share this share on reddit opens in new window reddit share on x opens in new window x share on tumblr opens in new window tumblr share on linkedin opens in new window linkedin share on pinterest opens in new window pinterest share on whatsapp opens in new window whatsapp share on telegram opens in new window telegram email a link to a friend opens in new window email print opens in new window print like loading posted in environment medicine tagged climate climate change environment health news nov 07 particulate matter ozone allergens worsening with climate change posted by zedie 0 three environmental factors that have an impact on lung health are being worsened with events of climate change climate change sparks a domino effect of harmful events conditions amidst climate change it is important that pulmonologists critical care experts consider the impact worsening particulate matter ozone and allergens have on their patients according to a presentation at the chest annual meeting vanessa kerry md msc critical care physician and director of the program in global public policy and social change in the department of global health and social medicine at harvard medical school presented this idea at this year s keynote address amidst climate change it is important that pulmonologists critical care experts consider the impact worsening particulate matter ozone and allergens have on their patients according to a presentation kerry also ceo and co founder of seed global health as well as the director general s special envoy for climate change and health for who highlighted these three factors to demonstrate how climate change plays a major role in lung health air pollution particulate matter the first factor she addressed was air pollution and particulate matter although air pollutants are especially harmful to patients with lung diseases conditions kerry noted that they impact all individuals according to her presentation slide air pollution is behind 8 34 million deaths a year what s happening is that the chemical species that lead to the degradation in air quality are frequently being co emitted with greenhouse gasses kerry said as we re driving up temperatures from greenhouse gasses we re also emitting the factors that directly damage our lung health be it nitric oxides ozone or particulate matter other important environmental factors to consider within the context of air pollution are wildfires droughts and increasing temperatures kerry said as healio previously reported patients with asthma used reliever inhalers more on days with unhealthy air quality during the canadian wildfires notably when looking at the entire world individuals living in low and middle income countries are more frequently those who die due to long term exposure to ambient particulate matter pm 2 5 and ozone kerry said about 92 of all pollution related deaths are being seen in those countries but nowhere in the world is necessarily immune kerry said a key player in high all cause mortality attributable to air pollution is fossil fuels during her presentation kerry emphasized this point by showed that removal of all fossil fuel emissions would lower these deaths by 85 in high income countries she also said that an even greater decrease in deaths due to air pollution in these countries would be seen if removal of all anthropogenic emissions took place 94 encompassed within air pollution is particulate matter which kerry noted can be divided into three categories based on size where it penetrates the lung pm 10 is 10 µm or less in diameter pm 2 5 is 2 5 µm or less in diameter and pm 0 1 is 0 1 µm or less in diameter as healio previously reported exposure to pm 2 5 and pm 10 was associated with a higher risk for respiratory ed visits while all particulate matter of any size is a concern the small diameter is particularly worrisome because it can penetrate deeply kerry said to drive home the point that particulate matter is dangerous to the lungs kerry highlighted a study from 2019 analyzing exposure to pm 10 and pm 2 5 in adults from the u k biobank the study found that higher exposures to each pollutant were significantly associated with lower lung function and copd kerry said there s no safe threshold level in any of this kerry added the problem is that our particulate matter exposure is variable and not always in our control when discussing how individuals have little control over air pollutant exposure kerry revisited wildfires and mentioned this disaster in the domino effect that comes with climate change climate change is increasing heat and drought leading to the increased risk of wildfires and smoke from wildfires create particulate matter ozone and toxic gasses and chemicals which are all linked to shortness of breath asthma copd and have been associated with premature death in infants and low birth weight kerry said as climate change continues to progress kerry brought up the need for policy changes and highlighted the u s environmental protection agency epa finalized change to the national ambient air quality standard for fine particulate pollution from 12 µg m 3 to 9 µg m 3 in february as healio previously reported the epa wrote that this change will prevent up to 4 500 premature deaths prevent 290 000 lost workdays and result in as much as 46 billion in net health benefits in 2032 ozone allergens ozone is the second environmental factor that influences lung health and is being worsened because of climate change kerry said during her presentation ozone as you well know creates bronchial inflammation airway hyperresponsiveness via oxidative injury and inflammation kerry said a notable patient group that struggles when ground level ozone levels are high are those with copd according to kerry one of every nine copd deaths globally is attributable to ozone seventy percent of those deaths are in india and china so maybe not the united states because of dense urban populations large populations and terrible air quality but don t kid yourself those exist in our communities here maybe not at countrywide scale but certainly at a community level and a neighborhood scale and probably is affecting your patients kerry said ozone also impacts asthma events which kerry highlighted through a study published in jama that tracked ozone and other air pollutant levels before during and after the 1996 olympics in atlanta during the 17 day olympic games period researchers reported a 27 9 reduction in peak daily ozone concentrations and a 41 6 reduction in acute asthma care events these findings are demonstrating the daily impact you can imagine that many of our patients have in the community from traffic or other gas emissions and the potential for us to reduce harm through strategic interventions kerry said the third and final environmental factor outlined by kerry as becoming worse with climate change is allergens as previously reported on healio climate change alters factors related to pollen and aeroallergens leading to longer pollen seasons climate change is contributing to the potency of allergens kerry said with more carbon dioxide in the air and warmer temperatures plants are producing more pollen we re seeing them grow in more locations and flower over longer periods so we re having earlier and longer pollen seasons and higher pollen potency importantly mold growth also goes hand in hand with climate change as climate change brings about more instances of wildfires drought and flooding kerry said share this share on reddit opens in new window reddit share on x opens in new window x share on tumblr opens in new window tumblr share on linkedin opens in new window linkedin share on pinterest opens in new window pinterest share on whatsapp opens in new window whatsapp share on telegram opens in new window telegram email a link to a friend opens in new window email print opens in new window print like loading posted in environment medicine tagged air pollution air quality asthma allergens dust mites extrinsic asthma asthma environment health ozone particulate matter sustainability nov 07 glp 1 drugs may reduce uterine fibroid risk for women with type 2 diabetes posted by zedie 0 compared with metformin and insulin glp 1 receptor agonists may protect against new uterine fibroids in women with type 2 diabetes more research is needed to understand the underlying mechanisms women with type 2 diabetes prescribed any glp 1 receptor agonist were less likely to develop any new onset uterine fibroids over 5 years compared with those who used metformin or insulin researchers reported type 2 diabetes and obesity both contribute to insulin resistance which is associated with increased risk for uterine fibroids tina yi jin hsieh md mph a student in the department of biomedical informatics at harvard medical school said during a presentation at the asrm scientific congress expo in january 2020 american diabetes association guidelines recommended glp 1 receptor agonists and sglt2 inhibitors as first line agents to lower hba1c promote weight loss and provide cv and renal protection for adults with type 2 diabetes hsieh said compared with metformin and insulin glp 1 receptor agonists may protect against new uterine fibroids in women with type 2 diabetes image adobe stock glp 1 receptor agonists exert many effects across different systems in the human body and also have anti inflammatory effects to treat a wide variety of diseases hsieh said however the effects of glp 1 receptor agonists against uterine fibroids a condition associated with obesity remain unexplored for the retrospective study researchers analyzed electronic health records from 30 036 women who initiated glp 1 receptor agonists therapy compared with 30 036 women who initiated metformin as well as 30 036 women who initiated glp 1 receptor agonists compared with 30 036 women who initiated insulin using data from the trinetx u s collaborative network researchers used propensity score matching by demographics comorbidities bmi hba1c and health care utilization for both arms participants received at least two doses of exclusive glp 1 receptor agonist therapy metformin or insulin after a diagnosis of type 2 diabetes the study period ranged from may 2005 after the approval of the first glp 1 receptor agonist through 2021 researchers followed patients for 5 years from drug initiation until onset of fibroids loss to follow up or september 2024 whichever came first researchers found women who received at least two doses of a glp 1 receptor agonist had a 27 lower risk for developing any new onset fibroids compared with metformin users rr 0 73 95 ci 0 66 0 81 with similar results in analyses stratified by fibroid type researchers observed greater protection against new onset fibroids for women who received at least six doses of any glp 1 receptor agonist rr 0 65 95 ci 0 56 0 76 women who used a glp 1 receptor agonist similarly has a 23 lower risk for fibroids compared with insulin users hr 0 77 95 ci 0 69 0 85 hsieh noted that there was no detailed information available about fibroid size severity or symptoms between 82 and 85 of lesion locations were coded as unspecified the sample size was not large enough to compare differences by race in women with type 2 diabetes glp 1 receptor agonists may protect against new onset uterine fibroids compared to both metformin and insulin hsieh said we recommend further research including prospective cohorts and basic research to understand the underlying therapeutic mechanisms share this share on reddit opens in new window reddit share on x opens in new window x share on tumblr opens in new window tumblr share on linkedin opens in new window linkedin share on pinterest opens in new window pinterest share on whatsapp opens in new window whatsapp share on telegram opens in new window telegram email a link to a friend opens in new window email print opens in new window print like loading posted in medicine obs gyn pharmacology tagged diabetes glp 1 drugs health obesity ozempic uterine fibroid weight loss nov 07 vonoprazan delivers a quick sustained relief to nerd heartburn posted by zedie 0 patients with nonerosive reflux disease who manage their heartburn with daily vonoprazan also report durable and rapid onset relief when transitioning to use the drug as an on demand treatment according to results presented at acg 2024 in a new post hoc analysis presented at acg 2024 researchers found vonoprazan voquenza phantom gave patients with nonerosive reflux disease rapid and durable heartburn relief previously reported results from the phase 2 nerd non erosive reflux disease 201 trial showed that the potassium competitive acid blocker vonoprazan voquezna phathom taken in response to a heartburn episode was significantly better than placebo in providing complete relief within three hours and sustained relief within 24 hours after drug consumption aliment pharmacol ther 2023 58 10 1016 1027 this new post hoc analysis of nerd 201 was designed to evaluate the frequency of heartburn episodes when a patient switched to on demand treatment after achieving symptom control with daily treatment for four weeks and to also evaluate how rapidly symptoms improved when treating new episodes during the on demand treatment reported investigator ronnie fass md the director of the division of gastroenterology and hepatology at metrohealth medical center in cleveland oral...
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