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to disseminate his ideas about evening primrose oil and fatty acids 14 popular science edit in the popular science book the madness of adam and eve 2001 horrobin outlined his hypothesis that schizophrenia contributed to the evolution of modern humans according to horrobin fat metabolism was altered as humans evolved from other primates leading to early humans with schizophrenia these humans were more creative and did not experience as much physical pain as others 41 horrobin suggested that the genes for schizophrenia are responsible for most of the religious sense most of the technical and artistic creativity and most of the leadership qualities of modern human beings 42 the madness of adam and eve was one of six books shortlisted for the 2002 aventis prize now the royal society prizes for science books the prize was won that year by stephen hawking s the universe in a nutshell 43 reviews of the book were mixed writing of a useful contribution that was also highly partisan and selective 41 an engaging and plausible argument that is not so convincingly argued 42 and a book brightly written but with a huge hole in its central premise 44 horrobin was somewhat critical of his theory describing it as a just so story perhaps fed by my own personal delusions 45 the book was compared unfavorably to similar works by kay redfield jamison who examines a possible link between bipolar disorder and artistic creativity 42 tim crow a professor of psychiatry at oxford university who had proposed a similar theory in 1995 accused horrobin of failing to acknowledge crow s contributions to the development of his ideas when novelist sebastian faulks stated that horrobin s ideas influenced his novel human traces published in 2005 crow protested that much of the credit for his theory has been misdirected by faulks to the late maverick doctor and writer david horrobin 46 death and obituary controversy edit in 2001 horrobin was diagnosed with mantle cell lymphoma he died of pneumonia as a complication of this cancer in 2003 horrobin was survived by his wife sherri clarkson and two children from a previous marriage 9 a number of obituaries were published both in medical journals such as the lancet 47 and horrobin s prostaglandins leukotrienes and essential fatty acids 12 and in the popular press 9 28 most obituaries referred to horrobin as a highly intelligent creative and persuasive individual according to the telegraph horrobin was a founding father of the biotechnology industry and regarded by some as one of britain s finest original thinkers in medicine but the same obituary also noted that horrobin s implication of fatty acid metabolism in schizophrenia was not accepted by other scientists that his approach was unorthodox and unpopular and that his major business venture failed 9 the many problems at scotia under horrobin s leadership which led to the company s eventual collapse were a theme in several obituaries 28 including two highly critical and controversial accounts written by former horrobin colleague caroline richmond and published in the british medical journal bmj 15 and the independent 11 the bmj obituary sparked a months long controversy 5 12 13 14 48 49 50 51 52 53 54 the obituary described horrobin as effortlessly prolific and one of the most persuasive people on earth but also criticised him as excessively promoting evening primrose oil despite a lack of scientific evidence noting that some critics questioned his ethics it suggested that horrobin may prove to be the greatest snake oil salesman of his age stating that his evening primrose oil would go down in history as the remedy for which there is no disease and reporting that several of scotia s product licences were later withdrawn because the drugs were ineffective 15 the obituary generated the largest e mail response to an obituary in the history of the bmj 55 respondents including horrobin s colleagues friends and family were largely critical of the negative tone of the obituary 56 on behalf of horrobin s family horrobin s son in law adam kelliher filed a complaint with the british press complaints commission alleging that the bmj obituary was inaccurate and intrusive at a time of grief in violation of the code of practice 57 kelliher was founder and at the time chief executive of equazen a company marketing fish and evening primrose oils including a formulation called eye q said to improve scholastic ability in children however in his initial complaint to the bmj kelliher stated that he had no competing interests in reaction the bmj published an apology to horrobin s family expressing regret for any distress caused the journal corrected what its editor considered several insignificant 58 spelling and factual errors and published three further obituaries of horrobin however the journal also defended its original obituary as fairly presenting both the positive and negative aspects of its subject s life 55 56 58 kelliher did not accept the bmj apology as genuine and maintained that inaccuracies and unjustified slander remained but the press complaints commission declined to take any action against the journal stating that the bmj had offered sufficient remedial action according to the commission the journal was not obliged to omit negative information including the journal s contention that dr horrobin was in some ways a charlatan 57 posthumous honours edit in june 2004 the scientific publisher elsevier having acquired the journal medical hypotheses created an annual david horrobin prize for medical theory in his honour 59 he was posthumously awarded the stephen s chang award by the american oil chemists society in 2003 60 selected bibliography edit scholia has a profile for david horrobin q5235151 horrobin david f 1964 the communication systems of the body new york basic books p 214 isbn 0 465 01287 6 cite book isbn date incompatibility help horrobin david f 1970 principles of biological control aylesbury medical and technical pub co ltd p 70 isbn 0 85200 002 2 horrobin david f 1971 essential biochemistry endocrinology and nutrition new york medical and technical publishing co ltd p 118 isbn 0 85200 025 1 horrobin david f 1972 a guide to kenya and northern tanzania scribner p 304 isbn 0 684 12629 x horrobin david f 1977 medical hubris a reply to ivan illich montreal lunesdale house p 146 isbn 0 88831 086 2 horrobin david f 1983 the role of essential fatty acids and prostaglandins in the premenstrual syndrome j reprod med 28 7 465 8 pmid 6350579 horrobin david f 1987 essential fatty acids prostaglandins and alcoholism an overview alcohol clin exp res 11 1 2 9 doi 10 1111 j 1530 0277 1987 tb01250 x pmid 3032012 horrobin david f ed 1990 omega 6 essential fatty acids pathophysiology and roles in clinical medicine new york wiley liss isbn 0 471 56693 4 horrobin david f 1990 gamma linolenic acid reviews in contemporary pharmacotherapy 1 1 carnforth uk marius press 1 45 issn 0954 8602 oclc 729348324 horrobin david f 1993 omega 6 and omega 3 essential fatty acids in atherosclerosis semin thromb hemost 19 2 129 37 doi 10 1055 s 2007 994016 pmid 8356458 s2cid 40590225 horrobin david f 1994 unsaturated lipids a new approach to the treatment of cancer world rev nutr diet world review of nutrition and dietetics 76 77 80 doi 10 1159 000423997 isbn 978 3 8055 6040 5 pmid 7856241 cite journal cs1 maint periodical has isbn link horrobin david f 1997 essential fatty acids in the management of impaired nerve function in diabetes diabetes 46 suppl 2 s90 3 doi 10 2337 diab 46 2 s90 pmid 9285506 s2cid 10174746 horrobin david f 2000 essential fatty acid metabolism and its modification in atopic eczema am j clin nutr 71 1 suppl 367s 72s doi 10 1093 ajcn 71 1 367s pmid 10617999 horrobin david f 2001 the madness of adam eve how schizophrenia shaped humanity london bantam isbn 0 593 04649 8 peet m 2003 glen i horrobin df eds phospholipid spectrum disorders in psychiatry and neurology 2nd ed carnforth uk marius press isbn 1 871622 25 5 a more extensive bibliography is available on the institute for scientific information website 33 references edit 1 2 court mark 2 april 2003 pioneer of uk biotechnology dies of cancer the times archived from the original on 12 june 2011 quote dr horrobin was best known for creating scotia holdings a once sprawling biotechnology company which has the unfortunate distinction of being the uk s only quoted biotechnology company to have collapsed into administration horrobin df 1991 interactions between n 3 and n 6 essential fatty acids efas in the regulation of cardiovascular disorders and inflammation prostaglandins leukot essent fatty acids 44 2 127 31 doi 10 1016 0952 3278 91 90196 c pmid 1745654 1 2 3 4 f d a in battle on health food frauds the new york times 1 june 1989 archived from the original on 6 july 2022 retrieved 7 february 2017 1 2 general nutrition officials indicted lexington herald leader ky 15 november 1984 p c9 1 2 3 4 5 6 7 primrose oil and eczema how research was promoted and suppressed stephen barrett quackwatch 31 january 2004 1 2 3 4 how to avoid the bitter pill of regulation ben goldacre bad science column the guardian 23 september 2003 1 2 hoare c li wan po a williams h 2004 systematic review of treatments of atopic eczema health technology assessment 4 37 epogam and efamast lose product licences the pharmaceutical journal 269 7215 352 september 2002 archived from the original on 4 december 2008 retrieved 15 september 2009 1 2 3 4 5 6 7 8 9 10 11 david horrobin the telegraph obituary london 2 may 2003 archived from the original on 29 june 2011 retrieved 16 september 2009 should we give the biotechies money to burn rosie murray west the telegraph 11 september 2004 1 2 3 4 5 6 7 richmond c 17 april 2003 david horrobin champion of evening primrose oil the independent london archived from the original on 13 march 2010 retrieved 15 september 2009 1 2 3 stein j 2004 david horrobin 1939 2003 a memoir prostaglandins leukot essent fatty acids 70 4 339 43 doi 10 1016 j plefa 2004 01 001 pmid 15085824 1 2 a rotter a snake oil salesman a chancer how scientist s obituary sparked a storm a vitriolic attack in the british medical journal has devastated eminent academic david horrobin s family reports robin mckie robin mckie the observer in the guardian 25 may 2003 1 2 3 allport susan 2008 the queen of fats why omega 3s were removed from the western diet and what we can do to replace them university of california press isbn 978 0 520 25380 3 1 2 3 4 5 6 7 richmond c 2003 obituary david horrobin british medical journal 326 7394 885 doi 10 1136 bmj 326 7394 885 pmc 1125787 1 2 fears over future of quantanova the herald glasgow 23 march 2002 his initial interest was in schizophrenia but after failing to raise funding for more research he founded the cash cow operation that would become scotia 1 2 3 4 5 clark andrew 26 january 2001 scotia collapses into bickering the arguments get personal as trading in biotech firm s shares is halted the guardian london retrieved 14 september 2009 staples r 1995 scotia pharmaceuticals harnessing the power of plants pharmaceutical executive jan 1995 56 62 general nutrition will withhold 13 products ap morning call allentown pa 7 december 1984 p a 04 takwale a tan e agarwal s barclay g ahmed i hotchkiss k thompson jr chapman t berth jones j 13 december 2003 efficacy and tolerability of borage oil in adults and children with atopic eczema randomised double blind placebo controlled parallel group trial bmj 327 7428 1385 0 doi 10 1136 bmj 327 7428 1385 pmc 292992 pmid 14670885 1 2 the investment column scotia scrabbles for a success magnus grimond the independent 25 september 1997 1 2 scotia s hopes for magic bullet tom stevenson the investment column the independent 11 september 1996 1 2 scotia s unusual approach may yet silence critics a small drug firm thinks big erik ipsen the new york times 27 may 1995 1 2 dyer o 2003 gmc reprimands doctor for 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