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onic diary entries n 207 the patients eligible for the on demand period were randomized to four arms vonoprazan at 10 mg 20 mg and 40 mg or placebo and followed for another week patients reported heartburn episodes as they occurred in an electronic diary and symptoms were assessed at the time of treatment in 20 minute increments for up to three hours after patients took the drug patients reported heartburn severity as none mild moderate severe or very severe and documented if they did not have heartburn episodes within 24 hours of drug consumption dr fass said improvement in severity was regarded as a minimum of one grade reduction from initial severity e g from moderate to mild on demand dosing permitted only one dose of study drug every 24 hours during the screening period patients only reported 16 of days as heartburn free during the run in period of daily treatment patients reported 83 heartburn free days this percentage fell to approximately 72 when patients switched to on demand treatment but that was still significantly higher than during the screening period dr fass said nerd 201 succeeded at its primary outcome of complete relief at three hours and sustained relief for 24 hours but this didn t capture how quickly symptoms started to improve dr fass said therefore we further examined the percentage of episodes that improved from the initial reported severity the differences between vonoprazan and placebo were evident within as little as one hour he noted in addition 90 of patients in the treatment arms had their symptoms improved in severity within two hours this was seen at every dose of vonoprazan compared with placebo regardless of the initial level of symptom severity although it appears severe episodes may have a higher improvement rate dr fass said our findings support the use of vonoprazan as an on demand option for patients with nonerosive reflux disease although a confirmatory study in a larger patient population with a longer on demand period is warranted share this share on reddit opens in new window reddit share on x opens in new window x share on tumblr opens in new window tumblr share on linkedin opens in new window linkedin share on pinterest opens in new window pinterest share on whatsapp opens in new window whatsapp share on telegram opens in new window telegram email a link to a friend opens in new window email print opens in new window print like loading posted in medicine pharmacology tagged acid reflux gerd health heartburn nerd heartburn reflux vonoprazan nov 07 prenatal cannabis use linked to child aggression and cognitive deficits posted by zedie 0 summary new research shows that prenatal exposure to cannabis can negatively impact children s thinking and behavioral skills including impulse control attention and aggression which are key for academic and social success the study observed preschool aged children with prenatal cannabis exposure and found they showed poorer control over impulses and emotions these findings align with earlier research and come as cannabis potency has increased over the years underscoring concerns about use during pregnancy experts recommend pregnant women avoid cannabis and consult healthcare providers for safer alternatives to manage pregnancy symptoms major pediatric and obstetric organizations advise against cannabis use during pregnancy due to potential health risks to mother and child key facts prenatal cannabis exposure affects impulse control attention and aggression increased cannabis potency today may heighten risks compared to past decades experts recommend safer alternatives for managing pregnancy related symptoms source nationwide children s hospital as cannabis is legalized and is more accessible in various forms across the country there is increasing concern among health care providers about potential impact on children researchers at nationwide children s hospital have new findings to add to the existing evidence that cannabis exposure before birth can negatively impact children results showed children exposed to cannabis had more difficulty controlling their impulses paying attention and planning and showed more aggressive behavior when researchers observed their behavior in a play laboratory environment credit neuroscience news in a study published today in jama pediatrics researchers found prenatal cannabis exposure was associated in early childhood with poorer thinking skills and behaviors such as impulse control paying attention planning ability and more aggressive behavior all of which play a vital role in how children perform in school and interact with others although cannabis is a natural product there are still many risks to using it during pregnancy said sarah keim phd principal investigator in the center for biobehavioral health at nationwide children s and lead author of the study some women may turn to cannabis to help deal with some common issues of pregnancy including nausea sleep problems and stress this is not recommended consulting with a health care provider to find safer options to help with these issues during pregnancy is important researchers used multiple assessments including asking parents about their child s typical behaviors and measurement of skills related to impulse control paying attention solving problems and managing emotions in preschool aged children results showed children exposed to cannabis had more difficulty controlling their impulses paying attention and planning and showed more aggressive behavior when researchers observed their behavior in a play laboratory environment our findings were not surprising they actually confirm and expand on longstanding evidence from previous research said dr keim with our more contemporary and diverse sample of women and children and with much higher potency of cannabis now than in past decades this study validates previous research and supports existing clinical recommendations for patients the american academy of pediatrics and the american college of obstetricians and gynecologists both caution against cannabis use during pregnancy because of possible health risks to mothers and children abstract prenatal cannabis exposure and executive function and aggressive behavior at age 5 years importance cannabis use during pregnancy is increasingly common in the us and may affect the development and behavior of preschool aged children objective to prospectively investigate the association of prenatal cannabis exposure with executive function and aggressive behavior at age 5 years design setting participants this cohort study was conducted from 2016 through 2020 data analysis was conducted from 2022 through 2024 patients aged 16 through 50 years who were able to communicate in english and intended to deliver at the ohio state university wexner medical center were enrolled in a pregnancy research repository participants n 355 who gave consent for future contact and whose child ren was presumed to be alive were invited to participate again at child age 5 years children born may 25 2010 through february 7 2016 and 250 children participated 70 exposure cannabis exposure was measured prospectively by urine toxicology maternal self report and obstetric record abstraction main outcomes and measures executive function and aggressive behavior measured via multimodal assessment by staff masked to exposure status outcomes were chosen a priori results of 250 children 80 were exposed to cannabis 32 use of tobacco other drugs and alcohol during pregnancy was common 22 to 39 each most families were living in poverty there were 155 children who were black african american non hispanic 62 11 were hispanic 4 34 indicated more than one race or another race non hispanic 14 and 50 were white non hispanic 20 age corrected standard scores for children s attention and inhibitory control national institutes of health toolbox were about 0 4 sds lower for those exposed to cannabis compared with unexposed β 6 1 points 95 ci 10 8 to 1 4 following propensity score weighting and adjustment for confounders exposed children also exhibited poorer task based planning ability and more observed aggression caregiver ratings of executive function and behavior and laboratory assessments of other aspects of executive functioning showed no differences by exposure status conclusions and relevance results from this contemporary us cohort where prenatal cannabis exposure was common and indicated that exposed children exhibited some differences in aspects of executive function and behavior relevant to long term academic success and adaptive functioning these results may be considered in refining clinical recommendations regarding cannabis use during pregnancy share this share on reddit opens in new window reddit share on x opens in new window x share on tumblr opens in new window tumblr share on linkedin opens in new window linkedin share on pinterest opens in new window pinterest share on whatsapp opens in new window whatsapp share on telegram opens in new window telegram email a link to a friend opens in new window email print opens in new window print like loading posted in medicine tagged cannabis cognitive deficits health marijuana mental health prenatal cannabis prenatal cannabis use linked to child aggression and cognitive deficits weed nov 07 foods that help fight depression posted by zedie 0 1 10 milk it s a good source of vitamin d if you have very low levels of this nutrient in your body that can sometimes cause depression one norwegian study found that people who took a vitamin d supplement were less depressed a year later than those who didn t don t like milk boost the d in your diet with enriched cereals and juices and canned fish 2 10 turkey the traditional thanksgiving bird has the protein building block tryptophan which your body uses to make serotonin that s a brain chemical that plays a key role in depression researchers say in fact some antidepressant drugs work by targeting the way your brain uses serotonin you can get the same mood boosting effect from chicken and soybeans 3 10 brazil nuts this snack is rich in selenium which helps protect your body from tiny damaging particles called free radicals one study found that young people who didn t have enough of this nutrient in their diets were more likely to be depressed the researchers couldn t say that low selenium caused depression though just one brazil nut has almost half your daily requirement of the mineral so be careful to limit how many you eat other foods with this mineral include brown rice lean beef sunflower seeds and seafood 4 10 carrots they re full of beta carotene which you can also get from pumpkin spinach sweet potatoes and cantaloupe studies have linked this nutrient to lower levels of depression there s not enough evidence to say that it can prevent the disorder but it can t hurt to get more in your diet 5 10 clams and mussels these seafood favorites are a good source of b 12 some studies say that people with low levels of the vitamin are more likely to have depression it may be that a lack of it causes a shortage of a substance called s adenosylmethionine sam which your brain needs to process other chemicals that affect your mood if you re looking for other b 12 foods try lean beef milk and eggs 6 10 coffee a jolt of caffeine can be a pick me up that helps you feel more motivated but if you have postpartum depression or panic disorder some studies suggest that it might make your symptoms worse other researchers say a cup of joe can lower your risk of getting depression though they re not sure why 7 10 leafy greens they re packed with folate which your brain cells need to work well and which may help protect against depression food manufacturers in the u s add this vitamin also known as b9 to enriched grains like pasta and rice you can also get it from lentils lima beans and asparagus 8 10 salmon this and other fish like herring and tuna are high in polyunsaturated fats researchers think those can help you fight depression one type of these fats called omega 3 fatty acids may help brain cells use chemicals that can affect your mood a few small studies show that people who weren t depressed had higher levels of omega 3s than those with the mood disorder 9 10 caution alcohol it might seem like just the thing to take the edge off your worries or make you feel more social but most of the time it s best if you drink wine beer and mixed drinks only in moderation you might feel better in the moment but heavy drinking can make depression symptoms worse over time because alcohol makes your brain less active it also can make antidepressant medications less effective 10 10 caution junk food it may be fast and filling but these processed foods can be bad news for your mood scientists have studied how diets high in sugar simple carbohydrates and fatty foods affect how you feel many found some link between these unhealthy eats and depression your best bet a well balanced diet with plenty of fruits vegetables whole grains and lean protein share this share on reddit opens in new window reddit share on x opens in new window x share on tumblr opens in new window tumblr share on linkedin opens in new window linkedin share on pinterest opens in new window pinterest share on whatsapp opens in new window whatsapp share on telegram opens in new window telegram email a link to a friend opens in new window email print opens in new window print like loading posted in diatetics tagged depression health mental health nutrition wellness nov 07 can vaccines slash global antibiotic use who says yes posted by zedie 0 expanding vaccine use has the potential to reduce the administration of up to 2 5 billion doses of antimicrobials per year making a significant contribution to the fight against antimicrobial resistance amr one of the greatest public health challenges worldwide this information is included in a new world health organization who report on the subject which estimated the potential impact of increases in immunization rates the document emphasized that the role of vaccines in reducing amr has not been fully recognized even though vaccines can train the immune system to better defend against various pathogens before an infection begins or worsens vaccinated people will have fewer infections and thus will also be protected against potential complications from secondary infections that may trigger the use of antimicrobials or require admission to hospital the report stated who director general tedros adhanom ghebreyesus phd highlighted the importance of implementing preventive strategies tackling amr starts with infection prevention and vaccines are among the most powerful tools for this he stated prevention is better than cure so increasing access to available vaccines and developing new immunizations for critical diseases like tuberculosis is essential to save lives and reverse the current trend he added researchers calculated the total impact acros...
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