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description= FORMULATRIX® collaborates with researchers to simplify the preparation and analysis of proteins and nucleic acids by designing laboratory automation solutions without boundaries and bringing novel cutting-edge technology to the life science industry.;
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flo i8 pd liquid handler flo i8 pd 8 channel spanning positive displacement liquid handler learn more aµtopulse aµtopulse tff high throughput sample concentration diafiltration learn more crystallization of small molecules with robotic methods crystallization of small molecules with robotic methods watch the webinar bridging genomics and proteomics interrogation of prospective and archived samples for population scale biomarker discovery bridging genomics and proteomics interrogation of prospective and archived samples for population scale biomarker discovery watch the webinar cellmatic cellmatic automated cell culture learn more popular applications pcr assay development next gen sequencing protein crystallization ultrafiltration high throughput screening cell based assays nanoparticle processing bioconjugate cleanup virus processing trusted worldwide 6 797 products installed 2 709 customer sites 1 470 employees our clients include next previous next previous events la jolla cove research center la jolla united states 15 th july ucsd moores cancer center san diego united states 16 th july china nucleic acid drug conference tianjin china 6 th 7 th august bioprocessing summit boston boston united states 10 th 13 th august iucr 2026 calgary canada 11 th 18 th august mad ssci annual conference new brunswick united states 26 th 28 th august view all events webinars introducing the flo i8 pd precision speed and reliability with positive displacement enabling high throughput long read single cell sequencing by combining the sclis seq method and the f a s t liquid handler to deliver sensitive reproducible isoform data while streamlining complex workflows for transcriptomic research watch the webinar the future of hipsc workflows automated scalable reliable advancing hipsc workflows by combining fully automated cell culture with integrated liquid handling and intelligent scheduling to deliver consistent scalable and contamination controlled stem cell maintenance and differentiation watch the webinar data driven uf df at lab scale integrating automated tff with mid ir spectroscopy combining automated microfluidic tff with mid ir spectroscopy to deliver near real time insight into protein concentration and excipient behavior while reducing sample consumption in lab scale uf df workflows watch the webinar crystallization of small molecules with robotic methods transforming small molecule crystallization by combining robotic screening with automated imaging and analysis to deliver efficient low volume crystal growth for faster more reliable structure determination watch the webinar view all webinars application notes high throughput and automated whole blood netosis assays using the mantis whole blood netosis assays are difficult to scale without disrupting neutrophil responsiveness the mantis automates blood and reagent dispensing to support faster clinically relevant netosis research in 384 well plates read the application note simple and efficient cell harvesting using the µpulse tff system learn more about gentle high yield cell harvesting using the µpulse tff system achieving superior recovery preserved viability and reproducible performance compared to conventional centrifugation methods read the application note built in sterility proactive contamination control in the cellmatic system built in sterility proactive contamination control in the cellmatic system microbial contamination remains a persistent challenge in cell culture workflows the cellmatic delivers built in sterility through automated contamination control to support reliable contamination free cell culture read the application note automated imaging of microfluidic crystalchip experiments using the formulatrix rock imager 360 learn how the crystalchip and rock imager 360 work together to simplify protein crystallization imaging reducing manual effort while delivering faster more consistent and high quality crystal visualization results read the application note view all application notes news and updates bioconjugate cleanup tff adc purification without chromatography discover how formulatrix is transforming bioconjugate cleanup with the µpulse and aµtopulse tangential flow filtration tff systems by integrating purification concentration and buffer exchange into a single automated workflow these compact platforms streamline adc and bioconjugate processing while preserving delicate sample integrity experience higher recovery reproducible results and true walk away operation all without chromatography columns or manual centrifugation steps read the article formulatrix and spear bio advance automated ultra sensitive protein detection through ongoing collaboration formulatrix and spear bio have expanded their collaboration to automate the spear ultradetect ultrasensitive protein detection assay using the f a s t liquid handler this integration significantly reduces hands on time while improving precision throughput and workflow reproducibility the partnership advances high sensitivity biomarker analysis for life science and diagnostic research read the press release automating hipscs workflows with the cellmatic explore how our cellmatic system is transforming hipsc research with fully automated workflows the system enables hands free maintenance expansion and differentiation of human induced pluripotent stem cells addressing variability and genomic instability challenges by standardizing scalable protocols the cellmatic supports reproducible high throughput experiments for disease modeling regenerative medicine and patient specific therapeutic development with unmatched precision and efficiency read the white paper automated protein crystallization discover how formulatrix is advancing structural biology with fully automated protein crystallization solutions by integrating custom screen building nanoliter scale liquid handling high throughput imaging and ai powered analysis our solutions replace slow manual workflows with scalable reproducible and precise automation from drop setup to diffraction quality crystal detection using uv mfi and sonicc modalities formulatrix accelerates drug discovery and structural biology research with unmatched efficiency accuracy and confidence read the article exobiosphere completes first parabolic flight demonstrates world first hts capabilities in microgravity discover how exobiosphere and formulatrix are pioneering high throughput drug screening in space with the mantis liquid dispenser now validated in microgravity their groundbreaking parabolic flight campaign demonstrated nanoliter scale dispensing into 384 and 1536 well plates in weightlessness enabling scalable automated biology experiments for orbital disease modeling and drug discovery with unmatched precision and reproducibility watch the flight view all news and updates publications citations 1191 structural and functional characterization of vapbc52 toxin antitoxin system from mycobacterium tuberculosis singh et al 2026 nucleic acids research link mycobacterium tuberculosis mtb encodes a huge repertoire of toxin antitoxin ta systems many of which remain uncharacterized here we report the crystal structures of the vapc toxin and vapbc ta complex at a resolution of and respectively we show that vapc adopts a unique open dimeric conformation and inhibits mycobacterial more related solutions rock imager mycobacterium tuberculosis mtb encodes a huge repertoire of toxin antitoxin ta systems many of which remain uncharacterized here we report the crystal structures of the vapc52 toxin and vapbc52 ta complex at a resolution of 2 6 and 3 2 å respectively we show that vapc52 adopts a unique open dimeric conformation and inhibits mycobacterial growth by cleaving trna at the variable or anticodon loop region structure reveals that vapb52 adopts a distinct structural architecture and binds vapc52 with a 1 2 stoichiometry respectively interestingly binding of ssdna activates vapb52 peptidase domain resulting in auto cleavage of vapb52 n terminal domain which is critical for vapbc complex formation and neutralization in addition to vapb52 co expression of several other non cognate vapb antitoxins abrogates the growth inhibition associated with vapc52 overexpression in mycobacterium smegmatis msm suggesting crosstalk among vapbc ta systems further we demonstrate that the vapbc52 locus is dispensable for in vitro growth but essential for mtb intracellular growth in macrophages and guinea pigs notably vapc52 also cleaves mycobacteriophage d29 encoded trnas and confers resistance to phage infection in msm taken together we show that vapbc52 adopts a unique structural architecture plays role in pathogenesis and is possibly involved in mycobacterial antiphage defense mechanisms less related solutions rock imager computational design and cellular synthesis of two protein topological isomers solomon link vs three twist knot xu et al 2026 pnas link chemical topology has emerged as a unique dimension in protein engineering motivating the pursuit of topologically nontrivial protein architectures for functional advantages such as enhanced stability and rich dynamics however the structural diversity of artificial mechanically interlocked proteins remains limited here we report the computational design and cellular synthesis of more related solutions nt8 chemical topology has emerged as a unique dimension in protein engineering motivating the pursuit of topologically nontrivial protein architectures for functional advantages such as enhanced stability and rich dynamics however the structural diversity of artificial mechanically interlocked proteins remains limited here we report the computational design and cellular synthesis of a pair of topological isomers via symmetric assembly of orthogonal entangling motifs by fusing two c2 symmetric entangling motifs i e p53dim and hp0242 in specific arrangements we programmed the formation of multiple crossings which upon cyclization yielded a protein solomon link and a protein three twist knot the fusion patterns and linker lengths were systematically optimized to direct the formation of the intended topologies their successful cellular synthesis was validated through biophysical and structural analyses including sodium dodecyl sulfate polyacrylamide gel electrophoresis size exclusion chromatography and liquid chromatography mass spectrometry notably we report the crystal structure of an artificial protein three twist knot both the solomon link and the three twist knot displayed increased structural compactness and stability relative to their controls with lower topological complexity e g hopf link trefoil knot and linear forms as evidenced by their superior thermal stability and resistance to chemical denaturation this modular design strategy provides a rational and extensible route to diverse mechanically interlocked proteins and could be generalized to access even more complex architectures such as protein chainmail like nanocages and woven protein frameworks less related solutions nt8 structural and functional mapping of protective human monoclonal antibodies against enterovirus a71 zhou et al 2026 science advances link ev a has been responsible for recent severe hfmd outbreaks we report structures for potently neutralizing human anti ev a monoclonal antibody fabs alone and complexed with virus most recognize the native antigenic state with epitopes that span interfaces together covering of the capsid surface the majority of bind the canyon while more related solutions rock imager ev a71 has been responsible for recent severe hfmd outbreaks we report structures for 12 potently neutralizing human anti ev a71 monoclonal antibody fabs alone and complexed with virus most recognize the native antigenic state with epitopes that span interfaces together covering 85 of the capsid surface the majority 8 of 12 bind the canyon while the others cluster around the icosahedral two and threefold axes blocking scarb2 recep...
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