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and lymphocyte activation molecular biology of the cell 4th ed garland science alberts b johnson a lewis j raff m roberts k walter p 2002 helper t cells and lymphocyte activation molecular biology of the cell 4th ed garland science p 1367 t cells derive their name from the organs in which they develop t cells develop mature in the thymus luckheeram rv zhou r verma ad xia b 2012 cd4 t cells differentiation and functions clinical developmental immunology 2012 925135 doi 10 1155 2012 925135 pmc 3312336 pmid 22474485 kondo m december 2016 one niche to rule both maintenance and loss of stemness in hscs immunity 45 6 1177 1179 doi 10 1016 j immuni 2016 12 003 pmid 28002722 osborne lc dhanji s snow jw priatel jj ma mc miners mj et al march 2007 impaired cd8 t cell memory and cd4 t cell primary responses in il 7r alpha mutant mice the journal of experimental medicine 204 3 619 631 doi 10 1084 jem 20061871 pmc 2137912 pmid 17325202 murphy kenneth 2011 janeway s immunobiology 8th ed garland 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