Meta tags:
Headings (most frequently used words):
krm, ii, 81, contents, references,
Text of the page (most frequently used words):
krm (12), the (9), wikipedia (8), acid (8), and (7), articles (6), modulators (6), page (5), chemical (5), anticonvulsant (5), receptor (5), gaba (5), sage (5), edit (5), contents (4), search (4), this (4), org (4), bromide (4), ethyl (4), chloral (4), cgs (4), hide (4), move (4), sidebar (4), view (3), short (3), description (3), from (3), wikidata (3), without (3), compounds (3), article (3), positive (3), constituents (3), dhp (3), etomidate (3), butomidate (3), diazepam (3), effects (3), for (3), references (3), has (3), tools (3), main (3), language (2), toggle (2), table (2), contact (2), about (2), privacy (2), policy (2), terms (2), site (2), you (2), non (2), was (2), with (2), categories (2), stub (2), source (2), ethynyl (2), related (2), help (2), information (2), also (2), tcs (2), unsorted (2), etifoxine (2), others (2), ether (2), chloroform (2), oxide (2), hydrate (2), propofol (2), tpa (2), 003 (2), 872 (2), dihydroyangonin (2), methoxyyangonin (2), cf3 (2), propoxate (2), baicalin (2), tetrabamate (2), febarbamate (2), difebarbamate (2), ro48 (2), pentanol (2), tert (2), butanol (2), knutson (2), daniel (2), smith (2), jodi (2), ping (2), xingjie (2), jin (2), xiaoming (2), mian (2), yeunus (2), sharmin (2), dishary (2), cerne (2), rok (2), cook (2), james (2), witkin (2), jeffrey (2), imidazodiazepine (2), novel (2), s2cid (2), pmid (2), issn (2), doi (2), 173321 (2), than (2), other (2), anxiolytic (2), inchi (2), appearance (2), upload (2), file (2), changes (2), links (2), history (2), read (2), log (2), create (2), account (2), donate (2), menu (2), add, topic, mobile, cookie, statement, statistics, developers, code, conduct, legal, safety, contacts, disclaimers, text, available, under, additional, may, apply, using, agree, registered, trademark, profit, organization, wikimedia, foundation, inc, use, creative, commons, attribution, sharealike, license, rendered, parsoid, last, edited, december, 2025, utc, hidden, all, different, containing, unverified, infoboxes, unii, kegg, cas, registry, number, matches, stubs, anxiolytics, anticonvulsants, gabaa, oxazoles, imidazobenzodiazepines, pyridyl, retrieved, https, index, php, title, oldid, 1330318034, can, adding, missing, metabolism, transport, signaling, see, 1205, 1105, mrk, 409, 0343, pinene, benzodiazepine, valerenol, valerenic, isovaleramide, isovaleric, valerian, topiramate, borneol, terpenoids, trional, tetronal, sulfonmethane, sulfonal, sulfonylalkanes, stiripentol, seproxetine, safranal, retigabine, ezogabine, propanidid, phenytoin, 435, ntx, 1955, 7308480, nicotinamide, nicotinic, nezavist, dcuk, oet, monastrol, menthyl, isovalerate, validolum, loreclezole, obovatol, magnolol, honokiol, methylhonokiol, lignans, lavender, oil, lanthanum, hopantenic, flupirtine, fluoxetine, tolfenamic, niflumic, mefenamic, flufenamic, fenamates, etazepine, efavirenz, ds2, ergoloid, dihydroergotoxine, dihydroergotamine, dihydroergosine, dihydroergocryptine, dihydroergolines, deuterated, deabl, darigabat, clomethiazole, chlormezanone, chloralose, carbamazepine, sodium, potassium, lithium, ivermectin, avermectins, alogabat, 29504, emtbl, hydroxybutanal, vinyl, trichloroethylene, trichloroethane, methyl, toluene, teflurane, synthane, sevoflurane, roflurane, propylene, propane, paraldehyde, norflurane, nitrous, nitrogen, nitric, methoxypropane, methoxyflurane, kerosine, isoflurane, halothane, halopropane, gasoline, fluroxene, ethylene, chloride, enflurane, diethyl, dichloromethane, dichloralphenazone, desflurane, cryofluorane, betaine, centalun, butylene, butane, benzene, aliflurane, acetylglycinamide, acetophenone, acetone, gases, volatiles, 164, nitromethaqualone, methylmethaqualone, methaqualone, mecloqualone, mebroqualone, etaqualone, diproqualone, cloroqualone, afloqualone, quinazolinones, tracazolate, ici, 190, 622, etazolate, cartazolate, pyrazolopyridines, pyrithyldione, piperidione, methyprylon, glutethimide, piperidinediones, thymol, hemisuccinate, fospropofol, cipepofol, phenols, 23684, viqualine, 90042, 89843a, 023, tgsc01aa, 3228, 205, 384, rwj, 51204, rod, 188, pipequaline, 11821, 11394, 2710, 2664, miltirone, rosmariquinone, lirequinil, ro41, 3696, 838, 417, 1232, imepitoin, gbld, 345, enx, 102, 023b, elb, 139, ctp, 354, 615, 218, 20625, 13767, 9896, 8216, axs, baer, 101, azd, 7325, adipiplon, zaleplon, taniplon, panadiplon, ocinaplon, lorediplon, indiplon, fasiplon, divaplon, pyrazolopyrimidines, zolpidem, saripidem, necopidem, alpidem, imidazopyridines, zopiclone, suriclone, suproclone, pazinaclone, pagoclone, eszopiclone, cyclopyrrolones, nonbenzodiazepines, zuranolone, thdoc, testosterone, 689, 516, 324, 105, renanolone, progesterone, pregnanolone, eltanolone, prax, 114, posovolone, 185, 21465, 20599, nora, 520, minaxolone, lpcn, 1154, hydroxydione, ganaxolone, etx, 155, etiocholanolone, dht, dhdoc, hydrocortisone, cortisol, cholesterol, certain, anabolic, androgenic, steroids, androsterone, androstenol, androstanediol, alfaxalone, alfadolone, allopregnanolone, brexanolone, acebrochol, neurosteroids, ectylurea, capuride, carbromal, bromisoval, apronal, apronalide, acecarbromal, monoureides, yangonin, dihydromethysticin, methysticin, dehydromethysticin, tetrahydroyangonin, dihydrokavain, hydroxykavain, kavain, methoxy, hydroxydehydrokavain, desmethoxyyangonin, hydroxyyangonin, kava, dichloro, fluoroetomidate, flutomidate, cf2, sec, iso, isopropoxate, methoxyetomidate, metomidate, imidazoles, wogonin, skullcap, ome, luteolin, linarin, hispidulin, egcg, egc, catechin, baicalein, apigenin, ampelopsin, dihydromyricetin, methylapigenin, flavonoids, tybamate, styramate, procymate, phenprobamate, pentabamate, nisobamate, meprobamate, mebutamate, lorbamate, hydroxyphenamate, hexapropymate, felbamate, ethinamate, emylcamate, cyclarbamate, clocental, carisoprodol, carisbamate, carbamates, zomebazam, zolazepam, zapizolam, uldazepam, tuclazepam, triflunordazepam, ro5, 2904, triflubazam, triazolam, tolufazepam, tetrazepam, temazepam, sulazepam, 053, ch3, 8684, 6791, ripazepam, rilmazafone, remimazolam, reclazepam, quazepam, pyrazolam, proflazepam, premazepam, prazepam, pivoxazepam, pinazepam, phenazepam, oxazolam, oxazepam, nortetrazepam, nordazepam, nitrazolam, nitrazepate, nitrazepam, nimetazepam, nifoxipam, desalkylflurazepam, motrazepam, midazolam, mexazolam, metaclazepam, menitrazepam, medazepam, meclonazepam, lormetazepam, lorazepam, loprazolam, lopirazepam, lofendazam, ketazolam, irazepine, imidazenil, iclazepam, haloxazolam, halazepam, gidazepam, fosazepam, flutoprazepam, flutemazepam, flutazolam, flurazepam, flunitrazolam, flunitrazepam, fludiazepam, flubromazolam, flubromazepam, fletazepam, 8205, etizolam, loflazepate, dirazepate, carfluzepate, estazolam, elfazepam, doxefazepam, dimdazenil, diclazepam, demoxepam, delorazepam, cyprazepam, 1414s, cloxazolam, clotiazepam, clorazepate, cloniprazepam, clonazolam, clonazepam, clobazam, climazolam, clazolam, cinolazepam, cinazepam, ciclotizolam, chlordiazepoxide, carburazepam, camazepam, brotizolam, bromazolam, bromazepam, bretazenil, bentazepam, avizafone, arfendazam, alprazolam, adinazolam, hydroxyphenazepam, oxoquazepam, benzodiazepines, vinylbital, vinbarbital, valofane, thiotetrabarbital, thiopental, thiobutabarbital, thiobarbital, thiamylal, thialbarbital, tetrabarbital, talbutal, spirobarbital, sigmodal, secobarbital, reposal, proxibarbital, propylbarbital, propallylonal, probarbital, primidone, phetharbital, phenobarbital, phenallymal, pentobarbital, nealbarbital, narcobarbital, methylphenobarbital, methohexital, methitural, metharbital, methallatal, hexobarbital, hexethal, heptobarbital, heptabarb, eterobarb, ethallobarbital, enallylpropymal, cyclopentobarbital, cyclobarbital, crotylbarbital, carbubarb, butallylonal, butobarbital, buthalital, butalbital, butabarbital, secbutabarbital, brophebarbital, brallobarbital, benzylbutylbarbiturate, benzobarbital, barbital, barbexaclone, aprobarbital, amobarbital, alphenal, allobarbital, dmbb, barbiturates, trifluoroethanol, triclofos, trichloroethanol, tribromoethanol, 2m2b, 2m2p, propanol, petrichloral, methylpentynol, methanol, menthol, isopropanol, isobutanol, ethchlorvynol, alcoholic, drink, ethanol, alcohol, chlorobutanol, cloretone, chloralodol, brometone, alcohols, golani, lalit, guanguan, tiruveedhula, phani, babu, rashid, farjana, jahan, rajwana, 2020, produces, like, antiseizure, 2637, 221123396, 32786313, 1948, 7193, 1805, 28047, hdl, 1021, acschemneuro, 0c00295, 2624, acs, neuroscience, lippa, arnold, biggerstaff, andrew, kivell, bronwyn, pandey, kamal, february, 2022, 245963990, 35041859, 1873, 5177, 1016, pbb, 2021, 213, pharmacology, biochemistry, behavior, example, newly, emerging, generation, gabakines, neurological, psychiatric, disorders, study, shown, better, treating, seizures, selective, subunits, displays, however, less, adverse, some, low, sedation, tolerance, development, pams, antidepressant, alpha3, alpha2, allosteric, modulator, compound, infobox, except, where, otherwise, noted, data, are, given, materials, their, 100, kpa, standard, state, mol, 351, 369, molar, mass, formula, properties, cc1, cc2, n3c, c3cn, c2c4, co5, smiles, key, kncuewywbuiftq, uhfffaoysa, c21h13n5o, 13h, 10h2, 122582003, cid, pubchem, 76742771, chemspider, chembl4062225, chembl, interactive, image, model, jsmol, identifiers, pyridin, imidazo, benzodiazepin, oxazole, iupac, name, names, free, encyclopedia, item, projects, printable, version, download, pdf, print, export, switch, legacy, parser, get, shortened, url, cite, permanent, link, what, here, general, actions, english, talk, اردو, top, personal, special, pages, recent, community, portal, learn, contribute, random, current, events, navigation, jump, content,
Text of the page (random words):
krm ii 81 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references toggle the table of contents krm ii 81 1 language اردو edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia novel anticonvulsant and anxiolytic krm ii 81 1 names iupac name 5 8 ethynyl 6 pyridin 2 yl 4h imidazo 1 5 a 1 4 benzodiazepin 3 yl 1 3 oxazole identifiers 3d model jsmol interactive image chembl chembl4062225 chemspider 76742771 pubchem cid 122582003 inchi inchi 1s c21h13n5o c1 2 14 6 7 17 15 9 14 20 16 5 3 4 8 23 16 24 10 18 21 25 12 26 17 18 19 11 22 13 27 19 h1 3 9 11 13h 10h2 key kncuewywbuiftq uhfffaoysa n smiles c cc1 cc2 c c c1 n3c nc c3cn c2c4 cc cc n4 c5 cn co5 properties chemical formula c 21 h 13 n 5 o molar mass 351 369 g mol 1 except where otherwise noted data are given for materials in their standard state at 25 c 77 f 100 kpa infobox references chemical compound krm ii 81 is a positive allosteric modulator of the gaba a receptor it is selective for the alpha2 and alpha3 subunits krm ii 81 displays anxiolytic antidepressant and anticonvulsant effects however it has less adverse effects than some other gaba a pams it has low to no sedation and no tolerance development 2 a study has also shown krm ii 81 to be better at treating seizures than diazepam 3 references edit krm ii 81 witkin jeffrey m lippa arnold smith jodi l jin xiaoming ping xingjie biggerstaff andrew kivell bronwyn m knutson daniel e sharmin dishary pandey kamal p mian md yeunus cook james m cerne rok february 2022 the imidazodiazepine krm ii 81 an example of a newly emerging generation of gabakines for neurological and psychiatric disorders pharmacology biochemistry and behavior 213 173321 doi 10 1016 j pbb 2021 173321 issn 1873 5177 pmid 35041859 s2cid 245963990 knutson daniel e smith jodi l ping xingjie jin xiaoming golani lalit k li guanguan tiruveedhula v v n phani babu rashid farjana mian md yeunus jahan rajwana sharmin dishary cerne rok cook james m witkin jeffrey m 2020 09 02 imidazodiazepine anticonvulsant krm ii 81 produces novel non diazepam like antiseizure effects acs chemical neuroscience 11 17 2624 2637 doi 10 1021 acschemneuro 0c00295 hdl 1805 28047 issn 1948 7193 pmid 32786313 s2cid 221123396 v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valerenic acid valerenol unsorted benzodiazepine site positive modulators α pinene mrk 409 mk 0343 tcs 1105 tcs 1205 see also receptor signaling modulators gaba receptor modulators gaba metabolism transport modulators this anticonvulsant related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title krm ii 81 oldid 1330318034 categories 2 pyridyl compounds imidazobenzodiazepines oxazoles gabaa receptor modulators ethynyl compounds anticonvulsants anxiolytics anticonvulsant stubs hidden categories articles with short description short description matches wikidata chemical articles without cas registry number articles without kegg source articles without unii source articles containing unverified chemical infoboxes short description is different from wikidata all stub articles this page was last edited on 30 december 2025 at 19 08 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents krm ii 81 1 language add topic
|
