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that guy from ff that guy from ff https www patreon com onigumo paypal me feedonigumo cash me botanicalog i d rather you not reblog if your tumblr is full of dicks or vaginas or assholes 36 straight demi gainer feedee with huge fantasies p s don t call me pig hog etc p p s for only pics vids search ssbhm home archive subscribe rss tell me stuff submit a post random post catching elephant is a theme by andy taylor thelostskeleton urie calling dolly parton a country singer is like calling jesus christ a carpenter it is technically true but theres a lot more you could say this person put it into perspective in a way that made me stop and sit down with it for a bit because yeah exactly originally from urie reblogged from comingupwurlsisnotmything permalink posted 14 hours ago tweet this 53 765 notes segamascott originally from segamascott reblogged from skipperdamned ed you gotta get her the wine man permalink posted 15 hours ago tweet this 3 289 notes wizardarchetypes wizardarchetypes got attacked b y 2 dogs last night but only one of em got me while i was picking up a free item from my neighbor and i can t stop saying well actually it wasn t free it cost ️ 1 dog bite okay after speaking to my gp on the phone just now it turns out it will also cost ️ ferry ticket to the hospital for a rabies vax originally from wizardarchetypes reblogged from skipperdamned permalink posted 15 hours ago tweet this 1 058 notes punkahudsonia ospreyonthemoon alexaloraetheris hecksadecimal alexaloraetheris homunculus argument i can understand how modern person thrown into the past gets by pretending to be a healer doctor is as surprisingly common of a trope as it is i mean i m fluent enough at bullshitting to be pretty sure i could pull it off to impersonate a doctor in any time pre 1800s if i have no idea what something is or how to treat it i could just get the opinion of the other whatever passes as medical professionals around but if their suggestions sound like bullshit i m not doing it and i ll beat the shit out of anyone suggesting bloodletting or mercury with my healing stick i ve tied little bells on it that jingle comically with every smack the awesome curative powers of my healing stick come from two separate sources placebo and me using it to beat anyone trying to give my patients mercury ooooh you reminded me of that protocol i wrote about how to reinvent penicilin with only alchemical tools you know just in case i did end up dumped in the past and needed a stable income w what s the protocol i am so glad you asked i unfortunately lost the protocol because it was probably on my laptop but i remember the broad strokes so in case anyone does end up stuck in the middle ages and can find a kindly old alchemist willing to lend you his gear here s the revamped penicilin re discovery protocol 0 wash your goddamn hands we re not working in a lab here cross conatamination will happen your job is to minimize it as much as possible if you end up in a place where soap hasn t been invented yet wash your hands in distilled alcohol your skin won t thank you but you can afford all the nice hand creams after you cure the plague and get rich find some penicillium mushrooms yes penicilin is produced by mushrooms though ascomycotes are usually called moulds it s a fungus and it makes me laugh to call it a mushroom plus in the middle ages mushrooms were known to have medicinal properties so you ll get a lot farther by calling them mushrooms rather than molds first thing you need mouldy fruit oranges or cantaloupes are preferred here s the thing mold is everywhere so getting it will be the easiest part the tricky part start with identifying the correct mold you don t want to feed your patients black mold do you so leave some fruit out the more the better because you want to up your chances then let it rot in warm and humid places after a while pick any fruit that looks white on the outside and green in the middle not the best picture but that s what it should look like 2 transplanting your potential penicillium mushrooms until you get it on a plate it s damn near impossible to tell which mold you got get ready for some trial and error because you will have to sift through a lot of unwanted mold you might want to wear a mask first you need something to transplant it onto making modern agar plates is probably impossible but thankfully not needed you just need glass plates the kind that can be closed you want to minimize cross contamination 1 2 cup of hot water preferably distilled ask your alchemist if he can do that 1 cup whole milk should be 13g of lactose per cup if your penicillium won t grow adjust the water milk ration in favor of milk if available instead of milk use corn steep liquor unfortunately only available after america was discovered so ymmw but penicillium loves this stuff it will make your life so much easier if it s available pinch of salt 1 teaspoon yeast extract get it from a baker 3 6 teaspoons gelatin get it from a butcher disclaimer the ratio of each of the ingredients will have to be adjusted depending on the purity of the ingredients and on the conventional measuring sizes of the place you end up gently mix it all in and pour out into the plates let it solidify if you end up dumped far enough that such refinement isn t possible make bone broth and strain it through cheesecloth several times to make it as clear as possible then mix it 5 6 broth and 1 6 milk again if available use corn steep liquor but if not milk is fine add gelatin should still be able to get it from the butcher as needed to solidify it i m afraid experimentation will be needed depending on the resources you will be working with when you re done you should have something like this now that you have your plates run an inoculation loop through a flame to sterilize it something like this wave it through the air to cool it so you don t kill your mold grab it from your fruit and geeeeeently spread it on top of your improvised agar without breaking the surface of the gelatin you can see the motions on this one pretty well close your plates stack them about a meter 3ft from the fireplace judge for yourself but ideally somewhere you would consider comfortably warm 20 24 c 3 identifying your penicillium mushrooms if all went well you are going to have something that looks like this well realistically it will look something like this we re not actually doing it in a lab after all but ideally it will look like the above it doesn t have to be perfect you just need to be able to identify penicillium molds for now ideally on the plate that matches the description of the penicillium mold you ll see an exclusion zone of bacteria around the mold like the fourth plate in the second row so you know you have a potential winner but if you managed to avoid bacterial growth you need to take a few extra steps penicillium molds have characteristic rings of growth grey green white rings they re easy to differentiate from bacteria because the molds are fuzzy and the bacteria as smooth and slimy in the above picture there are four plates that potentially have what we want and two are less certain than others wash out the unwanted ones make new agar plates sterilize your inoculation loop and transplant your best candidates you might need to do this several times two types are confirmed to produce penicilin p chrysogenum and p rubens the former is far more widely used today but since we re sourcing them from literally thin air we re more likely to get p rubens but unless you re a mycologist you probably won t be able to tell the difference thankfully you won t need to because they both produce penicillin which brings me to the next step 4 confirming it s the penicillin producing mushroom we re gonna need more agar plates for this one and believe it or not you re gonna need to mix blood into your agar wash your hands throughly theoretically you can get away with just milk but identifying the correct bacterial colony on white agar is going to be a nightmare so just add some sheep blood to your agar conventionally it s about 5 by volume but you might need more to make it you need some gram positive bacteria preferably of the bacillota type please don t go out and find a patient with fucking botulism or tetanus you need to live long enough to make the cure instead if you have a vagina scrape some of the white mucousy stuff from there and plant it on your plate if you don t have your own vagina a borrowed one is fine penicilin also works on treponema pallidum so if you get a syphilis affected prostitute that should also work just wear gloves ideally you get something like this this is actually lactobacillus brevis but lactobacillus colonies all look relatively the same the important thing is that it s all gram positive and will therefore be affected by penicillin take new plates again plant your penicillium mold in the middle and the bacteria all around it getting as close to the center as possible you can put down a paper marker for the mold wait for about 20 days ideally on at least one plate you will get something like this this is literally a textbook example of testing antibiotics but the zone of inhibition is what you re looking for it means the mold is releasing a compound to kill the competing bacteria for resources in this case beta lactam antibiotic or penicillin make sure to pick the one with the widest zoi because that s the one that produces most penicillin so now we have the root stock but our problems have just begun this is the part where you re absolutely going to need an alchemist s help the problem is that a human body is not a petri dish it s quite a bit larger and you want the good bacteria destroying stuff without all the nasty contaminants so you need a shitload of mold producing a lot of penicillin and then you need a way to filter it you are going to need actual lab equipment for that or near as they had it since i lost the original protocol i m going to need to do research all over again how to do that with alchemy equipment or at least a microbrewery so that will be in the next installment fascinating concept generic fantasy adventure where the wizard has a crackpot assistant and he explains sadly that while hreithbert is an excellent person for keeping the wizard tower tidy and the homonculi fed they re obsessed with cooking like ten million plates of inedible goop but it makes them happy so he permits it and at the end of the story the big reveal is hreithbert is a time displaced biochemist who has finally fucking refined their process for penicillin originally from homunculus argument reblogged from comingupwurlsisnotmything permalink posted 15 hours ago tweet this 64 081 notes cyber christ originally from cyber christ reblogged from tymorrowland permalink posted 18 hours ago tweet this 5 298 notes bogmonstergirl snowing in cyberspace originally from snowing in cyberspace reblogged from spejoku permalink posted 18 hours ago tweet this 105 577 notes blumineck the vast majority of you all are lovely but some people out there never learned to play nicely with women and it shows originally from blumineck reblogged from spejoku permalink posted 18 hours ago tweet this 27 999 notes doggiedyke memewhore peace and love on planet earth originally from memewhore reblogged from spejoku permalink posted 18 hours ago tweet this 176 900 notes frootfrooot gluttonygirls the reason they call it a crush is because you want them to be fat enough to crush you originally posted by tartrazeen originally from gluttonygirls reblogged from smandraws what i m hearing is i m crush worthy permalink posted 18 hours ago tweet this 1 820 notes wayneradiotv wayneradiotv can someone post cid banana i do everything myself originally from wayneradiotv reblogged from spejoku permalink posted 19 hours ago tweet this 33 029 notes older