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also first time those concepts will continue reading aging health disease more than philosophical arguments agecurve limited and gen p my business angle on aging and longevity january 2 2017 january 2 2017 posted in business longevity partial immortalization after 20 something years of living a diverse educational and professional life motivated by healthy lifespan extension and dominated by science and technology i have reached the riskiest and most rewarding phase launching a business around it and making it real i have founded a startup called agecurve limited and we are already offering a product continue reading agecurve limited and gen p my business angle on aging and longevity 1 day apache spark training randomish insights february 9 2015 february 9 2015 posted in partial immortalization last week i ve participated in a one day apache spark workshop in london developed by databricks and organised by big data partnership databricks training resources is the most important link you need to know in order to get started contains the whole training material let me share some short comments spark is the next logical generalised step leveraging the continue reading 1 day apache spark training randomish insights distributed computing hadoop mapreduce spark big list of markov chain monte carlo mcmc applications december 29 2014 december 30 2014 posted in partial immortalization i became quite obsessed with markov chain monte carlo methods lately it is said that mcmc methods form the most frequently used class of algorithms in computer science however when i was searching for a comprehensive list of mcmc applications across different domains to my surprise i have found none so i d like to ask continue reading big list of markov chain monte carlo mcmc applications mcmc sampling simulation human longevity inc and calico healthy lifespan extension is a win win game and a competition against time december 21 2014 december 21 2014 posted in biotechnology business calico hli longevity partial immortalization a snippet from the following interview the regeneration generation a conversation with bob hariri vice chairman and co founder of human longevity inc hadoop 101 for bioinformaticians 1 hour crash course code and slides november 29 2014 december 1 2014 posted in partial immortalization earlier this year february april i ran 9 short 1 hour hands on sessions 5 persons session called hadoop 101 for bioinformaticians at the genome campus for european bioinformatics institute and sanger institute people the participants were bioinformaticians developers and sysadmins my idea was to start with a 20 minutes long theoretical introduction so it provides some handles on whether continue reading hadoop 101 for bioinformaticians 1 hour crash course code and slides bioinformatics hadoop mapreduce crowdsourcing google s new mission statement newgooglemissionstatement november 3 2014 november 3 2014 posted in partial immortalization larry page acknowledges in a recent interview that the google s mission statement is outdated and became irritatingly narrow google mission statement changing the game absolute protein quantification by relating histone mass spec signals to dna amounts and cell numbers september 17 2014 september 17 2014 posted in bioinformatics biology proteomics quantification one thing system biologists want is to have by and large absolute protein concentrations or copy numbers per cells available cheaply for their models leveraging all sorts of omics data looks like such results can now be easily delivered based on a study published on the 15th of september by the mann lab in molecular cellular continue reading changing the game absolute protein quantification by relating histone mass spec signals to dna amounts and cell numbers pleasingly parallel mcmc cracked wide open for mapreduce and hadoop march 9 2014 february 14 2015 posted in partial immortalization mcmc methods guarantee an accurate enough result say parameter estimation for a phylogenetic tree but they give it to you usually in the long run and many burn in steps might be necessary before performing ok and if the data size grows larger the number of operations to draw a sample grows larger too n o n continue reading pleasingly parallel mcmc cracked wide open for mapreduce and hadoop bioinformatics computer science hadoop mapreduce markov chain monte carlo mcmc 2 recent global alliance for genomics and health standard candidates adam and google genomics march 3 2014 march 6 2014 posted in partial immortalization global alliance for genomics and health includes 150 health and research organizations to progress accelerate secure and responsible sharing of genomic and clinical data ga4gh for short is something you will here about more and more in the short term future in the context of genomics standards think of mainly data formats and code to access and process continue reading 2 recent global alliance for genomics and health standard candidates adam and google genomics genomics global alliance for genomics and health google standards 3 recent hadoop mapreduce applications in the life sciences rna structure prediction neuroimaging genetics eeg signal analysis february 26 2014 february 26 2014 posted in partial immortalization 3 open access papers 3 prototypes source code available only for 1 healthy diversification of topics 1 enhancement of accuracy and efficiency for rna secondary structure prediction by sequence segmentation and mapreduce code available haven t found it referenced in the paper our previous research shows that cutting long sequences into shorter chunks predicting secondary structures of continue reading 3 recent hadoop mapreduce applications in the life sciences rna structure prediction neuroimaging genetics eeg signal analysis biology clinical data hadoop life sciences mapreduce google invests into dnanexus aging driven big data bioinformatics without the hadoop ecosystem january 3 2014 january 4 2014 posted in calico genomics google partial immortalization first time dnanexus made me think a little about what they can achieve was when they came up with an alternative search and browse interface for the complete sequence read archive sra database they came to the rescue as ncbi discontinued sra in 2011 although later they ve changed their mind so sra is still up and running there continue reading google invests into dnanexus aging driven big data bioinformatics without the hadoop ecosystem calico dnanexus genomics google hadoop mapreduce proteomics coming of age for proteogenomics 10 less human protein coding genes based on mass spec proteomics data december 30 2013 posted in partial immortalization guessing the number of real protein coding genes is an ancient bioinformatics game and now a new argument newish research field has been applied to this problem proteogenomics can refer to different type of studies but the basic idea is that mass spectrometry peptide protein evidences are used to improve genome annotations now a joint spanish continue reading coming of age for proteogenomics 10 less human protein coding genes based on mass spec proteomics data genomics human mass spectrometry protein coding genes proteogenomics proteomics three links in aging regenerative medicine healthy lifespan extension 17 december 2013 december 17 2013 posted in aging bioinformatics biology calico cancer epigenetics life extension partial immortalization 1 dna methylation age of human tissues and cell types by steve horvath this is the type of relevant data mining study most bioinformaticians are dreaming of you pull together a large body of publicly available datasets cpg methylation that are not too heterogeneous infinium type ii assay on illumina 27k or illumina 450k array platform derive robust continue reading three links in aging regenerative medicine healthy lifespan extension 17 december 2013 three links in aging regenerative medicine healthy lifespan extension 8 december 2013 december 7 2013 december 7 2013 posted in aging biology fda life extension 1 is aging linear or does it follow a step function a good simple question on quora that surprised even aubrey de grey if you are a bioinformatician out there looking for a new pet project go pull together some data try to plot it let me know if you have something continue reading three links in aging regenerative medicine healthy lifespan extension 8 december 2013 calico three links in aging regenerative medicine healthy lifespan extension 24 november 2013 november 24 2013 posted in partial immortalization introducing a new post format by reutilising nat torkington s four short links format over at o reilly radar thanks nat 1 the hallmarks of aging good review by european scientists trying to put some pieces next to each other but not necessarily together the 9 hallmarks are genomic instability telomere attrition epigenetic alterations loss of proteostasis continue reading three links in aging regenerative medicine healthy lifespan extension 24 november 2013 aging lifspan extension regenerative medicine stem cells how to build a colorful life around life extension using different skills a personal story october 9 2013 october 9 2013 posted in aging career life extension partial immortalization personal here s an edited version of my quora answer to the question life decisions how do people who are talented in many areas decide what to do with their lives let me provide a personal story illuminating one option ruchira is talking about pick a complex challenge that you are passionate about that will require many different continue reading how to build a colorful life around life extension using different skills a personal story lavaamp cheapest pocket pcr thermocycler dreamed for diy biologists october 31 2009 october 31 2009 posted in biodiy biohacking biology biotechnology diy dna geek open science sci foo science science hacks scifoo 108 comments the lavaamp is a portable pcr thermocycler that has the potential to become the default garage biology home biology biodiy diybio tool once it hits the market think of apple ii for personal computing or makerbot for 3d printing the 1st lavaamp prototype was shipped this week from biodesic to gahaga biosciences and the process continue reading lavaamp cheapest pocket pcr thermocycler dreamed for diy biologists aging centric genetic health database in california 100k people 65yrs 700k snps telomeres too october 21 2009 october 21 2009 posted in aging california genetics genomics science usa 15 comments kaiser permanente alongside with ucsf plans for genetic analyses of an unprecedented 100 000 older californians the technology review writes in massive gene database planned in california the effort will make use of existing saliva samples taken from california patients whose average age is 65 their dna will be analyzed for 700 000 genetic variations called single nucleotide continue reading aging centric genetic health database in california 100k people 65yrs 700k snps telomeres too sage bionetworks update building an oa standard for human disease biology october 8 2009 october 8 2009 posted in bioinformatics biology science usa 18 comments sage bionetworks is a not for profit organization developing an open access pre competitive platform for networked and annotated models of human disease it s a huge and unparalleled bioinformatics enterprise starting with an anonymous 5 million donation and soon making high throughput large scale human and mouse biological data largely from merck available in the range that s already in the continue reading sage bionetworks update building an oa standard for human disease biology sage the nobel prize in physiology or medicine 2009 telomere telomerase blackburn greider szostak october 5 2009 october 5 2009 posted in aging cancer cell biology science marketing 16 comments for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase press release the award goes to elizabeth h blackburn carol w greider and jack w szostak the problem of telomere telomerases is highlighting the double but strictly related aging cancer problem space blackburn lab greider lab szostak lab top 10 plos articles based on online usage september 16 2009 posted in open access science 17 comments big news at plos today mark patterson announced on the plos blog that as part of our ongoing article level metrics program we re delighted to announce that all seven plos journals will now provide online usage data for published articles i downloaded the entire dataset and as a starter sorted it according to combined usage continue reading top 10 plos articles based on online usage plos mapping neurons without glial cells snp genotyping w o whole sequencing may 3 2009 may 4 2009 posted in biology genomics nature neural personalized genomics science 10 comments nature s journal club column is usually a good always a short read providing exciting angles on scientific topics papers from good researchers recently neuroscientist dave featherstone argued for a broader approach to brain mapping by not restricting it only to the connectome between neurons neurons are making up less than 10 of the human brain continue reading mapping neurons without glial cells snp genotyping w o whole sequencing visualize 23andme haplogroup defining snps with mitowheel april 7 2009 april 8 2009 posted in 23andme genetics genomics mitochondria mitowheel personalized genetics personalized genomics 33 comments last friday 23andme came up with haplogroup tree mutation mapper which is the first experimental feature that can be instantly tested by biogeek customers a large portion of the company s customer base in its freshly launched technology sandbox 23andme labs that is much like google labs haplogroup tree mutation mapper shows you which particular mutations continue reading visualize 23andme haplogroup defining snps with mitowheel bright cells big city cellular images hit broadway march 10 2009 march 10 2009 posted in biology image innovation new york photo science animation science marketing usa 6 comments surprise email from conor mckechnie ge healthcare proving the aesthetics of science and the value of blogging a while back you posted an inspiring piece linking to harvard s biovisions inner life of the cell it was 2006 it got me thinking that we could do something similarly inspiring with actual cellular images entered into continue reading bright cells big city cellular images hit broadway why the dyna vision g1 android telemedicine app can only be used by licensed physicians march 3 2009 march 3 2009 posted in biodiy diy future gadget geek medicine regulation technology 14 comments let us assume that you are a technological early adopter a maker a hacker a geek your software hardware skills and experiences are much better than the bulk of licensed physicians you also have a g1 now imagine a mobile application gadget in a belt pouch that is the most ad...