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description=Advancing RNA is a Life Science Connect community focused on the rapidly evolving field of RNA-based therapeutics. It aims to provide valuable insights, discussions, and resources for professionals developing RNA-based drugs. Primary members of the community consist of individuals from biopharma organizations engaged in pre-BLA development, often in the pre-IND discovery stage. The community addresses various challenges in RNA therapy development, including analytical, quality, manufacturing, and regulatory issues. Additionally, Advancing RNA is positioned within the broader Life Science Connect network, allowing members to access additional resources as needed for their RNA therapy development journey.;

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advancing rna get more advancing rna insight with our free newsletter sign me up log in or subscribe analytical quality manufacturing formulation outsourcing clinical trials supply chain watch now advancing rna live events advancing rna live precision medicine world conference pmwc arw on rna inside the in vivo car t boom where does mrna fit in i had the chance to sit down with parcelbio s ceo david weinberg to learn more about the emerging market dynamics in the in vivo car t space with a particular focus on the challenges facing rna biotechs looking to navigate this up and coming therapeutic class what oligo manufacturing risks are we underestimating what baby kj taught us about patient physician communication what baby kj taught us about mrna cogs more from arw on rna our expert network antibody oligonucleotide conjugates part 2 manufacturing let s delve into manufacturing strategy conjugation chemistry process development and scale up and purification the central manufacturing challenge cdmos co author the rna ecosystem praise to the rna innovators and our innovative service providers you ve brought us a long way still that progress hasn t necessarily made it easier to strategize the outsourcing of specific rna based projects we ve expanded development programs therapeutically and dialed up nuanced production requirements so the current question is what will the rna outsourcing ecosystem look like a few years from now here s some expert analysis antibody oligonucleotide conjugates part 1 approaching your aoc development plan the emergence of antibody oligonucleotide conjugates aocs addresses delivery issues with huge potential let s look at how to approach your development plan with molecular architecture defining the target product profile and cqas can engineering the passenger strand improve sirna performance how can we make the passenger strand easier to reject while keeping the sirna duplex sufficiently stable before it reaches the machinery that activates it the external partners delivering the components of rna therapies rna based therapeutics is now a diverse and wide field of application outsourcing the components of these programs is challenging executives at the society for rna therapeutics srt say assembling an entire supply chain can soak up time and resources which partners to select depends on what area of rna development you are pursuing a fundamental task before all rna sponsors is thinking deeply in terms of assembling development and manufacturing ecosystems starting at the earliest stages of research and company formation more from our expert network webinars developing custom gmp lipids a patient driven partnership scaling aav manufacturing to 1000 l strategies for robust and reproducible production apac scaling aav manufacturing to 1000 l strategies for robust and reproducible production mastering the path developing processes for successful clinical grade mrna manufacturing accelerating lnp process development with impinging jet mixing sterilizing grade filtration of mrna encapsulated lipid nanoparticles role of membrane chemistry and filter format in tff enhancing mrna lnp downstream processing via single pass tff more from webinars get the latest articles from advancing rna delivered to your inbox i agree to the terms i agree to the privacy policy sign me up meet arw i ve spent the past 10 years building relationships across the biologics and advanced therapies industry in addition to hosting conversations and writing thought leadership articles my goal as the editorial and community director for advancing rna is to find creative ways for the rna and broader atmp space to discuss debate and ultimately define a mature rna therapeutics industry start the conversation by following me on linkedin rna hot takes sticks carrots carolina reapers fact checking the death of the us mrna industry mrna hot takes ghost peppers global r d mrna hot takes habaneros headwinds the trough of disillusionment 2026 rna reality checks mrna hot takes fighting complacency and alternative facts in 2026 mrna hot takes building a solid foundation for your rna company products virtual events nobody puts plasmid in a corner essential considerations for mrna production the mrna therapeutics regulatory paradigm a closer look evolutions in mrna drug product analytical development closing the adoption gap for advanced single use materials advancements in grna manufacturing quality chemoenzymatic ligation a new frontier in sirna manufacturing more virtual events newsletter archive 10 15 26 which viral clearance step delivers the highest lrv 10 14 26 better translatability higher capping ultra low dsrna 10 14 26 what oligo manufacturing risks are we underestimating 10 07 26 what s driving the next wave of genome editing 10 07 26 analytical methods to watch in mrna lnp development 10 03 26 advancing rna newsletter best of september more newsletters partner with us request more information subscribe 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what topics interest you check all that apply each it personas pers index if index 2 0 if if pers isselected pers text else pers text if if index 2 0 index 0 if each if it personas length 2 0 if elif it subscriptions length you may also be interested in these industry newsletters each it subscriptions sub index if index 0 if index 2 0 if if sub isselected sub text else sub text if if index 2 0 if if each if it subscriptions length 2 0 if select all if finish