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home charm therapeutics skip to main content search close search menu menu addressing resistance in aml with a best in class menin inhibitor discover we are delivering transformational medicines through the understanding of protein ligand interactions new generation of menin inhibitors most acute myeloid leukemia aml therapies try to kill leukemic cells but what if you could reprogram them instead preventing the interaction that keeps them cancerous that s the promise of menin inhibitors charm is taking this one step further with its next generation best in class menin inhibitor designed to address resistance observed with first generation menin approaches and deliver a durable treatment to patients our approach navigate to the next section founded by leaders with a track record in ai and drug discovery the charm team is advancing its next generation menin inhibitor into the clinic to transform patient outcomes for aml charm has designed structurally optimised inhibitors that are highly potent and bind precisely within the kmt2a interface on menin about charm therapeutics 7 pancras sq london n1c 4ag info charmtx com b900 babraham research campus cambridge cb22 3at info charmtx com privacy policy cookies policy data protection complaints form consent preferences 2026 charm therapeutics ltd close menu home our approach about news contact charm therapeutics