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clinical psychology and psychiatry a closer look experimercials skip to main skip to sidebar clinical psychology and psychiatry a closer look psychiatric medications science marketing psychiatry in general and occasionally clinical psychology questioning the role of key opinion leaders and the use of science to promote commercial ends rather than the needs of people with mental health concerns friday december 15 2006 experimercials i have pointed out on many occasions that psychiatric research showing minimal to modest effects gets overhyped heavily by both drug companies and academic researchers for example see my post on injectable abilify from a couple days ago it made me think about a somewhat snarky letter to the editor by bernard carroll published in the american journal of psychiatry a couple years ago it s worth reading both his letter page 4 and the authors response page 5 go here to check it out remember folks if a trial has a huge number of participants a trivial difference between the drug and placebo will be labeled as statistically significant but don t be fooled we must also know the magnitude of the effect and as i ve noted on many occasions such as here here and here the size of the treatment effect is often fairly unimpressive i must include one quote from carroll s letter the study has all the hallmarks of an experimercial a cost is no object exercise driven by a corporate sponsor to create positive publicity for its product in a market niche this is reminiscent of the arise rd risperdal as an add on treatment for depression study that i have written much about recently here here and here in which relatively minimal treatment effects were seen yet the accompanying press release and indeed much of the discussion in the article itself is overly optimistic regarding the treatment posted by cl psych at 12 15 2006 05 20 00 am 2 comments james gaulte said thanks for introducing me to term experimercial one of the recurrent themes i have thought about and blogged about is the at times very sophisticated and not that easy to detect mis use of evidence based medicine to cook the books of clincial trials and hype the results friday december 15 2006 6 47 00 am cl psych said thanks for your interest dr gaulte i also enjoyed looking around your site i ll be back for more monday december 18 2006 10 57 00 am post a comment newer post older post home subscribe to post comments atom email email me blog archive 2011 1 february 1 2010 8 october 1 may 1 april 1 march 3 february 1 january 1 2009 33 december 1 october 1 september 2 august 1 july 4 june 4 may 2 april 5 march 5 february 2 january 6 2008 103 december 3 november 2 october 7 september 9 august 8 july 5 june 6 may 8 april 14 march 11 february 13 january 17 2007 328 december 11 november 16 october 14 september 24 august 8 july 11 june 23 may 31 april 31 march 37 february 59 january 63 2006 219 december 59 youthful tendency disorder on the rise vns therapy debate continues i m back sort of taking a break more on fda and ssri suicide link tmap part 2 tmap part 1 a vns debate zyprexa getting yet more furious nyt editorializes on zyprexa zyprexa it s getting furious zyprexa there s more corcept get rich quick seroquel cures all zyprexa coverup exposed could agomelatine be the ideal antidepressant experimercials more on fda conflicts of interest fda to issue stronger warning on antidepressants dumbest thing ever fda ssri panel and conflicts of interest agitating research using the best spin possible can ssris cause suicide the fda says mark your calendars so little time thank you mr dawdy uh oh chuck they out to get us man authorship again sunderland admits guilt new york says no to vns email problems the bad psychiatrist blog sexual side effects of ssris even more troubling peter rost wow iloperidone saves the day congrats to kazdin good reader comment a good week for atypical antipsychotics go blackwell more on lexapro vs cymbalta cymbalta and zyprexa good news a silver bullet lexapro beats cymbalta this is depressing more conflicts of interest advocating for patients and or drugs effects the size of bolders meet the last psychiatrist try this on for sleazy seroquel is great drug safety monitoring anyone gsk commence phiring well duh alpha 2 agonists for ptsd nope therapeutic relationship and bipolar disorder outc is it really depression the end is near paxil in pregnancy cost benefits of new schizophrenia drugs doubted november 69 october 48 september 43 academia bitch ph d crooked timber inside higher ed pharma general brandweeknrx edrugsearch gooznews health care renewal jim edwards nrx dr peter rost pharma blogosphere pharma giles pharmagossip pharmalot pharma marketing blog world pharma news psychiatry and psychology david healy s adventures furious seasons the last psychiatrist the macguffin mind hacks psychsplash psychcentral seroxat secrets treatments online organizations center for science in the public interest healthy skepticism pharmedout social audit scientific misconduct alliance for human research protection scientific misconduct blog about me cl psych i m an academic with a respectable amount of clinical experience and no drug industry funding given my lack of time don t expect multiple daily updates certain things about clinical psychology the drug industry psychiatry and academics drive me nuts and you ll probably pick up on these pet peeves before long view my complete profile translate this page select a language english to spanish english to french english to german english to portuguese english to italian english to chinese english to russian english to japanese english to arabic onchange subscribe via email enter your email powered by feedblitz