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Text of the page (random words):
lly drug 138 on placebo and 62 on lexapro br br but wait here comes the good news br blockquote both ly2216684 and escitalopram showed statistically significant improvement from baseline on the patient rated qids sr total score compared to placebo the results of this initial investigation of ly2216684 s efficacy suggest that span style color ff0000 it may have antidepressant potential span br blockquote the good news for lilly is that most people who claim to read journal articles really just browse the abstract without actually looking at the full text of the paper for the select few who have nothing better to do than read lilly propaganda take a look at table 2 a total of 12 secondary outcome measures are listed the lilly drug beat placebo on one of them lilly doesn t say much about how much better their drug was than placebo on the qids sr measure beside throwing around that often meaningless term of statistically significant people on the drug improved by 10 2 points whereas placebo patients improved 8 3 points so about a 20 difference if you bother to calculate an effect size it is d 24 which is quite small and clinically insignificant so on the one measure where the drug was better than placebo it was by a small margin and it missed the mark on 11 other secondary measures as well as on the primary outcome measure but it may have antidepressant potential hell yes i ve never been so exited about a new drug br br by the way lilly is apparently trying this wonder drug out in at least a href http clinicaltrials gov ct2 results term ly2216684 id yidi title five trials five trials a the journal in which this article appeared has published other a href http clinpsyc blogspot com 2008 09 cymbalta schatz storm duplicate html id ek6v title dubious eli lilly research dubious eli lilly research a in the past the editorial review process is clearly working wonders over at the journal of psychiatric research sad really the journal publishes some really good work but then runs this kind of junk as well br br b depression self report sidebar b the self reported measure on which the drug had an advantage the quick inventory of depressive symptoms qids it s really awesome according to lilly remember it s the only measure on which their experimental strike failure strike drug had an advantage over placebo so the authors wrote self reported depression symptoms such as those obtained by the qids sr may be more sensitive than clinician administered scales for signal detection in clinical studies of depression br br what does bristol myers squibb think in three trials of abilify for depression self reports of depression were unfavorable so the publications for these studies made sure to downplay these depression self reports by saying that these measures were a href http clinpsyc blogspot com 2009 01 abilify for depression im not only html id f86x title not sensitive not sensitive a that they weren t picking up improvements in depression br br so if a self report provided positive results then bam it s an awesome measure of depression but if it provided negative results then it s a horrendously inaccurate measure and should never have been used in the first place br br citation below yes one of the authors last names is kielbasa br br span class z3988 title ctx_ver z39 88 2004 rft_val_fmt info 3aofi 2ffmt 3akev 3amtx 3ajournal rft jtitle journal of psychiatric research rft_id info 3adoi 2f10 1016 2fj jpsychires 2009 09 013 rfr_id info 3asid 2fresearchblogging org rft atitle a study of the effects of ly2216684 2c a selective norepinephrine reuptake inhibitor 2c in the treatment of major depression rft issn 00223956 rft date 2010 rft volume 44 rft issue 6 rft spage 356 rft epage 363 rft artnum http 3a 2f 2flinkinghub elsevier com 2fretrieve 2fpii 2fs0022395609002131 rft au dub c3 a9 2c s rft au dellva 2c m rft au jones 2c m rft au kielbasa 2c w rft au padich 2c r rft au saha 2c a rft au rao 2c p rfe_dat bpr3 included 1 bpr3 tags health 2cpsychiatry dubé s dellva m jones m kielbasa w padich r saha a rao p 2010 a study of the effects of ly2216684 a selective norepinephrine reuptake inhibitor in the treatment of major depression span style font style italic journal of psychiatric research 44 span 6 356 363 doi a rev review href http dx doi org 10 1016 j jpsychires 2009 09 013 10 1016 j jpsychires 2009 09 013 a span cl psych http www blogger com profile 13990549972520745769 noreply blogger com 13 tag blogger com 1999 blog 33960805 post 1498938453147080677 2010 04 02t12 16 00 000 07 00 2010 04 02t12 29 14 076 07 00 charles nemeroff consultant extraordinaire the key opinion leader of key opinion leaders or a href http books google com books id 5w64wc_ jbmc pg pt225 lpg pt225 dq nemeroff boss bosses source bl ots nn13_my3ah sig wnugi6d4dtqigdm75pvnx5ltzms hl en ei yus2s9ktjjkmngfxy ijdq sa x oi book_result ct result resnum 9 ved 0ccaq6aewcdgk boss of bosses a if you prefer in any case take a peek at the following from charles nemeroff s page on the university of miami s a href http psychiatry med miami edu about department faculty120 charles nemeroff aspx website a seems like a href http www cjr org the_observatory reprimanded_psychiatrist_bad_a php something a must have happened in 2006 to slow down chuck s momentum div br div div what this is old news yeah i know but i just hadn t written much about our friends in the world of drug sales academics lately so i just had to do this br div br div div span class apple style span style webkit border horizontal spacing 2px webkit border vertical spacing 2px font family arial helvetica sans serif font size 12px p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px line height 22px font size 13px span style margin top 0px margin right 0px margin bottom 0px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px text decoration underline font weight bold pharmaceutical and clinical research company scientific advisory boards span p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px abbott laboratories br consultant abbott laboratories diagnostics division 1986 1992 br research and education advisory board for psychiatry br member 1990 2006 br executive board 1991 1993 2003 2006 br antidepressant advisory board 1991 1992 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px acadia pharmaceuticals clinical advisory board br member 2000 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px astrazeneca pharmaceuticals br psychiatry advisory board 1997 2001 br chairman 1999 2002 br neuroscience scientific advisory board 1999 present p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px bristol myers squibb br antipsychotic advisory board 2003 2006 br antidepressant advisory board 2003 2006 br emsam advisory board chairman 2005 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px cephalon pharmaceuticals br scientific advisory board 2002 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px comprehensive neuroscience inc br scientific advisory board 1999 2004 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px corcept br scientific advisory board 2001 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px cyberonics br scientific advisory board 2002 2006 br chair mechanism of action board 2003 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px cypress biosciences inc br board of directors 2001 2004 br consultant 2004 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px eli lilly and company br psychiatry advisory board 1990 2000 br bipolar advisory board 1998 1999 br consultant 2002 2003 br global neuroscience advisory board 2005 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px forest laboratories br citalopram clinical advisory board 1997 2002 br psychiatry scientific advisory board chairman 1999 2008 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px glaxosmithkline advisory board of psychiatrists br chairman 1991 2004 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px janssen pharmaceuticals br mood disorders advisory board member and chairman 1998 2004 br topiramate advisory board member and chairman 1999 2001 br antipsychotic advisory board member 1999 present p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px johnson johnson scientific advisory board 2007 present p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px lundbeck br consultant 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px merck sharp dohme research laboratories br consultant neuroscience research center 1994 br mood disorders advisory board 1999 2003 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px merck medco mental health advisory board br member 1996 1998 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px mt cook pharma br board of directors 2007 present p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px neurocrine biosciences br scientific advisory board 1994 2004 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px neuronetics br scientific advisory board 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px novadel pharma br board of directors 2003 present br chair scientific advisory committee br member compensation committee br member nominating committee p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px novartis pharmaceutical company br bipolar advisory board chairman 2001 2003 br pediatric bipolar advisory board 2002 2003 br antidepressant advisory board 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px organon pharmaceuticals psychiatry advisory board br member 1997 2004 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px otsuka psychiatry advisory board br chairman 2003 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px pharmaneuroboost br scientific advisory board 2006 present p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px pfizer pharmaceuticals br clinical neuroscience advisory board 2004 2006 br chair antipsychotic advisory board 2004 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px quintiles scientific advisory board 2004 present p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px revaax br stockholder p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px roche laboratories a division of hoffman laroche inc br mania advisory board 1993 br pharmocogenomics advisory board 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px sanofi synthelabo br psychiatry advisory board 2002 2005 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px scirex br scientific advisory board 1999 2003 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px solvay pharmaceuticals psychiatry advisory board br member 1991 1999 br chairman 1991 1999 br antipsychotic advisory board 2005 2006 p p style margin top 0px margin right 0px margin bottom 8px margin left 0px padding top 0px padding right 0px padding bottom 0px padding left 0px font size 13px line height 22px somerset pharmaceuticals psychiatry advisory boar...