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nction and health since insulin is inflammatory anti inflammatory vitamin d inhibits the production of the pro inflammatory cytokine th17 vitamin d can also increase cd4 cd25 t regulatory cells that play a calming role in the immune system and help the immune system accept the developing embryo t regulatory cells can also produce il10 which improves uterine blood flow and down regulates the immune response toward an embryo vitamin d also acts on dendritic cells that play an important role in maintaining immune tolerance during pregnancy sperm maintaining vitamin d levels within the normal range is important for proper sperm development and function low vitamin d is associated with low sperm number and motility while high vitamin d is associated with defects in sperm morphology the optimal blood serum concentration of vitamin d is between 50 and 125 nmol l your doctor can easily order this test or you can order it yourself at a lab such as direct labs vitamin d is also known as vitamin d 25 hydroxy 25oh vitamin d 25 hydroxy vitamin d we can obtain vitamin d in three ways 1 from sunlight with no sunscreen this is not effective for people that live the northern united states between the months of october and may 2 from food sources such as fatty fish salmon tuna sardines eggs shitake mushrooms and fortified cow s milk and cereal 3 from supplementation with vitamin d3 most of my clients take 1000 3000iu of vitamin d3 daily to get their levels within the normal range please ask your doctor to test your levels and help you to determine how much vitamin d you may need posted on may 11 2014 recommendation i never get tired of receiving photos and letters from my clients after they have their babies here is one that i received this week after five miscarriages in four years and a dozen failed fertility treatments i was beginning to think my dream of having another child would never materialize fortunately a friend referred me to karen even before i decided to work with karen she had a lengthy consultation with me over the phone she confidently assured me that she would find a cause and solution to my secondary infertility and recurrent miscarriages after evaluating my lab work she sent me a comprehensive evaluation of my immunologic and thrombotic profile she suggested a treatment plan and within a few months i was pregnant with a baby i was able to carry to term as a physician myself i was very impressed with karen s knowledge and expertise i can t thank karen enough and recommend her services to anyone struggling with infertility conceivable solutions karen pace miscarriage reproductive immunology secondary infertility posted on april 25 2014 april 25 2014 resolve to know more about reproductive immunology resolve to know more about reproductive immunology if you are struggling with unexplained infertility or recurrent miscarriage take 10 minutes today to learn more about the field of reproductive immunology i know this field is controversial but it is full of women who have had success after multiple ivf failures or miscarriages the best way to learn more about reproductive immunology is to find women who have had success and speak to them join a reproductive immunology support board or just simply google reproductive immunology i promise we are out there there are also many specialists like me who are devoted to this field and can help you determine if your immune system is interfering with your ability to have a baby and to all of my fellow infertility survivors who were successful after treating their immune system please resolve to take 10 minutes today to share your story in order for people to know more we need to share more ivf karen pace miscarriage reproductive immunology resolve support unexplained infertility posted on august 27 2012 don t ignore don t ignore your inner voice and intuition these played a very powerful role in my own infertility journey and i am thankful every day that i listened to my own voice and not my diagnosis of unexplained infertility my intuition was telling me that there was a piece of the puzzle missing and that i would continue to look for it until i had a baby or until my inner voice was quiet and my questions had been answered ten years ago i was stuck in the world of infertility i was seeing reputable reproductive endocrinologists and doing everything that i was supposed to do month after month procedure after procedure resulted in a negative pregnancy test at almost every appointment i would bring up my immune system as a cause for my infertility and at every appointment my doctors would shake their heads and say no that could not be it it must be your eggs yet the little voice inside my head got louder and i began to do some research since the immune system played such a vital role in allowing an embryo to implant and survive why couldn t something go wrong with this process why couldn t my immune system be destroying my embryos before they could properly implant and give me a positive pregnancy test it seemed to make sense to me by that point i had studied immunology for years and even had a ph d in immunology under my belt so as i failed 9 iuis and 3 ivfs my inner voice continued to ask the question what about my immune system finally i decided that it was time to listen i quit infertility treatments and found an amazing doctor that actually agreed with me and viola yes viola i was pregnant it was amazing i used prednisone ivig baby aspirin folgard and lovenox and i got pregnant naturally right away for my second daughter i needed to add in a few more treatments lit and metformin and conceiving her was just as easy today i have a 6 year old and a 3 years old and i am thankful everyday for them and for listening to my inner voice the journey of infertility changes us all in the end i feel that i was changed for the better i am an appreciative mom of two beautiful and talented daughters and i have one of the most rewarding careers anyone could ask for i help women listen to their own inner voice and intuition i ride the infertility roller coaster with them i help them find the solutions to their infertility or miscarriages and i get to celebrate with them when their babies are born in closing i would like to share an inspiring quote don t be trapped by dogma which is living with the results of other people s thinking don t let the noise of others opinions drown out your own inner voice and most important have the courage to follow your heart and intuition steven jobs this post was written as part of national infertility awareness week and resolve org s don t ignore campaign infertility iui ivf ivig lit lovenox reproductive immunology resolve posted on august 24 2012 august 24 2012 anti inflammatory diet last week i read about a study involving 147 infertility patients at massachusetts general hospital fertility center the study found that monounsaturated fat like that found in olive oil sunflower oil nuts seeds and avocados was better for would be mothers than other types of dietary fat women who ate the highest proportion of monounsaturated fat in their diet were 3 4 times more likely to have a baby after ivf while women that ate mostly saturated fat such as that found in butter and red meat produced fewer eggs and had a lower birth rate what i found most interesting but not surprising about this study was that the researchers suggested that monounsaturated fats could improve fertility by lowering inflammation and affecting insulin sensitivity as you all know i believe that many women are failing their fertility treatments or having miscarriages because their immune system chronic inflammation can drive the immune system to be over active against a pregnancy and not allow the embryo to implant or survive it can also decrease blood flow to the uterus and damage eggs does this mean that all of my clients are going to stop their ivig or prednisone and just start eating avocados probably not it does mean that decreasing chronic inflammation can help all women achieve a healthier pregnancy so if you are just starting out and want to make a few changes that you can do at home consider trying an anti inflammatory diet if you have celiac definitely avoid gluten and if you have pcos the more that you can do to avoid sugar and simple carbohydrates in order to maintain a stable insulin level and decrease inflammation the better and in the meantime have your immune system tested the top tests that i like to see are nk cytotoxicity including cd56 th1 th2 cytokine ratios leukocyte antibody detection panel hla and t regulatory cells to name a few diet fertility immunology ivf ivig miscarriage monounsaturated fats reproductive immunology posted on may 21 2011 may 22 2011 tips to decrease bruising with lovenox arixtra clexane injections i receive a lot of emails from women who want to learn how to decrease bruising from low molecular weight heparin injections such as lovenox clexane innohep fragmin or from fsh stims such as follistim gonal f menopur i used lovenox or innohep or arixtra or fsh for many months while trying to conceive both of my daughters and throughout both of my pregnancies so i consider myself a pro here are some tips that i would like to share with you never take a hot shower or bath immediately before or after your injection the warm water dilates abdominal blood vessels increasing blood flow to the injection site and decreasing the ability of the blood to clot the medication should be injected subcutaneously into the fat on the abdomen the injection should not go into muscle tissue finding just the right spot to inject is vital once a handful of good spots are found these areas should be remembered and reused in future injections after a while i discovered and remembered areas on my abdomen that hurt less and bleed less following an injection do not inject within 1 5 inches below above or to the left or right of the belly button these areas tend to bleed more blood vessels and nerves tend to be located next to each other a good way to stay away from blood vessels is to stay away from nerves to do this use the very tip of the needle to gently push on an area that you are considering for the injection if it hurts move away from that spot just a millimeter to the left or right and locate an area that does not really hurt if it does not hurt you are less likely to bleed a lot or get a large bruise or hematoma once a good spot is found the area can be iced before the injection although once i became a pro i just skipped the ice and did the injection i just didn t need it after a while but in the beginning it made the injection a lot easier swab the area with an alcohol prep pad and allow it to dry completely if it is still wet the injection may sting even more than it normally would gently pinch pinch is probably the wrong word i should say gather the fat between your finger tips the fat and skin at the injection site hold the needle at a 45 degree angle and inject so that the needle notice that the tip is beveled lead with the most pointed part of the needle goes into the fat layer at this point imagine holding the baby that you are trying to create this imagery makes the discomfort much more bearable and meaningful slowly inject the liquid once all liquid has been injected wait a second and then slowly release the fat and remove the needle do not put pressure on the injection site even if it is bleeding putting pressure on a site that has been injected with a blood thinner will not encourage the blood to clot faster and will likely make a bigger bruise or a hematoma do not use a band aid or a bandage on the injection site just wait patiently for it to stop bleeding if it bleeds at all usually if a good spot is found it will not bleed and it will only leave a 1mm circular purplish spot why would someone need a low molecular weight heparin when trying to conceive below i have listed some examples of hematologic abnormalities that may cause infertility or miscarriage mthfr gene polymorphism pai 1 gene polymorphisms low protein s protein c activity leiden factor v r506 or h1299 prothrombin mutations factor xiii gene polymorphism hpa 1 gene polymorphism anti cardiolipin antibodies anti phosphotidylserine antibodies anti phosphotidylethanolamine antibodies anti phosphatidic acid antibodies anti phosphotidylglycerol antibodies anti beta 2 glycoprotein i antibodies anti platelet antibodies anti thrombin iii lupus anti coagulant this information is not intended to be medical advice always follow your physician s instructions for administration and use of low molecular weight heparin products arixtra bruising clexane infertility injection ivf lovenox miscarriage posted on may 14 2011 may 21 2011 myth reproductive immunology treatments do not work as part of national infertility awareness week resolve the national infertility association has asked women to bust a myth about infertility the myth that i am going to bust was first realized on my own journey to have a baby busting this myth soon became my mission and now it is my career i was 32 years old i failed 9 iui and 3 ivf cycles i was doing a post doctoral fellowship in immunology and i asked my doctor could my immune system be interfering with my ability to have children she answered no that couldn t be it it is your eggs so without knowing it i set out to bust a myth i quickly discovered that i had many immune system abnormalities that can cause infertility to combat them i used a combination of medications to alter my immune system dexamethasone prednisone and intravenous immunoglobulin to decrease blood clotting and inflammation lovenox and baby aspirin to decrease homocysteine levels folgard metanx and to protect my baby from my immune system lymphocyte immune treatment shortly after i became pregnant naturally with my own eggs my daughter s name is sienna and she is now a beautiful 5 year old but why bust a myth only once why not crush it six years after i was told that my eggs were bad and old i went back on my immune protocol again and became pregnant naturally with my own eggs my daughter s name is chiara and she is now a gorgeous 2 year old i am now devoted to helping women with unexplained infertility and miscarriage crush the myth that immune treatments don t work immune treatments do work here are just some of the myths that my client s doctors have told them myth 1 we have done everything and tested for everything there is nothing left it is time for donor eggs myth crushed by the birth of baby g w following immune testing and treatment myth 2 immune treatments don t work if i told you to wear orange on tuesdays and you would get pregnant would you do that too myth crushed by the birth of baby l g and baby s g following immune treatments myth 3 you can do lymphocyte immune transfer if you want to but it won t work myth crushed by the birth of baby a w following immune treatments myth 4 those doctors that prescribe ...