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small molecule perturbations in signal transduction cybermashup com search home about us research area autophagy modulators 8 apoptosis related inhibitors 6 vegfr inhibitors 4 rip kinase inhibitors 4 transferase inhibitors 4 sting inhibitors 3 ppar inhibitors 3 trp channel inhibitors 3 rock inhibitors 3 c kit inhibitors 3 telomerase inhibitors 2 pdgfr inhibitors 2 ras inhibitors 2 kras inhibitors 2 src inhibitors 2 raf inhibitors 2 retinoid receptor agonists 2 iap inhibitors 1 serine protease inhibitors 1 wnt beta catenin inhibitors 1 scd inhibitors 1 rna methyltransferase inhibitors 1 secretase inhibitors 1 bacterial inhibitors 1 atp citrate lyase inhibitors 1 er stress inhibitors 1 e3 ligase inhibitors 1 sodium channel chemicals 1 dna methyltransferase inhibitors 1 mitochondrial metabolism inhibitors 1 chk inhibitors 1 tyrosinase inhibitors 1 antioxidant inhibitors 1 pyroptosis inhibitors 1 wrn inhibitors 1 flt inhibitors 1 lpl receptor inhibitors 1 synthetic lethality inhibitors 1 egfr inhibitors 1 survivin inhibitors 1 bcr abl inhibitors 1 beta amyloid inhibitors 1 stat inhibitors 1 s1p receptor modulators 1 btk inhibitors 1 tnf alpha inhibitors 1 sgk inhibitors 1 antibiotics inhibitors 1 her2 inhibitors 1 wee1 inhibitors 1 c ret inhibitors 1 proteasome inhibitors 1 sik inhibitors 1 ido tdo inhibitors 1 nampt inhibitors 1 notch inhibitors 1 covid 19 inhibitors 1 ferroptosis inhibitors activators 1 sars cov inhibitors 1 fgfr inhibitors 1 porcn inhibitors 1 archives 2026 09 42 2026 10 12 author contact us resources latest research posts rosiglitazone brl 49653 restores ppar γ cadm3 signaling to suppress gastric cancer metastasis ttnpb arotinoid acid arotinoid acid retinoid receptor agonist suppresses metastatic coad adagrasib mrtx849 ras inhibitor binding kinetics and non covalent engagement with human serum albumin lgk974 wnt974 lgk974 porcn inhibitor suppresses non canonical wnt5a signaling in ewing sarcoma mito tempo from selleck attenuates cisplatin induced renal injury by targeting mitochondrial reactive oxygen species ro4929097 rg 4733 rg 4733 secretase inhibition reverses transcriptomic signatures in metastatic melanoma gw9662 from selleck blocks ppar γ signaling in diabetic myocardial ischemia reperfusion injury tunicamycin tunicamycin disrupts endoplasmic reticulum unfolded protein response signaling cascades stm2457 inhibits mettl3 m6a methylation to attenuate tlr4 nf κb signaling in cardiac remodeling wh 4 023 wh4023 from selleck inhibits src kinase to maintain pluripotency c 176 sting inhibition suppresses cgas sting nlrp3 axis and neuroinflammation after spinal injury gsk872 from selleck targets ripk3 kinase to block mlkl mediated necroptosis necrostatin 1 nec 1 rip kinase inhibitor suppresses parp1 aifm1 signaling in heart failure models 2 bromohexadecanoic acid transferase inhibitor modulation of chikv tf cysteine palmitoylation fk866 daporinad fk866 transferase target engagement suppresses osteoarthritic cytokine signalling fty720 hydrochloride s1p receptor antagonist modulates lymphocyte egress and improves adherence in multiple sclerosis necrostatin 2 racemate nec 1s from selleck targets ripk1 kinase to prevent liver necrosis gw6471 inhibition of pparα impairs fear extinction during inflammatory nociceptive tone mrtx1133 reversible inhibition of krasg12d through switch ii pocket allosteric stabilization dabrafenib gsk2118436 selectively inhibits braf v600 mutant kinase in metastatic melanoma plx4032 vemurafenib from selleck targets mutated braf kinase in melanoma retinoic acid tretinoin vitamin a acid retinoic acid retinoid receptor agonist regulates gprc5a and ptreg immunity stattic inhibitor abrogates stat3 y705 phosphorylation to attenuate breast cancer stemness nx 1607 cbl b in 3 inhibits cbl b e3 ligase to reinvigorate t cell immunity thiazovivin tzv targeted viral rna synthesis inhibition in hospitalized covid 19 cohorts diabzi sting agonist1 diabzi sting agonist 1 tautomerism sting signaling activation h 151 h151 sting inhibitor reveals tbk1 dependent inflammatory control in human smooth muscle cells dasatinib bms 354825 bms354825 targeted inhibition of src kinase in hepatocellular carcinoma y 27632 rock inhibitor suppresses epidermal differentiation and extends primary keratinocyte lifespan mg132 from selleck promotes micb expression via atm atr chk2 signaling pathway y 27632 dihydrochloride suppresses rock mediated fibrogenesis and actomyosin contractility in stellate cells vvd 214 vvd 133214 ro7589831 targets wrn helicase to exploit kmt2d loss in msi cancers bibr 1532 telomerase target selectivity in disulfidptosis low cancers mfi8 inhibition of mitochondrial fusion exacerbates hepatic lipid accumulation fruquintinib hmpl 013 hmpl 013 vegfr kinase inhibition exhibits manageable real world safety in solid tumors apatinib yn968d1 mesylate vegfr 2 inhibition and immune checkpoint combination in advanced hepatocellular carcinoma gsk 3484862 targeted dnmt1 entrapment drives chromatin immobilization and degradation tac tert activator 1 modulation and radiotherapy response in inoperable hepatocellular carcinoma nafamostat mesilate fut 175 fut 175 from selleck suppresses serine proteases during extracorporeal circulation gsk650394 target sgk1 inhibition suppresses metastasis via autophagy induced snail degradation raptinal promotes intrinsic apoptosis via p53 bcl 2 bax caspase 3 signaling in colorectal carcinoma suzetrigine vx 548 from selleck inhibits nav1 8 channels for acute nociceptive pain suppression gsk2193874 inhibition of trpv4 ion channels attenuates intervertebral disc degeneration cediranib azd2171 azd2171 vegfr inhibitor targets vegfr1 3 in ovarian cancer combination regimens bbi 355 from selleck targets chk1 to disrupt replication stress response in ecdna tumors sb 204990 target engagement of atp citrate lyase suppresses aerobic glycolysis and tumor growth azenosertib zn c3 targeted wee1 kinase inhibition forces premature mitotic entry in solid tumors hc 067047 hc067047 targets trpv4 channels to attenuate mechanical hyperalgesia in cancer neuropathy a939572 from selleck suppresses scd1 to restore ferroptosis in pancreatic cancer bay 2927088 sevabertinib covalently inhibits her2 exon 20 insertions sparing wild type egfr sepantronium bromide ym155 target engagement and survivin promoter suppression in liposarcoma lenvatinib mesylate from selleck inhibits vegfr 2 and fgfr4 cascades in advanced liver cancer catadegbrutinib from selleck targets btk via crbn degradation in b cell malignancies bc 2059 inhibits rtkn2 and reverses gemcitabine resistance in cholangiocarcinoma resources target validation and intracellular network dynamics small molecule probes in cellular regulation studies cellular adaptation to targeted inhibitor treatments decoding signaling cascades via chemical inhibition mechanistic studies of small molecule drug targets cellular process modulation through targeted inhibitors pharmacological insights into intracellular pathways cellular phenotype mapping via chemical modulation translational analysis of targeted small molecules signaling pathway dynamics and inhibitor profiles comprehensive evaluation of intracellular inhibitors mapping biological networks through small molecule probes mechanistic profiling of intracellular signaling pathways cellular response dynamics to targeted inhibitors small molecule interventions in cellular networks translational insights into intracellular modulators cellular phenotype mapping via inhibitor applications receptor signaling dynamics and targeted inhibitors target validation and intracellular pathway regulation