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cystolith ageing and the human face cystolith diet and healthy ageing january 19 2009 at 5 23 pm diet diet in their paper in the ageing research reviews journal michael heinrich and josé prieto look back 100 years and assess how our diets will change in the next 100 years in relation to healthier ageing their argument centres around a series of dichotomies used to explain the changes in dietary habits the continuous move from local dietary traditions low in technological input and based on empiricism to diets which are global requiring high technological input and are more science based below is table 1 showing key developments in human diet ageing research reviews volume 7 issue 3 october 2008 pages 249 274 permalink leave a comment cytokeratin related loss of cellular integrity is not a major driving force of human intrinsic skin ageing november 25 2008 at 3 20 pm keratins skin keratins kamil oender and colleagues published a paper recently about cytoskeletal keratins on the journal mechanisms of ageing and development volume 129 issue 10 october 2008 pages 563 571 doi 10 1016 j mad 2008 05 008 below is the introduction aging is the progressive decline in cellular metabolic capacity accompanied by a loss of gene expression potential accumulation of somatic mutations and diminished structural integrity of the cell that ultimately is incompatible with life aging is acknowledged to be both under genetic control which contributes to intrinsic aging and cumulative environmental wear and tear extrinsic aging in sunlight exposed skin the primary exogenous cause of aging is ultraviolet irradiation hence the term photoaging the causes and mechanisms of intrinsic aging are far less well understood than for photoaging sun protected aged skin appears thin lax finely lined has a transparent quality and shows the clinical signs of increased fragility and loss of elasticity histologically the stratum corneum remains relatively unchanged but the epidermis and dermis both become thinner and there is a flattening of the dermo epidermal junction gilchrest 1982 at the ultrastructural level the collagen fibrils of the dermis of sun protected aged skin become fragmented and disorganized as compared to the skin of a child in addition to a reduction of type i procollagen synthesis the increased activity of matrix metalloproteinases mmp degrades the collagenous matrix in aged skin chung et al 2000 and varani et al 2000 at the molecular level aging is hypothesized to be caused by the effects of oxidative damage associated with cellular metabolism by genome instabilities such as telomere shortening mitochondrial dna mutations and chromosomal pathologies by accumulation of lipofuscin and by protein cross linking fisher et al 2002 and jenkins 2002 g jenkins molecular mechanisms of skin ageing mech ageing dev 123 2002 pp 801 810 article pdf 96 k view record in scopus cited by in scopus 52 jenkins 2002 cytoskeletal filaments function in the maintenance of cell morphology and polarity in endocytosis and intracellular trafficking and in contractility motility and cell division gourlay and ayscough 2005 cytokeratins a family of fibrous intermediate filament protein polymers are involved in epithelial structural maintenance protection from mechanical trauma and possibly communication between adjacent cells or cytoplasm components these structural proteins of epithelial cells that can be divided into two subgroups type 1 and type 2 keratins based on biochemical properties such as molecular weight and isoelectric point koch and roop 2004 and jacques et al 2005 based on the clinical appearance of intrinsically aged skin mechanical strength and renewability of the cytoskeleton are expected to become reduced with age recent work has indicated that during skin aging some cytoskeletal genes are regulated at the transcriptional level lener et al 2006 given the importance of the keratins to the overall function of epithelial cells we focused our study on genes encoding the cytoskeletal keratins k1 k23 intermediate filaments as well as actb microfilament jup junctional component and tuba microtubuli the latter constituting so called house keeping genes we show that the expression of house keeping genes at both the rna and protein levels becomes reduced with age whereas some of the keratins are up and some are down regulated fig 4 immunofluorescence staining of k19 k16 and k5 in young versus aged skin tissue samples k19 staining in the basal layer of the epidermis of a a young 1 year patient compared to an b aged 59 years patient where k19 seems to be absent immunofluorescence staining of k5 showed an equal protein expressin in the stratum basale in both c young 1 year and d aged 44 years patient e k16 staining in young 6 years is less dominant than k16 staining in f aged 44 years prominent f actin staining in g young skin 7 years shown by phalloidin conjugated with texas red fluorescence compared to h aged 76 years tissue a b g h magnification factor 200 c d e f magnification factor 400 d dermis ed epidermis view within article x permalink leave a comment hello world october 15 2008 at 1 47 pm uncategorized welcome to wordpress com this is your first post edit or delete it and start blogging permalink 1 comment pages about archives january 2009 november 2008 october 2008 categories diet keratins skin uncategorized search blogroll avon biotherm clarins clinique crème de la mer darphin decléor dior elemis elizabeth arden l oréal paris lancôme mac revive rodial shiseido sk ii skinceuticals the sanctuary tracie martyn vichy wordpress com wordpress org z bigatti zelens meta create account log in rss feed subscribe subscribed cystolith sign me up already have a wordpress com account log in now privacy cystolith subscribe subscribed sign up log in report this content view site in reader manage subscriptions collapse this bar loading comments write a comment email required name required website