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description=Direct-from-blood multiplex PCR targeting 95% of sepsis-causing pathogens;
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deepull home products deepull our values news contact contact direct from blood multiplex pcr targeting 95 of sepsis causing pathogens early detection represents our best chance of reducing the significant morbidity and mortality associated with sepsis at deepull we are developing technology to empower hospitals to do something never done before provide 50 reportable results identifying pathogens and antibiotic resistance markers directly from blood in about 1 hour what is sepsis product under development not currently available for diagnostic use what is sepsis early detection represents our best chance of reducing the significant morbidity and mortality associated with sepsis at deepull we are developing technology to empower hospitals to do something never done before provide 50 reportable results identifying pathogens and antibiotic resistance markers directly from blood in about 1 hour sepsis is hard to define and even harder to diagnose the most current literature defines sepsis as a life threatening organ dysfunction caused by a dysregulated host response to infection 1 if untreated this can lead to septic shock which is a dramatic drop in blood pressure that damages organs in severe cases this can lead to death every year about 49 million people are diagnosed with sepsis and about 11 million die across the globe 2 the u s cdc estimates that sepsis contributes to 1 of every 3 hospital deaths 3 early detection and effective antibiotic treatment are key to combatting sepsis however early diagnosis remains a challenge as the early symptoms of sepsis are non specific and easy to miss such as fever increased heart rate confusion and low blood pressure furthermore confirming and identifying the underlying infection is a complicated and time consuming task for the hospital laboratory the need for faster more sensitive diagnostic technology has been a recognized unmet medical need for decades this is the challenge that inspired the inception of deepull 1 definition of sepsis singer et al the third international consensus definition for sepsis and septic shock sepsis 3 jama february 2016 2 rudd et al global regional and national sepsis incidence and mortality 1990 2017 analysis for the global burden of disease study lancet london england 2020 395 10219 200 11 3 https www cdc gov sepsis what is sepsis html blood culture based pathogen identification has demonstrated limitations current sepsis guidelines recommend 1 hour and 3 hour bundles compliance with these guidelines however remains a significant challenge because blood culture based pathogen identification can take days and only detects viable organisms critical patient management decisions must be made during this time of diagnostic blindness should the patient be admitted transferred to icu should antibiotics be started which ones sepsis guidelines diagnostic delays contribute to poor patient outcomes studies have shown initial therapy is inadequate for 1 out of 5 septic patients 1 sepsis contributes to 1 out of 3 hospital deaths 2 mortality rate of 30 40 for patients with septic shock 3 4 5 overuse use of antibiotics drives antimicrobial resistance 6 7 8 overtreatment may be associated with a 20 increase in odds of death 1 undertreatment may be associated with a 40 increase in odds of death 1 references the surviving sepsis campaign 2021 guidelines the surviving sepsis campaign 2021 guidelines 1 contain the following recommendations antimicrobials should be administered within 1 hour of recognition of patients with definite or probable sepsis antimicrobials should be administered within 1 hour of recognition of patients with possible sepsis if shock is present antimicrobials should be administered within 3 hours of recognition of patients with possible sepsis if shock is absent and if concerns for infection persist rapid assessment of infectious vs non infectious causes for patients with possible sepsis if shock is absent should be completed within 3 hours of presentation use of procalcitonin plus clinical evaluation to decide when to start antimicrobials is not recommended for patients with suspected sepsis or septic shock 1 https www sccm org clinical resources guidelines guidelines surviving sepsis guidelines 2021 references 1 rhee et al prevalence of antibiotic resistant pathogens in culture proven sepsis and outcomes associated with inadequate and broad spectrum empiric antibiotic use jama april 2020 2 https www cdc gov sepsis about cdc_aaref_val https www cdc gov sepsis what is sepsis html march 2024 3 paoli et al epidemiology and costs of sepsis in the united states an analysis based on timing of diagnosis and severity level ccm december 2018 4 schoenberg et al outcome of patients with sepsis and septic shock after icu treatment langenbecks arch surg march 1998 5 bauer et al mortality in sepsis and septic shock in europe north america and australia between 2009 and 2019 results from a systematic review and meta analysis critical care may 2020 6 wonderink et al antibiotic stewardship in the intensive care unit an official american thoracic society workshop report in collaboration with the aacn chest cdc and sccm ann am thorac sox may 2020 7 https www who int news room fact sheets detail antimicrobial resistance text amr 20is 20a 20natural 20process in 20humans 2c 20ani mals 20and 20plants april 2024 8 levy et al antibacterial resistance worldwide causes challenges and responses nature medicine november 2004 standard of care blood culture testing lacks sensitivity the diagnostic value of blood culture is limited to viable organisms this restricts positive results to blood samples that contain bacteria and yeast capable of reproduction in incubated blood culture media detected by blood culture viable organisms detected by total microbial dna non viable organisms fastidious organisms microbial cell free dna total microbial dna the diagnostic value of blood culture is limited to viable organisms this restricts positive results to blood samples that contain bacteria and yeast capable of reproduction in incubated blood culture media however the use of highly sensitive molecular techniques creates further diagnostic value by detecting additional bacterial elements that can be found in blood non viable organisms most bacterial cells in blood are dead or otherwise damaged such as phagocytized microorganisms and no longer capable of reproduction studies have shown that quantitative bacterial load measured by pcr correlates with disease severity and poor patient outcomes 1 2 fastidious organisms some microbiologic species have a very complex or a very narrow set of nutritional requirements these fastidious organisms will only grow when specific nutrients are included in the medium these organisms can be particularly difficult to detect in blood culture systems which are inherently dependent on bacterial growth and include media designed to support growth in a broad range of bacterial species pcr based approaches do not share this limitation microbial cell free dna microbial cell free dna has emerged as a valuable target for identification of pathogens when traditional methods fail to identify the causative agent 3 1 linoj samuel direct from blood detection of pathogens a review of technology and challenges jcm 2023 jul 61 7 e00231 21 2 bacconi et al improved sensitivity for molecular detection of bacterial and candida infections in blood jcm september 2014 52 9 3164 74 doi 10 1128 jcm 00801 14 3 thompson et al utility of plasma microbial cell free dna testing for therapeutic management and antimicrobial stewardship open forum of inect dis 2023 dec 10 suppl 2 ofad500 1059 ullcore system extracts total microbial dna allows continuous loading for up to 8 samples can prioritize stat samples handles sample volumes of 0 1 to 10 ml automates sample to result testing completes a test in about 1 hour utilizes room temperature stable reagents offers lis connectivity 21 inch height adjustable user interface footprint 100 cm x 75 cm product under development not currently available for diagnostic use view more ullcore bsi test deepull is developing the ullcore bsi test for 8 ml of whole blood from patients with suspected infection or sepsis preliminary results based on prospectively obtained specimens from septic patients show high concordance with positive blood culture detection of more than twice as many clinically relevant pathogens compared to blood culture 1 hr turnaround time potential clinical benefits of the ullcore bsi test inform initial therapy decisions early administration of appropriate therapy may reduce the risks associated with both overuse and underuse of antibiotics and lead to better patient outcomes compliance with sepsis guidelines the surviving sepsis campaign 2021 guidelines recommend administration of antimicrobials within 3 hours of recognition of patients with possible sepsis if shock is absent and if concerns for infection persist guide antibiotic stewardship desicions minimizing patient exposure to broad spectrum empiric antibiotic therapy as well as targeted therapy are foundational principles of good antibiotic stewardship direct from blood the ullcore bsi test p rovides answers in about 1 hour directly from blood and targets 95 of sepsis causing pathogens about us at deepull we are inspired by the challenge of building novel diagnostic products to meet unmet medical needs leadership team 8 advisory board team 12 leadership 8 advisory 12 jordi carrera chief executive officer rafel bru chief technology officer claudia van de sand chief reagents officer kim chapin chief medical officer melissa finocchio chief qara officer wade stevenson chief marketing sales officer pilar casado chief financial officer bruno monschau chief operations officer rick ivey former global vp of r d at becton dickinson diagnostics usa chairman at deepull peter kaspar former director at roche and evp of microbiology at biomérieux germany alain pluquet former chief technology officer at biomérieux france greg meehan former vp of molecular diagnostics at becton dickinson usa mervyn singer co chair of sepsis 3 professor of intensive care medicine at university college london uk tom van der poll co author of sepsis 3 chair of department of medicine at amsterdam umc the netherlands michael bauer co author of sepsis 3 head of center for sepsis control and care in jena germany juan carlos ruiz sepsis code coordinator at vall d hebron hospital in barcelona spain jordi vila senior consultant department of clinical microbiology at barcelona clinic hospital spain gorm lisby senior consultant department of clinical microbiology hvidovre hospital in copenhagen denmark juan josé gonzález clinical microbiologist at vall d hebron hospital in barcelona spain robin patel professor of medicine and microbiology at mayo clinic usa our latest news see all news our values we are driven by integrity and respect for all our stakeholders for our customers we empower hospital laboratories to provide faster more comprehensive results to healthcare providers for improved patient care our products must be fairly priced to impact our communities for our employees we provide an inclusive and open work environment respecting diversity and recognizing individual merit employees must feel free to make decisions take action offer suggestions and voice concerns for our shareholders we are building a profitable business by promoting innovation and developing high quality products that address unmet medical needs are safe and environmentally clean deepull barcelona spain 34 93 655 3530 contact deepull com contact form follow us proyecto cpp2021 008464 financiado por mcin aei 10 13039 501100011033 y por la unión europea nextgenerationeu prtr product under development not currently available for diagnostic use whistleblower privacy policy legal notice cookies policy social media policy quality certifications by emascaró contact form 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