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home home search home feedback getting started build documentation rosetta tutorials rosetta basics rosetta applications rosetta scripting interfaces development documentation internal documentation how to write documentation faq glossary encyclopedia options list release notes what is rosetta rosetta is a comprehensive software suite for modeling macromolecular structures as a flexible multi purpose application it includes tools for structure prediction design and remodeling of proteins and nucleic acids since 1998 rosetta web servers have run billions of structure prediction and protein design simulations and billions or trillions more have been run on supercomputer clusters researchers use rosetta to better understand treatments of infectious diseases cancers and autoimmune disorders further applications involve the development of vaccines new materials targeted protein binders and enzyme design rosetta began as a structure prediction tool and has consistently been a strong performer in the critical assessment of structure prediction casp community wide blind prediction exercises it has grown to offer a wide variety of effective sampling algorithms to explore backbone side chain and sequence space and its excellence has generalized to more community wide exercises including rna puzzles and critical assessment of protein interactions capri rosetta boasts broadly tested scoring energy functions and contains an unparalleled breadth of applications from folding to docking to design rosetta is freely available to academic and government laboratories with over 10 000 free licenses already in use an active support forum allows users to easily collaborate within the broad research community of rosetta users to download rosetta please request a license if you think you re ready to give rosetta a try we suggest starting here and trying out these tutorials note to rosetta developers make edits at this link and they will show up for all users here at the same time that weekly builds are released