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view source for edgewood arsenal human experiments wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in view source for edgewood arsenal human experiments add languages article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file page information get shortened url switch to legacy parser in other projects wikidata item appearance move to sidebar hide edgewood arsenal human experiments you do not have permission to edit this page for the following reason this ip address range has been globally blocked this does not affect your ability to read wikipedia pages most people who see this message have done nothing wrong some kinds of blocks restrict editing from specific service providers or telecom companies in response to recent abuse or vandalism and can sometimes affect other users who are unrelated to that abuse review the information below for assistance if you do not believe that you have done anything wrong this block affects editing on all wikimedia wikis the ip address or range 5 135 0 0 16 has been globally blocked by jon kolbert for the following reason s open proxy webhost visit the faq if you are affected this block will expire on 04 29 8 january 2027 your current ip address is 5 135 42 194 even while globally blocked you will usually still be able to edit pages on meta wiki if you believe you were blocked by mistake you can find additional information and instructions in the stewards block wizard other useful links global blocks help i have been blocked you can view and copy the source of this page acetylcholine related experiments much of the experimentation at edgewood arsenal surrounded the modulation of acetylcholine or acetylcholinesterase or the deactivation and reactivation of substances which did the same ref name 0 these experiments represented a significant enough proportion of the total experimentation to earn a dedicated volume in the main experimental documentation much of the follow up data on the acetylcholine related experiments are lacking or entirely missing due to a combination of remaining classified information in the united states classification and failures on the part of the united states department of veterans affairs and united states department of defense to follow the subjects of the experimentation ref name 3 citation needed reason the cited ref has never been defined since it was added on 18 september 2024 date september 2025 anticholinesterase experiments anticholinesterase s are substances that interfere with the central nervous system and the peripheral nervous system by inhibiting acetylcholinesterase and therefore sustaining the effect of acetylcholine or butyrylcholine within the chemical synapse s ref cite journal last1 colovic first1 mirjana b last2 krstic first2 danijela z last3 lazarevic pasti first3 tamara d last4 bondzic first4 aleksandra m last5 vasic first5 vesna m date 2013 04 01 title acetylcholinesterase inhibitors pharmacology and toxicology url https www eurekaselect com article 50871 journal current neuropharmacology volume 11 issue 3 pages 315 335 doi 10 2174 1570159x11311030006 issn 1570 159x pmc 3648782 pmid 24179466 ref resulting in a cholinergic crisis and possibly death if untreated ref cite book title current therapy of trauma and surgical critical care date 2016 publisher elsevier isbn 978 0 323 07980 8 editor last asenio editor first juan a edition 2nd location philadelphia editor last2 trunkey editor first2 donald d ref long term side effects of exposure to anticholinesterase s including at levels below the threshold for profound illness and death can include paralysis and peripheral neuropathy ref cite journal last morgan first john p date 1978 08 01 title jamaica ginger paralysis url http dx doi org 10 1001 archneur 1978 00500320050011 journal archives of neurology volume 35 issue 8 pages 530 532 doi 10 1001 archneur 1978 00500320050011 pmid 666613 issn 0003 9942 url access subscription ref sleep disturbance ref cite journal last1 metcalf first1 david r last2 holmes first2 joseph h date june 1969 title eeg psychological and neurological alterations in humans with organophosphorus exposure url http dx doi org 10 1111 j 1749 6632 1969 tb15857 x journal annals of the new york academy of sciences volume 160 issue 1 pages 357 365 doi 10 1111 j 1749 6632 1969 tb15857 x pmid 5257403 bibcode 1969nyasa 160 357m issn 0077 8923 url access subscription ref genetic mutation and cancer ref name 0 in total 1 406 subjects were tested with 16 agents some of which included reactivating agents and protective agents ref name 0 anticholinergic experiments anticholinergic s are substances that interfere with the central nervous system and the peripheral nervous system by inhibiting acetylcholine resulting in what is essentially the opposite effect of a cholinesterase inhibitor to the extreme ref citation last1 sanders first1 kenton m chapter organization and electrophysiology of interstitial cells of cajal and smooth muscle cells in the gastrointestinal tract date 2012 title physiology of the gastrointestinal tract pages 511 556 chapter url http dx doi org 10 1016 b978 0 12 382026 6 00018 x access date 2024 09 15 publisher elsevier isbn 978 0 12 382026 6 last2 koh first2 sang don last3 ward first3 sean m doi 10 1016 b978 0 12 382026 6 00018 x chapter url access subscription ref this can result in anticholinergic syndrome and possibly death if untreated ref citation last1 marx first1 john a chapter dedication date 2010 title rosen s emergency medicine concepts and clinical practice pages v chapter url http dx doi org 10 1016 b978 0 323 05472 0 00205 x access date 2024 09 15 publisher elsevier isbn 978 0 323 05472 0 last2 hockberger first2 robert s last3 walls first3 ron m doi 10 1016 b978 0 323 05472 0 00205 x chapter url access subscription ref ref cite journal last wilson first t r date september 1973 title belladonna alkaloids and synthetic anticholinergics uses and toxicity url http dx doi org 10 1192 bjp 123 3 366 a journal british journal of psychiatry volume 123 issue 574 pages 366 367 doi 10 1192 bjp 123 3 366 a issn 0007 1250 url access subscription ref available data from both experiment patients ref name 0 and pharmaceutical research indicates that short term exposure to anticholinergic compounds especially the extremely limited exposures described in the documentation is associated with no long term effects in the decades since their introduction to medical use research has begun to suggest a causal relationship between long term anticholinergic drug use and later development or worsening of dementia ref cite journal last1 dmochowski first1 roger r last2 thai first2 sydney last3 iglay first3 kristy last4 enemchukwu first4 ekene last5 tee first5 silvia last6 varano first6 susann last7 girman first7 cynthia last8 radican first8 larry last9 mudd first9 paul n last10 poole first10 charles date january 2021 title increased risk of incident dementia following use of anticholinergic agents a systematic literature review and meta analysis journal neurourology and urodynamics language en volume 40 issue 1 pages 28 37 doi 10 1002 nau 24536 issn 0733 2467 pmc 7821204 pmid 33098213 ref in total 1 752 subjects were tested with 21 agents some of whom received exposure to more than one chemical agent ref name 0 cholinesterase reactivator experiments pralidoxime cholinesterase reactivators are substances which reactivate acetylcholinesterase which has been inactivated by an anticholinesterase ref cite journal last1 jokanović first1 milan last2 stojiljković first2 miloš p date december 2006 title current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning url https linkinghub elsevier com retrieve pii s0014299906010818 journal european journal of pharmacology language en volume 553 issue 1 3 pages 10 17 doi 10 1016 j ejphar 2006 09 054 pmid 17109842 url access subscription ref ref name 0 this action can be precipitated through a variety of mechanisms including directly binding and deactivating the anticholinesterase itself ref cite journal last1 hackley first1 b e last2 steinberg first2 g m last3 lamb first3 j c date january 1959 title formation of potent inhibitors of ache by reaction of pyridinaldoximes with isopropyl methylphosphonofluoridate gb url http dx doi org 10 1016 0003 9861 59 90359 5 journal archives of biochemistry and biophysics volume 80 issue 1 pages 211 214 doi 10 1016 0003 9861 59 90359 5 issn 0003 9861 url access subscription ref blocking the reaction between the anticholinesterase and the acetylcholinesterase ref cite journal last scaife first j f date 1960 03 01 title protection of human red cell cholinesterase against inhibition by tabun and o o diethyl s 2 diethylaminoethyl phosphorothiolate url http dx doi org 10 1139 o60 033 journal canadian journal of biochemistry and physiology volume 38 issue 3 pages 301 303 doi 10 1139 o60 033 issn 0576 5544 url access subscription ref changing the release of acetylcholine ref cite journal last1 sánchez pastor first1 enrique last2 trujillo first2 xóchitl last3 huerta first3 miguel last4 andrade first4 felipa date 2007 01 31 title effects of cannabinoids on synaptic transmission in the frog neuromuscular junction url http dx doi org 10 1124 jpet 106 116319 journal journal of pharmacology and experimental therapeutics volume 321 issue 2 pages 439 445 doi 10 1124 jpet 106 116319 pmid 17267583 issn 0022 3565 url access subscription ref blocking acetylcholine s cholinolytic effect ref cite journal last1 bethe first1 k last2 erdmann first2 w d last3 lendle first3 l last4 schmidt first4 g date 1957 title spezifische antidot behandlung bei protrahierter vergiftung mit alkylphosphaten paraoxon parathion dfp und eserin an meerschweinchen url http dx doi org 10 1007 bf00246123 journal naunyn schmiedebergs archiv for experimentelle pathologie und pharmakologie volume 231 issue 1 doi 10 1007 bf00246123 issn 0028 1298 url access subscription ref or by increasing the excretion of the anticholinesterase ref cite journal last1 heilbronn first1 e last2 appelgren first2 i e last3 sundwall first3 a date august 1964 title the fate of tabun in atropine and atropine oxime treated rats and mice url http dx doi org 10 1016 0006 2952 64 90120 0 journal biochemical pharmacology volume 13 issue 8 pages 1189 1195 doi 10 1016 0006 2952 64 90120 0 pmid 14222516 issn 0006 2952 url access subscription ref available data from the experiments ref name 0 and from prescribing information ref name 1 cite web title tnaa atropine and pralidoxime chloride auto injector full prescribing information url https nctr crs fda gov fdalabel services spl set ids 596c7a8f 27cd 4de2 9491 476f43570b8b spl doc hl pralidoxime 20chloride access date website fdalabel version 2 9 publisher meridian medical technologies llc ref from modern marketing of these substances concludes that little risk exists of long term effects from exposure it is noted however in both the prescribing information for modern variants and in toxicology toxicological research on the subject that it has been the subject of insufficient research to conclude this beyond a reasonable doubt ref cite journal last1 voicu first1 victor last2 rădulescu first2 flavian ştefan last3 medvedovici first3 andrei date jan 2013 title toxicological considerations of acetylcholinesterase reactivators url http www tandfonline com doi full 10 1517 17425255 2013 736489 journal expert opinion on drug metabolism toxicology language en volume 9 issue 1 pages 31 50 doi 10 1517 17425255 2013 736489 pmid 23176543 issn 1742 5255 url access subscription ref ref name 1 in total 219 subjects were tested with four agents ref name 0 return to edgewood arsenal human experiments retrieved from https en wikipedia org wiki edgewood_arsenal_human_experiments privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search view source for edgewood arsenal human experiments add languages add topic