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adam8 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 function 2 see also 3 references 4 further reading 5 external links toggle the table of contents adam8 3 languages bosanski русский українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein coding gene in humans adam8 identifiers aliases adam8 cd156 cd156a ms2 adam metallopeptidase domain 8 external ids omim 602267 mgi 107825 genecards adam8 available structures pdb ortholog search pdbe rcsb list of pdb id codes 4dd8 gene location human chr chromosome 10 human 1 band 10q26 3 start 133 262 420 bp 1 end 133 276 868 bp 1 gene location mouse chr chromosome 7 mouse 2 band 7 7 f4 start 139 558 845 bp 2 end 139 572 475 bp 2 rna expression pattern bgee human mouse ortholog top expressed in granulocyte blood spleen monocyte bone marrow cell pancreatic ductal cell periodontal fiber appendix upper lobe of left lung right lung top expressed in granulocyte stroma of bone marrow decidua trachea calvaria tibiofemoral joint lumbar spinal ganglion gastrula vein mesenteric lymph nodes more reference expression data biogps more reference expression data gene ontology molecular function metal ion binding protein self association peptidase activity protein binding metalloendopeptidase activity hydrolase activity cell adhesion molecule binding calcium ion binding serine type endopeptidase activity metallopeptidase activity zinc ion binding cellular component cytoplasm integral component of membrane alpha9 beta1 integrin vascular cell adhesion molecule 1 complex membrane tertiary granule integral component of plasma membrane cell surface specific granule dense core granule membrane podosome phagolysosome alpha9 beta1 integrin adam8 complex plasma membrane specific granule membrane tertiary granule membrane ficolin 1 rich granule membrane biological process positive regulation of inflammatory response extracellular matrix disassembly proteolysis positive regulation of cellular extravasation positive regulation of neutrophil extravasation positive regulation of protein processing regulation of cell cell adhesion positive regulation of protein secretion inflammatory response cellular response to hypoxia positive regulation of t cell migration positive regulation of tumor necrosis factor ligand superfamily member 11 production positive regulation of acute inflammatory response cell morphogenesis positive regulation of thymocyte apoptotic process positive regulation of bone resorption negative regulation of neuron apoptotic process positive regulation of fibronectin dependent thymocyte migration positive regulation of eosinophil migration positive regulation of nf kappab transcription factor activity leukocyte migration involved in inflammatory response positive regulation of membrane protein ectodomain proteolysis positive regulation of protein kinase b signaling positive regulation of t cell differentiation in thymus lymphocyte chemotaxis positive regulation of cell adhesion angiogenesis neutrophil degranulation cell cell adhesion positive regulation of map kinase activity positive regulation of innate immune response sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 101 11501 ensembl ensg00000151651 ensmusg00000025473 uniprot p78325 q05910 refseq mrna nm_001109 nm_001164489 nm_001164490 nm_001291066 nm_007403 refseq protein np_001100 np_001157961 np_001157962 np_001277995 np_031429 location ucsc chr 10 133 26 133 28 mb chr 7 139 56 139 57 mb pubmed search 3 4 wikidata view edit human view edit mouse a disintegrin and metalloproteinase domain containing protein 8 is an enzyme that in humans is encoded by the adam8 gene 5 6 function edit this gene encodes a member of the adam a disintegrin and metalloproteinase domain family members of this family are membrane anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell cell and cell matrix interactions including fertilization muscle development and neurogenesis the protein encoded by this gene may be involved in cell adhesion during neurodegeneration 6 see also edit cluster of differentiation references edit 1 2 3 grch38 ensembl release 89 ensg00000151651 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000025473 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine yoshiyama k higuchi y kataoka m matsuura k yamamoto s april 1997 cd156 human adam8 expression primary amino acid sequence and gene location genomics 41 1 56 62 doi 10 1006 geno 1997 4607 pmid 9126482 1 2 entrez gene adam8 adam metallopeptidase domain 8 further reading edit yamamoto s higuchi y yoshiyama k shimizu e kataoka m hijiya n matsuura k june 1999 adam family proteins in the immune system immunology today 20 6 278 84 doi 10 1016 s0167 5699 99 01464 4 pmid 10354553 schlomann u rathke hartlieb s yamamoto s jockusch h bartsch jw november 2000 tumor necrosis factor alpha induces a metalloprotease disintegrin adam8 cd 156 implications for neuron glia interactions during neurodegeneration the journal of neuroscience 20 21 7964 71 doi 10 1523 jneurosci 20 21 07964 2000 pmc 6772711 pmid 11050116 amour a knight cg english wr webster a slocombe pm knäuper v docherty aj becherer jd blobel cp murphy g july 2002 the enzymatic activity of adam8 and adam9 is not regulated by timps febs letters 524 1 3 154 8 bibcode 2002febsl 524 154a doi 10 1016 s0014 5793 02 03047 8 pmid 12135759 s2cid 37423323 ishikawa n daigo y yasui w inai k nishimura h tsuchiya e kohno n nakamura y december 2004 adam8 as a novel serological and histochemical marker for lung cancer clinical cancer research 10 24 8363 70 doi 10 1158 1078 0432 ccr 04 1436 pmid 15623614 foley sc mogas ak olivenstein r fiset po chakir j bourbeau j ernst p lemière c martin jg hamid q april 2007 increased expression of adam33 and adam8 with disease progression in asthma the journal of allergy and clinical immunology 119 4 863 71 doi 10 1016 j jaci 2006 12 665 pmid 17339047 gómez gaviro m domínguez luis m canchado j calafat j janssen h lara pezzi e fourie a tugores a valenzuela fernández a mollinedo f sánchez madrid f díaz gonzález f june 2007 expression and regulation of the metalloproteinase adam 8 during human neutrophil pathophysiological activation and its catalytic activity on l selectin shedding journal of immunology 178 12 8053 63 doi 10 4049 jimmunol 178 12 8053 pmid 17548643 valkovskaya n kayed h felix k hartmann d giese na osinsky sp friess h kleeff j 2008 adam8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer journal of cellular and molecular medicine 11 5 1162 74 doi 10 1111 j 1582 4934 2007 00082 x pmc 4401277 pmid 17979891 external links edit the merops online database for peptidases and their inhibitors m12 208 dead link adam8 human gene location in the ucsc genome browser adam8 human gene details in the ucsc genome browser pdbe kb provides an overview of all the structure information available in the pdb for human disintegrin and metalloproteinase domain containing protein 8 adam8 this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons v t e proteases metalloendopeptidases ec 3 4 24 adam proteins alpha secretases adam9 adam10 adam17 adam19 adam2 adam7 adam8 adam11 adam12 adam15 adam18 adam22 adam23 adam28 adam33 adamts1 adamts2 adamts3 adamts4 adamts5 adamts8 adamts9 adamts10 adamts12 adamts13 matrix metalloproteinases collagenases mmp1 mmp8 gelatinases mmp2 mmp9 mmp3 mmp7 mmp10 mmp11 mmp12 mmp13 mmp14 mmp15 mmp16 mmp17 mmp19 mmp20 mmp21 mmp23a mmp23b mmp24 mmp25 mmp26 mmp27 mmp28 other neprilysin procollagen peptidase thermolysin pappalysin 1 bone morphogenetic protein 1 lysostaphin insulin degrading enzyme zmpste24 v t e enzymes activity active site binding site catalytic triad oxyanion hole enzyme promiscuity diffusion limited enzyme cofactor enzyme catalysis regulation allosteric regulation cooperativity enzyme inhibitor enzyme activator classification ec number enzyme superfamily enzyme family list of enzymes kinetics enzyme kinetics eadie hofstee diagram hanes woolf plot lineweaver burk plot michaelis menten kinetics types ec1 oxidoreductases list ec2 transferases list ec3 hydrolases list ec4 lyases list ec5 isomerases list ec6 ligases list ec7 translocases list portal biology this membrane protein related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title adam8 oldid 1374760954 categories genes on human chromosome 10 clusters of differentiation proteases ec 3 4 24 adam metalloproteinases membrane protein stubs hidden categories articles with short description short description is different from wikidata use dmy dates from june 2016 all articles with dead external links articles with dead external links from january 2026 wikipedia articles incorporating text from the united states national library of medicine all stub articles this page was last edited on 13 september 2026 at 23 55 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents adam8 3 languages add topic