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#adipiplon (15), the (14), acid (12), and (10), gaba (9), antidepressants (9), tooltip (9), wikipedia (8), with (8), receptor (8), modulators (8), bromide (8), others (8), etc (8), chloral (7), antipsychotics (7), for (7), this (6), from (6), inhibitors (6), edit (6), page (5), drugs (5), positive (5), ethyl (5), sage (5), serotonin (5), reuptake (5), selective (5), contents (4), search (4), code (4), legal (4), was (4), articles (4), anxiolytic (4), org (4), hydrate (4), propofol (4), cgs (4), alpidem (4), etomidate (4), trazodone (4), phenibut (4), gabapentin (4), clinical (4), 2008 (4), neurogen (4), hide (4), move (4), sidebar (4), view (3), about (3), which (3), changes (3), chemical (3), identifier (3), status (3), short (3), description (3), wikidata (3), gabaa (3), allosteric (3), imidazoles (3), article (3), see (3), also (3), constituents (3), etifoxine (3), sodium (3), methyl (3), zolpidem (3), dhp (3), propoxate (3), butomidate (3), meprobamate (3), carisoprodol (3), 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ance move to sidebar hide from wikipedia the free encyclopedia chemical compound not to be confused with adipiodone pharmaceutical compound adipiplon clinical data routes of administration oral atc code none legal status legal status in general uncontrolled identifiers iupac name 7 2 3 fluoropyridin 2 yl 1h imidazol 1 yl methyl 2 methyl 8 propyl 1 2 4 triazolo 1 5 c pyrimidine cas number 840486 93 3 n chemspider 9373993 y unii opl214poj1 kegg d08840 y chembl chembl2103791 n comptox dashboard epa dtxsid40232944 chemical and physical data formula c 18 h 18 f n 7 molar mass 351 389 g mol 1 3d model jsmol interactive image smiles n4c c nc1n4cnc c1ccc cn2ccnc2 c3ncccc3f inchi inchi 1s c18h18fn7 c1 3 5 13 15 22 11 26 17 13 23 12 2 24 26 10 25 9 8 21 18 25 16 14 19 6 4 7 20 16 h4 6 9 11h 3 5 10h2 1 2h3 y key uamaihoeglexsv uhfffaoysa n y n y what is this verify adipiplon developmental code name ng2 73 is an anxiolytic drug developed by neurogen corporation it has similar effects to benzodiazepine drugs but is structurally distinct and classed as a nonbenzodiazepine anxiolytic adipiplon is a subtype selective gaba a receptor partial agonist which binds preferentially to the α 3 subtype this is significant as while several previous nonbenzodiazepine drugs have been developed that are selective for α 2 3 over the other subtypes adipiplon is one of the first drugs selected for clinical development which can discriminate between α 2 and α 3 as well as showing a little affinity for the α 1 or α 5 subtypes alpidem is selective for α 3 over α 2 but still has moderate affinity for α 1 whereas adipiplon is highly α 3 selective with little affinity for either α 1 α 2 or α 5 1 adipiplon was being researched as a potential medication for the treatment of anxiety and insomnia and in 2008 it was being used in phase iib trials 2 3 4 these trials were suspended after significant next day side effects were discovered 5 see also edit list of investigational antipsychotics list of investigational hypnotics alpidem references edit vinkers ch olivier b hanania t min w schreiber r hopkins sc et al october 2011 discriminative stimulus properties of gabaa receptor positive allosteric modulators tpa023 ocinaplon and ng2 73 in rats trained to discriminate chlordiazepoxide or zolpidem european journal of pharmacology 668 1 2 190 193 doi 10 1016 j ejphar 2011 06 054 pmid 21762686 pipeline summary gaba adipiplon neurogen archived from the original on april 11 2008 neurogen announces adipiplon preclinical and clinical data meet adipiplon the new insomnia drug sleep review archived from the original on april 15 2008 neurogen announces suspension of insomnia study with adipiplon fierce biotech 14 july 2008 v t e anxiolytics n05b 5 ht 1a r tooltip 5 ht1a receptor agonists buspirone gepirone tandospirone gaba a r tooltip gabaa receptor pams tooltip positive allosteric modulators benzodiazepines adinazolam alprazolam bromazepam camazepam chlordiazepoxide clobazam clonazepam clorazepate clotiazepam cloxazolam diazepam ethyl loflazepate etizolam fludiazepam halazepam ketazolam lorazepam medazepam nordazepam oxazepam pinazepam prazepam others alpidem barbiturates e g phenobarbital carbamates e g meprobamate carisoprodol chlormezanone ethanol alcohol etifoxine gabapentinoids α 2 δ vdcc blockers gabapentin gabapentin enacarbil phenibut baclofen pregabalin antidepressants ssris tooltip selective serotonin reuptake inhibitors e g escitalopram snris tooltip serotonin norepinephrine reuptake inhibitors e g duloxetine saris tooltip serotonin antagonist and reuptake inhibitors e g trazodone tcas tooltip tricyclic antidepressants e g clomipramine tecas tooltip tetracyclic antidepressants e g mirtazapine maois tooltip monoamine oxidase inhibitors e g phenelzine others agomelatine bupropion tianeptine vilazodone vortioxetine sympatholytics antiadrenergics alpha 1 blockers e g prazosin alpha 2 agonists e g clonidine dexmedetomidine guanfacine beta blockers e g propranolol atenolol betaxolol nadolol oxprenolol pindolol others benzoctamine cycloserine fabomotizole hydroxyzine lorpiprazole mebicar mepiprazole nicotine tobacco opipramol oxaflozane phenaglycodol phenibut picamilon selank tiagabine tofisopam validolum who em withdrawn from market clinical trials phase iii never to phase iii v t e hypnotics sedatives n05c gaba a alcohols 2m2b chloralodol ethanol alcohol diethylpropanediol ethchlorvynol methylpentynol trichloroethanol barbiturates allobarbital amobarbital aprobarbital barbital butabarbital butobarbital cyclobarbital ethallobarbital heptabarb hexobarbital mephobarbital methohexital narcobarbital pentobarbital phenallymal phenobarbital propylbarbital proxibarbal reposal secobarbital talbutal thiamylal thiopental thiotetrabarbital vinbarbital vinylbital benzodiazepines brotizolam cinolazepam climazolam clobazam clonazolam doxefazepam estazolam flubromazolam flunitrazolam flunitrazepam flurazepam flutemazepam flutoprazepam loprazolam lormetazepam midazolam nimetazepam nitemazepam nitrazepam nitrazolam quazepam temazepam triazolam carbamates carisoprodol emylcamate ethinamate hexapropymate meprobamate methocarbamol phenprobamate procymate tybamate imidazoles etomidate metomidate propoxate monoureides acecarbromal apronal apronalide bromisoval capuride carbromal ectylurea neurosteroids acebrochol alfadolone alfaxolone brexanolone allopregnanolone eltanolone pregnanolone ganaxolone hydroxydione minaxolone progesterone renanolone zuranolone nonbenzodiazepines eszopiclone indiplon lirequinil necopidem pagoclone pazinaclone saripidem suproclone suriclone zaleplon zolpidem zopiclone phenols cipepofol ciprofol fospropofol propofol propofol hemisuccinate piperidinediones glutethimide methyprylon piperidione pyrithyldione quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 others acetophenone acetylglycinamide chloral hydrate bromide compounds lithium bromide potassium bromide sodium bromide centalun chloral betaine chloral hydrate chloralose clomethiazole dichloralphenazone gaboxadol thip ibotenic acid amanita muscaria kavalactones loreclezole muscimol amanita muscaria paraldehyde petrichloral sesquiterpene isovaleramide isovaleric acid valerenic acid sulfonylalkanes sulfonmethane sulfonal tetronal trional triclofos gaba b 1 4 butanediol 4 fluorophenibut aceburic acid baclofen gabob ghb sodium oxybate gbl gvl jzp 386 phenibut tolibut valiloxybate xw 10172 h 1 antihistamines captodiame cyproheptadine diphenhydramine doxylamine hydroxyzine methapyrilene perlapine pheniramine promethazine propiomazine antidepressants serotonin antagonists and reuptake inhibitors etoperidone nefazodone trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc α 2 adrenergic clonidine detomidine dexmedetomidine lofexidine medetomidine romifidine tasipimidine tizanidine xylazine 5 ht 2a antidepressants trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc others niaprazine melatonin agomelatine melatonin ramelteon tasimelteon orexin daridorexant lemborexant suvorexant α 2 δ vdcc atagabalin baclofen gabapentin gabapentin enacarbil mirogabalin phenibut pregabalin others cannabinoids e g cannabis tetrahydrocannabinol dronabinol nabilone cannabidiol zenivol chlorophenylalkyldiols fenpentadiol metaglycodol phenaglycodol diethylpropanediol metamizil evoxine fenadiazole gaba reuptake inhibitors e g tiagabine guaifenesin related muscle relaxants chlorphenesin mephenesin mephenoxalone metaxalone methocarbamol midaflur opioids e g morphine passion flower pellotine phemerazole scopolamine serotonin precursors e g tryptophan 5 hydroxytryptophan 5 htp oxitriptan trazodone tributyrin umb68 valnoctamide v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valerenic acid valerenol unsorted benzodiazepine site positive modulators α pinene mrk 409 mk 0343 tcs 1105 tcs 1205 see also receptor signaling modulators gaba receptor modulators gaba metabolism transport modulators this article about an anxiolytic is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title adipiplon oldid 1357688905 categories drugs not assigned an atc code anxiolytic...