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bms 906024 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references toggle the table of contents bms 906024 3 languages italiano srpskohrvatski српскохрватски српски srpski edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia chemical compound pharmaceutical compound bms 906024 identifiers iupac name 2 r 3 s n 3 s 1 methyl 2 oxo 5 phenyl 2 3 dihydro 1 h 1 4 benzodiazepin 3 yl 2 3 bis 3 3 3 trifluoropropyl succinamide cas number 1401066 79 2 pubchem cid 66550890 pubchem sid 152143555 chemspider 28536138 unii drl23n424r comptox dashboard epa dtxsid30161234 chemical and physical data formula c 26 h 26 f 6 n 4 o 3 molar mass 556 509 g mol 1 3d model jsmol interactive image smiles cn1c2ccccc2c n c h c1 o nc o c h ccc f f f c h ccc f f f c o n c3ccccc3 inchi inchi 1s c26h26f6n4o3 c1 36 19 10 6 5 9 18 19 20 15 7 3 2 4 8 15 34 22 24 36 39 35 23 38 17 12 14 26 30 31 32 16 21 33 37 11 13 25 27 28 29 h2 10 16 17 22h 11 14h2 1h3 h2 33 37 h 35 38 t16 17 22 m0 s1 key ayouddaetnmcbw gshuggbrsa n bms 906024 is a drug with a benzodiazepine structure developed by bristol myers squibb and disclosed at the spring 2013 american chemical society meeting in new orleans to treat breast lung colon cancers and leukemia 1 the drug works as a pan notch inhibitor the structure is one of a set patented in 2012 2 and is being studied in clinical trials 3 4 5 references edit drahl c 2013 liveblogging first time disclosures of drug structures from acsnola chemical and engineering news american chemical society wo 2012129353 quesnelle c kim sh lee f gavai a bisfluoroalkyl 1 4 benzodiazepinone compounds published 27 september 2012 assigned to bristol myers squibb company gavai av quesnelle c norris d han wc gill p shan w et al may 2015 discovery of clinical candidate bms 906024 a potent pan notch inhibitor for the treatment of leukemia and solid tumors acs medicinal chemistry letters 6 5 523 7 doi 10 1021 acsmedchemlett 5b00001 pmc 4434460 pmid 26005526 morgan km fischer bs lee fy shah jj bertino jr rosenfeld j et al december 2017 gamma secretase inhibition by bms 906024 enhances efficacy of paclitaxel in lung adenocarcinoma molecular cancer therapeutics 16 12 2759 2769 doi 10 1158 1535 7163 mct 17 0439 pmc 5716926 pmid 28978720 sosa iglesias v theys j groot aj barbeau lm lemmens a yaromina a et al 2018 synergistic effects of notch γ secretase inhibition and standard of care treatment modalities in non small cell lung cancer cells frontiers in oncology 8 460 doi 10 3389 fonc 2018 00460 pmc 6234899 pmid 30464927 v t e benzodiazepines 1 4 benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam bromazepam bromonordiazepam bms 906024 camazepam carburazepam chlordiazepoxide cinazepam cinolazepam clonazepam cloniprazepam clorazepate cyprazepam delorazepam demoxepam desmethylflunitrazepam devazepide diazepam diclazepam difludiazepam doxefazepam elfazepam ethyl carfluzepate ethyl dirazepate ethyl loflazepate flubromazepam fletazepam fludiazepam flunitrazepam flurazepam flutemazepam flutoprazepam fosazepam gidazepam halazepam iclazepam irazepine kenazepine ketazolam lorazepam lormetazepam lufuradom meclonazepam medazepam menitrazepam metaclazepam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitemazepam nitrazepam nitrazepate nordazepam nortetrazepam oxazepam phenazepam pinazepam pivoxazepam prazepam proflazepam quazepam qh ii 66 reclazepam ro4491533 ro05 4082 ro5 4864 ro07 5220 ro07 9749 ro20 8065 ro20 8552 sh i 048a sulazepam temazepam tetrazepam tifluadom timelotem tolufazepam triflunordazepam tuclazepam uldazepam 1 5 benzodiazepines arfendazam clobazam cp 1414s lofendazam triflubazam 2 3 benzodiazepines girisopam gyki 52466 gyki 52895 nerisopam talampanel tofisopam triazolobenzodiazepines adinazolam alprazolam bromazolam clonazolam estazolam ethylbromazolam fluadinazolam flualprazolam flubromazolam flunitrazolam nitrazolam phenazolam pyrazolam rilmazolam active metabolite of rilmazafone triazolam imidazobenzodiazepines bretazenil climazolam evt 201 fg 8205 flumazenil gl ii 73 imidazenil 123 i iomazenil l 655 708 loprazolam midazolam pwz 029 remimazolam ro15 4513 ro48 6791 ro48 8684 ro4938581 sarmazenil sh 053 r ch3 2 f oxazolobenzodiazepines cloxazolam flutazolam haloxazolam mexazolam oxazolam thienodiazepines bentazepam clotiazepam ro09 9212 thienotriazolodiazepines α hydroxyetizolam apafant brotizolam ciclotizolam clotizolam deschloroclotizolam deschloroetizolam etizolam flubrotizolam fluclotizolam fluetizolam israpafant jq1 metizolam thienobenzodiazepines olanzapine telenzepine pyridodiazepines lopirazepam pyridotriazolodiazepines zapizolam pyrazolodiazepines razobazam ripazepam zolazepam zomebazam zometapine pyrrolodiazepines premazepam tetrahydroisoquinobenzodiazepines clazolam pyrrolobenzodiazepines anthramycin benzodiazepine prodrugs alprazolam triazolobenzophenone avizafone rilmazafone others unsorted ntx 1955 ro 7308480 atypical activity profile not gaba a receptor ligands this antineoplastic or immunomodulatory drug article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title bms 906024 oldid 1330130981 categories benzodiazepines experimental cancer treatments antineoplastic and immunomodulating drug stubs hidden categories articles with short description short description matches wikidata short description is different from wikidata articles without ebi source chemical pages without drugbank identifier articles without kegg source drugs missing an atc code drugs with no legal status articles containing unverified chemical infoboxes all stub articles this page was last edited on 29 december 2025 at 17 02 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents bms 906024 3 languages add topic