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catalysis, ugt1a4, ugt2b10, ugt2b4, ugt1a3, ugt1a6, ugt1a9, ugt2b7, ugt2b15, formed, cyp3a5, additionally, cyp2c9, catalyse, incubations, screened, linked, vitro, pooled, human, liver, fractions, incubated, did, show, any, present, body, individuals, suspected, taking, analysed, all, four, these, same, three, mono, mainly, studied, depth, results, described, below, lever, discrimination, test, performed, rats, trained, discriminate, against, evaluate, abuse, resulted, full, dose, dependent, comparison, respectively, somnolence, balance, ataxia, loss, coordination, thinking, self, assessment, capability, weakness, confusion, slurred, speech, blurred, vision, dizziness, drowsiness, lethargy, fatigue, palpitations, high, doses, induce, delirium, auditory, visual, hallucinations, deep, sleep, coma, similarly, prescription, usage, tolerance, rarely, fatal, taken, alone, nervous, system, depression, combined, medication, medical, relaxation, sedation, anxiolysis, anticonvulsive, therefore, 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e 28 united kingdom in the united kingdom bromazolam is a class c controlled substance 6 see also edit clobromazolam flualprazolam flubromazolam pyrazolam triazolam references edit anvisa 2023 03 31 rdc nº 784 listas de substâncias entorpecentes psicotrópicas precursoras e outras sob controle especial collegiate board resolution no 784 lists of narcotic psychotropic precursor and other substances under special control in brazilian portuguese diário oficial da união published 2023 04 04 archived from the original on 2023 08 03 retrieved 2023 08 16 1 2 dea emergency schedules bromazolam drug enforcement administration march 18 2026 retrieved march 19 2026 manchester kr lomas ec waters l dempsey fc maskell pd january 2018 the emergence of new psychoactive substance nps benzodiazepines a review drug testing and analysis 10 1 37 53 doi 10 1002 dta 2211 pmid 28471096 europol 2016 annual report on the implementation of council decision 2005 387 jha emcdda pdf european monitoring centre for drugs and drug addiction emcdda and european union agency for law enforcement cooperation europol 2017 waters l manchester kr maskell pd haegeman c haider s may 2018 the use of a quantitative structure activity relationship qsar model to predict gaba a receptor binding of newly emerging benzodiazepines science justice 58 3 219 225 doi 10 1016 j scijus 2017 12 004 pmid 29685303 1 2 3 4 zawilska jb wojcieszak j july 2019 an expanding world of new psychoactive substances designer benzodiazepines neurotoxicology 73 8 16 bibcode 2019neutx 73 8z doi 10 1016 j neuro 2019 02 015 pmid 30802466 s2cid 73461430 clayton t poe mm rallapalli s biawat p savić mm rowlett jk et al 2015 a review of the updated pharmacophore for the alpha 5 gaba a benzodiazepine receptor model international journal of medicinal chemistry 2015 430248 doi 10 1155 2015 430248 pmc 4657098 pmid 26682068 1 2 critical review report bromazolam pdf 20 october 2023 1 2 3 4 5 6 7 wagmann l manier sk felske c gampfer tm richter mj eckstein n et al november 2021 flubromazolam derived designer benzodiazepines toxicokinetics and analytical toxicology of clobromazolam and bromazolam journal of analytical toxicology 45 9 1014 1027 doi 10 1093 jat bkaa161 pmid 33048135 1 2 tan kr rudolph u lüscher c april 2011 hooked on benzodiazepines gabaa receptor subtypes and addiction trends in neurosciences 34 4 188 197 doi 10 1016 j tins 2011 01 004 pmc 4020178 pmid 21353710 dear jw bateman dn march 2016 benzodiazepines medicine 44 3 145 doi 10 1016 j mpmed 2015 12 025 orsolini l corkery jm chiappini s guirguis a vento a de berardis d et al september 2020 new designer benzodiazepines an analysis of the literature and psychonauts trip reports current neuropharmacology 18 9 809 837 doi 10 2174 1570159x18666200110121333 pmc 7569319 pmid 31933443 critical review report bromazolam pdf expert committee on drug dependence 2023 1 2 safaei ghomi j hatami a january 2008 facile and efficient one pot protocol for synthesis of 5 phenyl 1 4 benzodiazepine 2 one derivatives synthetic communications 38 2 297 302 doi 10 1080 00397910701750078 issn 0039 7911 1 2 wade lg simek jw 2017 organic chemistry ninth global ed harlow pearson education limited isbn 978 1 292 15110 6 brown tl lemay he bursten be murphy cj woodward pm stoltzfus mw 2022 chemistry the central science 15th global edition in si units ed harlow pearson isbn 978 1 292 40761 6 batlle e lizano e viñas m pujol md 2019 03 13 1 4 benzodiazepines and new derivatives description analysis and organic synthesis medicinal chemistry intechopen doi 10 5772 intechopen 79879 isbn 978 1 78985 173 1 us20040082573a1 cook j huang q he x li x yu j han d lelas s mcelroy j anxiolytic agents with reduced sedative and ataxic effects issued 2004 04 29 us7618958b2 cook j zhou h huang s sarma pv stereospecific anxiolytic and anticonvulsant agents with reduced muscle relaxant sedative hypnotic and ataxic effects issued 2009 11 17 us8835424b2 cook j huang s edwankar r namjoshi oa selective agents for pain suppression issued 2014 09 16 schedules of controlled substances temporary placement of bromazolam in schedule i federal register 2025 12 15 retrieved 2025 12 15 chapter 34 law lis virginia gov archived from the original on 2023 03 23 warren county grand jury of february 2023 indictments royal examiner 18 february 2023 florida man sentenced for selling counterfeit drugs on the dark net eastern district of virginia united states department of justice 24 august 2021 cousins s 9 august 2021 drug charges filed recently in madison county the telegraph 720 ilcs 570 illinois controlled substances act state of illinois 14 june 2024 papsun dm krotulski aj mastrovito r walton se logan bk 15 june 2022 bromazolam prevalence surging across the united states driven in part by increasing detections alongside fentanyl ncjrs virtual library u s department of justice bromazolam warning about deadly street drug bromazolam 9 december 2022 v t e benzodiazepines 1 4 benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam bromazepam bromonordiazepam bms 906024 camazepam carburazepam chlordiazepoxide cinazepam cinolazepam clonazepam cloniprazepam clorazepate cyprazepam delorazepam demoxepam desmethylflunitrazepam devazepide diazepam diclazepam difludiazepam doxefazepam elfazepam ethyl carfluzepate ethyl dirazepate ethyl loflazepate flubromazepam fletazepam fludiazepam flunitrazepam flurazepam flutemazepam flutoprazepam fosazepam gidazepam halazepam iclazepam irazepine kenazepine ketazolam lorazepam lormetazepam lufuradom meclonazepam medazepam menitrazepam metaclazepam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitemazepam nitrazepam nitrazepate nordazepam nortetrazepam oxazepam phenazepam pinazepam pivoxazepam prazepam proflazepam quazepam qh ii 66 reclazepam ro4491533 ro05 4082 ro5 4864 ro07 5220 ro07 9749 ro20 8065 ro20 8552 sh i 048a sulazepam temazepam tetrazepam tifluadom timelotem tolufazepam triflunordazepam tuclazepam uldazepam 1 5 benzodiazepines arfendazam clobazam cp 1414s lofendazam triflubazam 2 3 benzodiazepines girisopam gyki 52466 gyki 52895 nerisopam talampanel tofisopam triazolobenzodiazepines adinazolam alprazolam bromazolam clonazolam estazolam ethylbromazolam fluadinazolam flualprazolam flubromazolam flunitrazolam nitrazolam phenazolam pyrazolam rilmazolam active metabolite of rilmazafone triazolam imidazobenzodiazepines bretazenil climazolam evt 201 fg 8205 flumazenil gl ii 73 imidazenil 123 i iomazenil l 655 708 loprazolam midazolam pwz 029 remimazolam ro15 4513 ro48 6791 ro48 8684 ro4938581 sarmazenil sh 053 r ch3 2 f oxazolobenzodiazepines cloxazolam flutazolam haloxazolam mexazolam oxazolam thienodiazepines bentazepam clotiazepam ro09 9212 thienotriazolodiazepines α hydroxyetizolam apafant brotizolam ciclotizolam clotizolam deschloroclotizolam deschloroetizolam etizolam flubrotizolam fluclotizolam fluetizolam israpafant jq1 metizolam thienobenzodiazepines olanzapine telenzepine pyridodiazepines lopirazepam pyridotriazolodiazepines zapizolam pyrazolodiazepines razobazam ripazepam zolazepam zomebazam zometapine pyrrolodiazepines premazepam tetrahydroisoquinobenzodiazepines clazolam pyrrolobenzodiazepines anthramycin benzodiazepine prodrugs alprazolam triazolobenzophenone avizafone rilmazafone others unsorted ntx 1955 ro 7308480 atypical activity profile not gaba a receptor ligands v t e hypnotics sedatives n05c gaba a alcohols 2m2b chloralodol ethanol alcohol diethylpropanediol ethchlorvynol methylpentynol trichloroethanol barbiturates allobarbital amobarbital aprobarbital barbital butabarbital butobarbital cyclobarbital ethallobarbital heptabarb hexobarbital mephobarbital methohexital narcobarbital pentobarbital phenallymal phenobarbital propylbarbital proxibarbal reposal secobarbital talbutal thiamylal thiopental thiotetrabarbital vinbarbital vinylbital benzodiazepines brotizolam cinolazepam climazolam clobazam clonazolam doxefazepam estazolam flubromazolam flunitrazolam flunitrazepam flurazepam flutemazepam flutoprazepam loprazolam lormetazepam midazolam nimetazepam nitemazepam nitrazepam nitrazolam quazepam temazepam triazolam carbamates carisoprodol emylcamate ethinamate hexapropymate meprobamate methocarbamol phenprobamate procymate tybamate imidazoles etomidate metomidate propoxate monoureides acecarbromal apronal apronalide bromisoval capuride carbromal ectylurea neurosteroids acebrochol alfadolone alfaxolone brexanolone allopregnanolone eltanolone pregnanolone ganaxolone hydroxydione minaxolone progesterone renanolone zuranolone nonbenzodiazepines eszopiclone indiplon lirequinil necopidem pagoclone pazinaclone saripidem suproclone suriclone zaleplon zolpidem zopiclone phenols cipepofol ciprofol fospropofol propofol propofol hemisuccinate piperidinediones glutethimide methyprylon piperidione pyrithyldione quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 others acetophenone acetylglycinamide chloral hydrate bromide compounds lithium bromide potassium bromide sodium bromide centalun chloral betaine chloral hydrate chloralose clomethiazole dichloralphenazone gaboxadol thip ibotenic acid amanita muscaria kavalactones loreclezole muscimol amanita muscaria paraldehyde petrichloral sesquiterpene isovaleramide isovaleric acid valerenic acid sulfonylalkanes sulfonmethane sulfonal tetronal trional triclofos gaba b 1 4 butanediol 4 fluorophenibut aceburic acid baclofen gabob ghb sodium oxybate gbl gvl jzp 386 phenibut tolibut valiloxybate xw 10172 h 1 antihistamines captodiame cyproheptadine diphenhydramine doxylamine hydroxyzine methapyrilene perlapine pheniramine promethazine propiomazine antidepressants serotonin antagonists and reuptake inhibitors etoperidone nefazodone trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc α 2 adrenergic clonidine detomidine dexmedetomidine lofexidine medetomidine romifidine tasipimidine tizanidine xylazine 5 ht 2a antidepressants trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc others niaprazine melatonin agomelatine melatonin ramelteon tasimelteon orexin daridorexant lemborexant suvorexant α 2 δ vdcc atagabalin baclofen gabapentin gabapentin enacarbil mirogabalin phenibut pregabalin others cannabinoids e g cannabis tetrahydrocannabinol dronabinol nabilone cannabidiol zenivol chlorophenylalkyldiols fenpentadiol metaglycodol phenaglycodol diethylpropanediol metamizil evoxine fenadiazole gaba reuptake inhibitors e g tiagabine guaifenesin related muscle relaxants chlorphenesin mephenesin mephenoxalone metaxalone methocarbamol midaflur opioids e g morphine passion flower pellotine phemerazole scopolamine serotonin precursors e g tryptophan 5 hydroxytryptophan 5 htp oxitriptan trazodone tributyrin umb68 valnoctamide v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolon...