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enzyme, linked, il17re, il17rd, il17rc, il17rb, il17ra, il17, il18r1, il18r, il1r2, il1r1, il1, ifngr2, ifngr1, ifnar2, ifnar1, il28r, il20rb, il20ra, il20r, il22ra2, il22ra1, il22r, il10rb, il10ra, il10r, prolactin, hormone, il23r, il12rb2, il12r, cntfr, lifr, osmr, il27ra, il11ra, il6ra, gp130, il5ra, il5r, il3ra, il3r, il21r, il9r, il7ra, il7r, il13ra2, il13ra1, il13r, il4r, il15r, il2rb, il2ra, il2r, stat, tnfrsf27, eda2r, tnfrsf25, dr3, tnfrsf21, dr6, tnfrsf19, taj, troy, tnfrsf18, gitr, tnfrsf17, bcma, tnfrsf16, ngfr, tnfrsf14, hvem, tnfrsf13c, baffr, tnfrsf13b, taci, tnfrsf12a, tweakr, tnfrsf11b, osteoprotegerin, tnfrsf11a, rank, tnfrsf10d, dcr2, tnfrsf10c, dcr1, tnfrsf10b, dr5, tnfrsf10a, dr4, tnfrsf9, tnfrsf8, cd30, tnfrsf7, cd27, tnfrsf6b, dcr3, tnfrsf6, fas, tnfrsf5, cd40, tnfrsf4, tnfrsf3, ltbr, cmklr1, ackr, xcr1, cx3c, cx3cr1, cxcr6, cxcr5, cxcr4, cxcr3, cxcr2, cxcr1, cxc, ccr10, ccr9, ccr8, ccr7, ccr6, ccr5, ccr4, ccr3, ccrl2, ccr2, ccr1, gpcrs, 370, 369, 368, 367, 366, 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cd120 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 receptor subtypes 2 signaling pathway 3 see also 4 references 5 external links toggle the table of contents cd120 3 languages español فارسی русский edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein family tumor necrosis factor receptor superfamily member 1a identifiers symbol tnfrsf1a alt symbols cd120a tnfr1 ncbi gene 7132 hgnc 11916 omim 191190 refseq nm_001065 uniprot p19438 other data locus chr 12 p13 2 search for structures swiss model domains interpro tumor necrosis factor receptor superfamily member 1b identifiers symbol tnfrsf1b alt symbols cd120a tnfr2 ncbi gene 7133 hgnc 11917 omim 191191 refseq nm_001066 uniprot p20333 other data locus chr 1 p36 22 search for structures swiss model domains interpro cd120 c luster of d ifferentiation 120 can refer to two members of the tumor necrosis factor receptor superfamily tumor necrosis factor receptor 1 tnfr1 and tumor necrosis factor receptor 2 tnfr2 1 2 receptor subtypes edit there are two variants of the receptor each encoded by a separate gene cd120a tnfr1 tnfr superfamily member 1a cd120b tnfr2 tnfr superfamily member 1b tnfr1 is the receptor type responsible for mediation of tnf alpha induced sickness behavior 3 and is involved in neurotoxic processes 4 elevated levels of tnfr1 has been found in severe mental disorders 5 signaling pathway edit signaling pathway of tnf r1 dashed grey lines represent multiple steps see also edit cluster of differentiation references edit locksley rm killeen n lenardo mj 2001 the tnf and tnf receptor superfamilies integrating mammalian biology cell 104 4 487 501 doi 10 1016 s0092 8674 01 00237 9 pmid 11239407 s2cid 7657797 hehlgans t pfeffer k 2005 the intriguing biology of the tumour necrosis factor tumour necrosis factor receptor superfamily players rules and the games immunology 115 1 1 20 doi 10 1111 j 1365 2567 2005 02143 x pmc 1782125 pmid 15819693 palin k bluthé rm mccusker rh levade t moos f dantzer r kelley kw january 2009 the type 1 tnf receptor and its associated adapter protein fan are required for tnfalpha induced sickness behavior psychopharmacology 201 4 549 56 doi 10 1007 s00213 008 1331 4 pmc 2711641 pmid 18825372 mccoy mk tansey mg 2008 tnf signaling inhibition in the cns implications for normal brain function and neurodegenerative disease j neuroinflammation 5 1 45 doi 10 1186 1742 2094 5 45 pmc 2577641 pmid 18925972 hope s melle i aukrust p steen ne birkenaes ab lorentzen s agartz i ueland t andreassen oa november 2009 similar immune profile in bipolar disorder and schizophrenia selective increase in soluble tumor necrosis factor receptor i and von willebrand factor bipolar disord 11 7 726 34 doi 10 1111 j 1399 5618 2009 00757 x hdl 10852 34620 pmid 19839997 external links edit cd120a antigen at the u s national library of medicine medical subject headings mesh cd120b antigen at the u s national library of medicine medical subject headings mesh v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons v t e cytokine receptors chemokine receptor gpcrs cc ccr1 ccr2 ccrl2 ccr3 ccr4 ccr5 ccr6 ccr7 ccr8 ccr9 ccr10 cxc cxcr1 cxcr2 cxcr3 cxcr4 cxcr5 cxcr6 other cx3c cx3cr1 xc xcr1 ackr 1 2 3 4 5 cmklr1 tnf receptor 1 10 tnfr1 tnfrsf1a tnfr2 tnfrsf1b ltbr tnfrsf3 tnfrsf4 cd40 tnfrsf5 fas receptor tnfrsf6 dcr3 tnfrsf6b cd27 tnfrsf7 cd30 tnfrsf8 tnfrsf9 11 20 dr4 tnfrsf10a dr5 tnfrsf10b dcr1 tnfrsf10c dcr2 tnfrsf10d rank tnfrsf11a osteoprotegerin tnfrsf11b tweakr tnfrsf12a taci tnfrsf13b baffr tnfrsf13c hvem tnfrsf14 ngfr tnfrsf16 bcma tnfrsf17 gitr tnfrsf18 taj troy tnfrsf19 21 27 dr6 tnfrsf21 dr3 tnfrsf25 eda2r tnfrsf27 jak stat type i γ chain interleukin receptors il2r il2ra il2rb il15r il4r il13r il13ra1 il13ra2 il7r il7ra il9r il21r β chain interleukin receptors il3r il3ra il5r il5ra gm csf gp130 interleukin receptors il6ra 11 il11ra 27 il27ra osmr lifr cntfr il12rb1 interleukin receptors il12r il12rb1 il12rb2 il23r other other csf receptors epo g csf thrombopoietin hormone receptor gh prolactin type ii interleukin receptors il10r il10ra il10rb il22r il22ra1 il22ra2 il20r il20ra il20rb il28r interferon receptors α β ifnar1 ifnar2 γ ifngr1 ifngr2 ig superfamily il1 il1r1 il1r2 il18r il18r1 il 17 family il17 il17ra il17rb il17rc il17rd il17re enzyme linked receptor tyr csf1r kit ser thr tgf beta tgfbr1 tgfbr2 family category commons v t e cytokine receptor modulators chemokine see here instead csf erythropoietin agonists ara 290 asialo erythropoietin carbamylated erythropoietin cnto 530 darbepoetin alfa epoetin alfa epoetin beta epoetin delta epoetin epsilon epoetin gamma epoetin kappa epoetin omega epoetin theta epoetin zeta erythropoietin epo erythropoietin fc methoxy polyethylene glycol epoetin beta cera mircera peginesatide pegol sihematide epo 018b g csf csf3 agonists filgrastim granulocyte colony stimulating factor lenograstim leridistim lipegfilgrastim nartograstim pegfilgrastim pegnartograstim gm csf csf2 agonists ecogramostim granulocyte macrophage colony stimulating factor milodistim molgramostim regramostim sargramostim antibodies mavrilimumab namilumab otilimab m csf csf1 agonists cilmostim interleukin 34 lanimostim macrophage colony stimulating factor mirimostim kinase inhibitors agerafenib scf c kit see here instead thrombopoietin agonists eltrombopag pegacaristim promegapoietin romiplostim avatrombopag lusutrombopag thrombopoietin thpo mgdf interferon ifnar α β i agonists albinterferon interferon alpha interferon alfa ifn α interferon alfa ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 interferon alfa 2a interferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 interferon beta ifn β ifnb1 ifnb3 interferon beta 1a interferon beta 1b interferon kappa ifn ε κ τ ζ ifnk interferon omega ifn ω ifnw1 peginterferon alfa 2a peginterferon alfa 2b antibodies anifrolumab faralimomab medi 545 rontalizumab sifalimumab decoy receptors bifarcept ifngr γ ii agonists interferon gamma ifn γ interferon gamma 1b antibodies emapalumab fontolizumab ifnlr λ iii see il 28r ifnlr here instead interleukin see here instead tgfβ see here instead tnf see here instead others jak inhibitors jak1 abrocitinib baricitinib deuruxolitinib filgotinib momelotinib oclacitinib peficitinib ruxolitinib tofacitinib tasocitinib upadacitinib jak2 atiprimod azd 1480 baricitinib chz868 cucurbitacin i elatericin b jsi 124 cyt387 deuruxolitinib lestaurtinib nsc 7908 nsc 33994 pacritinib peficitinib ruxolitinib sd 1008 tofacitinib tasocitinib jak3 cercosporamide decernotinib vx 509 peficitinib ritlecitinib tcs 21311 tofacitinib tasocitinib whi p 154 zm 39923 zm 449829 tyk2 deucravacitinib others additional cytokines cardiotrophin 1 ct 1 fms like tyrosine kinase 3 ligand flt3l leukemia leukocyte inhibitory factor lif oncostatin m osm thymic stromal lymphopoietin tslp additional cytokine receptor modulators emfilermin lestaurtinib midostaurin quizartinib sorafenib sunitinib retrieved from https en wikipedia org w index php title cd120 oldid 1372998183 categories genes on human chromosome 12 genes on human chromosome 1 hidden categories articles with short description short description matches wikidata protein pages needing a picture this page was last edited on 3 september 2026 at 12 13 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents cd120 3 languages add topic