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cd7 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 function 2 see also 3 interactions 4 clinical significance 5 references 6 further reading 7 external links toggle the table of contents cd7 10 languages deutsch español français galego italiano polski русский татарча tatarça українська 中文 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia mammalian protein found in humans cd7 identifiers aliases cd7 gp40 leu 9 tp41 tp40 cd7 molecule external ids omim 186820 mgi 88344 genecards cd7 gene location human chr chromosome 17 human 1 band 17q25 3 start 82 314 868 bp 1 end 82 317 608 bp 1 gene location mouse chr chromosome 11 mouse 2 band 11 e2 11 84 85 cm start 120 927 573 bp 2 end 120 930 244 bp 2 rna expression pattern bgee human mouse ortholog top expressed in granulocyte blood spleen appendix lymph node thymus mucosa of transverse colon upper lobe of left lung bone marrow cell right lung top expressed in morula zygote primary oocyte blood secondary oocyte duodenum thymus spleen jejunum intestinal villus more reference expression data biogps more reference expression data gene ontology molecular function signaling receptor activity cellular component integral component of membrane plasma membrane membrane biological process adaptive immune response t cell activation immune response transmembrane receptor protein tyrosine kinase signaling pathway immune system process sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 924 12516 ensembl ensg00000173762 ensmusg00000025163 uniprot p09564 p50283 refseq mrna nm_006137 nm_009854 refseq protein np_006128 np_033984 location ucsc chr 17 82 31 82 32 mb chr 11 120 93 120 93 mb pubmed search 3 4 wikidata view edit human view edit mouse cd7 c luster of d ifferentiation 7 is a protein that in humans is encoded by the cd7 gene 5 function edit this gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily this protein is found on thymocytes and mature t cells it plays an essential role in t cell interactions and also in t cell b cell interaction during early lymphoid development 5 see also edit cluster of differentiation dc 7 interactions edit cd7 has been shown to interact with pik3r1 6 7 clinical significance edit cd7 can be aberrantly expressed in refractory anaemia with excess blasts raeb and may confer a worse prognosis 8 also a lack of cd7 expression could insinuate mycosis fungoides mf or sezary syndrome ss 9 references edit 1 2 3 grch38 ensembl release 89 ensg00000173762 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000025163 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine 1 2 entrez gene cd7 cd7 molecule lee dm patel dd pendergast am haynes bf august 1996 functional association of cd7 with phosphatidylinositol 3 kinase interaction via a yedm motif international immunology 8 8 1195 203 doi 10 1093 intimm 8 8 1195 pmid 8918688 subrahmanyam g rudd ce schneider h january 2003 association of t cell antigen cd7 with type ii phosphatidylinositol 4 kinase a key component in pathways of inositol phosphate turnover european journal of immunology 33 1 46 52 doi 10 1002 immu 200390006 pmid 12594831 s2cid 26388891 ogata k kakumoto k matsuda a tohyama k tamura h ueda y kurokawa m takeuchi j shibayama h emi n motoji t miyazaki y tamaki h mitani k naoe t sugiyama h takaku f october 2012 differences in blast immunophenotypes among disease types in myelodysplastic syndromes a multicenter validation study leukemia research 36 10 1229 36 doi 10 1016 j leukres 2012 05 006 pmid 22682984 stevens sr baron ed masten s cooper kd october 2002 circulating cd4 cd7 lymphocyte burden and rapidity of response predictors of outcome in the treatment of sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis archives of dermatology 138 10 1347 50 doi 10 1001 archderm 138 10 1347 pmid 12374541 s2cid 40541131 further reading edit stillwell r bierer be 2002 t cell signal transduction and the role of cd7 in costimulation immunologic research 24 1 31 52 doi 10 1385 ir 24 1 31 pmid 11485208 s2cid 23446615 baker e sandrin ms garson om sutherland gr mckenzie if webber lm 1990 localization of the cell surface antigen cd7 by chromosomal in situ hybridization immunogenetics 31 5 6 412 3 doi 10 1007 bf02115022 pmid 1695199 s2cid 2959698 schanberg le fleenor de kurtzberg j haynes bf kaufman re january 1991 isolation and characterization of the genomic human cd7 gene structural similarity with the murine thy 1 gene proceedings of the national academy of sciences of the united states of america 88 2 603 7 bibcode 1991pnas 88 603s doi 10 1073 pnas 88 2 603 pmc 50860 pmid 1703303 yoshikawa k seto m ueda r obata y notake k yokochi t takahashi t 1991 molecular cloning of the gene coding for the human t cell differentiation antigen cd7 immunogenetics 33 5 6 352 60 doi 10 1007 bf00216694 pmid 1711009 s2cid 20322510 ware re scearce rm dietz ma starmer cf palker tj haynes bf december 1989 characterization of the surface topography and putative tertiary structure of the human cd7 molecule journal of immunology 143 11 3632 40 doi 10 4049 jimmunol 143 11 3632 pmid 2479685 osada s utsumi kr ueda r akao y tsuge i nishida k okada j matsuoka h takahashi t 1988 assignment of a gene coding for a human t cell antigen with a molecular weight of 40 000 daltons to chromosome 17 cytogenetics and cell genetics 47 1 2 8 10 doi 10 1159 000132494 pmid 3258561 aruffo a seed b november 1987 molecular cloning of two cd7 t cell leukemia antigen cdnas by a cos cell expression system the embo journal 6 11 3313 6 doi 10 1002 j 1460 2075 1987 tb02651 x pmc 553785 pmid 3501369 maruyama k sugano s january 1994 oligo capping a simple method to replace the cap structure of eukaryotic mrnas with oligoribonucleotides gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 pmid 8125298 lee dm schanberg le fleenor de seldin mf haynes bf kaufman re 1996 the mouse cd7 gene identification of a new element common to the human cd7 and mouse thy 1 promoters immunogenetics 44 2 108 14 doi 10 1007 s002510050097 pmid 8662072 s2cid 29837811 bevec t stoka v pungercic g dolenc i turk v april 1996 major histocompatibility complex class ii associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin l the journal of experimental medicine 183 4 1331 8 doi 10 1084 jem 183 4 1331 pmc 2192513 pmid 8666891 leta e hou z lederman l jung lk october 1996 interaction between the extracellular domain of cd7 and concanavalin a a clue to the identity of the ligand for cd7 cellular immunology 173 1 15 21 doi 10 1006 cimm 1996 0247 pmid 8871597 lee dm patel dd pendergast am haynes bf august 1996 functional association of cd7 with phosphatidylinositol 3 kinase interaction via a yedm motif international immunology 8 8 1195 203 doi 10 1093 intimm 8 8 1195 pmid 8918688 suzuki y yoshitomo nakagawa k maruyama k suyama a sugano s october 1997 construction and characterization of a full length enriched and a 5 end enriched cdna library gene 200 1 2 149 56 doi 10 1016 s0378 1119 97 00411 3 pmid 9373149 slentz kesler ka hale lp kaufman re february 1998 identification and characterization of k12 sectm1 a novel human gene that encodes a golgi associated protein with transmembrane and secreted isoforms genomics 47 3 327 40 doi 10 1006 geno 1997 5151 pmid 9480746 steegmaier m yang b yoo js huang b shen m yu s luo y scheller rh december 1998 three novel proteins of the syntaxin snap 25 family the journal of biological chemistry 273 51 34171 9 doi 10 1074 jbc 273 51 34171 pmid 9852078 pace ke lee c stewart pl baum lg october 1999 restricted receptor segregation into membrane microdomains occurs on human t cells during apoptosis induced by galectin 1 journal of immunology 163 7 3801 11 doi 10 4049 jimmunol 163 7 3801 pmid 10490978 lyman sd escobar s rousseau am armstrong a fanslow wc february 2000 identification of cd7 as a cognate of the human k12 sectm1 protein the journal of biological chemistry 275 5 3431 7 doi 10 1074 jbc 275 5 3431 pmid 10652336 rotem yehudar r galperin e horowitz m august 2001 association of insulin like growth factor 1 receptor with ehd1 and snap29 the journal of biological chemistry 276 35 33054 60 doi 10 1074 jbc m009913200 pmid 11423532 rossi mi yokota t medina kl garrett kp comp pc schipul ah kincade pw january 2003 b lymphopoiesis is active throughout human life but there are developmental age related changes blood 101 2 576 84 doi 10 1182 blood 2002 03 0896 pmid 12393702 external links edit cd7 protein human at the u s national library of medicine medical subject headings mesh human cd7 genome location and cd7 gene details page in the ucsc genome browser v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons v t e cluster of differentiation by lineage lymphoid b cell pre b cell cd10 calla cd79a mature cd19 cd20 cd21 cr2 cd23 fcεrii cd127 cd40 plasma cell cd38 cd138 t nk t cell pan t antigens cd3 cd7 cd1 cd4 cd8 cd13 cd18 cd26 cd27 cd28 nk cell cd16 cd56 ncam cd57 all cd2 all cd5 myeloid cfu gm myelomonocyte cd11c cd14 cd15 cd31 cd64 cd68 mep cfu meg cd34 cd36 cd42 cd41 cd61 cfu e cd36 cd71 all pan myeloid cd13 cd33 stem cell cd34 this membrane protein related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title cd7 oldid 1301316201 categories genes on human chromosome 17 clusters of differentiation membrane protein stubs hidden categories articles with short description short description is different from wikidata all stub articles this page was last edited on 19 july 2025 at 05 21 utc page was rendered with parsoid text is available under 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