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cdh11 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 function 2 relevance to cancer 3 drug interactions 4 interactions 5 references 6 further reading 7 external links toggle the table of contents cdh11 5 languages العربية مصرى cymraeg татарча tatarça українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein coding gene in humans cdh11 identifiers aliases cdh11 cad11 cdhob ob osf 4 cadherin 11 esws tbhs2 external ids omim 600023 mgi 99217 genecards cdh11 available structures pdb ortholog search pdbe rcsb list of pdb id codes 2a4c 2a4e gene location human chr chromosome 16 human 1 band 16q21 start 64 943 753 bp 1 end 65 126 112 bp 1 gene location mouse chr chromosome 8 mouse 2 band 8 d1 8 50 44 cm start 103 358 727 bp 2 end 103 512 274 bp 2 rna expression pattern bgee human mouse ortholog top expressed in periodontal fiber stromal cell of endometrium tibia visceral pleura achilles tendon decidua left ovary right ovary germinal epithelium smooth muscle tissue top expressed in calvaria vas deferens dermis body of femur gonadal ridge efferent ductule human fetus left lung lobe maxillary prominence molar more reference expression data biogps more reference expression data gene ontology molecular function metal ion binding calcium ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding cellular component plasma membrane membrane cytoplasm integral component of membrane extracellular exosome cell surface catenin complex synapse schaffer collateral ca1 synapse glutamatergic synapse biological process homophilic cell adhesion via plasma membrane adhesion molecules skeletal system development adherens junction organization ossification corticospinal tract morphogenesis cell adhesion cell morphogenesis cell cell junction assembly calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules cell cell adhesion mediated by cadherin modulation of chemical synaptic transmission cell cell adhesion sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 1009 12552 ensembl ensg00000140937 ensmusg00000031673 uniprot p55287 p55288 refseq mrna nm_001308392 nm_001797 nm_001330576 nm_033664 nm_009866 refseq protein np_001295321 np_001317505 np_001788 np_033996 location ucsc chr 16 64 94 65 13 mb chr 8 103 36 103 51 mb pubmed search 3 4 wikidata view edit human view edit mouse cadherin 11 is a protein that in humans is encoded by the cdh11 gene 5 6 function edit this gene encodes a type ii classical cadherin from the cadherin superfamily integral membrane proteins that mediate calcium dependent cell cell adhesion mature cadherin proteins are composed of a large n terminal extracellular domain a single membrane spanning domain and a small highly conserved c terminal cytoplasmic domain type ii atypical cadherins are defined based on their lack of a hav cell adhesion recognition sequence specific to type i cadherins expression of this particular cadherin in osteoblastic cell lines and its upregulation during differentiation suggests a specific function in bone development and maintenance 6 the mammalian cdh 11 homologues are termed calsyntenin 7 relevance to cancer edit cdh11 is overexpressed in 15 of breast cancers and seems essential to tumour progression in some other cancer types 8 9 drug interactions edit arthritis drug celecoxib binds to cdh11 8 9 interactions edit cdh11 has been shown to interact with cdh2 10 references edit 1 2 3 grch38 ensembl release 89 ensg00000140937 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000031673 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine kremmidiotis g baker e crawford j eyre hj nahmias j callen df aug 1998 localization of human cadherin genes to chromosome regions exhibiting cancer related loss of heterozygosity genomics 49 3 467 71 doi 10 1006 geno 1998 5281 pmid 9615235 1 2 entrez gene cdh11 cadherin 11 type 2 ob cadherin osteoblast vogt l schrimpf sp meskenaite v frischknecht r kinter j leone dp ziegler u sonderegger p 2001 calsyntenin 1 a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium binding domain mol cell neurosci 17 1 151 66 doi 10 1006 mcne 2000 0937 pmid 11161476 s2cid 30856590 1 2 new therapeutic approach could target both cancer and arthritis 15 nov 2013 1 2 assefnia s dakshanamurthy s guidry auvil jm hampel c anastasiadis pz kallakury b uren a foley dw brown ml shapiro l brenner m haigh d byers sw mar 2014 cadherin 11 in poor prognosis malignancies and rheumatoid arthritis common target common therapies oncotarget 5 6 1458 74 doi 10 18632 oncotarget 1538 pmc 4039224 pmid 24681547 straub bk boda j kuhn c schnoelzer m korf u kempf t spring h hatzfeld m franke ww dec 2003 a novel cell cell junction system the cortex adhaerens mosaic of lens fiber cells j cell sci 116 pt 24 4985 95 doi 10 1242 jcs 00815 pmid 14625392 further reading edit suzuki s sano k tanihara h 1991 diversity of the cadherin family evidence for eight new cadherins in nervous tissue cell regul 2 4 261 70 doi 10 1091 mbc 2 4 261 pmc 361775 pmid 2059658 tanihara h sano k heimark rl st john t suzuki s 1995 cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin cell adhes commun 2 1 15 26 doi 10 3109 15419069409014199 pmid 7982033 okazaki m takeshita s kawai s kikuno r tsujimura a kudo a amann e 1994 molecular cloning and characterization of ob cadherin a new member of cadherin family expressed in osteoblasts j biol chem 269 16 12092 8 doi 10 1016 s0021 9258 17 32685 6 pmid 8163513 getsios s chen gt stephenson md leclerc p blaschuk ow maccalman cd 1998 regulated expression of cadherin 6 and cadherin 11 in the glandular epithelial and stromal cells of the human endometrium dev dyn 211 3 238 47 doi 10 1002 sici 1097 0177 199803 211 3 238 aid aja5 3 0 co 2 i pmid 9520111 s2cid 43022919 pishvaian mj feltes cm thompson p bussemakers mj schalken ja byers sw 1999 cadherin 11 is expressed in invasive breast cancer cell lines cancer res 59 4 947 52 pmid 10029089 kawaguchi j takeshita s kashima t imai t machinami r kudo a 1999 expression and function of the splice variant of the human cadherin 11 gene in subordination to intact cadherin 11 j bone miner res 14 5 764 75 doi 10 1359 jbmr 1999 14 5 764 pmid 10320525 s2cid 12829659 braungart e schumacher c hartmann e nekarda h becker kf höfler h atkinson mj 2000 functional loss of e cadherin and cadherin 11 alleles on chromosome 16q22 in colonic cancer j pathol 187 5 530 4 doi 10 1002 sici 1096 9896 199904 187 5 530 aid path293 3 0 co 2 c pmid 10398117 s2cid 22384331 kashima t kawaguchi j takeshita s kuroda m takanashi m horiuchi h imamura t ishikawa y ishida t mori s machinami r kudo a 1999 anomalous cadherin expression in osteosarcoma possible relationships to metastasis and morphogenesis am j pathol 155 5 1549 55 doi 10 1016 s0002 9440 10 65471 5 pmc 1866957 pmid 10550312 lecanda f cheng sl shin cs davidson mk warlow p avioli lv civitelli r 2000 differential regulation of cadherins by dexamethasone in human osteoblastic cells j cell biochem 77 3 499 506 doi 10 1002 sici 1097 4644 20000601 77 3 499 aid jcb14 3 0 co 2 0 pmid 10760957 s2cid 13331343 braungart e hartman e bechler k höfler h atkinson mj 2002 the intracellular domain of cadherin 11 is not required for the induction of cell aggregation adhesion or gap junction formation cell commun adhes 8 1 15 27 doi 10 3109 15419060109080704 pmid 11775026 s2cid 23322445 straub bk boda j kuhn c schnoelzer m korf u kempf t spring h hatzfeld m franke ww 2004 a novel cell cell junction system the cortex adhaerens mosaic of lens fiber cells j cell sci 116 pt 24 4985 95 doi 10 1242 jcs 00815 pmid 14625392 morimoto am tan n west k mcarthur g toner gc manning wc smolich bd cherrington jm 2004 gene expression profiling of human colon xenograft tumors following treatment with su11248 a multitargeted tyrosine kinase inhibitor oncogene 23 8 1618 26 doi 10 1038 sj onc 1207268 pmid 14985702 s2cid 23251484 marchong mn chen d corson tw lee c harmandayan m bowles e chen n gallie bl 2005 minimal 16q genomic loss implicates cadherin 11 in retinoblastoma mol cancer res 2 9 495 503 doi 10 1158 1541 7786 495 2 9 pmid 15383628 s2cid 24674595 oliveira am perez atayde ar inwards cy medeiros f derr v hsi bl gebhardt mc rosenberg ae fletcher ja 2004 usp6 and cdh11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so called secondary aneurysmal bone cysts am j pathol 165 5 1773 80 doi 10 1016 s0002 9440 10 63432 3 pmc 3278819 pmid 15509545 kiener hp brenner mb 2005 building the synovium cadherin 11 mediates fibroblast like synoviocyte cell to cell adhesion arthritis research therapy 7 2 49 54 doi 10 1186 ar1495 pmc 1065331 pmid 15743489 kiener hp lee dm agarwal sk brenner mb 2006 cadherin 11 induces rheumatoid arthritis fibroblast like synoviocytes to form lining layers in vitro am j pathol 168 5 1486 99 doi 10 2353 ajpath 2006 050999 pmc 1606584 pmid 16651616 external links edit cdh11 human gene location in the ucsc genome browser cdh11 human gene details in the ucsc genome browser v t e pdb gallery 2a4c crystal structure of mouse cadherin 11 ec1 2a4e crystal structure of mouse cadherin 11 ec1 2 v t e membrane proteins cell adhesion molecules calcium independent igsf cam n cam myelin protein zero icam 1 5 vcam 1 pe cam l1 family l1 cam nrcam nfasc chl1 nectin pvrl1 pvrl2 pvrl3 cadm1 cadm2 cadm3 cd155 integrins lfa 1 cd11a cd18 integrin alphaxbeta2 cd11c cd18 macrophage 1 antigen cd11b cd18 vla 4 cd49d cd29 glycoprotein iib iiia itga2b itgb3 calcium dependent cadherins classical cdh1 cdh2 cdh3 desmosomal desmoglein dsg1 dsg2 dsg3 dsg4 desmocollin dsc1 dsc2 dsc3 protocadherin pcdh1 pcdh15 pcdh19 unconventional ungrouped t cadherin cdh4 cdh5 cdh6 cdh8 cdh11 cdh12 cdh15 cdh16 cdh17 cdh9 cdh10 selectins e selectin l selectin p selectin other lymphocyte homing receptor cd44 l selectin integrin vla 4 lfa 1 carcinoembryonic antigen cd24 cd44 cd146 epcam this article on a gene on human chromosome 16 is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title cdh11 oldid 1374783000 categories genes on human chromosome 16 human chromosome 16 gene stubs cadherins hidden categories articles with short description short description is different from wikidata all stub articles this page was last edited on 14 september 2026 at 02 15 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents cdh11 5 languages add topic