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icam3, encoded, designated, np_573501, np_055072, np_001138383, np_001138382, np_001138381, np_001138380, np_001138379, np_001138378, np_001138377, np_001138376, nm_133238, nm_214676, nm_214675, nm_014257, nm_001144911, nm_001144910, nm_001144909, nm_001144908, nm_001144907, nm_001144906, nm_001144905, nm_001144904, mrna, q91zx1, q9h2x3, uniprot, 170786, 10332, species, oma, ncbi, databases, orthologs, sources, quickgo, amigo, into, attachment, innate, modulation, replication, system, endocytosis, processing, presentation, signal, transduction, leukocyte, extracellular, region, cytoplasm, signaling, mannose, calcium, dependent, metal, ion, molecular, function, ontology, biogps, ear, carotid, body, white, adipose, tissue, spleen, muscle, thigh, kidney, abdomen, lip, granulocyte, cortex, gland, ovary, placenta, testicle, pancreatic, ductal, germinal, epithelium, bgee, pattern, rna, 798, 984, 793, 397, 769, 605, 763, 210, 3jqh, codes, rcsb, pdbe, structures, genecards, 2157942, mgi, 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clec4m wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references 2 further reading 3 external links toggle the table of contents clec4m 6 languages العربية cymraeg فارسی русский татарча tatarça українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein coding gene in humans clec4m identifiers aliases clec4m cd209l cd299 dc sign2 dc signr dcsignr hp10347 l sign lsign c type lectin domain family 4 member m external ids omim 605872 mgi 2157942 genecards clec4m available structures pdb ortholog search pdbe rcsb list of pdb id codes 1k9j 1sl6 1xar 1xph 3jqh gene location human chr chromosome 19 human 1 band 19p13 2 start 7 763 210 bp 1 end 7 769 605 bp 1 gene location mouse chr chromosome 8 mouse 2 band 8 8 a1 1 start 3 793 397 bp 2 end 3 798 984 bp 2 rna expression pattern bgee human mouse ortholog top expressed in right lobe of liver germinal epithelium lymph node pancreatic ductal cell right lung testicle placenta left ovary right adrenal gland left adrenal cortex top expressed in granulocyte lip skin of abdomen right kidney muscle of thigh spleen right lung lobe white adipose tissue carotid body skin of external ear more reference expression data biogps more reference expression data gene ontology molecular function peptide antigen binding virus receptor activity metal ion binding calcium dependent protein binding mannose binding virion binding icam 3 receptor activity carbohydrate binding signaling receptor activity protein binding cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region host cell biological process leukocyte cell cell adhesion cell cell recognition intracellular transport of virus intracellular signal transduction antigen processing and presentation endocytosis adaptive immune response immune system process viral genome replication peptide antigen transport modulation by virus of host process innate immune response viral process virion attachment to host cell viral entry into host cell sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 10332 170786 ensembl ensg00000104938 ensmusg00000031494 uniprot q9h2x3 q91zx1 refseq mrna nm_001144904 nm_001144905 nm_001144906 nm_001144907 nm_001144908 nm_001144909 nm_001144910 nm_001144911 nm_014257 nm_214675 nm_214676 nm_133238 refseq protein np_001138376 np_001138377 np_001138378 np_001138379 np_001138380 np_001138381 np_001138382 np_001138383 np_055072 np_573501 location ucsc chr 19 7 76 7 77 mb chr 8 3 79 3 8 mb pubmed search 3 4 wikidata view edit human view edit mouse c type lectin domain family 4 member m is a protein that in humans is encoded by the clec4m gene 5 clec4m has also been designated as cd299 cluster of differentiation 299 this gene encodes l sign liver lymph node specific intracellular adhesion molecules 3 grabbing non integrin a type ii integral membrane protein that is 77 identical to cd209 antigen an hiv gp120 binding protein this protein like cd209 efficiently binds both intercellular adhesion molecule 3 icam3 and hiv 1 gp120 and enhances hiv 1 infection of t cells this gene is mapped to 19p13 3 in a cluster with the cd209 and cd23 fcer2 genes multiple alternatively spliced transcript variants have been found for this gene but the biological validity of some variants has not been determined 6 references edit 1 2 3 grch38 ensembl release 89 ensg00000104938 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000031494 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine yokoyama kobayashi m yamaguchi t sekine s kato s apr 1999 selection of cdnas encoding putative type ii membrane proteins on the cell surface from a human full length cdna bank gene 228 1 2 161 7 doi 10 1016 s0378 1119 99 00004 9 pmid 10072769 entrez gene clec4m c type lectin domain family 4 member m further reading edit baribaud f doms rw pöhlmann s 2006 the role of dc sign and dc signr in hiv and ebola virus infection can potential therapeutics block virus transmission and dissemination expert opin ther targets 6 4 423 31 doi 10 1517 14728222 6 4 423 pmid 12223058 s2cid 21541850 becker y 2004 hiv 1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes but the induced il 4 synthesis by fcepsilonri hematopoietic cells damages the adaptive immunity a review hypothesis and implications virus genes 29 1 147 65 doi 10 1023 b viru 0000032797 43537 d3 pmid 15215692 s2cid 5666009 lalor pf lai wk curbishley sm et al 2006 human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo world j gastroenterol 12 34 5429 39 doi 10 3748 wjg v12 i34 5429 pmc 4088223 pmid 17006978 curtis bm scharnowske s watson aj 1992 sequence and expression of a membrane associated c type lectin that exhibits cd4 independent binding of human immunodeficiency virus envelope glycoprotein gp120 proc natl acad sci u s a 89 17 8356 60 bibcode 1992pnas 89 8356c doi 10 1073 pnas 89 17 8356 pmc 49917 pmid 1518869 gattegno l ramdani a jouault t et al 1992 lectin carbohydrate interactions and infectivity of human immunodeficiency virus type 1 hiv 1 aids res hum retroviruses 8 1 27 37 doi 10 1089 aid 1992 8 27 pmid 1736938 soilleux ej barten r trowsdale j 2000 dc sign a related gene dc signr and cd23 form a cluster on 19p13 j immunol 165 6 2937 42 doi 10 4049 jimmunol 165 6 2937 pmid 10975799 pöhlmann s soilleux ej baribaud f et al 2001 dc signr a dc sign homologue expressed in endothelial cells binds to human and simian immunodeficiency viruses and activates infection in trans proc natl acad sci u s a 98 5 2670 5 bibcode 2001pnas 98 2670p doi 10 1073 pnas 051631398 pmc 30196 pmid 11226297 bashirova aa geijtenbeek tb van duijnhoven gc et al 2001 a dendritic cell specific intercellular adhesion molecule 3 grabbing nonintegrin dc sign related protein is highly expressed on human liver sinusoidal endothelial cells and promotes hiv 1 infection j exp med 193 6 671 8 doi 10 1084 jem 193 6 671 pmc 2193415 pmid 11257134 mummidi s catano g lam l et al 2001 extensive repertoire of membrane bound and soluble dendritic cell specific icam 3 grabbing nonintegrin 1 dc sign1 and dc sign2 isoforms inter individual variation in expression of dc sign transcripts j biol chem 276 35 33196 212 doi 10 1074 jbc m009807200 pmid 11337487 mitchell da fadden aj drickamer k 2001 a novel mechanism of carbohydrate recognition by the c type lectins dc sign and dc signr subunit organization and binding to multivalent ligands j biol chem 276 31 28939 45 doi 10 1074 jbc m104565200 pmid 11384997 feinberg h mitchell da drickamer k weis wi 2002 structural basis for selective recognition of oligosaccharides by dc sign and dc signr science 294 5549 2163 6 doi 10 1126 science 1066371 pmid 11739956 s2cid 25046581 alvarez cp lasala f carrillo j et al 2002 c type lectins dc sign and l sign mediate cellular entry by ebola virus in cis and in trans j virol 76 13 6841 4 doi 10 1128 jvi 76 13 6841 6844 2002 pmc 136246 pmid 12050398 soilleux ej morris ls rushbrook s et al 2002 expression of human immunodeficiency virus hiv binding lectin dc signr consequences for hiv infection and immunity hum pathol 33 6 652 9 doi 10 1053 hupa 2002 124036 pmid 12152166 strausberg rl feingold ea grouse lh et al 2003 generation and initial analysis of more than 15 000 full length human and mouse cdna sequences proc natl acad sci u s a 99 26 16899 903 bibcode 2002pnas 9916899m doi 10 1073 pnas 242603899 pmc 139241 pmid 12477932 lin g simmons g pöhlmann s et al 2003 differential n linked glycosylation of human immunodeficiency virus and ebola virus envelope glycoproteins modulates interactions with dc sign and dc signr j virol 77 2 1337 46 doi 10 1128 jvi 77 2 1337 1346 2003 pmc 140807 pmid 12502850 pöhlmann s zhang j baribaud f et al 2003 hepatitis c virus glycoproteins interact with dc sign and dc signr j virol 77 7 4070 80 doi 10 1128 jvi 77 7 4070 4080 2003 pmc 150620 pmid 12634366 ota t suzuki y nishikawa t et al 2004 complete sequencing and characterization of 21 243 full length human cdnas nat genet 36 1 40 5 doi 10 1038 ng1285 pmid 14702039 engering a van vliet sj hebeda k et al 2004 dynamic populations of dendritic cell specific icam 3 grabbing nonintegrin positive immature dendritic cells and liver lymph node specific icam 3 grabbing nonintegrin positive endothelial cells in the outer zones of the paracortex of human lymph nodes am j pathol 164 5 1587 95 doi 10 1016 s0002 9440 10 63717 0 pmc 1615649 pmid 15111305 v t e pdb gallery 1k9j complex of dc signr and glcnac2man3 1sl6 crystal structure of a fragment of dc signr containing the carbohydrate recognition domain and two repeats of the neck complexed with lewis x 1xar crystal structure of a fragment of dc signr containing the carbohydrate recognition domain and two repeats of the neck 1xph structure of dc signr and a portion of repeat domain 8 external links edit clec4m protein human at the u s national library of medicine medical subject headings mesh clec4m human gene location in the ucsc genome browser clec4m human gene details in the ucsc genome browser this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons this membrane protein related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title clec4m oldid 1309240662 categories genes on human chromosome 19 clusters of differentiation membrane protein stubs hidden categories articles with short description short description is different from wikidata wikipedia articles incorporating text from the united states national library of medicine all stub articles this page was last edited on 2 september 2025 at 23 22 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents clec4m 6 languages add topic