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i m 1990 cadherins a molecular family important in selective cell cell adhesion annual review of biochemistry 59 237 52 doi 10 1146 annurev bi 59 070190 001321 pmid 2197976 ozawa m baribault h kemler r june 1989 the cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species the embo journal 8 6 1711 7 doi 10 1002 j 1460 2075 1989 tb03563 x pmc 401013 pmid 2788574 garcía castro mi vielmetter e bronner fraser m may 2000 n cadherin a cell adhesion molecule involved in establishment of embryonic left right asymmetry science 288 5468 1047 51 bibcode 2000sci 288 1047g doi 10 1126 science 288 5468 1047 pmid 10807574 angst bd khan lu severs nj whitely k rothery s thompson rp et al january 1997 dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium circulation research 80 1 88 94 doi 10 1161 01 res 80 1 88 pmid 8978327 radice gl rayburn h matsunami h knudsen ka takeichi m hynes ro january 1997 developmental defects in mouse embryos lacking n cadherin developmental biology 181 1 64 78 doi 10 1006 dbio 1996 8443 pmid 9015265 kostetskii i moore r kemler r radice gl june 2001 differential adhesion leads to segregation and exclusion of n cadherin deficient cells in chimeric embryos developmental biology 234 1 72 9 doi 10 1006 dbio 2001 0250 pmid 11356020 linask kk knudsen ka gui yh may 1997 n cadherin catenin interaction necessary component of cardiac cell compartmentalization during early vertebrate heart development developmental biology 185 2 148 64 doi 10 1006 dbio 1997 8570 pmid 9187080 ong ll kim n mima t cohen gould l mikawa t january 1998 trabecular myocytes of the embryonic heart require n cadherin for migratory unit identity developmental biology 193 1 1 9 doi 10 1006 dbio 1997 8775 pmid 9466883 peters ns severs nj rothery sm lincoln c yacoub mh green cr august 1994 spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium circulation 90 2 713 25 doi 10 1161 01 cir 90 2 713 pmid 8044940 forbes ms sperelakis n 1985 intercalated discs of mammalian heart a review of structure and function tissue cell 17 5 605 48 doi 10 1016 0040 8166 85 90001 1 pmid 3904080 vite a radice gl june 2014 n cadherin catenin complex as a master regulator of intercalated disc function cell communication adhesion 21 3 169 79 doi 10 3109 15419061 2014 908853 pmc 6054126 pmid 24766605 zuppinger c schaub mc eppenberger hm april 2000 dynamics of early contact formation in cultured adult rat cardiomyocytes studied by n cadherin fused to green fluorescent protein journal of molecular and cellular cardiology 32 4 539 55 doi 10 1006 jmcc 1999 1086 pmid 10756112 dou jp jiao b sheng jj yu zb october 2014 dynamic assembly of intercalated disc during postnatal development in the rat myocardium sheng li xue bao 66 5 569 74 pmid 25332002 goncharova ej kam z geiger b january 1992 the involvement of adherens junction components in myofibrillogenesis in cultured cardiac myocytes development 114 1 173 83 doi 10 1242 dev 114 1 173 pmid 1576958 hertig cm eppenberger eberhardt m koch s eppenberger hm january 1996 n cadherin in adult rat cardiomyocytes in culture i functional role of n cadherin and impairment of cell cell contact by a truncated n cadherin mutant journal of cell science 109 pt 1 1 1 10 doi 10 1242 jcs 109 1 1 pmid 8834785 ferreira cornwell mc luo y narula n lenox jm lieberman m radice gl april 2002 remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart journal of cell science 115 pt 8 1623 34 doi 10 1242 jcs 115 8 1623 pmid 11950881 kostetskii i li j xiong y zhou r ferrari va patel vv et al february 2005 induced deletion of the n cadherin gene in the heart leads to dissolution of the intercalated disc structure circulation research 96 3 346 54 doi 10 1161 01 res 0000156274 72390 2c pmid 15662031 cheng l yung a covarrubias m radice gl june 2011 cortactin is required for n cadherin regulation of kv1 5 channel function the journal of biological chemistry 286 23 20478 89 doi 10 1074 jbc m111 218560 pmc 3121477 pmid 21507952 entrez gene cdh2 cadherin 2 type 1 n cadherin neuronal halperin d stavsky a kadir r drabkin m wormser o yogev y october 2021 cdh2 mutation affecting n cadherin function causes attention deficit hyperactivity disorder in humans and mice nature communications 6187 12 6187 625 30 bibcode 2021natco 12 6187h doi 10 1038 s41467 021 26426 1 pmc 8548587 pmid 34702855 ramis conde i chaplain ma anderson ar drasdo d march 2009 multi scale modelling of cancer cell intravasation the role of cadherins in metastasis physical biology 6 1 016008 bibcode 2009phbio 6a6008r doi 10 1088 1478 3975 6 1 016008 pmid 19321920 s2cid 206096620 moya pr dodman nh timpano kr rubenstein lm rana z fried rl et al august 2013 rare missense neuronal cadherin gene cdh2 variants in specific obsessive compulsive disorder and tourette disorder phenotypes european journal of human genetics 21 8 850 4 doi 10 1038 ejhg 2012 245 pmc 3722668 pmid 23321619 tsipis a athanassiadou am athanassiadou p kavantzas n agrogiannis g patsouris e september 2010 apoptosis related factors p53 bcl 2 and the defects of force transmission in dilated cardiomyopathy pathology research and practice 206 9 625 30 doi 10 1016 j prp 2010 05 007 pmid 20591580 1 2 3 4 5 straub bk boda j kuhn c schnoelzer m korf u kempf t et al december 2003 a novel cell cell junction system the cortex adhaerens mosaic of lens fiber cells journal of cell science 116 pt 24 4985 95 doi 10 1242 jcs 00815 pmid 14625392 1 2 3 wahl jk kim yj cullen jm johnson kr wheelock mj may 2003 n cadherin catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane the journal of biological chemistry 278 19 17269 76 doi 10 1074 jbc m211452200 pmid 12604612 izawa i nishizawa m ohtakara k inagaki m february 2002 densin 180 interacts with delta catenin neural plakophilin related armadillo repeat protein at synapses the journal of biological chemistry 277 7 5345 50 doi 10 1074 jbc m110052200 pmid 11729199 brady kalnay sm rimm dl tonks nk august 1995 receptor protein tyrosine phosphatase ptpmu associates with cadherins and catenins in vivo the journal of cell biology 130 4 977 86 doi 10 1083 jcb 130 4 977 pmc 2199947 pmid 7642713 brady kalnay sm mourton t nixon jp pietz ge kinch m chen h et al april 1998 dynamic interaction of ptpmu with multiple cadherins in vivo the journal of cell biology 141 1 287 96 doi 10 1083 jcb 141 1 287 pmc 2132733 pmid 9531566 besco ja hooft van huijsduijnen r frostholm a rotter a october 2006 intracellular substrates of brain enriched receptor protein tyrosine phosphatase rho rptprho ptprt brain research 1116 1 50 7 doi 10 1016 j brainres 2006 07 122 pmid 16973135 s2cid 23343123 sacco pa mcgranahan tm wheelock mj johnson kr august 1995 identification of plakoglobin domains required for association with n cadherin and alpha catenin the journal of biological chemistry 270 34 20201 6 doi 10 1074 jbc 270 34 20201 pmid 7650039 sinn hw balsamo j lilien j lin jj september 2002 localization of the novel xin protein to the adherens junction complex in cardiac and skeletal muscle during development developmental dynamics 225 1 1 13 doi 10 1002 dvdy 10131 pmid 12203715 s2cid 23393425 schroen b leenders jj van erk a bertrand at van loon m van leeuwen re et al may 2007 lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load induced cardiac myocyte hypertrophy the journal of experimental medicine 204 5 1227 35 doi 10 1084 jem 20070145 pmc 2118572 pmid 17485520 further reading edit doherty p smith p walsh fs 1997 shared cell adhesion molecule cam homology domains point to cams signalling via fgf receptors perspectives on developmental neurobiology 4 2 3 157 68 pmid 9168198 makrigiannakis a coukos g blaschuk o coutifaris c 2000 follicular atresia and luteolysis evidence of a role for n cadherin annals of the new york academy of sciences 900 1 46 55 bibcode 2000nyasa 900 46m doi 10 1111 j 1749 6632 2000 tb06215 x pmid 10818391 s2cid 30583247 hazan rb qiao r keren r badano i suyama k april 2004 cadherin switch in tumor progression annals of the new york academy of sciences 1014 1 155 63 bibcode 2004nyasa1014 155h doi 10 1196 annals 1294 016 pmid 15153430 s2cid 37486403 cavallaro u december 2004 n cadherin as an invasion promoter a novel target for antitumor therapy current opinion in investigational drugs 5 12 1274 8 pmid 15648948 salomon d ayalon o patel king r hynes ro geiger b may 1992 extrajunctional distribution of n cadherin in cultured human endothelial cells journal of cell science 102 pt 1 1 7 17 doi 10 1242 jcs 102 1 7 pmid 1500442 knudsen ka wheelock mj august 1992 plakoglobin or an 83 kd homologue distinct from beta catenin interacts with e cadherin and n cadherin the journal of cell biology 118 3 671 9 doi 10 1083 jcb 118 3 671 pmc 2289540 pmid 1639850 reid ra hemperly jj october 1990 human n cadherin nucleotide and deduced amino acid sequence nucleic acids research 18 19 5896 doi 10 1093 nar 18 19 5896 pmc 332345 pmid 2216790 walsh fs barton ch putt w moore se kelsell d spurr n goodfellow pn september 1990 n cadherin gene maps to human chromosome 18 and is not linked to the e cadherin gene journal of neurochemistry 55 3 805 12 doi 10 1111 j 1471 4159 1990 tb04563 x pmid 2384753 s2cid 29840435 selig s bruno s scharf jm wang ch vitale e gilliam tc kunkel lm april 1995 expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene proceedings of the national academy of sciences of the united states of america 92 9 3702 6 bibcode 1995pnas 92 3702s doi 10 1073 pnas 92 9 3702 pmc 42029 pmid 7731968 wallis j fox mf walsh fs july 1994 structure of the human n cadherin gene yac analysis and fine chromosomal mapping to 18q11 2 genomics 22 1 172 9 doi 10 1006 geno 1994 1358 pmid 7959764 andersson am edvardsen k skakkebaek ne august 1994 expression and localization of n and e cadherin in the human testis and epididymis international journal of andrology 17 4 174 80 doi 10 1111 j 1365 2605 1994 tb01239 x pmid 7995652 matsuyoshi n imamura s june 1997 multiple cadherins are expressed in human fibroblasts biochemical and biophysical research communications 235 2 355 8 bibcode 1997bbrc 235 355m doi 10 1006 bbrc 1997 6707 pmid 9199196 navarro p ruco l dejana e march 1998 differential localization of ve and n cadherins in human endothelial cells ve cadherin competes with n cadherin for junctional localization the journal of cell biology 140 6 1475 84 doi 10 1083 jcb 140 6 1475 pmc 2132661 pmid 9508779 gaidar ya lepekhin ea sheichetova ga witt m february 1998 distribution of n cadherin and ncam in neurons and endocrine cells of the human embryonic and fetal gastroenteropancreatic system acta histochemica 100 1 83 97 doi 10 1016 s0065 1281 98 80008 1 pmid 9542583 kremmidiotis g baker e crawford j eyre hj nahmias j callen df may 1998 localization of human cadherin genes to chromosome regions exhibiting cancer related loss of heterozygosity genomics 49 3 467 71 doi 10 1006 geno 1998 5281 pmid 9615235 lu q paredes m medina m zhou j cavallo r peifer m et al february 1999 delta catenin an adhesive junction associated protein which promotes cell scattering the journal of cell biology 144 3 519 32 doi 10 1083 jcb 144 3 519 pmc 2132907 pmid 9971746 shan ws tanaka h phillips gr arndt k yoshida m colman dr shapiro l february 2000 functional cis heterodimers of n and r cadherins the journal of cell biology 148 3 579 90 doi 10 1083 jcb 148 3 579 pmc 2174798 pmid 10662782 husi h ward ma choudhary js blackstock wp grant sg july 2000 proteomic analysis of nmda receptor adhesion protein signaling complexes nature neuroscience 3 7 661 9 doi 10 1038 76615 hdl 1842 742 pmid 10862698 s2cid 14392630 external links edit cdh2 protein human at the u s national library of medicine medical subject headings mesh cdh2 human gene location in the ucsc genome browser cdh2 human gene details in the ucsc genome browser this article incorporates text from the united states national library of medicine which is in the public domain v t e pdb gallery 1ncg structural basis of cell cell adhesion by cadherins 1nch structural basis of cell cell adhesion by cadherins 1nci structural basis of cell cell adhesion by cadherins 1ncj n cadherin two domain fragment v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons v t e membrane proteins cell adhesion molecules calcium independent igsf cam n cam myelin protein zero icam 1 5 vcam 1 pe cam l1 family l1 cam nrcam nfasc chl1 nectin pvrl1 pvrl2 pvrl3 cadm1 cadm2 cadm3 cd155 integrins lfa 1 cd11a cd18 integrin alphaxbeta2 cd11c cd18 macrophage 1 antigen cd11b cd18 vla 4 cd49d cd29 glycoprotein iib iiia itga2b itgb3 calcium dependent cadherins classical cdh1 cdh2 cdh3 desmosomal desmoglein dsg1 dsg2 dsg3 dsg4 desmocollin dsc1 dsc2 dsc3 protocadherin pcdh1 pcdh15 pcdh19 unconventional ungrouped t cadherin cdh4 cdh5 cdh6 cdh8 cdh11 cdh12 cdh15 cdh16 cdh17 cdh9 cdh10 selectins e selectin l selectin p selectin other lymphocyte homing receptor cd44 l selectin integrin vla 4 lfa 1 carcinoembryonic antigen cd24 cd44 cd146 epcam retrieved from https en wikipedia org w index php title cadherin 2 oldid 1374782700 categories genes on human chromosome 18 clusters of 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