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projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia triazolobenzodiazepine clonazepam derivative not to be confused with clonazepam or clorazolam pharmaceutical compound clonazolam clinical data dependence liability very high routes of administration oral legal status legal status au s9 prohibited substance br class b1 psychoactive drugs 1 ca unscheduled de npsg industrial and scientific use only nz class c illegal uk class c us schedule i un schedule iv identifiers iupac name 6 2 chlorophenyl 1 methyl 8 nitro 4 h 1 2 4 triazolo 4 3 a 1 4 benzodiazepine cas number 33887 02 4 pubchem cid 12317881 chemspider 15468596 unii hjh52yyc1x kegg c22814 comptox dashboard epa dtxsid301014166 echa infocard 100 428 803 chemical and physical data formula c 17 h 12 cl n 5 o 2 molar mass 353 77 g mol 1 3d model jsmol interactive image smiles cc1 nn c2n1c3 c c c c c3 n o o c nc2 c4 cc cc c4cl inchi inchi 1s c17h12cln5o2 c1 10 20 21 16 9 19 17 12 4 2 3 5 14 12 18 13 8 11 23 24 25 6 7 15 13 22 10 16 h2 8h 9h2 1h3 key xjrglcawbrzufc uhfffaoysa n clonazolam also known as clonitrazolam is a drug of the triazolobenzodiazepine tbzd class which are benzodiazepines bzds fused with a triazole ring although little research has been done about its effects and metabolism it is sold online as a designer drug 2 3 4 5 6 the synthesis of clonazolam was first reported in 1971 and the drug was described as the most active compound in the series tested 7 depending on dose consumed clonazolam may pose comparatively higher risk than other designer benzodiazepines due to its ability to produce strong sedation and amnesia at doses as small as 0 5 mg 2 8 legality edit united kingdom edit in the uk clonazolam has been classified as a class c drug by the may 2017 amendment to the misuse of drugs act 1971 along with several other designer benzodiazepine drugs 9 united states edit it is a schedule i controlled substance in the united states and is not fda approved for human consumption virginia state law has declared all of the following related medications are schedule i clonazolam etizolam flualprazolam flubromazolam and flubromazepam 10 minnesota declared clonazolam a schedule i drug in august 2020 citation needed on 23 december 2022 the dea announced it had begun consideration on the matter of placing clonazolam under temporary schedule i status 11 later on 25 july 2023 the dea published a pre print notice that clonazolam would become temporarily scheduled as a controlled substance from 26 july 2023 to 26 july 2025 12 on 25 july 2025 and effective the following day the dea extended the temporary scheduling until 26 july 2026 13 australia edit in australia clonazolam is schedule 9 under federal law 14 sweden edit sweden s public health agency suggested classifying clonazolam as a hazardous substance on 1 june 2015 15 effects edit clonazolam s effects are similar to other benzodiazepines such as anxiolysis disinhibition lethargy muscle relaxation and euphoria 2 8 while no dose of clonazolam is considered safe due to its lack of research and extreme potency doses higher than 0 5 mg can cause benzodiazepine overdose in some individuals 2 8 the effects of a benzodiazepine overdose include sedation confusion amnesia insufficient breathing loss of consciousness and death 2 8 because dependence can occur in a short period of time or even with a large initial dose withdrawal symptoms including seizures and death may occur acutely following the period of intoxication 2 8 see also edit adinazolam alprazolam clonazepam no triazole ring estazolam flubromazolam pyrazolam triazolam references edit anvisa 31 march 2023 rdc nº 784 listas de substâncias entorpecentes psicotrópicas precursoras e outras sob controle especial collegiate board resolution no 784 lists of narcotic psychotropic precursor and other substances under special control in brazilian portuguese diário oficial da união published 4 april 2023 archived from the original on 2023 08 03 retrieved 2023 08 16 1 2 3 4 5 6 huppertz lm bisel p westphal f et al july 2015 characterization of the four designer benzodiazepines clonazolam deschloroetizolam flubromazolam and meclonazepam and identification of their in vitro metabolites forensic toxicology 33 2 388 395 doi 10 1007 s11419 015 0277 6 s2cid 33278305 meyer mr bergstrand mp helander a beck o may 2016 identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam meclonazepam and nifoxipam by nano liquid chromatography high resolution mass spectrometry for drug testing purposes analytical and bioanalytical chemistry 408 13 3571 91 doi 10 1007 s00216 016 9439 6 pmid 27071765 s2cid 25831532 chaslot m el balkhi s robin t morichon j picard n saint marcoux f june 2016 exploration des métabolites de 8 benzodiazépines de synthèse toxicologie analytique et clinique 28 2 s32 bibcode 2016toxac 28s 32c doi 10 1016 j toxac 2016 03 053 pettersson bergstrand m helander a hansson t beck o april 2017 detectability of designer benzodiazepines in cedia emit ii plus heia and kims ii immunochemical screening assays drug testing and analysis 9 4 640 645 doi 10 1002 dta 2003 pmid 27366870 høiseth g tuv ss karinen r november 2016 blood concentrations of new designer benzodiazepines in forensic cases forensic science international 268 35 38 doi 10 1016 j forsciint 2016 09 006 pmid 27685473 hester jb rudzik ad kamdar bv november 1971 6 phenyl 4h s triazolo 4 3 a 1 4 benzodiazepines which have central nervous system depressant activity journal of medicinal chemistry 14 11 1078 81 doi 10 1021 jm00293a015 pmid 5165540 1 2 3 4 5 moosmann b king la auwärter v june 2015 designer benzodiazepines a new challenge world psychiatry 14 2 248 doi 10 1002 wps 20236 pmc 4471986 pmid 26043347 the misuse of drugs act 1971 amendment order 2017 retrieved 2023 04 15 54 1 3446 schedule i proposed rule schedules of controlled substances temporary placement of etizolam flualprazolam clonazolam flubromazolam and diclazepam in schedule i federal register dea 23 december 2022 schedules of controlled substances temporary placement of etizolam flualprazolam clonazolam flubromazolam and diclazepam in schedule i pdf federal register dea 25 july 2023 retrieved 2023 07 25 schedules of controlled substances extension of temporary placement of clonazolam diclazepam etizolam flualprazolam and flubromazolam in schedule i of the controlled substances act federal register 25 july 2025 retrieved 2025 08 13 therapeutic goods poisons standard february 2023 instrument 2023 legislation gov au 31 january 2023 retrieved 2023 04 15 23 nya ämnen kan klassas som narkotika eller hälsofarlig vara in swedish folkhälsomyndigheten retrieved 2015 08 06 v t e benzodiazepines 1 4 benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam bromazepam bromonordiazepam bms 906024 camazepam carburazepam chlordiazepoxide cinazepam cinolazepam clonazepam cloniprazepam clorazepate cyprazepam delorazepam demoxepam desmethylflunitrazepam devazepide diazepam diclazepam difludiazepam doxefazepam elfazepam ethyl carfluzepate ethyl dirazepate ethyl loflazepate flubromazepam fletazepam fludiazepam flunitrazepam flurazepam flutemazepam flutoprazepam fosazepam gidazepam halazepam iclazepam irazepine kenazepine ketazolam lorazepam lormetazepam lufuradom meclonazepam medazepam menitrazepam metaclazepam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitemazepam nitrazepam nitrazepate nordazepam nortetrazepam oxazepam phenazepam pinazepam pivoxazepam prazepam proflazepam quazepam qh ii 66 reclazepam ro4491533 ro05 4082 ro5 4864 ro07 5220 ro07 9749 ro20 8065 ro20 8552 sh i 048a sulazepam temazepam tetrazepam tifluadom timelotem tolufazepam triflunordazepam tuclazepam uldazepam 1 5 benzodiazepines arfendazam clobazam cp 1414s lofendazam triflubazam 2 3 benzodiazepines girisopam gyki 52466 gyki 52895 nerisopam talampanel tofisopam triazolobenzodiazepines adinazolam alprazolam bromazolam clonazolam estazolam ethylbromazolam fluadinazolam flualprazolam flubromazolam flunitrazolam nitrazolam phenazolam pyrazolam rilmazolam active metabolite of rilmazafone triazolam imidazobenzodiazepines bretazenil climazolam evt 201 fg 8205 flumazenil gl ii 73 imidazenil 123 i iomazenil l 655 708 loprazolam midazolam pwz 029 remimazolam ro15 4513 ro48 6791 ro48 8684 ro4938581 sarmazenil sh 053 r ch3 2 f oxazolobenzodiazepines cloxazolam flutazolam haloxazolam mexazolam oxazolam thienodiazepines bentazepam clotiazepam ro09 9212 thienotriazolodiazepines α hydroxyetizolam apafant brotizolam ciclotizolam clotizolam deschloroclotizolam deschloroetizolam etizolam flubrotizolam fluclotizolam fluetizolam israpafant jq1 metizolam thienobenzodiazepines olanzapine telenzepine pyridodiazepines lopirazepam pyridotriazolodiazepines zapizolam pyrazolodiazepines razobazam ripazepam zolazepam zomebazam zometapine pyrrolodiazepines premazepam tetrahydroisoquinobenzodiazepines clazolam pyrrolobenzodiazepines anthramycin benzodiazepine prodrugs alprazolam triazolobenzophenone avizafone rilmazafone others unsorted ntx 1955 ro 7308480 atypical activity profile not gaba a receptor ligands v t e hypnotics sedatives n05c gaba a alcohols 2m2b chloralodol ethanol alcohol diethylpropanediol ethchlorvynol methylpentynol trichloroethanol barbiturates allobarbital amobarbital aprobarbital barbital butabarbital butobarbital cyclobarbital ethallobarbital heptabarb hexobarbital mephobarbital methohexital narcobarbital pentobarbital phenallymal phenobarbital propylbarbital proxibarbal reposal secobarbital talbutal thiamylal thiopental thiotetrabarbital vinbarbital vinylbital benzodiazepines brotizolam cinolazepam climazolam clobazam clonazolam doxefazepam estazolam flubromazolam flunitrazolam flunitrazepam flurazepam flutemazepam flutoprazepam loprazolam lormetazepam midazolam nimetazepam nitemazepam nitrazepam nitrazolam quazepam temazepam triazolam carbamates carisoprodol emylcamate ethinamate hexapropymate meprobamate methocarbamol phenprobamate procymate tybamate imidazoles etomidate metomidate propoxate monoureides acecarbromal apronal apronalide bromisoval capuride carbromal ectylurea neurosteroids acebrochol alfadolone alfaxolone brexanolone allopregnanolone eltanolone pregnanolone ganaxolone hydroxydione minaxolone progesterone renanolone zuranolone nonbenzodiazepines eszopiclone indiplon lirequinil necopidem pagoclone pazinaclone saripidem suproclone suriclone zaleplon zolpidem zopiclone phenols cipepofol ciprofol fospropofol propofol propofol hemisuccinate piperidinediones glutethimide methyprylon piperidione pyrithyldione quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 others acetophenone acetylglycinamide chloral hydrate bromide compounds lithium bromide potassium bromide sodium bromide centalun chloral betaine chloral hydrate chloralose clomethiazole dichloralphenazone gaboxadol thip ibotenic acid amanita muscaria kavalactones loreclezole muscimol amanita muscaria paraldehyde petrichloral sesquiterpene isovaleramide isovaleric acid valerenic acid sulfonylalkanes sulfonmethane sulfonal tetronal trional triclofos gaba b 1 4 butanediol 4 fluorophenibut aceburic acid baclofen gabob ghb sodium oxybate gbl gvl jzp 386 phenibut tolibut valiloxybate xw 10172 h 1 antihistamines captodiame cyproheptadine diphenhydramine doxylamine hydroxyzine methapyrilene perlapine pheniramine promethazine propiomazine antidepressants serotonin antagonists and reuptake inhibitors etoperidone nefazodone trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc α 2 adrenergic clonidine detomidine dexmedetomidine lofexidine medetomidine romifidine tasipimidine tizanidine xylazine 5 ht 2a antidepressants trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc others niaprazine melatonin agomelatine melatonin ramelteon tasimelteon orexin daridorexant lemborexant suvorexant α 2 δ vdcc atagabalin baclofen gabapentin gabapentin enacarbil mirogabalin phenibut pregabalin others cannabinoids e g cannabis tetrahydrocannabinol dronabinol nabilone cannabidiol zenivol chlorophenylalkyldiols fenpentadiol metaglycodol phenaglycodol diethylpropanediol metamizil evoxine fenadiazole gaba reuptake inhibitors e g tiagabine guaifenesin related muscle relaxants chlorphenesin mephenesin mephenoxalone metaxalone methocarbamol midaflur opioids e g morphine passion flower pellotine phemerazole scopolamine serotonin precursors e g tryptophan 5 hydroxytryptophan 5 htp oxitriptan trazodone tributyrin umb68 valnoctamide v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n...