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from (90), cucurbitacin (87), and (46), the (37), edit (30), #cucurbitacins (23), doi (17), interferon (16), pmid (13), dihydrocucurbitacin (12), with (11), glucoside (11), epoetin (10), see (9), alfa (9), wilbrandia (9), ebracteata (9), bibcode (8), bitter (8), hemsleya (8), endecaphylla (8), also (8), picrorhiza (8), roots (8), wikipedia (7), cucurbitane (7), here (7), agonists (7), fruit (7), cucurbita (7), cucumber (7), plants (7), other (7), trichosanthes (7), isocucurbitacin (7), some (7), this (6), plant (6), beta (6), acetate (6), instead (6), s2cid (6), journal (6), squash (6), 2015 (6), colocynthis (6), biosynthesis (6), can (6), gene (6), page (5), glycosides (5), ifn (5), erythropoietin (5), 2012 (5), citrullus (5), zhang (5), fruits (5), andreana (5), for (5), ecballium (5), elaterium (5), are (5), cucumis (5), deoxocucurbitacin (5), tricuspidata (5), epi (5), helmseya (5), contents (4), search (4), articles (4), factor (4), csf (4), science (4), their (4), pmc (4), 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photosynthetic, response, bottle, lagenaria, siceraria, molina, standl, relationship, accumulation, tolerance, 143, 89836386, scienta, 2017, 027, 2018schor, 133m, 133, scientia, horticulturae, rymal, chambliss, bond, smith, april, 1984, 271, 30921968, 4315, 0362, 028x, food, protection, occurring, california, alabama, march, live, poisoned, women, lose, hair, kusin, angert, von, derau, horowitz, giffin, 189, case, series, diarrheal, illness, following, ingestion, 1999, 2011, annual, meeting, north, american, congress, nacct, october, las, vegas, usa, 720, 218859008, 3109, 15563650, 700015, 574, pharmacogn, rev, chawech, jarraya, girardi, vansteelandt, marti, nasri, september, 26437392, 6332406, 3390, molecules201018001, 18001, molecules, schrad, song, dai, xie, type, triterpenoid, saponins, isolated, ethyl, extract, 38269788, 25761128, 10286020, 1015999, 2015janpr, 813s, 813, pan, deng, xiang, gao, cai, 2007, hexanorcucurbitane, 27762659, 17885839, 10286020600782538, 2007janpr, 525w, 525, kupchan, meshulam, sneden, 1978, marah, oreganus, 769, s0031, 94223, 1978pchem, 767k, 767, halaweish, tallamy, 1993, profile, forcucurbita, candidate, tissue, culture, 23549863, 24249132, 1007, bf00987375, 1993jceco, 1135h, 1135, ecology, zheng, yang, 2008, octanorcucurbitane, hiv, 18088099, 1021, np0704396, 2008jnatp, 153c, 153, liao, kuo, liu, shih, december, 2010, 21139270, 1248, cpb, pharmaceutical, bulletin, cytoprotective, tert, butyl, hydroperoxide, induced, hepatotoxicity, hepg2, cells, zhou, duan, november, regulation, 6213, 206561241, 25430763, 1126, 1259215, 2014sci, 1084s, 1084, aeri, mir, pharmacognosy, reviews, gamlath, gunatilaka, alvi, atta, rahman, balasubramaniam, 1988, 3229, issn, 80031, 1988pchem, 3225g, 3225, vulgaris, chiu, nie, cordell, 2005, structures, activities, 16010347, 1039, b418841c, 386, product, reports, kapoor, its, rapidly, emerging, role, management, systemic, malignancies, besides, lung, carcinomas, 359, 23350897, 1089, cbr, 1373, biotherapy, radiopharmaceuticals, alghasham, 23559908, 3612419, 12816, 0006025, international, health, sciences, promising, target, therapy, zeitung, 2020, süddeutsche, gift, und, kürbis, siamenoside, scandenosides, r10, r11, neomogroside, momordicoside, momordicine, mogroside, euphol, goyaglycoside, consumption, sometimes, referred, concentration, toxin, could, result, wild, growth, temperature, cross, pollination, impart, melon, constituents, pentanorcucurbitacins, stems, dried, ethanol, glucopyranosides, colocynth, flower, called, exploding, squirting, 152, 156, 164, 165, there, substances, seen, deriving, skeleton, loss, groups, attached, adjacent, becoming, 130, aromatic, methyl, dihydrodeacetylpicracin, deoxy, acetylbryoamaride, bryoamaride, brydioside, deters, feeding, spinosides, datisca, glomerata, datiscosides, panacis, scandens, scandenoside, persea, perseapicroside, acetoxy, graciliflora, elaterin, strong, inhibits, cell, adhesion, antifeedant, sloanea, zuliaensis, amarinin, luffa, 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Text of the page (random words):
o glucoside from roots of picrorhiza kurrooa 4 4 deacetoxycucurbitacin b 2 o glucoside from roots of picrorhiza kurrooa 4 5 isocucurbitacin b from echinocystis fabacea 4 6 23 24 dihydroisocucurbitacin b 3 glucoside from wilbrandia ebracteata 4 7 23 24 dihydro 3 epi isocucurbitacin b from bryonia verrucosa 4 8 pentanorcucurbitacin b or 3 7 dioxo 23 24 25 26 27 pentanorcucurbit 5 en 22 oic acid c 25 h 36 o 4 white powder 8 2 cucurbitacin c edit cucurbitacin c from cucumis sativus cucumber 4 11 cucurbitacin d edit cucurbitacin d cucurbitacin d from trichosanthes kirilowii and many other plants 4 e g cucurbita andreana 10 12 3 epi isocucurbitacin d from species of physocarpus 4 14 and phormium tenax 11 22 deoxocucurbitacin d from hemsleya endecaphylla 14 mg 72 g 9 6 23 24 dihydrocucurbitacin d from trichosanthes kirilowii 4 13 also from h endecaphylla 80 mg 72 g 9 3 23 24 dihydro epi isocucurbitacin d from acanthosicyos horridus 4 20 22 deoxocucurbitacin d from wilbrandia ebracteata 4 21 anhydro 22 deoxo 3 epi isocucurbitacin d from ecballium elaterium 4 22 25 o acetyl 2 deoxycucurbitacin d amarinin from luffa amara 4 24 2 deoxycucurbitacin d from sloanea zuliaensis 4 23 cucurbitacin e edit cucurbitacin e α elaterin from roots of wilbrandia ebracteata strong antifeedant for the flea beetle inhibits cell adhesion 4 also in e g cucurbita andreana 10 27 22 23 dihydrocucurbitacin e from hemsleya endecaphylla 9 mg 72 g 9 8 and from roots of wilbrandia ebracteata 4 28 22 23 dihydrocucurbitacin e 2 glucoside from roots of wilbrandia ebracteata 4 29 isocucurbitacin e from cucumis prophetarum 4 30 23 24 dihydroisocucurbitacin e from cucumis prophetarum 4 31 cucurbitacin f edit cucurbitacin f from elaeocarpus dolichostylus 4 33 cucurbitacin f 25 acetate from helmseya graciliflora 4 34 23 24 dihydrocucurbitacin f from helmseya amabilis 4 35 25 acetoxy 23 24 dihydrocucurbitacin f from helmseya amabilis hemslecin a 4 36 23 24 dihydrocucurbitacin f glucoside from helmseya amabilis 4 40 cucurbitacin ii glucoside from helmseya amabilis 4 41 hexanorcucurbitacin f from elaeocarpus dolichostylus 4 43 perseapicroside a from persea mexicana 4 44 scandenoside r9 from hemsleya panacis scandens 4 45 15 oxo cucurbitacin f from cowania mexicana 4 46 15 oxo 23 24 dihydrocucurbitacin f from cowania mexicana 4 47 datiscosides b d and h from datisca glomerata 4 48 50 cucurbitacin g edit cucurbitacin g from roots of wilbrandia ebracteata 4 52 3 epi isocucurbitacin g from roots of wilbrandia ebracteata 4 54 cucurbitacin h edit cucurbitacin h stereoisomer of cucurbitacin g from roots of wilbrandia ebracteata 4 53 cucurbitacin i edit cucurbitacin i cucurbitacin i elatericin b from hemsleya endecaphylla 10 mg 72 g 9 7 also from ecballium elaterium 4 citrullus colocynthis 4 cucurbita andreana 10 deters feeding by flea beetle 4 55 hexanorcucurbitacin i from ecballium elaterium 4 56 23 24 dihydrocucurbitacin i see cucurbitacin l khekadaengosides d and k from the fruits of trichosanthes tricuspidata 4 57 58 11 deoxocucurbitacin i from desfontainia spinosa 4 59 spinosides a and b from desfontainia spinosa 4 61 62 23 24 dihydro 11 deoxocucurbitacin i from desfontainia spinosa 4 60 cucurbitacin j edit cucurbitacin j from iberis amara 4 69 cucurbitacin j 2 o β glucopyranoside from trichosanthes tricuspidata 4 71 cucurbitacin k edit cucurbitacin k stereoisomer of cucurbitacin j 12 2 from iberis amara 4 70 cucurbitacin k 2 o β glucopyranoside from trichosanthes tricuspidata 4 72 cucurbitacin l edit cucurbitacin l or 23 24 dihydrocucurbitacin i 4 63 12 1 brydioside a from bryonia dioica 4 64 bryoamaride from bryonia dioica 4 65 25 o acetylbryoamaride from trichosanthes tricuspidata 4 66 khekadaengosides a and b from trichosanthes tricuspidata 4 67 68 cucurbitacin o edit cucurbitacin o from brandegea bigelovii 4 73 cucurbitacin q 2 o glucoside from picrorhiza kurrooa 4 76 16 deoxy d 16 hexanorcucurbitacin o from ecballium elaterium 4 77 deacetylpicracin from picrorhiza scrophulariaeflora 4 78 deacetylpicracin 2 o glucoside from picrorhiza scrophulariaeflora 4 80 22 deoxocucurbitacin o from wilbrandia ebracteata 4 83 cucurbitacin p edit cucurbitacin p from brandegea bigelovii 4 74 picracin from picrorhiza scrophulariaeflora 4 79 picracin 2 o glucoside from picrorhiza scrophulariaeflora 4 79 cucurbitacin q edit cucurbitacin q cucurbitacin q from brandegea bigelovii 4 75 23 24 dihydrodeacetylpicracin 2 o glucoside from picrorhiza kurrooa 4 82 cucurbitacin q1 from cucumis species actually cucurbitacin f 25 acetate 4 cucurbitacin r edit cucurbitacin r is actually 23 24 dihydrocucurbitacin d 4 cucurbitacin s edit cucurbitacin s from bryonia dioica 4 84 85 cucurbitacin t edit cucurbitacin t from the fruits of citrullus colocynthis 4 86 28 29 norcucurbitacins edit this section needs expansion you can help by adding missing information february 2022 there are several substances that can be seen as deriving from cucurbit 5 ene skeleton by loss of one of the methyl groups 28 or 29 attached to carbon 4 often with the adjacent ring ring a becoming aromatic 4 87 130 other edit this section needs expansion you can help by adding missing information february 2022 several other cucurbitacins have been found in plants 4 152 156 164 165 occurrence and bitter taste edit fruit and flower of the ecballium elaterium also called the squirting cucumber or exploding cucumber containing cucurbitacin b constituents of the colocynth fruit and leaves citrullus colocynthis include cucurbitacins 13 14 15 the 2 o β d glucopyranosides of cucurbitacins k and l can be extracted with ethanol from fruits of cucurbita pepo cv dayangua 12 pentanorcucurbitacins a and b can be extracted with methanol from the stems of momordica charantia 8 cucurbitacins b and i and derivatives of cucurbitacins b d and e can be extracted with methanol from dried tubers of hemsleya endecaphylla 9 cucurbitacins impart a bitter taste in plant foods such as cucumber zucchini melon and pumpkin 7 toxicity edit the toxicity associated with consumption of foods high in cucurbitacins is sometimes referred to as toxic squash syndrome 16 17 the high concentration of toxin in the plants could result from cross pollination 18 with wild cucurbitaceae species or from plant growth stress due to high temperature and drought 19 see also edit goyaglycoside euphol hemslecin mogroside momordicine momordicoside neomogroside scandenosides r1 r8 r10 r11 siamenoside i references edit zeitung s 21 august 2015 gift in zucchini und kürbis süddeutsche de in german retrieved 2020 08 21 alghasham aa january 2013 cucurbitacins a promising target for cancer therapy international journal of health sciences 7 1 77 89 doi 10 12816 0006025 pmc 3612419 pmid 23559908 kapoor s may 2013 cucurbitacin b and its rapidly emerging role in the management of systemic malignancies besides lung carcinomas cancer biotherapy radiopharmaceuticals 28 4 359 doi 10 1089 cbr 2012 1373 pmid 23350897 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 chen jc chiu mh nie rl cordell ga qiu sx june 2005 cucurbitacins and cucurbitane glycosides structures and biological activities natural product reports 22 3 386 99 doi 10 1039 b418841c pmid 16010347 gamlath cb gunatilaka aa alvi ka atta ur rahman balasubramaniam s 1988 01 01 cucurbitacins of colocynthis vulgaris phytochemistry 27 10 3225 3229 bibcode 1988pchem 27 3225g doi 10 1016 0031 9422 88 80031 1 issn 0031 9422 kaushik u aeri v mir sr 2015 05 05 cucurbitacins an insight into medicinal leads from nature pharmacognosy reviews 9 17 12 18 doi 10 4103 0973 7847 156314 pmc 4441156 pmid 26009687 1 2 3 shang y ma y zhou y zhang h duan l chen h et al november 2014 plant science biosynthesis regulation and domestication of bitterness in cucumber science 346 6213 1084 8 bibcode 2014sci 346 1084s doi 10 1126 science 1259215 pmid 25430763 s2cid 206561241 1 2 3 chen cr liao yw wang l kuo yh liu hj shih wl et al december 2010 cucurbitane triterpenoids from momordica charantia and their cytoprotective activity in tert butyl hydroperoxide induced hepatotoxicity of hepg2 cells chemical pharmaceutical bulletin 58 12 1639 42 doi 10 1248 cpb 58 1639 pmid 21139270 1 2 3 4 5 6 7 chen jc zhang gh zhang zq qiu mh zheng yt yang lm et al january 2008 octanorcucurbitane and cucurbitane triterpenoids from the tubers of hemsleya endecaphylla with hiv 1 inhibitory activity journal of natural products 71 1 153 5 bibcode 2008jnatp 71 153c doi 10 1021 np0704396 pmid 18088099 1 2 3 4 halaweish ft tallamy dw june 1993 a new cucurbitacin profile forcucurbita andreana a candidate for cucurbitacin tissue culture journal of chemical ecology 19 6 1135 41 bibcode 1993jceco 19 1135h doi 10 1007 bf00987375 pmid 24249132 s2cid 23549863 kupchan s meshulam h sneden at 1978 new cucurbitacins from phormium tenax and marah oreganus phytochemistry 17 4 767 769 bibcode 1978pchem 17 767k doi 10 1016 s0031 9422 00 94223 7 1 2 3 wang dc pan hy deng xm xiang h gao hy cai h et al 2007 cucurbitane and hexanorcucurbitane glycosides from the fruits of cucurbita pepo cv dayangua journal of asian natural products research 9 6 8 525 9 bibcode 2007janpr 9 525w doi 10 1080 10286020600782538 pmid 17885839 s2cid 27762659 song f dai b zhang hy xie jw gu cz zhang j 2015 two new cucurbitane type triterpenoid saponins isolated from ethyl acetate extract of citrullus colocynthis fruit journal of asian natural products research 17 8 813 8 bibcode 2015janpr 17 813s doi 10 1080 10286020 2015 1015999 pmid 25761128 s2cid 38269788 chawech r jarraya r girardi c vansteelandt m marti g nasri i et al september 2015 cucurbitacins from the leaves of citrullus colocynthis l schrad molecules 20 10 18001 15 doi 10 3390 molecules201018001 pmc 6332406 pmid 26437392 kaushik u january june 2015 cucurbitacins an insight into medicinal leads from nature pharmacogn rev v 9 17 12 18 doi 10 4103 0973 7847 156314 pmc 4441156 pmid 26009687 kusin s angert t von derau k horowitz bz giffin s 2012 189 toxic squash syndrome a case series of diarrheal illness following ingestion of bitter squash 1999 2011 2012 annual meeting of the north american congress of clinical toxicology nacct october 1 6 2012 las vegas nv usa clinical toxicology 50 7 574 720 doi 10 3109 15563650 2012 700015 s2cid 218859008 poisoned by bitter squash two women lose their hair live science march 28 2018 rymal ks chambliss ol bond md smith da april 1984 squash containing toxic cucurbitacin compounds occurring in california and alabama journal of food protection 47 4 270 271 doi 10 4315 0362 028x 47 4 270 pmid 30921968 mashilo j odindo ao shimelis ha musenge p tesfay sz magwaza ls 2018 photosynthetic response of bottle gourd lagenaria siceraria molina standl to drought stress relationship between cucurbitacins accumulation and drought tolerance scientia horticulturae 231 133 143 bibcode 2018schor 231 133m doi 10 1016 j scienta 2017 12 027 s2cid 89836386 v t e cytokine receptor modulators chemokine see here instead csf erythropoietin agonists ara 290 asialo erythropoietin carbamylated erythropoietin cnto 530 darbepoetin alfa epoetin alfa epoetin beta epoetin delta epoetin epsilon epoetin gamma epoetin kappa epoetin omega epoetin theta epoetin zeta erythropoietin epo erythropoietin fc methoxy polyethylene glycol epoetin beta cera mircera peginesatide pegol sihematide epo 018b g csf csf3 agonists filgrastim granulocyte colony stimulating factor lenograstim leridistim lipegfilgrastim nartograstim pegfilgrastim pegnartograstim gm csf csf2 agonists ecogramostim granulocyte macrophage colony stimulating factor milodistim molgramostim regramostim sargramostim antibodies mavrilimumab namilumab otilimab m csf csf1 agonists cilmostim interleukin 34 lanimostim macrophage colony stimulating factor mirimostim kinase inhibitors agerafenib scf c kit see here instead thrombopoietin agonists eltrombopag pegacaristim promegapoietin romiplostim avatrombopag lusutrombopag thrombopoietin thpo mgdf interferon ifnar α β i agonists albinterferon interferon alpha interferon alfa ifn α interferon alfa ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 interferon alfa 2a interferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 interferon beta ifn β ifnb1 ifnb3 interferon beta 1a interferon beta 1b interferon kappa ifn ε κ τ ζ ifnk interferon omega ifn ω ifnw1 peginterferon alfa 2a peginterferon alfa 2b antibodies anifrolumab faralimomab medi 545 rontalizumab sifalimumab decoy receptors bifarcept ifngr γ ii agonists interferon gamma ifn γ interferon gamma 1b antibodies emapalumab fontolizumab ifnlr λ iii see il 28r ifnlr here instead interleukin see here instead tgfβ see here instead tnf see here instead others jak inhibitors jak1 abrocitinib baricitinib deuruxolitinib filgotinib momelotinib oclacitinib peficitinib ruxolitinib tofacitinib tasocitinib upadacitinib jak2 atiprimod azd 1480 baricitinib chz868 cucurbitacin i elatericin b jsi 124 cyt387 deuruxolitinib lestaurtinib nsc 7908 nsc 33994 pacritinib peficitinib ruxolitinib sd 1008 tofacitinib tasocitinib jak3 cercosporamide decernotinib vx 509 peficitinib ritlecitinib tcs 21311 tofacitinib tasocitinib whi p 154 zm 39923 zm 449829 tyk2 deucravacitinib others additional cytokines cardiotrophin 1 ct 1 fms like tyrosine kinase 3 ligand flt3l leukemia leukocyte inhibitory factor lif oncostatin m osm thymic stromal lymphopoietin tslp additional cytokine receptor modulators emfilermin lestaurtinib midostaurin quizartinib sorafenib sunitinib v t e tetracyclics classes polyketides tetracenes steroids antibiotics tetracyclines tetracycline chlortetracycline demeclocycline doxycycline eravacycline lymecycline minocycline omadacycline oxytetracycline rolitetracycline sarecycline glycylcyclines tigecycline triterpenes fusidanes fusidic acid helvolic acid cephalosporin p 1 antidepressants tecas azipramine ciclopramine esmirtazapine mianserin mirtazapine naranol oxaprotiline setiptiline steroids gonanes steranes cholane cholestane ergostane sex hormone steroids androstanes androstenediol dehydroepiandrosterone testosterone estranes estetrol estradiol estriol estrone pregnanes progestogens progesterone progestins acetomepregenol chlormadinone acetate danazol delmadinone acetate etonogestrel gestodene hydroxyprogesterone caproate levonorgestrel norethisterone norgestrel segesterone acetate tibolone corticosteroids cortisone cortisol prednisone prednisolone aldosterone allopregnanes norpregnane retropregnane sterols phytosterols campesterol beta sitosterol ergosterols secosteroids ergocalciferol cholecalciferol cholesterol stanol esters triterpenes cycloartane cucurbitacins cucurbitane dammarane euphane lanostane protostane retrieved from https en wikipedia org w index php title cucurbitacin oldid 1371731106 categories set index articles on ...