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death receptor 6 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 function 2 clinical significance 3 references 4 further reading toggle the table of contents death receptor 6 8 languages العربية مصرى cymraeg فارسی italiano русский татарча tatarça українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein found in humans tnfrsf21 identifiers aliases tnfrsf21 bm 018 cd358 dr6 tumor necrosis factor receptor superfamily member 21 tnf receptor superfamily member 21 external ids omim 605732 mgi 2151075 genecards tnfrsf21 available structures pdb ortholog search pdbe rcsb list of pdb id codes 3qo4 3u3p 3u3q 3u3s 3u3t 3u3v 2dbh gene location human chr chromosome 6 human 1 band 6p12 3 start 47 231 532 bp 1 end 47 309 905 bp 1 gene location mouse chr chromosome 17 mouse 2 band 17 17 b3 start 43 327 446 bp 2 end 43 400 080 bp 2 rna expression pattern bgee human mouse ortholog top expressed in islet of langerhans mucosa of urinary bladder periodontal fiber subthalamic nucleus epithelium of nasopharynx inferior ganglion of vagus nerve pons lateral nuclear group of thalamus beta cell pars reticulata top expressed in right kidney epithelium of stomach decidua pyloric antrum proximal tubule mucous cell of stomach human kidney facial motor nucleus granulocyte anterior horn of spinal cord more reference expression data biogps more reference expression data gene ontology molecular function tumor necrosis factor activated receptor activity cellular component integral component of membrane membrane integral component of plasma membrane axon plasma membrane intrinsic component of plasma membrane cytoplasm biological process regulation of apoptotic process immune system process cellular response to tumor necrosis factor response to lipopolysaccharide regulation of cell population proliferation immune response apoptotic signaling pathway inflammatory response negative regulation of myelination signal transduction apoptotic process oligodendrocyte apoptotic process negative regulation of b cell proliferation neuron apoptotic process humoral immune response myelination negative regulation of t cell proliferation t cell receptor signaling pathway tumor necrosis factor mediated signaling pathway b cell apoptotic process adaptive immune response regulation of oligodendrocyte differentiation regulation of lipid metabolic process axonal fasciculation sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 27242 94185 ensembl ensg00000146072 ensmusg00000023915 uniprot o75509 q9epu5 refseq mrna nm_014452 nm_178589 refseq protein np_055267 np_848704 location ucsc chr 6 47 23 47 31 mb chr 17 43 33 43 4 mb pubmed search 3 4 wikidata view edit human view edit mouse death receptor 6 dr6 also known as tumor necrosis factor receptor superfamily member 21 tnfrsf21 is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the jnk and nf κb pathways 5 6 it is mostly expressed in the thymus spleen and white blood cells 7 the gene for dr6 is 78 450 bases long and is found on the 6th chromosome this is transcribed into a 655 amino acid chain weighing 71 8 kda post transcriptional modifications of this protein include glycosylation on the asparagines at the 82 141 252 257 278 and 289 amino acid locations 8 function edit the protein encoded by this gene is a member of the tnf receptor superfamily this receptor has been shown to activate nf κb and mapk8 jnk and induce cell apoptosis through its death domain this receptor interacts with tradd protein which is known to serve as an adaptor that mediates signal transduction of tnf receptors knockout studies in mice suggested that this gene plays a role in t helper cell activation and may be involved in inflammation and immune regulation 6 the dr6 is an alpha helical integral membrane receptor protein that shows evidence that it has something to do with the inhibition of blood vessels forming on tumors which would allow them to grow larger death receptor 6 gets a chemical message and starts a signaling pathway that causes apoptosis also known as cell death to occur 9 it is also expressed in endothelial cells tumor cells can induce through exposition of amyloid precursor protein app dr6 mediated endothelial cell necroptosis allowing tumors metastasis clinical significance edit the free serum levels of this dr6 are heightened with anti cell death factors in patients that have later stage ovarian cancer 10 dr6 is also thought to be involved in neurodegeneration in the brain that causes alzheimer s disease as well as signal transduction in stress response and cellular survival 11 dr6 induces apoptosis when it is over expressed however the manner in which the death signal is intracellularly transduced is currently unknown it has been determined that bax translocation is necessary for the apoptosis triggered by dr6 but through an unknown pathway instead of the traditional pathways of intrinsic versus extrinsic citation needed app amyloid precursor protein is the natural ligand of dr6 and is first cleaved into aβ and n app n app is the fragment that interacts with dr6 to trigger axonal degradation in alzheimer s patients 12 this pathway is essentially hi jacked in the aging brain references edit 1 2 3 grch38 ensembl release 89 ensg00000146072 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000023915 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine pan g bauer jh haridas v wang s liu d yu g et al july 1998 identification and functional characterization of dr6 a novel death domain containing tnf receptor pdf febs letters 431 3 351 356 bibcode 1998febsl 431 351p doi 10 1016 s0014 5793 98 00791 1 hdl 2027 42 116991 pmid 9714541 s2cid 11151198 1 2 entrez gene tnfrsf21 tumor necrosis factor receptor superfamily member 21 salido gm rosado ja 2009 apoptosis involvement of oxidative stress and intracellular ca2 homeostasis heidelberg germany springer p 37 isbn 978 1 4020 9873 4 mungall aj palmer sa sims sk edwards ca ashurst jl wilming l et al october 2003 the dna sequence and analysis of human chromosome 6 nature 425 6960 805 811 bibcode 2003natur 425 805m doi 10 1038 nature02055 pmid 14574404 daniel pt wieder t sturm i schulze osthoff k jul 2001 the kiss of death promises and failures of death receptors and ligands in cancer therapy leukemia 15 7 1022 1032 doi 10 1038 sj leu 2402169 pmid 11455969 s2cid 24538645 sasaroli d gimotty pa pathak hb hammond r kougioumtzidou e katsaros d et al aug 2011 novel surface targets and serum biomarkers from the ovarian cancer vasculature cancer biology therapy 12 3 169 180 doi 10 4161 cbt 12 3 16260 pmc 3230481 pmid 21617380 kuester m kemmerzehl s dahms so roeser d than me june 2011 the crystal structure of death receptor 6 dr6 a potential receptor of the amyloid precursor protein app journal of molecular biology 409 2 189 201 doi 10 1016 j jmb 2011 03 048 pmid 21463639 osherovich l 2009 genentech s new paradigm science business exchange 2 8 1 5 doi 10 1038 scibx 2009 300 further reading edit pan g bauer jh haridas v wang s liu d yu g et al july 1998 identification and functional characterization of dr6 a novel death domain containing tnf receptor pdf febs letters 431 3 351 356 bibcode 1998febsl 431 351p doi 10 1016 s0014 5793 98 00791 1 hdl 2027 42 116991 pmid 9714541 s2cid 11151198 liu j na s glasebrook a fox n solenberg pj zhang q et al july 2001 enhanced cd4 t cell proliferation and th2 cytokine production in dr6 deficient mice immunity 15 1 23 34 doi 10 1016 s1074 7613 01 00162 5 pmid 11485735 zhao h yan m wang h erickson s grewal is dixit vm november 2001 impaired c jun amino terminal kinase activity and t cell differentiation in death receptor 6 deficient mice the journal of experimental medicine 194 10 1441 1448 doi 10 1084 jem 194 10 1441 pmc 2193683 pmid 11714751 kasof gm lu jj liu d speer b mongan kn gomes bc et al november 2001 tumor necrosis factor alpha induces the expression of dr6 a member of the tnf receptor family through activation of nf kappab oncogene 20 55 7965 7975 doi 10 1038 sj onc 1204985 pmid 11753679 s2cid 25063448 mai t wang x zhang z xin d na y guo y october 2004 androgen receptor coregulator ara267 alpha interacts with death receptor 6 revealed by the yeast two hybrid science in china series c life sciences 47 5 442 448 doi 10 1360 03yc0214 pmid 15623156 klíma m zájedová j doubravská l andera l october 2009 functional analysis of the posttranslational modifications of the death receptor 6 biochimica et biophysica acta 1793 10 1579 1587 doi 10 1016 j bbamcr 2009 07 008 pmid 19654028 this article incorporates text from the united states national library of medicine which is in the public domain v t e pdb gallery 2dbh solution structure of the carboxyl terminal card like domain in human tnfr related death receptor 6 v t e cytokine receptors chemokine receptor gpcrs cc ccr1 ccr2 ccrl2 ccr3 ccr4 ccr5 ccr6 ccr7 ccr8 ccr9 ccr10 cxc cxcr1 cxcr2 cxcr3 cxcr4 cxcr5 cxcr6 other cx3c cx3cr1 xc xcr1 ackr 1 2 3 4 5 cmklr1 tnf receptor 1 10 tnfr1 tnfrsf1a tnfr2 tnfrsf1b ltbr tnfrsf3 tnfrsf4 cd40 tnfrsf5 fas receptor tnfrsf6 dcr3 tnfrsf6b cd27 tnfrsf7 cd30 tnfrsf8 tnfrsf9 11 20 dr4 tnfrsf10a dr5 tnfrsf10b dcr1 tnfrsf10c dcr2 tnfrsf10d rank tnfrsf11a osteoprotegerin tnfrsf11b tweakr tnfrsf12a taci tnfrsf13b baffr tnfrsf13c hvem tnfrsf14 ngfr tnfrsf16 bcma tnfrsf17 gitr tnfrsf18 taj troy tnfrsf19 21 27 dr6 tnfrsf21 dr3 tnfrsf25 eda2r tnfrsf27 jak stat type i γ chain interleukin receptors il2r il2ra il2rb il15r il4r il13r il13ra1 il13ra2 il7r il7ra il9r il21r β chain interleukin receptors il3r il3ra il5r il5ra gm csf gp130 interleukin receptors il6ra 11 il11ra 27 il27ra osmr lifr cntfr il12rb1 interleukin receptors il12r il12rb1 il12rb2 il23r other other csf receptors epo g csf thrombopoietin hormone receptor gh prolactin type ii interleukin receptors il10r il10ra il10rb il22r il22ra1 il22ra2 il20r il20ra il20rb il28r interferon receptors α β ifnar1 ifnar2 γ ifngr1 ifngr2 ig superfamily il1 il1r1 il1r2 il18r il18r1 il 17 family il17 il17ra il17rb il17rc il17rd il17re enzyme linked receptor tyr csf1r kit ser thr tgf beta tgfbr1 tgfbr2 family category commons v t e cytokine receptor modulators chemokine see here instead csf erythropoietin agonists ara 290 asialo erythropoietin carbamylated erythropoietin cnto 530 darbepoetin alfa epoetin alfa epoetin beta epoetin delta epoetin epsilon epoetin gamma epoetin kappa epoetin omega epoetin theta epoetin zeta erythropoietin epo erythropoietin fc methoxy polyethylene glycol epoetin beta cera mircera peginesatide pegol sihematide epo 018b g csf csf3 agonists filgrastim granulocyte colony stimulating factor lenograstim leridistim lipegfilgrastim nartograstim pegfilgrastim pegnartograstim gm csf csf2 agonists ecogramostim granulocyte macrophage colony stimulating factor milodistim molgramostim regramostim sargramostim antibodies mavrilimumab namilumab otilimab m csf csf1 agonists cilmostim interleukin 34 lanimostim macrophage colony stimulating factor mirimostim kinase inhibitors agerafenib scf c kit see here instead thrombopoietin agonists eltrombopag pegacaristim promegapoietin romiplostim avatrombopag lusutrombopag thrombopoietin thpo mgdf interferon ifnar α β i agonists albinterferon interferon alpha interferon alfa ifn α interferon alfa ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 interferon alfa 2a interferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 interferon beta ifn β ifnb1 ifnb3 interferon beta 1a interferon beta 1b interferon kappa ifn ε κ τ ζ ifnk interferon omega ifn ω ifnw1 peginterferon alfa 2a peginterferon alfa 2b antibodies anifrolumab faralimomab medi 545 rontalizumab sifalimumab decoy receptors bifarcept ifngr γ ii agonists interferon gamma ifn γ interferon gamma 1b antibodies emapalumab fontolizumab ifnlr λ iii see il 28r ifnlr here instead interleukin see here instead tgfβ see here instead tnf see here instead others jak inhibitors jak1 abrocitinib baricitinib deuruxolitinib filgotinib momelotinib oclacitinib peficitinib ruxolitinib tofacitinib tasocitinib upadacitinib jak2 atiprimod azd 1480 baricitinib chz868 cucurbitacin i elatericin b jsi 124 cyt387 deuruxolitinib lestaurtinib nsc 7908 nsc 33994 pacritinib peficitinib ruxolitinib sd 1008 tofacitinib tasocitinib jak3 cercosporamide decernotinib vx 509 peficitinib ritlecitinib tcs 21311 tofacitinib tasocitinib whi p 154 zm 39923 zm 449829 tyk2 deucravacitinib others additional cytokines cardiotrophin 1 ct 1 fms like tyrosine kinase 3 ligand flt3l leukemia leukocyte inhibitory factor lif oncostatin m osm thymic stromal lymphopoietin tslp additional cytokine receptor modulators emfilermin lestaurtinib midostaurin quizartinib sorafenib sunitinib this membrane protein related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title death_receptor_6 oldid 1361277259 categories genes on human chromosome 6 tnf receptor family membrane protein stubs hidden categories articles with short description short description is different from wikidata all articles with unsourced statements articles with unsourced statements from december 2019 wikipedia articles incorporating text from the united states national library of medicine all stub articles this page was last edited on 26 june 2026 at 21 46 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents death receptor 6 8 languages add topic