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desensitization medicine wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 application to allergies 2 see also 3 references toggle the table of contents desensitization medicine 10 languages العربية gaeilge italiano қазақша polski srpskohrvatski српскохрватски српски srpski türkçe oʻzbekcha ўзбекча 粵語 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia see also desensitization psychology medical intervention desensitization medicine icd 9 cm 99 12 mesh d003888 ops 301 code 8 030 in medicine desensitization is a method to reduce or eliminate an organism s negative reaction to a substance or stimulus in pharmacology drug desensitization refers to two related concepts first desensitization may be equivalent to drug tolerance and refers to subjects reactions positive or negative to a drug reducing following its repeated use this is a macroscopic organism level effect and differs from the second meaning of desensitization which refers to a biochemical effect where individual receptors become less responsive after repeated application of an agonist this may be mediated by phosphorylation for instance by beta adrenoceptor kinase at the beta adrenoceptor application to allergies edit main article allergen immunotherapy for example if a person with diabetes mellitus has a bad allergic reaction to taking a full dose of beef insulin the person is given a very small amount of the insulin at first so small that the person has no adverse reaction or very limited symptoms as a result over a period of time larger doses are given until the person is taking the full dose this is one way to help the body get used to the full dose and to avoid having the allergic reaction to beef origin insulin a temporary desensitization method involves the administration of small doses of an allergen to produce an ige mediated response in a setting where an individual can be treated in the event of anaphylaxis this approach through uncharacterized mechanisms eventually overrides the hypersensitive ige response 1 desensitization approaches for food allergies are generally at the research stage they include 2 oral immunotherapy which involves building up tolerance by eating a small amount of usually baked food sublingual immunotherapy which involves placing a small drop of milk or egg white under the tongue epicutaneous immunotherapy which injects the allergic food under the skin monoclonal anti ige antibodies which non specifically reduce the body s capacity to produce an allergic reaction a chinese herbal formulation fahf 2 another non specific approach currently being studied in peanut allergy use of probiotics helminthic therapy a drug to suppress toll like receptor 9 tlr9 and mepolizumab to treat eosinophilic esophagitis see also edit penicillin desensitization references edit castells mariana c ed 2011 anaphylaxis and hypersensitivity reactions new york humana press springer pp 60 62 isbn 978 1 60327 950 5 oclc 701718637 cite book cs1 maint publisher location link nowak węgrzyn a sampson ha march 2011 future therapies for food allergies j allergy clin immunol 127 3 558 73 quiz 574 5 doi 10 1016 j jaci 2010 12 1098 pmc 3066474 pmid 21277625 retrieved from https en wikipedia org w index php title desensitization_ medicine oldid 1371453182 category allergology hidden categories articles with short description short description is different from wikidata cs1 maint publisher location this page was last edited on 26 august 2026 at 14 51 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents desensitization medicine 10 languages add topic