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gimbrone, 1987, 2827173, 299728, 1987pnas, 9238b, inducible, 8th, edition, innate, chapter, aoki, laroy, fierro, hudson, 18579791, 2572800, 149641, 3744, henson, schnaar, 21329670, 061, 2011bbrc, 423s, 423, reynolds, e44529, 22970241, 3435295, 0044529, 744529s, mac, novel, delgadillo, cuckler, tees, benencia, 2015, c68, 25339657, 4281670, 00094, 308, isoforms, conditions, gout, tremblay, organ, selectivity, 11272581, 17891461, s10585, 007, 9096, descheny, trujillo, nguyen, 15994950, 1472661, 4653, 5750, kannagi, izawa, koike, miyazaki, kimura, 27761640, 15132763, 11159147, 1349, 7006, tb03219, 377, angiogenesis, zou, shinde, patil, dagia, smith, wargo, interliggi, c415, 15814589, 00289, kumar, philadelphia, saunders, 7216, 7335, pathologic, andrade, toloi, april, effects, soy, bean, huvec, 29123853, 22066752, 13697137, 582970, climacteric, e31874, 22384091, 3286450, 0031874, 731874h, modulation, eniola, adefeso, leeuwenberg, smeets, neefjes, shaffer, cinek, jeunhomme, 1992, 1283598, 1421640, 543, immunology, intercellular, new, york, garland, 8153, 4101, health, esko, freeze, stanley, bertozzi, hart, etzler, eds, 2nd, plainview, cold, spring, harbor, laboratory, press, 978, 87969, 770, essentials, glycobiology, somers, tang, shaw, camphausen, october, 12719907, 11081633, s0092, 8674, 00138, 467, insights, revealed, graves, crowther, chandran, rumberger, 6463, 4338500, 7509040, 367532a0, 1994natur, 532g, 532, williams, johnston, eddy, 1991, 1703529, 52267, 2466, chromosomal, grcm38, grch38, emerging, some, cancers, recurrences, formation, rupture, promoting, weakening, artery, walls, smoking, highly, enhanced, likelihood, inducing, dysfunction, upregulated, exposure, addictive, tobacco, regulated, increase, transcription, therefore, rrd, target, benefit, cigarette, csrc, arr1, nachrs, immunohistochemical, expressions, significantly, plaques, group, especially, neovascular, positively, density, reaction, plaque, associated, intima, study, umbilical, vein, increases, 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eability leads to edema swelling of the skeletal endothelium blood vessel linings resulting in skeletal muscle ischemia restricted blood supply and eventually necrosis cell death this underlying pathology is the cause of the symptomatic disease critical illness polyneuromyopathy cipnm 43 traditional chinese herbal medicines like berberine downregulate e selectin 44 pathogen attachment edit study shows the adherence of porphyromonas gingivalis to human umbilical vein endothelial cells increases with the induction of e selectin expression by tnf α an antibody to e selectin and sialyl lewis x suppressed p gingivalis adherence to stimulated huvecs p gingivalis mutants lacking ompa like proteins pgm6 7 had reduced adherence to stimulated huvecs but fimbriae deficient mutants were not affected e selecin mediated p gingivalis adherence activated endothelial exocytosis these results suggest that the interaction between host e selectin and pathogen pgm6 7 mediates p gingivalis adherence to endothelial cells and may trigger vascular inflammation 45 acute coronary syndrome edit the immunohistochemical expressions of e selectin and pecam 1 were significantly increased at intima in vulnerable plaques of acute coronary syndrome acs group especially in neovascular endothelial cells and positively correlated with inflammatory cell density suggesting that pecam 1 and e selectin might play an important role in inflammatory reaction and development of vulnerable plaque e selectin ser128arg polymorphism is associated with acs and it might be a risk factor for acs 46 nicotine mediated induction edit smoking is highly correlated with enhanced likelihood of atherosclerosis by inducing endothelial dysfunction in endothelial cells various cell adhesion molecules including e selectin are shown to be upregulated upon exposure to nicotine the addictive component of tobacco smoke nicotine stimulated adhesion of monocytes to endothelial cells is dependent on the activation of α7 nachrs β arr1 and csrc regulated increase in e2f1 mediated transcription of e selectin gene therefore agents such as rrd 251 that can target activity of e2f1 may have potential therapeutic benefit against cigarette smoke induced atherosclerosis 47 cerebral aneurysm edit it s also found that e selectin expression increased in human ruptured cerebral aneurysm tissues e selectin might be an important factor involved in the process of cerebral aneurysm formation and rupture by promoting inflammation and weakening cerebral artery walls 48 as a biomarker edit e selectin is also an emerging biomarker for the metastatic potential of some cancers including colorectal cancer and recurrences 49 references edit 1 2 3 grch38 ensembl release 89 ensg00000007908 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000026582 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine collins t williams a johnston gi kim j eddy r shows t et al february 1991 structure and chromosomal location of the gene for endothelial leukocyte adhesion molecule 1 the journal of biological chemistry 266 4 2466 73 doi 10 1016 s0021 9258 18 52267 5 pmid 1703529 graves bj crowther rl chandran c rumberger jm li s huang ks et al february 1994 insight into e selectin ligand interaction from the crystal structure and mutagenesis of the lec egf domains nature 367 6463 532 8 bibcode 1994natur 367 532g doi 10 1038 367532a0 pmid 7509040 s2cid 4338500 somers ws tang j shaw gd camphausen rt october 2000 insights into the molecular basis of leukocyte tethering and rolling revealed by structures of p and e selectin bound to sle x and psgl 1 cell 103 3 467 79 doi 10 1016 s0092 8674 00 00138 0 pmid 11081633 s2cid 12719907 cummings rd 2008 selectins in varki a cummings rd esko jd freeze hh stanley p bertozzi cr hart gw etzler me eds essentials of glycobiology 2nd ed plainview n y cold spring harbor laboratory press isbn 978 0 87969 770 9 janeway c 2005 immunobiology the immune system in health and disease new york garland science isbn 0 8153 4101 6 1 2 leeuwenberg jf smeets ef neefjes jj shaffer ma cinek t jeunhomme tm et al december 1992 e selectin and intercellular adhesion molecule 1 are released by activated human endothelial cells in vitro immunology 77 4 543 9 pmc 1421640 pmid 1283598 huang rb eniola adefeso o 2012 shear stress modulation of il 1β induced e selectin expression in human endothelial cells plos one 7 2 e31874 bibcode 2012ploso 731874h doi 10 1371 journal pone 0031874 pmc 3286450 pmid 22384091 andrade cm sá mf toloi mr april 2012 effects of phytoestrogens derived from soy bean on expression of adhesion molecules on huvec climacteric 15 2 186 94 doi 10 3109 13697137 2011 582970 pmid 22066752 s2cid 29123853 1 2 3 robbins sl cotran rs kumar v collins t 1999 robbins pathologic basis of disease philadelphia wb saunders isbn 0 7216 7335 x zou x shinde patil vr dagia nm smith la wargo mj interliggi ka et al august 2005 psgl 1 derived from human neutrophils is a high efficiency ligand for endothelium expressed e selectin under flow american journal of physiology cell physiology 289 2 c415 24 doi 10 1152 ajpcell 00289 2004 pmid 15814589 kannagi r izawa m koike t miyazaki k kimura n may 2004 carbohydrate mediated cell adhesion in cancer metastasis and angiogenesis cancer science 95 5 377 84 doi 10 1111 j 1349 7006 2004 tb03219 x pmc 11159147 pmid 15132763 s2cid 27761640 dimitroff cj descheny l trujillo n kim r nguyen v huang w et al july 2005 identification of leukocyte e selectin ligands p selectin glycoprotein ligand 1 and e selectin ligand 1 on human metastatic prostate tumor cells cancer research 65 13 5750 60 doi 10 1158 0008 5472 can 04 4653 pmc 1472661 pmid 15994950 gout s tremblay pl huot j 2008 selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis clinical experimental metastasis 25 4 335 44 doi 10 1007 s10585 007 9096 4 pmid 17891461 s2cid 11272581 shirure vs liu t delgadillo lf cuckler cm tees df benencia f et al january 2015 cd44 variant isoforms expressed by breast cancer cells are functional e selectin ligands under flow conditions american journal of physiology cell physiology 308 1 c68 78 doi 10 1152 ajpcell 00094 2014 pmc 4281670 pmid 25339657 shirure vs reynolds nm burdick mm 2012 mac 2 binding protein is a novel e selectin ligand expressed by breast cancer cells plos one 7 9 e44529 bibcode 2012ploso 744529s doi 10 1371 journal pone 0044529 pmc 3435295 pmid 22970241 shirure vs henson ka schnaar rl nimrichter l burdick mm march 2011 gangliosides expressed on breast cancer cells are e selectin ligands biochemical and biophysical research communications 406 3 423 9 bibcode 2011bbrc 406 423s doi 10 1016 j bbrc 2011 02 061 pmid 21329670 nimrichter l burdick mm aoki k laroy w fierro ma hudson sa et al november 2008 e selectin receptors on human leukocytes blood 112 9 3744 52 doi 10 1182 blood 2008 04 149641 pmc 2572800 pmid 18579791 janeway s immunobiology 8th edition pattern recognition by cells of the innate immunity system chapter 3 page 83 bevilacqua mp pober js mendrick dl cotran rs gimbrone ma december 1987 identification of an inducible endothelial leukocyte adhesion molecule proceedings of the national academy of sciences of the united states of america 84 24 9238 42 bibcode 1987pnas 84 9238b doi 10 1073 pnas 84 24 9238 pmc 299728 pmid 2827173 walz g aruffo a kolanus w bevilacqua m seed b november 1990 recognition by elam 1 of the sialyl lex determinant on myeloid and tumor cells science 250 4984 1132 5 bibcode 1990sci 250 1132w doi 10 1126 science 1701275 pmid 1701275 khatib am kontogiannea m fallavollita l jamison b meterissian s brodt p march 1999 rapid induction of cytokine and e selectin expression in the liver in response to metastatic tumor cells cancer research 59 6 1356 61 pmid 10096570 sawada r tsuboi s fukuda m january 1994 differential e selectin dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials the journal of biological chemistry 269 2 1425 31 doi 10 1016 s0021 9258 17 42275 7 pmid 7507108 dimitroff cj lechpammer m long woodward d kutok jl august 2004 rolling of human bone metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by e selectin cancer research 64 15 5261 9 doi 10 1158 0008 5472 can 04 0691 pmid 15289332 s2cid 11632075 laferrière j houle f huot j 2004 adhesion of ht 29 colon carcinoma cells to endothelial cells requires sequential events involving e selectin and integrin beta4 clinical experimental metastasis 21 3 257 64 doi 10 1023 b clin 0000037708 09420 9a pmid 15387376 s2cid 22354589 barthel sr hays dl yazawa em opperman m walley kc nimrichter l et al january 2013 definition of molecular determinants of prostate cancer cell bone extravasation 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62 doi 10 1017 s0317167100012439 pmid 22030423 sato h usuda n kuroda m hashimoto s maruta m maeda k november 2010 significance of serum concentrations of e selectin and ca19 9 in the prognosis of colorectal cancer japanese journal of clinical oncology 40 11 1073 80 doi 10 1093 jjco hyq095 pmid 20576794 external links edit e selectin at the u s national library of medicine medical subject headings mesh v t e pdb gallery 1esl insight into e selectin slash ligand interaction from the crystal structure and mutagenesis of the lec slash egf domains 1g1t crystal structure of e selectin lectin egf domains complexed with slex v t e membrane proteins cell adhesion molecules calcium independent igsf cam n cam myelin protein zero icam 1 5 vcam 1 pe cam l1 family l1 cam nrcam nfasc chl1 nectin pvrl1 pvrl2 pvrl3 cadm1 cadm2 cadm3 cd155 integrins lfa 1 cd11a cd18 integrin alphaxbeta2 cd11c cd18 macrophage 1 antigen cd11b cd18 vla 4 cd49d cd29 glycoprotein iib iiia itga2b itgb3 calcium dependent cadherins classical cdh1 cdh2 cdh3 desmoso...