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evinacumab, ec7, translocases, ec6, ligases, ec5, isomerases, ec4, lyases, ec3, hydrolases, ec2, transferases, ec1, oxidoreductases, michaelis, menten, lineweaver, burk, hanes, woolf, eadie, hofstee, diagram, superfamily, number, classification, activator, inhibitor, cooperativity, catalysis, cofactor, diffusion, limited, promiscuity, oxyanion, hole, triad, active, zap70, txk, itk, btk, bmx, lyn, lck, hck, blk, yes1, fyn, fgr, tyk2, jak3, jak2, jak1, srms, brk, fer, pyk2, matk, tnk1, ack1, ack, abl2, abl1, abl, styk1, uncategorised, tyro3, mer, aatyk2, ros1, ros, ddr2, ddr1, ddr, ror2, ror1, ror, tek, alk, ephx, ephb6, ephb5, ephb4, ephb3, ephb2, ephb1, epha8, epha7, epha6, epha5, epha4, epha3, epha2, epha1, eph, ntrk3, ntrk2, ntrk1, vegfr3, vegfr2, vegfr1, pdgfrb, pdgfra, pdgfr, flt3, csf1r, insrr, insr, igf1r, egfr, category, 370, 369, 368, 367, 366, 365, 364, 363, 362, 361, 360, 358, 357, 355, 354, 353, 352, 349, 344, 339, 338, 337, 336, 335, 333, 332, 331, 329, 328, 327, 326, 325, 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43a, mol, evol, ornitz, colvin, 8663044, kaptein, paillard, saunders, 8626374, dominant, mutant, inhibits, interleukin, induced, stat, klint, 8576110, association, kda, slotky, shaoul, berman, 8530375, chimeric, molecules, define, confer, specificities, maruyama, sugano, oligo, capping, simple, method, replace, cap, eukaryotic, mrnas, oligoribonucleotides, 8125298, 0378, 1119, 90802, jaakkola, salmikangas, nylund, amplification, cancers, 19513080, 8099571, ijc, 2910540305, 378, shuai, stark, kerr, phosphotyrosine, residue, stat91, required, interferon, gamma, 5129, 1126, 1993sci, 1744s, 1744, chedid, 7680645, 53334, 5388, high, affinity, but, not, quelle, thierfelder, witthuhn, 7657660, purified, janus, epidermal, wen, zhong, 6717533, 7543024, 0092, 8674, 90311, maximal, transcription, requires, wennström, 7518429, 32309, 18320, comparison, 2247464, 55070, 1990pnas, 8913p, putative, 562, cells, holtrich, bräuninger, strebhardt, rübsamen, waigmann, 1720539, 52938, 1991pnas, 8810411h, two, fourth, intracellular, eerola, 1709094, 452793, tb07654, 1347, distinct, bellosta, 1385111, 557000, tb05526, 4273, shows, features, cannizzaro, localization, 5q33, qter, 6377972, 1377018, gcc, 2870040116, chromosomes, warrington, bailey, radiation, hybrid, map, hormone, neurotransmitter, distal, long, arm, 1322355, 0888, 7543, 90156, 803, genomics, doherty, smith, walsh, shared, adhesion, molecule, cam, homology, point, cams, signalling, via, 9168198, perspectives, developmental, neurobiology, kan, wang, mckeehan, 1999, 10336501, 0021, determined, heparan, sulfate, binary, loo, darwish, saarikettu, vihko, hermonen, goldman, jalkanen, 2000, production, characterization, recombinant, england, 10736564, 1357, s1357, 00145, 489, biochem, frullanti, 2011, pooled, analyses, prognostic, 347, 29668012, 21412156, 1097, cej, 0b013e3283457274, eur, prev, grcm38, grch38, shown, fgf1, interact, where, sequence, highly, conserved, throughout, differ, one, another, their, affinities, distribution, full, length, representative, would, consist, composed, spanning, segment, portion, interacts, setting, motion, downstream, signals, ultimately, influencing, mitogenesis, compared, encompasses, rather, than, there, evidence, half, varies, alternate, forms, indicated, particular, preferentially, binds, its, specific, overexpressed, tumor, samples, suggesting, role, ovarian, tumorigenesis, analysis, study, functional, rs351855, significantly, associated, nodal, involvement, overall, survival, patients, different, igiii, terminal, alternative, splicing, exons, cytoplasmic, hydrophobic, amino, humans, designated, cluster, ucsc, np_032037, np_001341913, np_998812, np_075252, np_002002, np_001278909, nm_008011, nm_001354984, nm_213647, nm_022963, nm_002011, nm_001291980, mrna, q03142, p22455, uniprot, 14186, 2264, oma, ncbi, databases, orthologs, sources, quickgo, amigo, nervous, system, development, apoptotic, angiogenesis, cholesterol, peptidyl, autophosphorylation, 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ion positive regulation of cell population proliferation positive regulation of dna biosynthetic process positive regulation of erk1 and erk2 cascade positive regulation of proteolysis protein autophosphorylation peptidyl tyrosine phosphorylation cell migration phosphatidylinositol phosphate biosynthetic process positive regulation of catalytic activity phosphatidylinositol 3 phosphate biosynthetic process positive regulation of protein kinase b signaling cholesterol homeostasis angiogenesis negative regulation of signal transduction cell differentiation negative regulation of apoptotic process transmembrane receptor protein tyrosine kinase signaling pathway nervous system development sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 2264 14186 ensembl ensg00000160867 ensmusg00000005320 uniprot p22455 q03142 refseq mrna nm_001291980 nm_002011 nm_022963 nm_213647 nm_001354984 nm_008011 refseq protein np_001278909 np_002002 np_075252 np_998812 np_001341913 np_032037 location ucsc chr 5 177 09 177 1 mb chr 13 55 3 55 32 mb pubmed search 3 4 wikidata view edit human view edit mouse fibroblast growth factor receptor 4 fgfr 4 is a protein that in humans is encoded by the fgfr4 gene fgfr4 has also been designated as cd334 cluster of differentiation 334 the protein encoded by this gene is a member of the fibroblast growth factor receptor family where amino acid sequence is highly conserved between members and throughout evolution fgfr family members differ from one another in their ligand affinities and tissue distribution a full length representative protein would consist of an extracellular region composed of three immunoglobulin like domains a single hydrophobic membrane spanning segment and a cytoplasmic tyrosine kinase domain the extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation the genomic organization of this gene compared to members 1 3 encompasses 18 exons rather than 19 or 20 although alternative splicing has been observed there is no evidence that the c terminal half of the igiii domain of this protein varies between three alternate forms as indicated for members 1 3 this particular family member preferentially binds acidic fibroblast growth factor and although its specific function is unknown it is overexpressed in gynecological tumor samples suggesting a role in breast and ovarian tumorigenesis 5 in a meta analysis study the functional polymorphism gly388arg rs351855 of fgfr4 was observed to be significantly associated with nodal involvement and overall survival in patients with different types of cancer 6 interactions edit fibroblast growth factor receptor 4 has been shown to interact with fgf1 7 8 references edit 1 2 3 grch38 ensembl release 89 ensg00000160867 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000005320 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine entrez gene fgfr4 fibroblast growth factor receptor 4 frullanti e 2011 meta and pooled analyses of fgfr4 gly388arg polymorphism as a cancer prognostic factor eur j cancer prev 20 4 340 347 doi 10 1097 cej 0b013e3283457274 pmid 21412156 s2cid 29668012 loo b b darwish k k vainikka s s saarikettu j j vihko p p hermonen j j goldman a a alitalo k k jalkanen m m may 2000 production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4 int j biochem cell biol 32 5 england 489 97 doi 10 1016 s1357 2725 99 00145 4 issn 1357 2725 pmid 10736564 kan m wu x wang f mckeehan w l may 1999 specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase j biol chem 274 22 united states 15947 52 doi 10 1074 jbc 274 22 15947 issn 0021 9258 pmid 10336501 further reading edit doherty p smith p walsh fs 1997 shared cell adhesion molecule cam homology domains point to cams signalling via fgf receptors perspectives on developmental neurobiology 4 2 3 157 68 pmid 9168198 warrington ja bailey sk armstrong e et al 1992 a radiation hybrid map of 18 growth factor growth factor receptor hormone receptor or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5 genomics 13 3 803 8 doi 10 1016 0888 7543 92 90156 m pmid 1322355 armstrong e partanen j cannizzaro l et al 1992 localization of the fibroblast growth factor receptor 4 gene to chromosome region 5q33 qter genes chromosomes cancer 4 1 94 8 doi 10 1002 gcc 2870040116 pmid 1377018 s2cid 6377972 vainikka s partanen j bellosta p et al 1992 fibroblast growth factor receptor 4 shows novel features in genomic structure ligand binding and signal transduction embo j 11 12 4273 80 doi 10 1002 j 1460 2075 1992 tb05526 x pmc 557000 pmid 1385111 partanen j mäkelä tp eerola e et al 1991 fgfr 4 a novel acidic fibroblast growth factor receptor with a distinct expression pattern embo j 10 6 1347 54 doi 10 1002 j 1460 2075 1991 tb07654 x pmc 452793 pmid 1709094 holtrich u bräuninger a strebhardt k rübsamen waigmann h 1992 two additional protein tyrosine kinases expressed in human lung fourth member of the fibroblast growth factor receptor family and an intracellular protein tyrosine kinase proc natl acad sci u s a 88 23 10411 5 bibcode 1991pnas 8810411h doi 10 1073 pnas 88 23 10411 pmc 52938 pmid 1720539 partanen j mäkelä tp alitalo r et al 1991 putative tyrosine kinases expressed in k 562 human leukemia cells proc natl acad sci u s a 87 22 8913 7 bibcode 1990pnas 87 8913p doi 10 1073 pnas 87 22 8913 pmc 55070 pmid 2247464 vainikka s joukov v wennström s et al 1994 signal transduction by fibroblast growth factor receptor 4 fgfr 4 comparison with fgfr 1 j biol chem 269 28 18320 6 doi 10 1016 s0021 9258 17 32309 8 pmid 7518429 wen z zhong z darnell je 1995 maximal activation of transcription by stat1 and stat3 requires both tyrosine and serine phosphorylation cell 82 2 241 50 doi 10 1016 0092 8674 95 90311 9 pmid 7543024 s2cid 6717533 quelle fw thierfelder w witthuhn ba et al 1995 phosphorylation and activation of the dna binding activity of purified stat1 by the janus protein tyrosine kinases and the epidermal growth factor receptor j biol chem 270 35 20775 80 doi 10 1074 jbc 270 35 20775 pmid 7657660 ron d reich r chedid m et al 1993 fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor j biol chem 268 8 5388 94 doi 10 1016 s0021 9258 18 53334 2 pmid 7680645 shuai k stark gr kerr im darnell je 1993 a single phosphotyrosine residue of stat91 required for gene activation by interferon gamma science 261 5129 1744 6 bibcode 1993sci 261 1744s doi 10 1126 science 7690989 pmid 7690989 jaakkola s salmikangas p nylund s et al 1993 amplification of fgfr4 gene in human breast and gynecological cancers int j cancer 54 3 378 82 doi 10 1002 ijc 2910540305 pmid 8099571 s2cid 19513080 maruyama k sugano s 1994 oligo capping a simple method to replace the cap structure of eukaryotic mrnas with oligoribonucleotides gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 pmid 8125298 reich slotky r shaoul e berman b et al 1996 chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities j biol chem 270 50 29813 8 doi 10 1074 jbc 270 50 29813 pmid 8530375 vainikka s joukov v klint p alitalo k 1996 association of a 85 kda serine kinase with activated fibroblast growth factor receptor 4 j biol chem 271 3 1270 3 doi 10 1074 jbc 271 3 1270 pmid 8576110 kaptein a paillard v saunders m 1996 dominant negative stat3 mutant inhibits interleukin 6 induced jak stat signal transduction j biol chem 271 11 5961 4 doi 10 1074 jbc 271 11 5961 pmid 8626374 ornitz dm xu j colvin js et al 1996 receptor specificity of the fibroblast growth factor family j biol chem 271 25 15292 7 doi 10 1074 jbc 271 25 15292 pmid 8663044 agnès f toux mm andré c galibert f 1997 genomic organization of the extracellular coding region of the human fgfr4 and flt4 genes evolution of the genes encoding receptor tyrosine kinases with immunoglobulin like domains j mol evol 45 1 43 9 bibcode 1997jmole 45 43a doi 10 1007 pl00006199 pmid 9211733 s2cid 34208733 external links edit fgfr4 protein human at the u s national library of medicine medical subject headings mesh this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons v t e protein kinases tyrosine kinases ec 2 7 10 receptor tyrosine kinases ec 2 7 10 1 growth factor receptors egf receptor family egfr erbb2 erbb3 erbb4 insulin receptor family igf1r insr insrr pdgf receptor family csf1r flt3 kit pdgfr pdgfra pdgfrb fgf receptor family fgfr1 fgfr2 fgfr3 fgfr4 vegf receptor family vegfr1 vegfr2 vegfr3 hgf receptor family met ron trk receptor family ntrk1 ntrk2 ntrk3 eph receptor family epha1 epha2 epha3 epha4 epha5 epha6 epha7 epha8 ephb1 ephb2 ephb3 ephb4 ephb5 ephb6 ephx ltk receptor family ltk alk tie receptor family tie tek ror receptor family ror1 ror2 ddr receptor family ddr1 ddr2 ptk7 receptor family ptk7 ryk receptor family ryk musk receptor family musk ros receptor family ros1 aatyk receptor family aatyk aatyk2 axl receptor family axl mer tyro3 ret receptor family ret uncategorised styk1 non receptor tyrosine kinases ec 2 7 10 2 abl family abl1 abl2 ack family ack1 tnk1 csk family csk matk fak family fak pyk2 fes family fes fer frk family frk brk srms jak family jak1 jak2 jak3 tyk2 src a family src fgr fyn yes1 src b family blk hck lck lyn tec family tec bmx btk itk txk syk family syk zap70 v t e enzymes activity active site binding site catalytic triad oxyanion hole enzyme promiscuity diffusion limited enzyme cofactor enzyme catalysis regulation allosteric regulation cooperativity enzyme inhibitor enzyme activator classification ec number enzyme superfamily enzyme family list of enzymes kinetics enzyme kinetics eadie hofstee diagram hanes woolf plot lineweaver burk plot michaelis menten kinetics types ec1 oxidoreductases list ec2 transferases list ec3 hydrolases list ec4 lyases list ec5 isomerases list ec6 ligases list ec7 translocases list v t e growth factor receptor modulators angiopoietin agonists angiopoietin 1 angiopoietin 4 antagonists angiopoietin 2 angiopoietin 3 kinase inhibitors altiratinib ce 245677 rebastinib antibodies evinacumab against angiopoietin 3 nesvacumab against angiopoietin 2 cntf agonists axokine cntf dapiclermin egf erbb egf erbb1 her1 agonists amphiregulin betacellulin egf urogastrone epigen epiregulin heparin binding egf like growth factor hb egf murodermin nepidermin transforming growth factor alpha tgfα kinase inhibitors afatinib agerafenib brigatinib canertinib dacomitinib erlotinib gefitinib grandinin icotinib lapatinib neratinib osimertinib vandetanib whi p 154 antibodies cetuximab depatuxizumab depatuxizumab mafodotin futuximab imgatuzumab matuzumab necitumumab nimotuzumab panitumumab zalutumumab erbb2 her2 agonists unknown none antibodies ertumaxomab pertuzumab trastuzumab trastuzumab deruxtecan trastuzumab duocarmazine trastuzumab emtansine kinase inhibitors afatinib lapatinib mubritinib neratinib tucatinib erbb3 her3 agonists neuregulins heregulins 1 2 6 neuroglycan c antibodies duligotuzumab patritumab seribantumab erbb4 her4 agonists betacellulin epigen heparin binding egf like growth factor hb egf neuregulins heregulins 1 2 3 4 5 tomoregulin tmeff fgf fgfr1 agonists ersofermin fgf 1 2 bfgf 3 4 5 6 8 10 kgf2 20 repifermin selpercatinib trafermin velafermin fgfr2 agonists ersofermin fgf 1 2 bfgf 3 4 5 6 7 kgf 8 9 10 kgf2 17 18 22 palifermin repifermin selpercatinib sprifermin trafermin antibodies aprutumab aprutumab ixadotin kinase inhibitors infigratinib fgfr3 agonists ersofermin fgf 1 2 bfgf 4 8 9 18 23 selpercatinib sprifermin trafermin antibodies burosumab against fgf23 fgfr4 agonists ersofermin fgf 1 2 bfgf 4 6 8 9 19 trafermin unsorted agonists fgf15 19 hgf c met agonists fosgonimeton hepatocyte growth factor potentiators dihexa pnb 0408 kinase inhibitors altiratinib am7 amg 458 amuvatinib bms 777607 cabozantinib capmatinib crizotinib foretinib golvatinib incb28060 jnj 38877605 k252a mk 2461 pf 04217903 pf 2341066 pha 665752 savolitinib su 11274 tivantinib antibodies emibetuzumab ficlatuzumab flanvotumab onartuzumab rilotumumab telisotuzumab telisotuzumab vedotin igf igf 1 agonists des 1 3 igf 1 insulin like growth factor 1 somatomedin c igf 1 lr3 insulin like growth factor 2 somatomedin a insulin mecasermin mecasermin rinfabate kinase inhibitors bms 754807 linsitinib nvp adw742 nvp aew541 osl 906 antibodies ave 1642 cixutumumab dalotuzumab figitumumab ganitumab robatumumab r1507 teprotumumab xentuzumab against igf 1 and igf 2 igf 2 agonists insulin like growth factor 2 somatomedin a antibodies dusigitumab xentuzumab against igf 1 and igf 2 others binding proteins igfbp 1 2 3 4 5 6 7 cleavage products derivatives with unknown target glypromate gpe 1 3 igf 1 trofinetide lngf p75 ntr agonists bdnf bnn 20 bnn 27 cenegermin dhea dhea s ngf nt 3 nt 4 antagonists ale 0540 dexamethasone evt 901 sar 127963 testosterone antibodies against ngf abt 110 pg110 asp 6294 fasinumab frunevetmab fulranumab medi 578 ranevetmab tanez...