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#fosazepam (25), and (21), the (18), sleep (13), with (12), diazepam (10), effects (10), benzodiazepines (9), benzodiazepine (8), acid (8), nitrazepam (8), wikipedia (7), ethyl (7), pmid (6), clinical (6), edit (6), about (5), page (5), modulators (5), also (5), sage (5), metabolite (5), doi (5), has (5), main (5), contents (4), search (4), use (4), was (4), which (4), org (4), gaba (4), receptor (4), bromide (4), chloral (4), cgs (4), ro48 (4), active (4), long (4), 1111 (4), journal (4), pharmacology (4), hypnotic (4), sedative (4), hide (4), move (4), sidebar (4), view (3), code (3), may (3), this (3), changes (3), short (3), from (3), not (3), see (3), unsorted (3), constituents (3), others (3), dhp (3), etomidate (3), butomidate (3), rilmazafone (3), nordazepam (3), flurazepam (3), alprazolam (3), acting (3), 1977 (3), pmc (3), british (3), anxiety (3), soluble (3), other (3), 100 (3), similar (3), morning (3), increased (3), impaired (3), upon (3), drug (3), withdrawal (3), are 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Text of the page (random words):
atski српскохрватски српски srpski türkçe tiếng việt edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia benzodiazepine pharmaceutical compound fosazepam clinical data atc code none identifiers iupac name 7 chloro 1 dimethylphosphorylmethyl 5 phenyl 3h 1 4 benzodiazepin 2 one cas number 35322 07 7 y pubchem cid 37114 chemspider 34056 y unii 13ak3h33sg kegg d04248 y comptox dashboard epa dtxsid10188828 chemical and physical data formula c 18 h 18 cl n 2 o 2 p molar mass 360 78 g mol 1 3d model jsmol interactive image smiles clc1 cc2 c c c1 n cp c c o c cn c2c3 cc cc c3 o inchi inchi 1s c18h18cln2o2p c1 24 2 23 12 21 16 9 8 14 19 10 15 16 18 20 11 17 21 22 13 6 4 3 5 7 13 h3 10h 11 12h2 1 2h3 y key jmycgcxyzzhwmo uhfffaoysa n y verify fosazepam 1 is a drug belonging to the benzodiazepine class which are primarily anti anxiety and sedative hypnotic agents it is a water soluble derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water 2 3 at equipotent doses 100 mg fosazepam and 10 mg diazepam it possesses sedative and anxiolytic properties that are qualitatively and quantitatively similar to the effects of diazepam with equal sedative hypnotic anti convulsive and muscle relaxant effects in comparison to an equipotent dose of nitrazepam 100 mg fosazepam and 10 mg nitrazepam its effects tended to be of noticeably milder magnitude 4 fosazepam has similar effects on sleep as other benzodiazepines in a clinical trial it was reported that fosazepam to lead to increased sleep duration with less broken sleep but sleep quality was worsened with suppressed deep sleep and increased light sleep adverse effects included feelings of impaired morning vitality and upon discontinuing the drug benzodiazepine withdrawal symptoms of anxiety impaired concentration and impaired morning vitality were experienced 4 another clinical trial also found worsening of sleep while on benzodiazepines as well as during withdrawal with suppression of deep sleep stages including rem sleep with increased light sleep upon withdrawal 5 the main metabolites of fosazepam are 3 hydroxyfosazepam and the active metabolite desmethyldiazepam which has a very long elimination half life of about 3 days 4 tolerance to the hypnotic effects of fosazepam starts to develop after about 7 days of use 6 due to the very long elimination half life of the active metabolite of fosazepam it is not recommended for use as a hypnotic 7 the main pharmacological effects of fosazepam may be due to its metabolite nordiazepam desmethyldiazepam rather than the parent drug 2 the long acting active metabolite nordazepam can cause extended sedative effects at high doses or with prolonged use and may produce residual sedation upon awakening 7 fosazepam is of relatively low potency compared to other benzodiazepine derivatives with a 100 mg dose of fosazepam equivalent to 10 mg of diazepam and 10 mg nitrazepam 5 60 mg of fosazepam has also been estimated to be equivalent to about 6 mg of diazepam 3 fosazepam has similar effects to nitrazepam but with a shorter duration of action and less tendency to cause over sedation motor impairment amnesia rebound insomnia and morning grogginess 6 see also edit benzodiazepine references edit de patent 2022503 1 2 nicholson an wright cm august 1977 activity of fosazepam a soluble analogue of diazepam british journal of clinical pharmacology 4 4 494 6 doi 10 1111 j 1365 2125 1977 tb00773 x pmc 1429035 pmid 409424 1 2 clarke ch ferres hm nicholson an stone bm october 1975 proceedings effect of diazepam and a soluble salt of diazepam fosazepam on sleep in man british journal of pharmacology 55 2 262p doi 10 1111 j 1476 5381 1975 tb07634 x pmc 1666850 pmid 1201402 1 2 3 allen s oswald i february 1976 anxiety and sleep after fosazepam british journal of clinical pharmacology 3 1 165 8 doi 10 1111 j 1365 2125 1976 tb00584 x pmc 1428810 pmid 184806 1 2 risberg am henricsson s ingvar dh october 1977 evaulation sic of the effect of fosazepam a new benzodiazepine nitrazepam and placebo on sleep patterns in normal subjects european journal of clinical pharmacology 12 2 105 9 doi 10 1007 bf00645130 pmid 200435 s2cid 21051544 1 2 viukari m linnoila m aalto u january 1978 efficacy and side effects of flurazepam fosazepam and nitrazepam as sleeping aids in psychogeriatric patients acta psychiatrica scandinavica 57 1 27 35 doi 10 1111 j 1600 0447 1978 tb06871 x pmid 24980 s2cid 23137060 1 2 breimer dd jochemsen r von albert hh 1980 pharmacokinetics of benzodiazepines short acting versus long acting arzneimittel forschung 30 5a 875 81 pmid 6106488 v t e benzodiazepines 1 4 benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam bromazepam bromonordiazepam bms 906024 camazepam carburazepam chlordiazepoxide cinazepam cinolazepam clonazepam cloniprazepam clorazepate cyprazepam delorazepam demoxepam desmethylflunitrazepam devazepide diazepam diclazepam difludiazepam doxefazepam elfazepam ethyl carfluzepate ethyl dirazepate ethyl loflazepate flubromazepam fletazepam fludiazepam flunitrazepam flurazepam flutemazepam flutoprazepam fosazepam gidazepam halazepam iclazepam irazepine kenazepine ketazolam lorazepam lormetazepam lufuradom meclonazepam medazepam menitrazepam metaclazepam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitemazepam nitrazepam nitrazepate nordazepam nortetrazepam oxazepam phenazepam pinazepam pivoxazepam prazepam proflazepam quazepam qh ii 66 reclazepam ro4491533 ro05 4082 ro5 4864 ro07 5220 ro07 9749 ro20 8065 ro20 8552 sh i 048a sulazepam temazepam tetrazepam tifluadom timelotem tolufazepam triflunordazepam tuclazepam uldazepam 1 5 benzodiazepines arfendazam clobazam cp 1414s lofendazam triflubazam 2 3 benzodiazepines girisopam gyki 52466 gyki 52895 nerisopam talampanel tofisopam triazolobenzodiazepines adinazolam alprazolam bromazolam clonazolam estazolam ethylbromazolam fluadinazolam flualprazolam flubromazolam flunitrazolam nitrazolam phenazolam pyrazolam rilmazolam active metabolite of rilmazafone triazolam imidazobenzodiazepines bretazenil climazolam evt 201 fg 8205 flumazenil gl ii 73 imidazenil 123 i iomazenil l 655 708 loprazolam midazolam pwz 029 remimazolam ro15 4513 ro48 6791 ro48 8684 ro4938581 sarmazenil sh 053 r ch3 2 f oxazolobenzodiazepines cloxazolam flutazolam haloxazolam mexazolam oxazolam thienodiazepines bentazepam clotiazepam ro09 9212 thienotriazolodiazepines α hydroxyetizolam apafant brotizolam ciclotizolam clotizolam deschloroclotizolam deschloroetizolam etizolam flubrotizolam fluclotizolam fluetizolam israpafant jq1 metizolam thienobenzodiazepines olanzapine telenzepine pyridodiazepines lopirazepam pyridotriazolodiazepines zapizolam pyrazolodiazepines razobazam ripazepam zolazepam zomebazam zometapine pyrrolodiazepines premazepam tetrahydroisoquinobenzodiazepines clazolam pyrrolobenzodiazepines anthramycin benzodiazepine prodrugs alprazolam triazolobenzophenone avizafone rilmazafone others unsorted ntx 1955 ro 7308480 atypical activity profile not gaba a receptor ligands v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valerenic acid valerenol unsorted benzodiazepine site positive modulators α pinene mrk 409 mk 0343 tcs 1105 tcs 1205 see also receptor signaling modulators gaba receptor modulators gaba metabolism transport modulators retrieved from https en wikipedia org w index php title fosazepam oldid 1366262568 categories drugs not assigned an atc code benzodiazepines chloroarenes lactams hidden categories articles with short description short description is different from wikidata articles without ebi source chemical pages without drugbank identifier drugs with no legal status drugboxes which contain changes to watched fields this page was last edited on 27 july 2026 at 02 18 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search 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