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glycoprotein iib iiia wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 gpiib iiia complex formation 2 pathology 3 medicine 4 see also 5 references 6 external links toggle the table of contents glycoprotein iib iiia 7 languages العربية català فارسی עברית italiano português русский edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia integrin complex found on platelets integrin alpha 2b platelet glycoprotein iib of iib iiia complex antigen cd41 identifiers symbol itga2b alt symbols gp2b ncbi gene 3674 hgnc 6138 omim 607759 refseq nm_000419 uniprot p08514 other data locus chr 17 q21 32 search for structures swiss model domains interpro integrin beta 3 platelet glycoprotein iiia antigen cd61 identifiers symbol itgb3 alt symbols gp3a ncbi gene 3690 hgnc 6156 omim 173470 refseq nm_000212 uniprot p05106 other data locus chr 17 q21 32 search for structures swiss model domains interpro in biochemistry and medicine glycoprotein iib iiia gpiib iiia also known as integrin α iib β 3 is an integrin complex found on platelets it is a transmembrane receptor for fibrinogen 1 and von willebrand factor and aids platelet activation the complex is formed via calcium dependent association of gpiib and gpiiia a required step in normal platelet aggregation and endothelial adherence 2 3 platelet activation by adp blocked by clopidogrel leads to the aforementioned conformational change in platelet gpiib iiia receptors that induces binding to fibrinogen 1 the gpiib iiia receptor is a target of several drugs including abciximab eptifibatide and tirofiban gpiib iiia complex formation edit once platelets are activated granules secrete clotting mediators including both adp and txa2 these then bind their respective receptors on platelet surfaces in both an autocrine and paracrine fashion binds both itself and other platelets the binding of these receptors result in a cascade of events resulting in an increase in intracellular calcium e g via g q receptor activation leading to ca 2 release from platelet endoplasmic reticulum ca 2 stores which may activate protein kinase c hence this calcium increase triggers the calcium dependent association of gpiib and gpiiia to form the activated membrane receptor complex gpiib iiia which is capable of binding fibrinogen factor i resulting in many platelets sticking together as they may connect to the same strands of fibrinogen resulting in a clot the coagulation cascade then follows to stabilize the clot as thrombin factor iia converts the soluble fibrinogen into insoluble fibrin strands these strands are then cross linked by factor xiii to form a stabilized blood clot pathology edit defects in glycoprotein iib iiia cause glanzmann s thrombasthenia 4 autoantibodies against iib iiia can be produced in immune thrombocytopenic purpura 5 medicine edit glycoprotein iib iiia inhibitors like abciximab can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke see also edit glycoprotein iib iiia inhibitors references edit 1 2 vickers jd july 1999 binding of polymerizing fibrin to integrin alpha iib beta 3 on chymotrypsin treated rabbit platelets decreases phosphatidylinositol 4 5 bisphosphate and increases cytoskeletal actin platelets 10 4 228 37 doi 10 1080 09537109976077 pmid 16801097 calvete jj april 1995 on the structure and function of platelet integrin alpha iib beta 3 the fibrinogen receptor proceedings of the society for experimental biology and medicine 208 4 346 60 doi 10 3181 00379727 208 43863a pmid 7535429 s2cid 9298838 shattil sj august 1999 signaling through platelet integrin alpha iib beta 3 inside out outside in and sideways thrombosis and haemostasis 82 2 318 25 doi 10 1055 s 0037 1615849 pmid 10605720 s2cid 83902334 bellucci s caen j september 2002 molecular basis of glanzmann s thrombasthenia and current strategies in treatment blood reviews 16 3 193 202 doi 10 1016 s0268 960x 02 00030 9 pmid 12163005 mcmillan r october 2007 the pathogenesis of chronic immune thrombocytopenic purpura seminars in hematology 44 4 suppl 5 s3 s11 doi 10 1053 j seminhematol 2007 11 002 pmid 18096470 external links edit glycoproteins iib iiia at the u s national library of medicine medical subject headings mesh v t e membrane proteins cell adhesion molecules calcium independent igsf cam n cam myelin protein zero icam 1 5 vcam 1 pe cam l1 family l1 cam nrcam nfasc chl1 nectin pvrl1 pvrl2 pvrl3 cadm1 cadm2 cadm3 cd155 integrins lfa 1 cd11a cd18 integrin alphaxbeta2 cd11c cd18 macrophage 1 antigen cd11b cd18 vla 4 cd49d cd29 glycoprotein iib iiia itga2b itgb3 calcium dependent cadherins classical cdh1 cdh2 cdh3 desmosomal desmoglein dsg1 dsg2 dsg3 dsg4 desmocollin dsc1 dsc2 dsc3 protocadherin pcdh1 pcdh15 pcdh19 unconventional ungrouped t cadherin cdh4 cdh5 cdh6 cdh8 cdh11 cdh12 cdh15 cdh16 cdh17 cdh9 cdh10 selectins e selectin l selectin p selectin other lymphocyte homing receptor cd44 l selectin integrin vla 4 lfa 1 carcinoembryonic antigen cd24 cd44 cd146 epcam v t e integrins alpha a1 a2 a3 a4 a5 a6 a7 a8 a9 a10 a11 ad ae al am av ax beta b1 b2 b3 b4 b5 b6 b7 b8 dimers cytoadhesin integrin alpha6beta4 glycoprotein iib iiia itga2b itgb3 fibrinogen macrophage 1 antigen cd11b cd18 fibronectin integrin alpha2beta1 integrin alpha4beta1 integrin alpha5beta1 leukocyte adhesion lfa 1 cd11a cd18 macrophage 1 antigen cd11b cd18 integrin alphaxbeta2 cd11c cd18 very late antigen integrin alpha1beta1 integrin alpha2beta1 integrin alpha3beta1 vla 4 cd49d cd29 alpha 5 beta 1 integrin alpha6beta1 vitronectin alpha v beta 3 alpha v beta 5 see also cell surface receptor deficiencies v t e coagulation cascade coagulation factors primary hemostasis platelet activation von willebrand factor vwf platelet membrane glycoproteins glycoprotein ib gpib gp1ba gp1bb glycoprotein ix gp9 glycoprotein iib iiia gpiib gpiiia glycoprotein vi gpvi intrinsic pathway contact activation high molecular weight kininogen hmwk bradykinin prekallikrein kallikrein factor xii hageman factor factor xi factor ix factor viii extrinsic pathway tissue factor factor iii tissue factor factor vii common pathway factor x factor v prothrombin factor ii thrombin factor iia fibrinogen factor i fga fgg fibrin factor ia factor xiii anticoagulant factors antithrombin inhibits fii fix fx fxi fxii protein c inhibits fv fviii protein s cofactor for protein c protein z inhibits fx protein z related protease inhibitor zpi inhibits fx fxi tissue factor pathway inhibitor tfpi inhibits fiii fibrinolytic factors plasminogen plasmin tissue plasminogen activator tpa urokinase plasminogen activator inhibitor 1 pai 1 plasminogen activator inhibitor 2 pai 2 α 2 antiplasmin α 2 macroglobulin thrombin activatable fibrinolysis inhibitor tafi coagulation markers platelet activation platelet factor 4 pf4 β thromboglobulin β tg thrombin generation prothrombin fragment 1 2 f1 2 thrombin antithrombin complex tat activated protein c protein c inhibitor apc pci fibrin generation fibrinopeptide a fpa fibrinopeptide b fpb fibrin monomers fm fibrinolysis plasmin α 2 antiplasmin complex pap d dimer dd this article on a gene on human chromosome 17 is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title glycoprotein_iib iiia oldid 1345373792 categories genes on human chromosome 17 integrins human chromosome 17 gene stubs hidden categories articles with short description short description matches wikidata protein pages needing a picture all stub articles this page was last edited on 25 march 2026 at 19 36 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents glycoprotein iib iiia 7 languages add topic