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#halazepam (17), the (15), and (13), edit (12), drugs (10), benzodiazepines (9), tooltip (9), wikipedia (8), acid (8), ethyl (8), was (7), from (7), for (7), retrieved (6), modulators (6), receptor (6), others (6), com (6), this (5), page (5), org (5), information (5), gaba (5), benzodiazepine (5), sage (5), contents (4), search (4), code (4), with (4), also (4), bromide (4), chloral (4), cgs (4), ro48 (4), nordazepam (4), diazepam (4), chlordiazepoxide (4), alprazolam (4), inhibitors (4), links (4), schedule (4), 2014 (4), december (4), 2023 (4), effects (4), hide (4), move (4), sidebar (4), view (3), legal (3), under (3), cs1 (3), missing (3), title (3), changes (3), wikidata (3), trifluoroethyl (3), withdrawn (3), https (3), article (3), help (3), metabolism (3), see (3), unsorted (3), positive (3), constituents (3), etifoxine (3), dhp (3), etomidate (3), butomidate (3), triflubazam (3), rilmazafone (3), quazepam (3), prazepam (3), pinazepam (3), oxazepam (3), medazepam (3), 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metabolized, into, desmethyldiazepam, hydroxyhalazepam, liver, peak, levels, intermediate, slow, onset, action, were, listed, june, follows, include, drowsiness, confusion, dizziness, sedation, gastrointestinal, side, have, been, reported, including, dry, mouth, nausea, used, treatment, derivative, that, brand, spain, portugal, paxipam, verify, key, wyclkvqlvuqknz, uhfffaoysa, c17h12clf3n2o, c18, 10h2, cn1c, c1c, smiles, interactive, image, model, jsmol, mol, 352, molar, mass, formula, chemical, physical, 041, 281, dtxsid5023118, epa, comptox, dashboard, chembl970, chembl, d00338, kegg, 320yc168lf, unii, 29343, chemspider, db00801, drugbank, 7195, iuphar, bps, 31640, cid, pubchem, 23092, cas, number, benzodiazepin, iupac, name, identifiers, renal, metabolites, elimination, hepatic, pharmacokinetic, prescription, only, higher, doses, anlage, psychoactive, class, n05ba13, atc, oral, routes, pregnancy, category, a684001, medlineplus, micromedex, detailed, consumer, ahfs, diazabicyclo, 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pharmacodynamics 4 regulatory information 5 commercial production 6 see also 7 references 8 external links toggle the table of contents halazepam 16 languages cymraeg deutsch español فارسی suomi français hrvatski italiano 日本語 polski português română srpskohrvatski српскохрватски српски srpski svenska tiếng việt edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia discontinued benzodiazepine pharmaceutical compound halazepam clinical data other names 9 chloro 6 phenyl 2 2 2 2 trifluoroethyl 2 5 diazabicyclo 5 4 0 undeca 5 8 10 12 tetraen 3 one ahfs drugs com micromedex detailed consumer information medlineplus a684001 pregnancy category routes of administration oral atc code n05ba13 who legal status legal status br class b1 psychoactive drugs 1 ca schedule iv de prescription only anlage iii for higher doses us schedule iv pharmacokinetic data metabolism hepatic elimination half life 14 hours halazepam 50 100 hours metabolites excretion renal identifiers iupac name 7 chloro 5 phenyl 1 2 2 2 trifluoroethyl 3 h 1 4 benzodiazepin 2 one cas number 23092 17 3 y pubchem cid 31640 iuphar bps 7195 drugbank db00801 y chemspider 29343 y unii 320yc168lf kegg d00338 y chembl chembl970 y comptox dashboard epa dtxsid5023118 echa infocard 100 041 281 chemical and physical data formula c 17 h 12 cl f 3 n 2 o molar mass 352 74 g mol 1 3d model jsmol interactive image smiles fc f cn1c cn c c2 cc cc c2 c3 c1c cc cl c3 o f inchi inchi 1s c17h12clf3n2o c18 12 6 7 14 13 8 12 16 11 4 2 1 3 5 11 22 9 15 24 23 14 10 17 19 20 21 h1 8h 9 10h2 y key wyclkvqlvuqknz uhfffaoysa n y verify halazepam is a benzodiazepine derivative that was marketed under the brand names paxipam in the united states 2 alapryl in spain 3 and pacinone in portugal 4 medical uses edit halazepam was used for the treatment of anxiety 2 adverse effects edit adverse effects include drowsiness confusion dizziness and sedation gastrointestinal side effects have also been reported including dry mouth and nausea 2 pharmacokinetics and pharmacodynamics edit pharmacokinetics and pharmacodynamics were listed in current psychotherapeutic drugs published on june 15 1998 as follows 5 onset of action intermediate to slow plasma half life 14 hr for parent drug and 30 100 hr for its metabolite peak plasma levels 1 3 hr for parent drug and 3 6 hf for its metabolite metabolism metabolized into desmethyldiazepam and 3 hydroxyhalazepam in the liver excretion excreted through kidneys protein binding 98 bound to plasma protein regulatory information edit halazepam is classified as a schedule 4 controlled substance with a corresponding code 2762 by the drug enforcement administration dea 6 commercial production edit halazepam was invented by schlesinger walter in the u s it was marketed as an anti anxiety agent in 1981 however halazepam is not commercially available in the united states because it was withdrawn by its manufacturer for poor sales 2 7 see also edit benzodiazepines nordazepam diazepam chlordiazepoxide quazepam fletazepam triflubazam benzodiazepines with trifluoromethyl group attached references edit anvisa 2023 03 31 rdc nº 784 listas de substâncias entorpecentes psicotrópicas precursoras e outras sob controle especial collegiate board resolution no 784 lists of narcotic psychotropic precursor and other substances under special control in brazilian portuguese diário oficial da união published 2023 04 04 archived from the original on 2023 08 03 retrieved 2023 08 16 1 2 3 4 halazepam drugs com retrieved december 11 2014 alapryl drugs com retrieved december 11 2014 pacinone drugs com retrieved december 11 2014 sellers em 1998 antianxiety agents benzodiazepine derivatives in quitkin fm et al eds current psychotherapeutic drugs 2nd ed washington american psychiatric press p 166 isbn 978 0 88048 994 2 schedules of controlled substances code of federal regulations 2012 04 01 pp 1308 14 schedule iv retrieved december 12 2014 restored dead link vvia wayback archive to a 2016 screenshot of drugs com overview of this medication https web archive org web 20160413011232 https www drugs com mtm halazepam html archived from the original on 13 april 2016 cite web missing or empty title help external links edit inchem halazepam v t e benzodiazepines 1 4 benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam bromazepam bromonordiazepam bms 906024 camazepam carburazepam chlordiazepoxide cinazepam cinolazepam clonazepam cloniprazepam clorazepate cyprazepam delorazepam demoxepam desmethylflunitrazepam devazepide diazepam diclazepam difludiazepam doxefazepam elfazepam ethyl carfluzepate ethyl dirazepate ethyl loflazepate flubromazepam fletazepam fludiazepam flunitrazepam flurazepam flutemazepam flutoprazepam fosazepam gidazepam halazepam iclazepam irazepine kenazepine ketazolam lorazepam lormetazepam lufuradom meclonazepam medazepam menitrazepam metaclazepam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitemazepam nitrazepam nitrazepate nordazepam nortetrazepam oxazepam phenazepam pinazepam pivoxazepam prazepam proflazepam quazepam qh ii 66 reclazepam ro4491533 ro05 4082 ro5 4864 ro07 5220 ro07 9749 ro20 8065 ro20 8552 sh i 048a sulazepam temazepam tetrazepam tifluadom timelotem tolufazepam triflunordazepam tuclazepam uldazepam 1 5 benzodiazepines arfendazam clobazam cp 1414s lofendazam triflubazam 2 3 benzodiazepines girisopam gyki 52466 gyki 52895 nerisopam talampanel tofisopam triazolobenzodiazepines adinazolam alprazolam bromazolam clonazolam estazolam ethylbromazolam fluadinazolam flualprazolam flubromazolam flunitrazolam nitrazolam phenazolam pyrazolam rilmazolam active metabolite of rilmazafone triazolam imidazobenzodiazepines bretazenil climazolam evt 201 fg 8205 flumazenil gl ii 73 imidazenil 123 i iomazenil l 655 708 loprazolam midazolam pwz 029 remimazolam ro15 4513 ro48 6791 ro48 8684 ro4938581 sarmazenil sh 053 r ch3 2 f oxazolobenzodiazepines cloxazolam flutazolam haloxazolam mexazolam oxazolam thienodiazepines bentazepam clotiazepam ro09 9212 thienotriazolodiazepines α hydroxyetizolam apafant brotizolam ciclotizolam clotizolam deschloroclotizolam deschloroetizolam etizolam flubrotizolam fluclotizolam fluetizolam israpafant jq1 metizolam thienobenzodiazepines olanzapine telenzepine pyridodiazepines lopirazepam pyridotriazolodiazepines zapizolam pyrazolodiazepines razobazam ripazepam zolazepam zomebazam zometapine pyrrolodiazepines premazepam tetrahydroisoquinobenzodiazepines clazolam pyrrolobenzodiazepines anthramycin benzodiazepine prodrugs alprazolam triazolobenzophenone avizafone rilmazafone others unsorted ntx 1955 ro 7308480 atypical activity profile not gaba a receptor ligands v t e anxiolytics n05b 5 ht 1a r tooltip 5 ht1a receptor agonists buspirone gepirone tandospirone gaba a r tooltip gabaa receptor pams tooltip positive allosteric modulators benzodiazepines adinazolam alprazolam bromazepam camazepam chlordiazepoxide clobazam clonazepam clorazepate clotiazepam cloxazolam diazepam ethyl loflazepate etizolam fludiazepam halazepam ketazolam lorazepam medazepam nordazepam oxazepam pinazepam prazepam others alpidem barbiturates e g phenobarbital carbamates e g meprobamate carisoprodol chlormezanone ethanol alcohol etifoxine gabapentinoids α 2 δ vdcc blockers gabapentin gabapentin enacarbil phenibut baclofen pregabalin antidepressants ssris tooltip selective serotonin reuptake inhibitors e g escitalopram snris tooltip serotonin norepinephrine reuptake inhibitors e g duloxetine saris tooltip serotonin antagonist and reuptake inhibitors e g trazodone tcas tooltip tricyclic antidepressants e g clomipramine tecas tooltip tetracyclic antidepressants e g mirtazapine maois tooltip monoamine oxidase inhibitors e g phenelzine others agomelatine bupropion tianeptine vilazodone vortioxetine sympatholytics antiadrenergics alpha 1 blockers e g prazosin alpha 2 agonists e g clonidine dexmedetomidine guanfacine beta blockers e g propranolol atenolol betaxolol nadolol oxprenolol pindolol others benzoctamine cycloserine fabomotizole hydroxyzine lorpiprazole mebicar mepiprazole nicotine tobacco opipramol oxaflozane phenaglycodol phenibut picamilon selank tiagabine tofisopam validolum who em withdrawn from market clinical trials phase iii never to phase iii v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valere...