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interferon alfa wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 adverse effects 2 composition 3 pharmacology 4 references toggle the table of contents interferon alfa 8 languages العربية español français bahasa indonesia ଓଡ଼ିଆ português татарча tatarça tiếng việt edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia pharmaceutical drug pharmaceutical compound interferon alfa clinical data ahfs drugs com international drug names routes of administration subcutaneous 1 intramuscular 2 atc code l03ab01 who identifiers drugbank db05258 y chemspider none n y what is this verify interferon alfa inn or huifn alpha le trade name multiferon is a pharmaceutical drug composed of natural interferon alpha ifn α obtained from the leukocyte fraction of human blood following induction with sendai virus interferon alfa contains several naturally occurring ifn α subtypes and is purified by affinity chromatography although the pharmaceutical product is often simply called interferon alpha or ifn α like its endogenous counterpart the product s international nonproprietary name inn is interferon alfa the spelling of alfa with f reflects inn naming conventions interferon alfa is used in a variety of treatments including certain forms of leukemia melanoma non hodgkin s lymphoma 3 hepatitis b and hepatitis c 4 5 6 it is typically administered as an injection under the skin 1 adverse effects edit common side effects 10 of people include increased risk of infection due to drop in white blood cells difficulty sleeping mood changes including irritability excitement restlessness or depression headaches and dizziness dry mouth blurred vision feeling or being sick abdominal pain diarrhoea sore mouth taste changes hair loss sweating joint and or muscle pain injection site reactions fatigue flu like symptoms loss of appetite and weight loss 1 the us fda has issued a black box warning regarding the potential for caus ing or aggravat ing fatal or life threatening neuropsychiatric autoimmune ischemic and infectious disorders 2 composition edit interferon alfa contains a mixture of several proteins all with structural serological and functional properties typical for natural interferon alpha ifn α the major subtypes identified are ifn α1 ifn α2 ifn α8 ifn α10 ifn α14 and ifn α21 of these ifn α2 and ifn α14 are glycosylated the ifn α content is expressed in international units per milliliter and the drug product is formulated in isotonic phosphate buffer solution at ph 7 2 and supplemented with human albumin at 1 5 mg ml the albumin used is a medicinal product approved in several countries and is indicated for subcutaneous injection therapy pharmacology edit ifn α8 enhances the proliferation of human b cells as well as being able to activate nk cells the subtypes α10 and α2 along with α8 are the most efficient and powerful nk cell activators subtypes α21 and α2 enhance the expression of ifn gamma inducible protein 10 ip 10 in dendritic cells activated dendritic cells initiate immune responses and induce the expression of ip 10 a chemokine which promotes a th1 inflammatory response ifn α1 causes increased hla ii expression and can directly inhibit tumor cell growth in vitro however it is a poor activator of nk cells has relatively little antiviral activity does not induce b cell proliferation and does not enhance hla i or tumor antigen expression despite its apparent inactivity it is still used clinically in the treatment of metastatic renal cell carcinoma with a reported lower toxicity than the recombinant ifn α2 overall ifn α has a general inflammatory action which skews the immune response towards a th1 profile subtype α2 increases the expression of hla i molecules which correlates with ifn α mediated activation of memory cd8 cells and increased cytolytic action against virally infected cells and tumor cells via cytotoxic cd8 cells references edit 1 2 3 interferon alfa cancer information cancer research uk www cancerresearchuk org archived from the original on 18 may 2021 retrieved 2021 10 17 1 2 product information intron a interferon alfa 2b recombinant for injection pdf us food and drug administration archived from the original pdf on october 18 2020 retrieved 1 april 2024 williams cd linch dc 1997 interferon alfa 2a british journal of hospital medicine 57 9 436 9 pmid 9274677 woo mh burnakis tg march 1997 interferon alfa in the treatment of chronic viral hepatitis b and c the annals of pharmacotherapy 31 3 330 7 doi 10 1177 106002809703100312 pmid 9066942 s2cid 31113832 interferon alfa drug information chemocare chemocare com archived from the original on 2023 04 21 retrieved 2021 10 17 alpha interferon livertox clinical and research information on drug induced liver injury bethesda md national institute of diabetes and digestive and kidney diseases 2012 pmid 31643203 retrieved 2021 10 17 v t e immunostimulants l03 endogenous cytokines colony stimulating factors g csf efbemalenograstim alfa eflapegrastim filgrastim lipegfilgrastim pegfilgrastim lenograstim gm csf molgramostim sargramostim scf ancestim interferons alpha albinterferon interferon alfa natural interferon alfa 2a peginterferon alfa 2a interferon alfa 2b peginterferon alfa 2b ropeginterferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 feline omega beta interferon beta natural interferon beta 1a interferon beta 1b interferon gamma interleukins aldesleukin nogapendekin alfa inbakicept oprelvekin other protein peptide growth hormone immunocyanin pegademase prolactin tasonermin other female sex steroids histamine dihydrochloride poly iclc vitamin d exogenous beta glucan lentinan heterocyclic compound plerixafor hydroxyquinoline roquinimex mifamurtide oligopeptides glatiramer acetate thymopentin thymosin α1 thymulin polyribonucleotide polyinosinic polycytidylic acid thiazolidine pidotimod inosine pranobex vaccines bacillus calmette guérin melanoma vaccine sipuleucel t cridanimod v t e cytokine receptor modulators chemokine see here instead csf erythropoietin agonists ara 290 asialo erythropoietin carbamylated erythropoietin cnto 530 darbepoetin alfa epoetin alfa epoetin beta epoetin delta epoetin epsilon epoetin gamma epoetin kappa epoetin omega epoetin theta epoetin zeta erythropoietin epo erythropoietin fc methoxy polyethylene glycol epoetin beta cera mircera peginesatide pegol sihematide epo 018b g csf csf3 agonists filgrastim granulocyte colony stimulating factor lenograstim leridistim lipegfilgrastim nartograstim pegfilgrastim pegnartograstim gm csf csf2 agonists ecogramostim granulocyte macrophage colony stimulating factor milodistim molgramostim regramostim sargramostim antibodies mavrilimumab namilumab otilimab m csf csf1 agonists cilmostim interleukin 34 lanimostim macrophage colony stimulating factor mirimostim kinase inhibitors agerafenib scf c kit see here instead thrombopoietin agonists eltrombopag pegacaristim promegapoietin romiplostim avatrombopag lusutrombopag thrombopoietin thpo mgdf interferon ifnar α β i agonists albinterferon interferon alpha interferon alfa ifn α interferon alfa ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 interferon alfa 2a interferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 interferon beta ifn β ifnb1 ifnb3 interferon beta 1a interferon beta 1b interferon kappa ifn ε κ τ ζ ifnk interferon omega ifn ω ifnw1 peginterferon alfa 2a peginterferon alfa 2b antibodies anifrolumab faralimomab medi 545 rontalizumab sifalimumab decoy receptors bifarcept ifngr γ ii agonists interferon gamma ifn γ interferon gamma 1b antibodies emapalumab fontolizumab ifnlr λ iii see il 28r ifnlr here instead interleukin see here instead tgfβ see here instead tnf see here instead others jak inhibitors jak1 abrocitinib baricitinib deuruxolitinib filgotinib momelotinib oclacitinib peficitinib ruxolitinib tofacitinib tasocitinib upadacitinib jak2 atiprimod azd 1480 baricitinib chz868 cucurbitacin i elatericin b jsi 124 cyt387 deuruxolitinib lestaurtinib nsc 7908 nsc 33994 pacritinib peficitinib ruxolitinib sd 1008 tofacitinib tasocitinib jak3 cercosporamide decernotinib vx 509 peficitinib ritlecitinib tcs 21311 tofacitinib tasocitinib whi p 154 zm 39923 zm 449829 tyk2 deucravacitinib others additional cytokines cardiotrophin 1 ct 1 fms like tyrosine kinase 3 ligand flt3l leukemia leukocyte inhibitory factor lif oncostatin m osm thymic stromal lymphopoietin tslp additional cytokine receptor modulators emfilermin lestaurtinib midostaurin quizartinib sorafenib sunitinib this antineoplastic or immunomodulatory drug article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title interferon_alfa oldid 1323047449 categories immunomodulating drugs antineoplastic and immunomodulating drug stubs hidden categories articles with short description short description matches wikidata short description is different from wikidata chemicals that do not have a chemspider id assigned infobox drug articles without a structure image chemical articles without cas registry number articles without ebi source articles without kegg source articles without inchi source articles without unii source drugs with no legal status drugboxes which contain changes to verified fields all stub articles this page was last edited on 19 november 2025 at 10 15 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents interferon alfa 8 languages add topic