Meta tags:

Headings (most frequently used words):

kit, gene, contents, function, structure, cell, surface, marker, mobilization, role, in, cancer, interactions, see, also, references, further, reading, external, links, anti, therapies, diagnostic, relevance,

Text of the page (most frequently used words):
the (147), kit (129), and (98), cell (87), receptor (84), kinase (68), pmid (61), factor (59), doi (56), tyrosine (41), family (36), stem (35), agonists (33), growth (31), regulation (31), journal (31), signaling (30), for (29), with (28), protein (28), cells (27), positive (25), cancer (24), human (23), activity (22), gene (20), inhibitors (20), antibodies (20), pathway (19), differentiation (19), receptors (18), edit (18), hematopoietic (18), interferon (17), pmc (17), binding (16), oncogene (16), biological (16), mast (15), see (14), other (13), tsp (13), 1016 (13), chemistry (13), cytokine (12), here (12), against (12), tumor (12), also (12), may (11), like (11), instead (11), beta (11), list (11), domain (11), cellular (11), molecular (11), are (11), ligand (10), epoetin (10), igf (10), enzyme (10), onco (10), proto (10), 1992 (10), phosphorylation (10), s2cid (10), october (10), been (10), used (10), this (9), from (9), modulators (9), alfa (9), scf (9), csf (9), blood (9), expression (9), february (9), tumors (9), associated (9), role (9), progenitors (9), which (9), mobilization (9), erythropoietin (8), proteins (8), egf (8), types (8), src (8), membrane (8), mutations (8), 1074 (8), phosphatidylinositol (8), surface (8), has (8), wikipedia (7), biology (7), interleukin (7), factors (7), negative (7), insulin (7), angiopoietin (7), kinases (7), type (7), 272 (7), national (7), activation (7), 2002 (7), signal (7), rönnstrand (7), jbc (7), that (7), mouse (7), search (6), site (6), page (6), september (6), leukemia (6), agerafenib (6), stimulating (6), vandetanib (6), altiratinib (6), allosteric (6), ono (6), dhea (6), bnn (6), ngf (6), fgf (6), tgf (6), tyr (6), bone (6), s0021 (6), 9258 (6), april (6), genetics (6), drug (6), myeloid (6), transduction (6), expressed (6), lennartsson (6), associates (6), biochemical (6), progenitor (6), proliferation (6), muscle (6), process (6), development (6), view (5), additional (5), links (5), superfamily (5), genes (5), sunitinib (5), lestaurtinib (5), stromal (5), jak (5), ifn (5), migration (5), derived (5), k252a (5), imatinib (5), somatomedin (5), tec (5), linked (5), structure (5), mutant (5), bibcode (5), november (5), 2006 (5), gists (5), 2005 (5), cd117 (5), december (5), activated (5), 1997 (5), response (5), binds (5), containing (5), research (5), transmembrane (5), anti (5), prostate (5), ensembl (5), have (5), smooth (5), important (5), levels (5), main (5), population (5), contents (4), terms (4), commons (4), sorafenib (4), others (4), 154 (4), azd (4), iii (4), decoy (4), thrombopoietin (4), colony (4), activating (4), vegf (4), 245677 (4), antagonists (4), thf (4), dhf (4), 004 (4), 110 (4), ret (4), trafermin (4), bfgf (4), ersofermin (4), trastuzumab (4), erbb (4), lyn (4), fes (4), stat (4), high (4), 269 (4), 267 (4), 100 (4), product (4), complex (4), location (4), medical (4), external (4), july (4), marrow (4), steel (4), induced (4), sciences (4), via (4), function (4), current (4), diagnostic (4), gastrointestinal (4), 1999 (4), 1128 (4), mcb (4), 1042 (4), association (4), dependent (4), region (4), 1996 (4), chemotaxis (4), can (4), germ (4), lymphoid (4), marker (4), express (4), melanocyte (4), chr (4), plasma (4), hide (4), move (4), sidebar (4), toggle (3), about (3), non (3), organization (3), was (3), wikidata (3), immunoglobulin (3), chromosome (3), quizartinib (3), whi (3), tofacitinib (3), tasocitinib (3), peficitinib (3), gamma (3), medi (3), alpha (3), macrophage (3), epo (3), wnt (3), tissue (3), toceranib (3), rebastinib (3), pazopanib (3), lapatinib (3), axitinib (3), plx (3), 7486 (3), 5390556 (3), 4474 (3), larotrectinib (3), 389988 (3), entrectinib (3), 6051 (3), 7057288 (3), 6918 (3), acd856 (3), ac26845 (3), 0026845 (3), trka (3), trk (3), pdgf (3), p75 (3), unknown (3), hgf (3), met (3), selpercatinib (3), kinetics (3), inhibitor (3), matk (3), csk (3), pdgfra (3), transcription (3), ras (3), mapk (3), akt (3), intracellular (3), low (3), nerve (3), 338 (3), 271 (3), 151 (3), 150 (3), structural (3), pdb (3), entry (3), library (3), medicine (3), 1991 (3), 1182 (3), normal (3), analysis (3), june (3), dominant (3), lev (3), yarden (3), givol (3), dimerization (3), wang (3), march (3), but (3), not (3), spritz (3), piebaldism (3), 1002 (3), sequence (3), 2007 (3), diagnosis (3), their (3), 2004 (3), 1007 (3), cytogenetics (3), international (3), genetic (3), linnekin (3), 1994 (3), 1038 (3), mediated (3), dubreuil (3), interaction (3), juxtamembrane (3), feng (3), grb2 (3), essential (3), direct (3), multiple (3), avraham (3), specific (3), sh2 (3), 2008 (3), adaptor (3), embo (3), crkl (3), van (3), 2003 (3), leong (3), 2015 (3), testicular (3), 1987 (3), information (3), pubmed (3), reference (3), help (3), such (3), appearance (3), carcinomas (3), seminomas (3), mutation (3), exon (3), encoding (3), plays (3), stemness (3), its (3), ovarian (3), gland (3), activates (3), article (3), skin (3), extracellular (3), cascade (3), contraction (3), pigmentation (3), component (3), oocyte (3), top (3), tools (3), languages (2), table (2), contact (2), privacy (2), policy (2), available (2), wikimedia (2), categories (2), wayback (2), short (2), description (2), different (2), retrieved (2), portal (2), thymic (2), leukocyte (2), inhibitory (2), lif (2), fms (2), tyk2 (2), jak3 (2), ruxolitinib (2), nsc (2), deuruxolitinib (2), 124 (2), baricitinib (2), jak2 (2), jak1 (2), tnf (2), tgfβ (2), ifnlr (2), peginterferon (2), omega (2), kappa (2), granulocyte (2), pegol (2), 290 (2), chemokine (2), phosphate (2), ramucirumab (2), nintedanib (2), motesanib (2), lenvatinib (2), cabozantinib (2), cyclotraxin (2), ripretinib (2), trkc (2), toltrazuril (2), ponazuril (2), acd855 (2), acd857 (2), r13 (2), braegen (2), bdnf (2), amitriptyline (2), trkb (2), rbm (2), aptamers (2), tanezumab (2), ranevetmab (2), 578 (2), fulranumab (2), frunevetmab (2), fasinumab (2), asp (2), 6294 (2), abt (2), pg110 (2), 120 (2), testosterone (2), dexamethasone (2), ale (2), 0540 (2), cenegermin (2), nilotinib (2), masitinib (2), dasatinib (2), unsorted (2), line (2), neurotrophic (2), avapritinib (2), platelet (2), ntr (2), target (2), xentuzumab (2), nvp (2), bms (2), mecasermin (2), telisotuzumab (2), hepatocyte (2), fgfr4 (2), sprifermin (2), fgfr3 (2), aprutumab (2), repifermin (2), kgf2 (2), fgfr2 (2), fgfr1 (2), neuregulins (2), heregulins (2), heparin (2), epigen (2), betacellulin (2), erbb4 (2), erbb3 (2), her3 (2), neratinib (2), afatinib (2), erbb2 (2), her2 (2), depatuxizumab (2), cntf (2), plot (2), enzymes (2), syk (2), frk (2), fak (2), abl (2), axl (2), aatyk (2), musk (2), ryk (2), ptk7 (2), tie (2), ltk (2), flt3 (2), csf1r (2), notch (2), ungrouped (2), fos (2), cbl (2), dna (2), cyclin (2), neurofibromin (2), suppressor (2), category (2), hormone (2), il12rb1 (2), chain (2), cxcr4 (2), affinity (2), 371 (2), 370 (2), 362 (2), 357 (2), 351 (2), 350 (2), 327 (2), 301 (2), 288 (2), 279 (2), 268 (2), 261 (2), 247 (2), 241 (2), 226 (2), 220 (2), 205 (2), 201 (2), 200 (2), 178 (2), 174 (2), 135 (2), 123 (2), 118 (2), 117 (2), 116 (2), 107 (2), 102 (2), 101 (2), clusters (2), basis (2), autoinhibition (2), sti (2), 571 (2), inhibition (2), 1t46 (2), 1t45 (2), 1pkg (2), ucsc (2), genome (2), dictionary (2), knight (2), clinical (2), investigation (2), 10873 (2), 1375232 (2), 50098 (2), 10866 (2), recombinant (2), ectodomain (2), retains (2), antagonizes (2), stimulated (2), responses (2), martin (2), genomic (2), 1587 (2), p21ras (2), giebel (2), holmes (2), american (2), 492 (2), nucleotide (2), august (2), mastocytosis (2), neoplastic (2), 2174 (2), targets (2), lasota (2), miettinen (2), 1053 (2), immunohistochemistry (2), review (2), acute (2), 1080 (2), s00018 (2), life (2), agents (2), biochemistry (2), early (2), pathways (2), basic (2), further (2), reading (2), mano (2), ihle (2), 8432 (2), blume (2), jensen (2), carlberg (2), map (2), sepulveda (2), deberry (2), mou (2), stat1 (2), 1993 (2), 3350 (2), phosphatase (2), after (2), lee (2), rottapel (2), 1998 (2), 2089 (2), mantel (2), interacts (2), serve (2), subunit (2), 2000 (2), s0014 (2), 482 (2), price (2), rivnay (2), 5915 (2), 1995 (2), 270 (2), 9661 (2), 27450 (2), lines (2), pdf (2), lnk (2), 568 (2), 12129 (2), sh3 (2), 216 (2), identification (2), 936 (2), primary (2), sites (2), 904 (2), socs1 (2), 991 (2), 979 (2), grb10 (2), 2010 (2), bbrc (2), 393 (2), biophysical (2), communications (2), required (2), dok (2), 10248 (2), induces (2), von (2), 3406 (2), formation (2), crk (2), 4413 (2), 1046 (2), haematology (2), 1033 (2), aps (2), ktn0182a (2), pyrrolobenzodiazepine (2), pbd (2), antibody (2), conjugate (2), vitro (2), vivo (2), range (2), 2014 (2), dynamics (2), insight (2), 1158 (2), overexpression (2), progression (2), seminoma (2), subtype (2), innate (2), single (2), adult (2), 456 (2), brooks (2), locus (2), white (2), 1460 (2), 2075 (2), actin (2), reorganization (2), new (2), entrez (2), feline (2), sarcoma (2), viral (2), homolog (2), center (2), biotechnology (2), 2017 (2), release (2), ensmusg00000005672 (2), ensg00000157404 (2), references (2), shown (2), interactions (2), markers (2), cytoplasmic (2), relevance (2), when (2), case (2), many (2), those (2), emphasized (2), eal (2), into (2), frequently (2), addition (2), implicated (2), disease (2), melanoma (2), therapies (2), leading (2), several (2), colon (2), small (2), epithelial (2), emt (2), ectopic (2), microenvironment (2), example (2), well (2), through (2), being (2), found (2), organs (2), liver (2), contribute (2), some (2), spermatogenesis (2), male (2), molecules (2), identify (2), mark (2), digestive (2), tract (2), common (2), cluster (2), domains (2), forms (2), known (2), survival (2), involved (2), scfr (2), refseq (2), hemopoiesis (2), metabolic (2), ion (2), rna (2), developmental (2), stimulus (2), assembly (2), somatic (2), maintenance (2), production (2), programmed (2), death (2), gonad (2), integral (2), side (2), secondary (2), lactiferous (2), ortholog (2), end (2), start (2), band (2), upload (2), file (2), changes (2), history (2), read (2), log (2), create (2), account (2), donate (2), menu (2), add, topic, mobile, cookie, statement, statistics, developers, code, conduct, legal, safety, contacts, disclaimers, text, under, apply, using, you, agree, registered, trademark, profit, foundation, inc, use, creative, attribution, sharealike, license, rendered, parsoid, last, edited, 2026, utc, hidden, webarchive, template, articles, acidocalcisomes, https, org, index, php, title, kit_gene, oldid, 1373940700, midostaurin, emfilermin, lymphopoietin, tslp, oncostatin, osm, flt3l, cardiotrophin, cytokines, deucravacitinib, 449829, 39923, tcs, 21311, ritlecitinib, decernotinib, 509, cercosporamide, 1008, pacritinib, 33994, 7908, cyt387, cucurbitacin, elatericin, jsi, chz868, 1480, atiprimod, upadacitinib, oclacitinib, momelotinib, filgotinib, abrocitinib, 28r, fontolizumab, emapalumab, ifngr, bifarcept, sifalimumab, rontalizumab, 545, faralimomab, anifrolumab, ifnw1, ifnk, ifnb3, ifnb1, alfacon, ifna21, ifna17, ifna16, ifna14, ifna13, ifna10, ifna8, ifna7, ifna6, ifna5, ifna4, ifna2, ifna1, albinterferon, ifnar, thpo, mgdf, lusutrombopag, avatrombopag, romiplostim, promegapoietin, pegacaristim, eltrombopag, mirimostim, lanimostim, cilmostim, csf1, otilimab, namilumab, mavrilimumab, sargramostim, regramostim, molgramostim, milodistim, ecogramostim, csf2, pegnartograstim, pegfilgrastim, nartograstim, lipegfilgrastim, leridistim, lenograstim, filgrastim, csf3, sihematide, 018b, peginesatide, methoxy, polyethylene, glycol, cera, mircera, zeta, theta, epsilon, delta, darbepoetin, cnto, 530, carbamylated, asialo, ara, neurotrophin, mixture, cerebrolysin, renalase, pleiotrophin, pituitary, adenylate, cyclase, peptide, pacap, oncomodulin, msf, prg4, midkine, negf2, msp, hlp, hgflp, interleukins, hepatoma, hdgf, glia, maturation, gmf, glucose, isomerase, gpi, pgi, phi, amf, ephrins, connective, ctgf, adrenomedullin, aflibercept, ranibizumab, icrucumab, bevacizumab, alacizumab, tivozanib, semaxanib, regorafenib, pegaptanib, fruquintinib, cediranib, figf, telbermin, placental, pgf, ligands, gossypetin, hhf, ana, tdp6, spv, 400, brad, norwogonin, acetylserotonin, lm22a, hioc, dmaq, diosmetin, deoxygedunin, dma, ren, 1820, trkad5, gbr, 900, sna, pegylated, milciclib, 902a, e2511, fx007, tavilermide, gambogic, amide, ancestim, persephin, pspn, gfrα4, artemin, artn, gfrα3, neurturin, nrtn, gfrα2, liatermin, glial, gdnf, gfrα1, gfl, tovetumab, olaratumab, radotinib, crenolanib, becaplermin, levi, evt, 901, sar, 127963, lngf, trofinetide, glypromate, gpe, cleavage, products, derivatives, igfbp, dusigitumab, teprotumumab, r1507, robatumumab, ganitumab, figitumumab, dalotuzumab, cixutumumab, ave, 1642, osl, 906, aew541, adw742, linsitinib, 754807, rinfabate, lr3, des, vedotin, rilotumumab, onartuzumab, flanvotumab, ficlatuzumab, emibetuzumab, tivantinib, 11274, savolitinib, pha, 665752, 2341066, 04217903, 2461, jnj, 38877605, incb28060, golvatinib, foretinib, crizotinib, capmatinib, 777607, amuvatinib, amg, 458, am7, dihexa, pnb, 0408, potentiators, fosgonimeton, fgf15, fgf23, burosumab, infigratinib, ixadotin, palifermin, kgf, velafermin, tomoregulin, tmeff, her4, seribantumab, patritumab, duligotuzumab, neuroglycan, tucatinib, mubritinib, emtansine, duocarmazine, deruxtecan, pertuzumab, ertumaxomab, none, zalutumumab, panitumumab, nimotuzumab, necitumumab, matuzumab, imgatuzumab, futuximab, mafodotin, cetuximab, osimertinib, icotinib, grandinin, gefitinib, erlotinib, dacomitinib, canertinib, brigatinib, transforming, tgfα, nepidermin, murodermin, epiregulin, urogastrone, amphiregulin, erbb1, her1, dapiclermin, axokine, nesvacumab, evinacumab, ec7, translocases, ec6, ligases, ec5, isomerases, ec4, lyases, ec3, hydrolases, ec2, transferases, ec1, oxidoreductases, michaelis, menten, lineweaver, burk, hanes, woolf, eadie, hofstee, diagram, number, classification, activator, cooperativity, catalysis, cofactor, diffusion, limited, promiscuity, oxyanion, hole, catalytic, triad, active, zap70, txk, itk, btk, bmx, lck, hck, blk, yes1, fyn, fgr, srms, brk, fer, pyk2, tnk1, ack1, ack, abl2, abl1, styk1, uncategorised, tyro3, mer, aatyk2, ros1, ros, ddr2, ddr1, ddr, ror2, ror1, ror, tek, alk, ephx, ephb6, ephb5, ephb4, ephb3, ephb2, ephb1, epha8, epha7, epha6, epha5, epha4, epha3, epha2, epha1, eph, ntrk3, ntrk2, ntrk1, ron, vegfr3, vegfr2, vegfr1, pdgfrb, pdgfr, insrr, insr, igf1r, egfr, stathmin, bcl, sdhd, sdhb, apoptosis, mitochondrion, klf6, myc, jun, vhl, mdm2, ubiquitin, ligase, brca2, brca1, fanconi, repair, p14arf, p16, wt1, prb, p53, cdk4, cycle, nucleus, maspin, raf, hras, erk, merlin, hippo, pten, pkb, smad4, smad2, apc, catenin, ptch1, hedgehog, cdh1, sis, oncogenes, tgfbr2, tgfbr1, ser, thr, il17re, il17rd, il17rc, il17rb, il17ra, il17, il18r1, il18r, il1r2, il1r1, il1, ifngr2, ifngr1, ifnar2, ifnar1, il28r, il20rb, il20ra, il20r, il22ra2, il22ra1, il22r, il10rb, il10ra, il10r, prolactin, il23r, il12rb2, il12r, cntfr, lifr, osmr, il27ra, il11ra, il6ra, gp130, il5ra, il5r, il3ra, il3r, il21r, il9r, il7ra, il7r, il13ra2, il13ra1, il13r, il4r, il15r, il2rb, il2ra, il2r, tnfrsf27, eda2r, tnfrsf25, dr3, tnfrsf21, dr6, tnfrsf19, taj, troy, tnfrsf18, gitr, tnfrsf17, bcma, tnfrsf16, ngfr, tnfrsf14, hvem, tnfrsf13c, baffr, tnfrsf13b, taci, tnfrsf12a, tweakr, tnfrsf11b, osteoprotegerin, tnfrsf11a, rank, tnfrsf10d, dcr2, tnfrsf10c, dcr1, tnfrsf10b, dr5, tnfrsf10a, dr4, tnfrsf9, tnfrsf8, cd30, tnfrsf7, cd27, tnfrsf6b, dcr3, tnfrsf6, fas, tnfrsf5, cd40, tnfrsf4, tnfrsf3, ltbr, tnfrsf1b, tnfr2, tnfrsf1a, tnfr1, cmklr1, ackr, xcr1, cx3c, cx3cr1, cxcr6, cxcr5, cxcr3, cxcr2, cxcr1, cxc, ccr10, ccr9, ccr8, ccr7, ccr6, ccr5, ccr4, ccr3, ccrl2, ccr2, ccr1, gpcrs, necrosis, epidermal, fibroblast, morphogenetic, activin, serine, threonine, ciliary, 369, 368, 367, 366, 365, 364, 363, 361, 360, 358, 355, 354, 353, 352, 349, 344, 340, 339, 337, 336, 335, 334, 333, 332, 331, 329, 328, 326, 325, 324, 322, 321, 320, 318, 317, 316, 315, 314, 312, 309, 307, 306, 305, 304, 303, 302, 300a, 299, 298, 297, 295, 294, w293, 292, 289, 286, 284, 283, 282, 281, 280, 278, 276, 275, 274, 273, 266, 265, 264, 263, 262, 258, 257, 256, 254, 253, 252, 251, 300, 249, 248, 246, 244, 243, 240d, 240ce, 239, 238, 236, 235, 234, 233, 230, 229, 228, 227, 225, 224, 223, 222, 221, 218, 217, 213a, 212, w210, 209, 208, 207, 206, 204, 202b, 250, w199, w198, 197, 196, 195, 194, 193, 192, 191, 186, 185, 184, 183, 182, 181, 180, 179, 177, 172, 171, 170, 169, 168, 167, 166, 164, 163, 162, 161, 160, 159, 158, 157, 156, 155, 153, 152, 148, 147, 146, 144, 143, 142, 141, 140b, 138, 137, 136, 134, 133, 132, 131, 130, 129, 127, 126, 125, 122, 121, 119, 115, 114, 113, 112, 111, 109, 108, 106, 105, 104, 103, gallery, browser, details, public, nci, mesh, subject, headings, ashman, cambareri, levinsky, juttner, 1712644, v78, yb5, antigen, alai, mui, cutler, bustelo, barbacid, krystal, 18025, 1381360, 37146, 18021, stimulates, p95vav, hemopoietic, vandenbark, decastro, taylor, dew, kaufman, cloning, 1266, 1377810, 1259, fleischman, 1717, 1376329, 295855, 1172, jci115772, 1713, piebald, trait, resulting, allele, andré, cornu, galibert, evolution, subclass, 691, 1373482, 685, duronio, abraham, dryden, schrader, 1591, 1371879, 48497, 1073, pnas, 1992pnas, 1587d, proceedings, academy, united, states, america, hemopoietin, requires, gtpase, welham, 1370874, 1682440, loss, droetto, fukushima, deletion, patient, 495, 1279971, ajmg, 1320440422, strunk, 2217, 1279499, 2207, patnaik, tefferi, pardanani, molecule, interest, treatment, disorders, 503, 17691909, 156800907781386614, 17193822, semdp, 006, seminars, pathology, 6912266, 16082245, 1097, pai, 0000173054, 83414, applied, morphology, tissues, clinicopathologic, correlation, larizza, magnani, beghini, kasumi, model, 255, 36086764, 15621809, 10428190400007565, lymphoma, kitamura, hirotab, 2931, 15583854, 11924580, 4273, 2924, oncogenic, sandberg, bridge, updates, soft, 12072198, s0165, 4608, 00546, valent, ghannadan, hauswirth, schernthaner, sperr, arock, antigens, 23033596, 12041664, bf02982124, hematology, gupta, bain, cytogenetic, abnormalities, systemic, 128, 20552257, 11919394, 1159, 000046642, acta, haematologica, canonico, felici, papa, 2001, 11388751, regulators, homeostatic, 10582339, s1357, 2725, 00078, 2548, 2602233, 15526160, 11924424, 4189, 2535, 16475976, 156800906775471725, 2012, science, implications, 1649, 23073628, 1152, physrev, 00046, 2011, 1619, physiological, reviews, tang, 8437, 7526158, 359382, phosphorylated, following, hermanson, pontén, 5553, 10523831, onc, 1202929, 5546, shc, necessary, induction, bayle, letard, frank, 12259, 14707129, m313381200, 12249, regulates, 9355737, 1218765, bj3270073, 3358, 7684496, 359793, stimulation, kozlowski, larose, siminovitch, 2099, 9528781, 121439, shp, negatively, modulates, 569, tauchi, marshall, shen, pawson, 25211, 7523381, 31518, 25206, ubiquitously, syp, hsu, besmer, 6030, 7509796, 37564, 6026, residue, 719, p85, cos, mancini, koch, stefan, niemann, tamura, pdz, mupp, terminus, regulated, 40159587, 11018522, 5793, 02036, 2000febsl, 54m, febs, letters, jiang, 5920, 9038210, homologous, chk, diphosphorylated, tyr568, 570, megakaryocytes, jhun, 9666, 7536744, manner, 27455, 9341198, gueller, gery, nowak, liu, koeffler, 245, 39310714, 18588518, bj20080102, 415, blechman, brizzi, leitner, pegoraro, 4406, 7680037, 53623, 4399, soluble, antireceptor, monoclonal, confine, ouyang, shi, gentz, 12132, 8647802, grap, novel, couples, thömmes, 10377264, 1220349, 0264, 6021, 3410211, 211, 341, 703, grb7, okkenhaug, rose, hawley, 915, 10022833, 1171183, 1093, emboj, signalling, suppresses, jahn, seipel

Text of the page (random words):
ession data biogps n a gene ontology molecular function stem cell factor receptor activity kinase activity transmembrane receptor protein tyrosine kinase activity atp binding cytokine binding protein kinase activity metal ion binding transferase activity protein homodimerization activity protease binding protein binding protein tyrosine kinase activity nucleotide binding phosphatidylinositol 4 5 bisphosphate 3 kinase activity receptor tyrosine kinase transmembrane signaling receptor activity sh2 domain binding cellular component cytoplasm membrane cell cell junction cytoplasmic side of plasma membrane cell surface integral component of membrane acrosomal vesicle external side of plasma membrane mast cell granule extracellular space plasma membrane integral component of plasma membrane receptor complex biological process melanocyte migration myeloid progenitor cell differentiation positive regulation of map kinase activity glycosphingolipid metabolic process positive regulation of phospholipase c activity hematopoietic stem cell migration stem cell population maintenance protein phosphorylation t cell differentiation spermatogenesis cell chemotaxis developmental pigmentation melanocyte differentiation positive regulation of notch signaling pathway lamellipodium assembly cytokine mediated signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway melanocyte adhesion lymphoid progenitor cell differentiation spermatid development erythrocyte differentiation negative regulation of programmed cell death protein autophosphorylation mast cell degranulation inflammatory response positive regulation of mapk cascade myeloid leukocyte differentiation male gonad development phosphorylation positive regulation of dna binding transcription factor activity epithelial cell proliferation stem cell differentiation detection of mechanical stimulus involved in sensory perception of sound regulation of cell shape ovarian follicle development ectopic germ cell programmed cell death pigmentation fc receptor signaling pathway response to radiation mast cell cytokine production positive regulation of receptor signaling pathway via jak stat dendritic cell cytokine production visual learning actin cytoskeleton reorganization megakaryocyte development intracellular signal transduction somatic stem cell population maintenance erythropoietin mediated signaling pathway kit signaling pathway positive regulation of cell migration somatic stem cell division mast cell chemotaxis mapk cascade positive regulation of phosphatidylinositol 3 kinase activity positive regulation of pseudopodium assembly positive regulation of gene expression positive regulation of long term neuronal synaptic plasticity regulation of cell population proliferation cellular response to thyroid hormone stimulus positive regulation of cell population proliferation embryonic hemopoiesis regulation of developmental pigmentation positive regulation of phosphatidylinositol 3 kinase signaling peptidyl tyrosine phosphorylation mast cell differentiation digestive tract development immature b cell differentiation germ cell migration signal transduction mast cell proliferation positive regulation of vascular associated smooth muscle cell differentiation phosphatidylinositol phosphate biosynthetic process regulation of transcription by rna polymerase ii positive regulation of tyrosine phosphorylation of stat protein tongue development response to cadmium ion positive regulation of pyloric antrum smooth muscle contraction regulation of bile acid metabolic process positive regulation of small intestine smooth muscle contraction positive regulation of colon smooth muscle contraction positive regulation of protein kinase b signaling hemopoiesis negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of erk1 and erk2 cascade hematopoietic progenitor cell differentiation b cell differentiation sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 3815 16590 ensembl ensg00000157404 ensmusg00000005672 uniprot p10721 p05532 refseq mrna nm_000222 nm_001093772 nm_001122733 nm_021099 refseq protein np_000213 np_001087241 np_001116205 np_066922 location ucsc chr 4 54 66 54 74 mb chr 5 75 74 75 82 mb pubmed search 3 4 wikidata view edit human view edit mouse proto oncogene c kit is the gene encoding the receptor tyrosine kinase protein known as tyrosine protein kinase kit cd117 cluster of differentiation 117 or mast stem cell growth factor receptor scfr 5 multiple transcript variants encoding different isoforms have been found for this gene 6 7 kit was first described by the german biochemist axel ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v kit 8 function edit kit is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types altered forms of this receptor may be associated with some types of cancer 9 kit is a receptor tyrosine kinase type iii which binds to stem cell factor also known as steel factor or c kit ligand when this receptor binds to stem cell factor scf it forms a dimer that activates its intrinsic tyrosine kinase activity that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell 10 after activation the receptor is ubiquitinated to mark it for transport to a lysosome and eventual destruction signaling through kit plays a role in cell survival proliferation and differentiation for instance kit signaling is required for melanocyte survival and it is also involved in haematopoiesis and gametogenesis 11 structure edit like other members of the receptor tyrosine kinase iii family kit consists of an extracellular domain a transmembrane domain a juxtamembrane domain and an intracellular tyrosine kinase domain the extracellular domain is composed of five immunoglobulin like domains and the protein kinase domain is interrupted by a hydrophilic insert sequence of about 80 amino acids the ligand stem cell factor binds via the second and third immunoglobulin domains 12 10 13 cell surface marker edit cluster of differentiation cd molecules are markers on the cell surface as recognized by specific sets of antibodies used to identify the cell type stage of differentiation and activity of a cell kit is an important cell surface marker used to identify certain types of hematopoietic blood progenitors in the bone marrow to be specific hematopoietic stem cells hsc multipotent progenitors mpp and common myeloid progenitors cmp express high levels of kit common lymphoid progenitors clp express low surface levels of kit kit also identifies the earliest thymocyte progenitors in the thymus early t lineage progenitors etp dn1 and dn2 thymocytes express high levels of c kit it is also a marker for mouse prostate stem cells 14 in addition mast cells melanocytes in the skin and interstitial cells of cajal in the digestive tract express kit in humans expression of c kit in helper like innate lymphoid cells ilcs which lack the expression of crth2 cd294 is used to mark the ilc3 population 15 cd117 c kit is expressed not only by bone marrow derived stem cells but also by those found in other adult organs such as the prostate liver and heart suggesting that scf c kit signaling pathways may contribute to stemness in some organs additionally c kit has been associated with numerous biological processes in other cell types for example c kit signaling has been shown to regulate oogenesis folliculogenesis and spermatogenesis playing important roles in female and male fertility 16 mobilization edit main article hematopoietic stem cell mobilization hematopoietic progenitor cells are normally present in the blood at low levels mobilization is the process by which progenitors are made to migrate from the bone marrow into the bloodstream thus increasing their numbers in the blood mobilization is used clinically as a source of hematopoietic stem cells for hematopoietic stem cell transplantation hsct signaling through kit has been implicated in mobilization at the current time g csf is the main drug used for mobilization it indirectly activates kit plerixafor an antagonist of cxcr4 sdf1 in combination with g csf is also being used for mobilization of hematopoietic progenitor cells direct kit agonists are currently being developed as mobilization agents role in cancer edit activating mutations in this gene are associated with gastrointestinal stromal tumors testicular seminoma mast cell disease melanoma acute myeloid leukemia while inactivating mutations are associated with the genetic defect piebaldism 6 c kit plays an important role in regulating many mechanisms leading to tumor formation and progression of carcinomas c kit has been proposed as a regulator of stemness in several cancers its expression has been linked to cancer stemness in ovarian cancer cells colon cancer cells non small cell lung cancer cells and prostate cancer cells c kit has also been linked to the epithelial mesenchymal transition emt which is important for tumor aggressiveness and metastatic potential ectopic expression of c kit and emt have been linked in denoid cystic carcinoma of the salivary gland thymic carcinomas ovarian cancer cells and prostate cancer cells several lines of evidence suggest that scf c kit signaling plays an important role in the tumor microenvironment for example in mice high levels of c kit in mast cells as well as its presence in the tumor microenvironment promote angiogenesis leading to increased tumor growth and metastasis 16 anti kit therapies edit kit is a proto oncogene meaning that overexpression or mutations of this protein can lead to cancer 17 seminomas a subtype of testicular germ cell tumors frequently have activating mutations in exon 17 of kit in addition the gene encoding kit is frequently overexpressed and amplified in this tumor type most commonly occurring as a single gene amplicon 18 mutations of kit have also been implicated in leukemia a cancer of hematopoietic progenitors melanoma mast cell disease and gastrointestinal stromal tumors gists the efficacy of imatinib trade name gleevec a kit inhibitor is determined by the mutation status of kit when the mutation has occurred in exon 11 as is the case many times in gists the tumors are responsive to imatinib however if the mutation occurs in exon 17 as is often the case in seminomas and leukemias the receptor is not inhibited by imatinib in those cases other inhibitors such as dasatinib avapritinib or nilotinib can be used researchers investigated the dynamic behavior of wild type and mutant d816h kit receptor and emphasized the extended a loop eal region 805 850 by conducting computational analysis 19 their atomic investigation of mutant kit receptor which emphasized on the eal region provided a better insight into the understanding of the sunitinib resistance mechanism of the kit receptor and could help to discover new therapeutics for kit based resistant tumor cells in gist therapy 19 the preclinical agent ktn0182a is an anti kit pyrrolobenzodiazepine pbd containing antibody drug conjugate which shows anti tumor activity in vitro and in vivo against a range of tumor types 20 diagnostic relevance edit antibodies to kit are widely used in immunohistochemistry to help distinguish particular types of tumour in histological tissue sections it is used primarily in the diagnosis of gists which are positive for kit but negative for markers such as desmin and s 100 which are positive in smooth muscle and neural tumors which have a similar appearance in gists kit staining is typically cytoplasmic with stronger accentuation along the cell membranes kit antibodies can also be used in the diagnosis of mast cell tumours and in distinguishing seminomas from embryonal carcinomas 21 interactions edit kit has been shown to interact with aps 22 bcr 23 cd63 24 cd81 24 cd9 24 crk 25 crkl 26 27 dok1 28 fes 29 grb10 30 grb2 31 32 33 kitlg 34 35 lnk 36 lyn 28 37 matk 38 39 mpdz 40 pik3r1 26 31 41 ptpn11 42 43 ptpn6 43 44 stat1 45 socs1 31 socs6 46 src 47 and tec 48 see also edit cytokine receptor list of genes mutated in pigmented cutaneous lesions references edit 1 2 3 grch38 ensembl release 89 ensg00000157404 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000005672 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine andre c hampe a lachaume p martin e wang xp manus v et al january 1997 sequence analysis of two genomic regions containing the kit and the fms receptor tyrosine kinase genes genomics 39 2 216 226 doi 10 1006 geno 1996 4482 pmid 9027509 1 2 entrez gene kit v kit hardy zuckerman 4 feline sarcoma viral oncogene homolog national cancer institute dictionary of cancer terms c kit accessed october 13 2014 yarden y kuang wj yang feng t coussens l munemitsu s dull tj et al november 1987 human proto oncogene c kit a new cell surface receptor tyrosine kinase for an unidentified ligand the embo journal 6 11 3341 3351 doi 10 1002 j 1460 2075 1987 tb02655 x pmc 553789 pmid 2448137 edling ce hallberg b 2007 c kit a hematopoietic cell essential receptor tyrosine kinase the international journal of biochemistry cell biology 39 11 1995 1998 doi 10 1016 j biocel 2006 12 005 pmid 17350321 1 2 blume jensen p claesson welsh l siegbahn a zsebo km westermark b heldin ch december 1991 activation of the human c kit product by ligand induced dimerization mediates circular actin reorganization and chemotaxis the embo journal 10 13 4121 4128 doi 10 1002 j 1460 2075 1991 tb04989 x pmc 453162 pmid 1721869 brooks s 2006 studies of genetic variability at the kit locus and white spotting patterns in the horse thesis university of kentucky doctoral dissertations pp 13 16 roskoski r december 2005 structure and regulation of kit protein tyrosine kinase the stem cell factor receptor biochemical and biophysical research communications 338 3 1307 1315 bibcode 2005bbrc 338 1307r doi 10 1016 j bbrc 2005 09 150 pmid 16226710 haase b brooks sa schlumbaum a azor pj bailey e alaeddine f et al november 2007 allelic heterogeneity at the equine kit locus in dominant white w horses plos genetics 3 11 e195 doi 10 1371 journal pgen 0030195 pmc 2065884 pmid 17997609 leong kg wang be johnson l gao wq december 2008 generation of a prostate from a single adult stem cell nature 456 7223 804 808 bibcode 2008natur 456 804l doi 10 1038 nature07427 pmid 18946470 s2cid 4410656 vallentin b barlogis v piperoglou c cypowyj s zucchini n chéné m et al october 2015 innate lymphoid cells in cancer cancer immunology research 3 10 1109 1114 doi 10 1158 2326 6066 cir 15 0222 pmid 26438443 1 2 sheikh e tran t vranic s levy a bonfil rd april 2022 role and significance of c kit receptor tyrosine kinase in cancer a re...