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5 exons which encode the leader peptide and the ig like domains have a larger proportion of nonsynonymous substitutions than do the 3 exons which encode the stem transmembrane region and the cytoplasmic tail 6 this indicates that stronger selection is occurring on the 5 exons which encodes the extracellular part of the kir that binds to the mhc 6 there is therefore evidence of strong selection on the kir ligand binding sites which is consistent with the high specificity of the kir ligand binding site as well as the rapid evolution of class i mhc molecules and viruses 6 23 genotype and haplotype diversity edit human genomes differ in their amount of kir genes in their proportion of inhibitory versus activating genes and in their allelic variations of each gene 10 8 as a result of these polygenic and polymorphic variations less than 2 of unrelated individuals have the same kir genotype and ethnic populations have broadly different kir genotype frequencies this incredible diversity likely reflects the pressure from rapidly evolving viruses 23 30 distinct haplotypes have been classified all of which can be broadly characterized by group a and group b haplotypes 23 the group a haplotype has a fixed set of genes which are kir3dl3 2l3 2dp1 2dl1 3dp1 2dl4 3dl1 2ds4 and 3dl2 20 23 group b haplotypes encompass all other haplotypes and therefore have a variable set of genes including several genes absent from group a including kir2ds1 2ds2 2ds3 2ds5 2dl2 2dl5 and 3ds1 20 23 because group b has both gene and allelic diversity compared to just allelic diversity in group a group b is even more diverse than group a 20 four kir genes 2dl4 3dl2 3dl3 and 3dp1 are present in nearly all kir haplotypes and as a result are known as framework genes inheritance of maternal and paternal haplotypes results in further diversity of individual kir genotype 23 group a only has one activating kir receptor whereas group b contains many activating kir receptors and as a result group b haplotype carriers have a stronger response to virally infected and transformed cells 23 as a result of the huge migrations peoples indigenous to india australia and the americas made from africa activating kir receptors became advantageous to these populations and as a result these populations acquired activating kir receptors 23 a study of the genotypes of 989 individuals representing eight distinct populations found 111 distinct kir genotypes individuals with the most frequent genotype which comprised 27 of the individuals studied are homozygous for the group a haplotype 10 the remaining 110 kir genotypes found in this study are either group a and group b heterozygotes or group b homozygotes who are indistinguishable from heterozygotes by genotype alone 41 46 of the genotypes identified were found in only one individual and 90 of individuals had the same 40 genotypes 5 clearly there is extensive diversity in human kir genotypes which allows for rapid evolution in response to rapidly evolving viruses role in disease edit genotypes that are inhibitory kir receptor dominant are likely susceptible to infection and reproductive disorders but protective against autoimmune diseases whereas activating kir receptor dominant genotypes are likely susceptible to autoimmunity but protective against viral infection and cancer 20 23 the relationship between inhibitory vs stimulatory kir genotype dominance however is more complicated than this because diseases are so diverse and have so many different causes and immune activation or de activation may not be protective or harmful at every stage of disease 20 kir2ds2 or 2ds1 which are activating receptors are strongly correlated with most autoimmune diseases which is logical because activating receptors induce signaling pathways that lead to cytolysis of target cells 20 23 another activating receptor kir3ds1 is protective to hepatitis c virus infection is associated with slowing down of aids progression and is associated with cervical cancer which is associated with a distinct strain of hpv 20 23 it is likely that kir3ds1 is associated with cervical cancer despite its stimulatory nature because cervical tumors generally associate with localized inflammation 20 as a drug target edit 1 7f9 is a human monoclonal antibody that binds to kir2dl1 2l3 28 very similar lirilumab is intended for the treatment of cancers e g leukemia 29 30 use of kirs in car t cell therapy edit the killer cell immunoglobulin like receptors kir are being explored 31 32 33 as an alternative activation method in car t cell therapy unlike the traditional approach that utilizes t cell receptors incorporating kirs into car t cells aims to exploit the cytotoxic properties and regulatory functions of natural killer nk cells essentially this method is aimed to mimic natural killer cell function to help their natural ability to kill cells with missing mhc class i expression this method is under investigation for its potential to enhance the targeting and destruction of cancer cells with the goal of addressing limitations seen in current car t cell therapies such as off target effects and resistance research is ongoing 34 35 to determine the effectiveness and safety of using kir based activation in car t cell treatments 36 role in cancer immunotherapy edit this section does not cite any sources please help improve this section by adding citations to reliable sources unsourced material may be challenged and removed august 2025 learn how and when to remove this message kir targeted therapies are a continuously evolving field in cancer immunotherapy and in cancers where the natural killer cells play a major role in the immune system such as in leukemia and lymphoma natural killer cells can be released to kill tumor cells and block the inhibitory kirs that would invade the immune response one of the most focused agents is the lirilumab iph2102 which is a monoclonal antibody that binds to kir2dl1 kir2dl2 and kir2dl3 which prevents their interaction with hla c ligands on tumor cells studies has shown that kir blockage can actually enhance the natural killer cell mediated cytotoxicity and cytokine production the lirilumab has been tested alongside other checkpoint inhibitors like nivolumab which is anti pd 1 in patients with solid tumors and the results have come out mixed but are suggesting that dual checkpoint blockade could improve efficiency over monotherapies there is also another approach in engineering the natural killer cells directly and using gene editing technology like crispr cas9 to knock out inhibitory kirs or help improve the activation of kir expression engineered natural killer cells from donors or made from induced pluripotent stem cells ipscs are still being developed but could help make a shift towards collecting innate immunity in cancer treatment along with the other methods as either monotherapy or in already existing immunotherapies research that is being done with kir targeted therapies and its effect on cancer patients the killer immunoglobulin receptor targeted therapies are still in its early stages of being worked on and scientists are still conducting studies with it for existing cancer patients and patients suffering with advanced solid tumors in their system see also edit nk 92 a natural killer cell line that does not express kir references edit 1 2 yawata m yawata n abi rached l parham p 2002 variation within the human killer cell immunoglobulin like receptor kir gene family critical reviews in immunology 22 5 6 463 82 pmid 12803322 1 2 bashirova aa martin mp mcvicar dw carrington m 2006 the killer immunoglobulin like receptor gene cluster tuning the genome for defense annual review of genomics and human genetics 7 277 300 doi 10 1146 annurev genom 7 080505 115726 pmid 16824023 1 2 3 4 5 wende h colonna m ziegler a volz a 1999 organization of the leukocyte receptor cluster lrc on human chromosome 19q13 4 mammalian genome 10 2 154 160 doi 10 1007 s003359900961 pmid 9922396 s2cid 25092393 roe david vierra green cynthia pyo chul woo geraghty daniel e spellman stephen r maiers martin kuang rui 2020 11 18 a detailed view of kir haplotype structures and gene families as provided by a new motif based multiple sequence alignment frontiers in immunology 11 585731 doi 10 3389 fimmu 2020 585731 pmc 7708349 pmid 33312175 1 2 3 4 raulet dh vance re mcmahon cw 2001 regulation of the natural killer cell receptor repertoire annual review of immunology 19 291 330 doi 10 1146 annurev immunol 19 1 291 pmid 11244039 1 2 3 4 5 6 7 8 vilches c parham p 2002 kir diverse rapidly evolving receptors of innate and adaptive immunity annual review of immunology 20 217 51 doi 10 1146 annurev immunol 20 092501 134942 pmid 11861603 1 2 3 4 5 6 rajalingam r 2012 overview of the killer cell immunoglobulin like receptor system immunogenetics methods in molecular biology vol 882 pp 3914 414 doi 10 1007 978 1 61779 842 9_23 isbn 978 1 61779 841 2 pmid 22665247 1 2 uhrberg m january 2005 the kir gene family life in the fast lane of evolution european journal of immunology 35 1 10 5 doi 10 1002 eji 200425743 pmid 15580655 s2cid 41486412 cite error invalid parameter name in ref tag did you mean name ljunggren hg karre k 1985 host resistance directed selectively against h 2 deficient lymphoma variants analysis of the mechanism journal of experimental medicine 162 6 1745 1759 doi 10 1084 jem 162 6 1745 pmc 2187973 pmid 3877776 1 2 3 ljunggren hg karre k 1990 in search of the missing self mhc molecules and nk cell recognition immunology today 11 7 237 244 doi 10 1016 0167 5699 90 90097 s pmid 2201309 1 2 moretta a bottino c vitale m pende d biassoni r mingari mc moretta l 1996 receptors for hla class i molecules in human natural killer cells annual review of immunology 14 619 648 doi 10 1146 annurev immunol 14 1 619 pmid 8717527 1 2 3 4 5 6 7 8 9 10 biassoni r malnati ms 2018 human natural killer receptors co receptors and their ligands current protocols in immunology 121 1 e47 doi 10 1002 cpim 47 pmid 30040219 s2cid 205710349 1 2 biassoni r cantoni c pende d sivori s parolini s vitale m bottino c moretta a 2001 human natural killer cell receptors and co receptors immunological reviews 181 203 214 doi 10 1034 j 1600 065x 2001 1810117 x pmid 11513142 s2cid 24523974 lanier ll 2005 nk cell recognition annual review of immunology 23 225 274 doi 10 1146 annurev immunol 23 021704 115526 pmid 15771571 long eo kim hs liu d peterson me rajagopalan s 2013 controlling natural killer cell responses integration of signals for activation and inhibition annual review of immunology 31 227 258 doi 10 1146 annurev immunol 020711 075005 pmc 3868343 pmid 23516982 parham p 2005 mhc class i molecules and kirs in human history health and survival nature reviews immunology 5 3 201 214 doi 10 1038 nri1570 pmid 15719024 s2cid 31182134 1 2 raulet dh vance re 2006 self tolerance of natural killer cells nature reviews immunology 6 7 520 531 doi 10 1038 nri1863 pmid 16799471 s2cid 8652332 wagtmann n biassoni r cantoni c verdiani s malnati m vitale m bottino c moretta l moretta a long eo 1995 molecular clones of the p58 natural killer cell receptor reveal immunoglobulin related molecules with diversity in both the extra and intracellular domains immunity 2 5 439 449 doi 10 1016 1074 7613 95 90025 x pmid 7749980 colonna m samaridis j 1995 cloning of immunoglobulin superfamily members associated with hla c and hla b recognition by human natural killer cells science 268 5209 405 408 bibcode 1995sci 268 405c doi 10 1126 science 7716543 pmid 7716543 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 andre p biassoni r colonna m cosman d lanier ll long eo lopez botet m moretta a moretta l parham p trowsdale j vivier e wagtmann n wilson mj 2001 new nomenclature for mhc receptors nature immunology 2 8 661 doi 10 1038 90589 pmid 11477395 s2cid 32201997 yokoyama wm kim s french ar 2004 the dynamic life of natural killer cells annual review of immunology 22 405 429 doi 10 1146 annurev immunol 22 012703 104711 pmid 15032583 boyington jc sun pd may 2002 a structural perspective on mhc class i recognition by killer cell immunoglobulin like receptors molecular immunology 38 14 1007 21 doi 10 1016 s0161 5890 02 00030 5 pmid 11955593 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 parham p feb 2005 immunogenetics of killer cells immunoglobulin like receptors molecular immunology 42 4 459 462 doi 10 1016 j molimm 2004 07 027 pmid 15607799 1 2 radaev s sun pd 2003 structure and function of natural killer cell surface receptors annual review of biophysics and biomolecular structure 32 93 114 doi 10 1146 annurev biophys 32 110601 142347 pmid 12471063 hao li nei masatoshi 2005 03 14 rapid expansion of killer cell immunoglobulin like receptor genes in primates and their coevolution with mhc class i genes gene 347 2 149 159 doi 10 1016 j gene 2004 12 012 issn 0378 1119 pmid 15733532 mariuzza roy a singh pragya karade sharanbasappa s shahid salman sharma vijay kumar january 2025 recognition of self and viral ligands by nk cell receptors immunological reviews 329 1 e13435 doi 10 1111 imr 13435 issn 1600 065x pmc 11695704 pmid 39748148 sambrook jennifer g sehra harminder coggill penny humphray sean palmer sophie sims sarah takamatsu haru hisa wileman thomas archibald alan l beck stephan june 2006 identification of a single killer immunoglobulin like receptor kir gene in the porcine leukocyte receptor complex on chromosome 6q immunogenetics 58 5 6 481 486 doi 10 1007 s00251 006 0110 9 issn 0093 7711 pmid 16738944 romagné f andré p spee p zahn s anfossi n gauthier l et al september 2009 preclinical characterization of 1 7f9 a novel human anti kir receptor therapeutic antibody that augments natural killer mediated killing of tumor cells blood 114 13 2667 77 doi 10 1182 blood 2009 02 206532 pmc 2756126 pmid 19553639 world health organization 2012 international nonproprietary names for pharmaceutical substances inn proposed inn list 107 pdf who drug information 26 2 statement on a nonproprietary name adopted by the usan council lirilumab american medical association definition of autologous anti mesothelin kir car transduced t cells synkir 110 www cancer gov february 2 2011 retrieved 2024 06 05 wang enxiu wang liang chuan tsai ching yi bhoj vijay gershenson zack moon edmund newick kheng sun jing lo albert baradet timothy feldman michael d barrett david puré ellen albelda steven milone michael c july 2015 generation of potent t cell immunotherapy for cancer using dap12 based multichain chimeric immunoreceptors cancer immunology research 3 7 815 826 doi 10 1158 2326 6066 cir 15 0054 issn 2326 6066 pmc 4490943 pmid 25941351 xu jun nunez cruz selene leferovich john m gulendran gayathri zhang chune yucel nora d blair megan c stanley william s johnson laura a siegel don l milone michael c 2024 03 22 abstract 6332 evaluating the relationship of affinity f...