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amino, sequences, howe, granger, hull, gabel, helenius, 7581, 3174652, 282235, 7577h, derived, insertion, conserved, siebert, 3747, 3131762, 280294, 3743v, apparent, approximately, equal, 000, mane, marzella, bainton, holt, cha, hildreth, 378, 2912382, 0003, 9861, 90597, mattei, matterson, williams, 7551, 2332441, 39148, 7548, localized, xq24, respectively, 20495, 2243102, 30530, 20488, polylactosaminoglycans, peptide, backbones, schleutker, haataja, renlund, puhakka, peltonen, 1991, confirmation, chromosomal, exclusion, candidate, salla, disease, 31520394, 1959930, bf00204936, genetics, chang, karageorgos, meikle, cd107b, 12144129, regulators, homeostatic, agents, lee, wang, 20487, 2243101, 30529, 20476, granulocytic, increase, attached, künzli, berberat, zhu, martignoni, kleeff, tempia, caliera, influences, prognosis, 12702437, 11815981, cncr, 10162, jensen, aaberg, jessen, christensen, kristensen, 2013, 1305, 23826410, 3693194, 1294, pathology, astrocytomas, sarafian, jadot, foidart, letesson, van, den, brûle, castronovo, 9426697, sici, 1097, 0215, 19980105, aid, ijc16, galectin, agarwal, srinivasan, godbole, budnar, gude, 2015, 1574, 9133450, 25614122, 11823972, s00432, 015, 1917, 1563, oncology, carbohydrates, lung, acevedo, schermerhorn, gray, bablin, gama, mccormick, complex, antigen, mlamp, distribution, analyses, 518, 9367636, excr, 3752, 510, laferte, dennis, 2719668, 1138546, 1042, bj2590569, 569, 259, biochemical, expressing, beta, branched, tumour, kima, burleigh, andrews, 486, 19192092, 11207602, 1046, 1462, 5822, 00071, 477, microbiology, targeted, enhances, exocytosis, invasion, trypanosoma, cruzi, andrejewski, punnonen, guhde, tanaka, lüllmann, rauch, hartmann, 12701, 10212251, 1074, jbc, morphology, mice, roth, piller, 18919, 3143719, 37369, 18911, isolation, sialoglycoproteins, carrying, wikigenes, protein1, atlas, eskelinen, roles, biogenesis, autophagy, 502, 16973206, mam, 005, 495, aspects, grcm38, grch38, cluster, astrocytoma, fibrosarcoma, following, number, correlates, indeed, some, between, lamps, serving, molecules, galectins, matrix, migration, although, reside, certain, cases, they, occur, serve, ligand, accordingly, migratory, invasive, often, correlate, platelets, cytotoxic, fusion, comprise, responsible, part, maintaining, integrity, deficiencies, will, lead, increased, therefore, share, similar, however, makes, determining, precise, difficult, because, while, little, than, wild, double, leads, lethality, vivo, catabolism, groups, involved, significant, quantities, traverse, trans, cisternae, sialic, polylactosamine, attachments, protect, glyocoprotein, degradation, proteases, addition, sugar, glycosylation, core, polypeptide, residing, these, consist, large, carbon, luminal, terminal, exposed, extracytoplasmic, contains, form, those, characteristics, include, immunoglobulin, disulphide, bridges, glycosylated, medium, levels, least, tissue, resides, provide, marker, play, cd8, lymphocytes, carbohydrate, transmembrane, immunofluorescence, staining, antibody, reveal, red, containing, nuclear, dna, blue, antibodies, image, courtesy, encor, intermediate, filaments, vimentin, hela, known, luster, ifferentiation, 107a, that, located, long, arm, ucsc, np_034814, np_001304282, np_005552, nm_001317353, nm_010684, nm_005561, mrna, p11438, p11279, uniprot, 16783, 3916, species, oma, ncbi, databases, orthologs, sources, quickgo, amigo, neutrophil, autophagic, death, granzyme, apoptotic, signaling, pathway, cytotoxicity, establishment, into, host, along, microtubule, stabilization, ficolin, rich, autolysosome, azurophil, cytosol, exosome, sarcolemma, perinuclear, phagocytic, dendrite, vacuole, soma, alveolar, lamellar, melanosome, cytolytic, phagolysosome, multivesicular, enzyme, virus, receptor, activity, specific, ontology, biogps, carotid, molar, mesenteric, lymph, nodes, sciatic, spermatocyte, lactiferous, right, calvaria, vestibular, cochlear, duct, stroma, bone, marrow, ductal, 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d spermatocyte sciatic nerve mesenteric lymph nodes molar carotid body more reference expression data biogps more reference expression data gene ontology molecular function protein domain specific binding virus receptor activity protein binding enzyme binding cellular component integral component of membrane multivesicular body phagolysosome membrane vesicle endosome late endosome membrane synaptic vesicle cytolytic granule melanosome integral component of plasma membrane alveolar lamellar body cell surface lysosomal membrane soma vacuole dendrite phagocytic vesicle perinuclear region of cytoplasm sarcolemma lysosome endosome membrane extracellular exosome cytoplasmic vesicle external side of plasma membrane cytosol cytoplasm plasma membrane azurophil granule membrane autolysosome ficolin 1 rich granule membrane integral component of synaptic vesicle membrane late endosome membrane biological process protein stabilization golgi to lysosome transport positive regulation of natural killer cell degranulation regulation of organelle transport along microtubule viral entry into host cell viral process establishment of protein localization to organelle positive regulation of natural killer cell mediated cytotoxicity granzyme mediated apoptotic signaling pathway autophagic cell death neutrophil degranulation sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 3916 16783 ensembl ensg00000185896 ensmusg00000031447 uniprot p11279 p11438 refseq mrna nm_005561 nm_010684 nm_001317353 refseq protein np_005552 np_001304282 np_034814 location ucsc chr 13 113 3 113 32 mb chr 8 13 21 13 23 mb pubmed search 3 4 wikidata view edit human view edit mouse lysosomal associated membrane protein 1 lamp 1 also known as lysosome associated membrane glycoprotein 1 and cd107a c luster of d ifferentiation 107a is a protein that in humans is encoded by the lamp1 gene the human lamp1 gene is located on the long arm q of chromosome 13 at region 3 band 4 13q34 immunofluorescence staining of hela cells with antibody to reveal lysosomal lamp1 in red and vimentin containing intermediate filaments in green nuclear dna is seen in blue antibodies and image courtesy encor biotechnology inc lysosomal associated membrane protein 1 is a glycoprotein from a family of lysosome associated membrane glycoproteins 5 the lamp 1 glycoprotein is a type i transmembrane protein 6 which is expressed at high or medium levels in at least 76 different normal tissue cell types 7 it resides primarily across lysosomal membranes 8 and functions to provide selectins with carbohydrate ligands 5 cd107a has also been shown to be a marker of degranulation on lymphocytes such as cd8 and nk cells 9 and may also play a role in tumor cell differentiation and metastasis structure edit residing primarily across lysosomal membranes these glycoproteins consist of a large highly glycosylated end with n linked carbon chains on the luminal side of the membrane and a short c terminal tail 6 exposed to the cytoplasm 8 the extracytoplasmic region contains a hinge like structure which can form disulphide bridges homologous to those observed in human immunoglobulin a 8 other characteristics of the structure of the lamp 1 glycoproteins include a polypeptide core of 40 kda 8 18 n glycosylation sites to help with the addition of sugar chains 10 polylactosamine attachments which protect the glyocoprotein from degradation by lysosomal proteases 10 significant quantities of polylactosaminoglycan and sialic acid to traverse the trans golgi cisternae 10 poly n acetyllactosamine groups which are involved in interactions with selectin and other glycan binding proteins 11 function edit lamp1 and lamp2 glycoproteins comprise 50 of all lysosomal membrane proteins 6 and are thought to be responsible in part for maintaining lysosomal integrity ph and catabolism 6 11 the expression of lamp1 and lamp2 glycoproteins are linked as deficiencies in lamp1 gene will lead to increased expression of lamp2 glycoproteins 11 the two are therefore thought to share similar functions in vivo 6 however this makes the determining the precise function of lamp1 difficult because while the lamp1 deficient phenotype is little different than the wild type due to lamp2 up regulation 6 11 the lamp1 lamp2 double deficient phenotype leads to embryonic lethality 11 although the lamp1 glycoproteins primarily reside across lysosomal membranes in certain cases they can be expressed across the plasma membrane of the cell 11 expression of lamp1 at the cell surface can occur due to lysosomal fusion with the cell membrane 12 cell surface expression of lamp1 can serve as a ligand for selectins 13 14 and help mediate cell cell adhesion 15 accordingly cell surface expression of lamp1 is seen in cells with migratory or invasive functions such as cytotoxic t cells platelets and macrophages 16 cell surface expression of lamp1 and lamp2 is also often seen in cancer cells 16 17 particularly cancers with high metastatic potential such as colon carcinoma and melanoma 16 and has been shown to correlate with their metastatic potential 11 role in cancer edit lamp1 expression on the surface of tumor cells has been observed for a number of different cancer types particularly in highly metastatic cancers such as pancreatic cancer 18 19 colon cancer 16 17 and melanoma 16 17 the structure of lamp1 correlates with differentiation 8 20 and metastatic potential 11 of tumor cells as it is thought to help mediate cell cell adhesion 17 and migration 15 18 indeed the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between lamp1 and lamp2 and e selectin and galectins with the lamps serving as ligands for the cell adhesion molecules 17 cell membrane expression of lamp 1 observed in the following cancer types human fibrosarcoma 17 colon adenocarcinoma 17 melanoma 17 pancreatic adenocarcinoma 19 and astrocytoma 18 see also edit cluster of differentiation references edit 1 2 3 grch38 ensembl release 89 ensg00000185896 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000031447 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine 1 2 lamp1 lysosomal associated membrane protein 1 entrez gene 1 2 3 4 5 6 eskelinen el 2006 roles of lamp 1 and lamp 2 in lysosome biogenesis and autophagy molecular aspects of medicine 27 5 6 495 502 doi 10 1016 j mam 2006 08 005 pmid 16973206 lamp1 the human protein atlas 1 2 3 4 5 carlsson sr fukuda m december 1989 structure of human lysosomal membrane glycoprotein 1 assignment of disulfide bonds and visualization of its domain arrangement the journal of biological chemistry 264 34 20526 20531 doi 10 1016 s0021 9258 19 47094 4 pmid 2584229 lamp1 lysosomal associated membrane protein1 wikigenes 1 2 3 carlsson sr roth j piller f fukuda m december 1988 isolation and characterization of human lysosomal membrane glycoproteins h lamp 1 and h lamp 2 major sialoglycoproteins carrying polylactosaminoglycan the journal of biological chemistry 263 35 18911 18919 doi 10 1016 s0021 9258 18 37369 1 pmid 3143719 1 2 3 4 5 6 7 8 andrejewski n punnonen el guhde g tanaka y lüllmann rauch r hartmann d et al april 1999 normal lysosomal morphology and function in lamp 1 deficient mice the journal of biological chemistry 274 18 12692 12701 doi 10 1074 jbc 274 18 12692 pmid 10212251 kima pe burleigh b andrews nw december 2000 surface targeted lysosomal membrane glycoprotein 1 lamp 1 enhances lysosome exocytosis and cell invasion by trypanosoma cruzi cellular microbiology 2 6 477 486 doi 10 1046 j 1462 5822 2000 00071 x pmid 11207602 s2cid 19192092 laferte s dennis jw april 1989 purification of two glycoproteins expressing beta 1 6 branched asn linked oligosaccharides from metastatic tumour cells the biochemical journal 259 2 569 576 doi 10 1042 bj2590569 pmc 1138546 pmid 2719668 sawada r jardine ka fukuda m april 1993 the genes of major lysosomal membrane glycoproteins lamp 1 and lamp 2 5 flanking sequence of lamp 2 gene and comparison of exon organization in two genes the journal of biological chemistry 268 12 9014 9022 doi 10 1016 s0021 9258 18 52972 0 pmid 8517882 1 2 acevedo schermerhorn c gray bablin j gama r mccormick pj november 1997 t complex associated embryonic surface antigen homologous to mlamp 1 ii expression and distribution analyses experimental cell research 236 2 510 518 doi 10 1006 excr 1997 3752 pmid 9367636 1 2 3 4 5 agarwal ak srinivasan n godbole r more sk budnar s gude rp et al september 2015 role of tumor cell surface lysosome associated membrane protein 1 lamp1 and its associated carbohydrates in lung metastasis journal of cancer research and clinical oncology 141 9 1563 1574 doi 10 1007 s00432 015 1917 2 pmc 11823972 pmid 25614122 s2cid 9133450 1 2 3 4 5 6 7 8 sarafian v jadot m foidart jm letesson jj van den brûle f castronovo v et al january 1998 expression of lamp 1 and lamp 2 and their interactions with galectin 3 in human tumor cells international journal of cancer 75 1 105 111 doi 10 1002 sici 1097 0215 19980105 75 1 105 aid ijc16 3 0 co 2 f pmid 9426697 1 2 3 jensen ss aaberg jessen c christensen kg kristensen b 2013 expression of the lysosomal associated membrane protein 1 lamp 1 in astrocytomas international journal of clinical and experimental pathology 6 7 1294 1305 pmc 3693194 pmid 23826410 1 2 künzli bm berberat po zhu zw martignoni m kleeff j tempia caliera aa et al january 2002 influences of the lysosomal associated membrane proteins lamp 1 lamp 2 and mac 2 binding protein mac 2 bp on the prognosis of pancreatic carcinoma cancer 94 1 228 239 doi 10 1002 cncr 10162 pmid 11815981 s2cid 12702437 lee n wang wc fukuda m november 1990 granulocytic differentiation of hl 60 cells is associated with increase of poly n acetyllactosamine in asn linked oligosaccharides attached to human lysosomal membrane glycoproteins the journal of biological chemistry 265 33 20476 20487 doi 10 1016 s0021 9258 17 30529 x pmid 2243101 further reading edit chang mh karageorgos le meikle pj 2003 cd107a lamp 1 and cd107b lamp 2 journal of biological regulators and homeostatic agents 16 2 147 151 pmid 12144129 schleutker j haataja l renlund m puhakka l viitala j peltonen l et al november 1991 confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for salla disease human genetics 88 1 95 97 doi 10 1007 bf00204936 pmid 1959930 s2cid 31520394 carlsson sr fukuda m november 1990 the polylactosaminoglycans of human lysosomal membrane glycoproteins lamp 1 and lamp 2 localization on the peptide backbones the journal of biological chemistry 265 33 20488 20495 doi 10 1016 s0021 9258 17 30530 6 pmid 2243102 mattei mg matterson j chen jw williams ma fukuda m may 1990 two human lysosomal membrane glycoproteins h lamp 1 and h lamp 2 are encoded by genes localized to chromosome 13q34 and chromosome xq24 25 respectively the journal of biological chemistry 265 13 7548 7551 doi 10 1016 s0021 9258 19 39148 3 pmid 2332441 carlsson sr fukuda m december 1989 structure of human lysosomal membrane glycoprotein 1 assignment of disulfide bonds and visualization of its domain arrangement the journal of biological chemistry 264 34 20526 20531 doi 10 1016 s0021 9258 19 47094 4 pmid 2584229 mane sm marzella l bainton df holt vk cha y hildreth je et al january 1989 purification and characterization of human lysosomal membrane glycoproteins archives of biochemistry and biophysics 268 1 360 378 doi 10 1016 0003 9861 89 90597 3 pmid 2912382 viitala j carlsson sr siebert pd fukuda m june 1988 molecular cloning of cdnas encoding lamp a a human lysosomal membrane glycoprotein with apparent mr approximately equal to 120 000 proceedings of the national academy of sciences of the united states of america 85 11 3743 3747 bibcode 1988pnas 85 3743v doi 10 1073 pnas 85 11 3743 pmc 280294 pmid 3131762 howe cl granger bl hull m green sa gabel ca helenius a et al october 1988 derived protein sequence oligosaccharides and membrane insertion of the 120 kda lysosomal membrane glycoprotein lgp120 identification of a highly conserved family of lysosomal membrane glycoproteins proceedings of the national academy of sciences of the united states of america 85 20 7577 7581 bibcode 1988pnas 85 7577h doi 10 1073 pnas 85 20 7577 pmc 282235 pmid 3174652 fukuda m viitala j matteson j carlsson sr december 1988 cloning of cdnas encoding human lysosomal membrane glycoproteins h lamp 1 and h lamp 2 comparison of their deduced amino acid sequences the journal of biological chemistry 263 35 18920 18928 doi 10 1016 s0021 9258 18 37370 8 pmid 3198605 ohno h stewart j fournier mc bosshart h rhee i miyatake s et al september 1995 interaction of tyrosine based sorting signals with clathrin associated proteins science 269 5232 1872 1875 bibcode 1995sci 269 1872o doi 10 1126 science 7569928 pmid 7569928 carlsson sr lycksell po fukuda m july 1993 assignment of o glycan attachment sites to the hinge like regions of human lysosomal membrane glycoproteins lamp 1 and lamp 2 archives of biochemistry and biophysics 304 1 65 73 doi 10 1006 abbi 1993 1322 pmid 8323299 sawada r jardine ka fukuda m april 1993 the genes of major lysosomal membrane glycoproteins lamp 1 and lamp 2 5 flanking sequence of lamp 2 gene and comparison of exon organization in two genes the journal of biological chemistry 268 12 9014 9022 doi 10 1016 s0021 9258 18 52972 0 pmid 8517882 rohrer j schweizer a russell d kornfeld s february 1996 the targeting of lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane the journal of cell biology 132 4 565 576 doi 10 1083 jcb 132 4 565 pmc 2199866 pmid 8647888 höning s sandoval iv von figura k august 1998 a di leucine based motif in the cytoplasmic tail of limp ii and tyrosinase mediates selective binding of ap 3 the embo journal 17 5 1304 1314 doi 10 1093 emboj 17 5 1304 pmc 1170479 pmid 9482728 furuta k yang xl chen js hamilton sr august jt may 1999 differential expression of the lysosome associated membrane proteins in normal human tissues archives of biochemistry and biophysics 365 1 75 82 doi 10 1006 abbi 1999 1147 pmid 10222041 raposo g moore m innes d leijendekker r leigh brown a benaroch p et al october 2002 human macrophages accumulate hiv 1 particles in mhc ii compartments traffic 3 10 718 729 doi 10 1034 j 1600 0854 2002 31004 x pmid 12230470 s2cid 7055266 zhang h li xj martin db aebersold r june 2003 identification and quantification of n linked glycoproteins using hydrazide chemistry stable isotope labeling and mass spectrometry nature biotechnology 21 6 660 666 doi 10 1038 nbt827 pmid 12754519 s2cid 581283 external links edit lamp1 protein human at the u s national library of medicine medical subject headings mesh pdbe kb provides an overview of all the s...