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Text of the page (random words):
of signaling receptor activity positive regulation of nik nf kappab signaling sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 8740 50930 ensembl ensg00000125735 ensmusg00000005824 uniprot o43557 q9qyh9 refseq mrna nm_003807 nm_172014 nm_001376887 nm_019418 refseq protein np_003798 np_742011 np_001363816 np_062291 location ucsc chr 19 6 66 6 67 mb chr 17 57 5 57 5 mb pubmed search 3 4 wikidata view edit human view edit mouse light also known as tumor necrosis factor superfamily member 14 tnfsf14 is a secreted protein of the tnf superfamily 5 6 7 it is recognized by herpesvirus entry mediator hvem as well as decoy receptor 3 nomenclature edit light stands for homologous to l ymphotoxin exhibits i nducible expression and competes with hsv g lycoprotein d for binding to h erpesvirus entry mediator a receptor expressed on t lymphocytes in the cluster of differentiation terminology it is classified as cd258 function edit the protein encoded by this gene is a member of the tumor necrosis factor tnf ligand family this protein is a ligand for tnfrsf14 which is a member of the tumor necrosis factor receptor superfamily and which is also known as a herpesvirus entry mediator hvem furthermore light interacts with the lymphotoxin β receptor ltβr to regulate the development of secondary lymphoid organs and tertiary lymphoid structures 8 two alternatively spliced transcript variant encoding distinct isoforms have been reported 6 this protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus this protein has been shown to stimulate the proliferation of t cells 9 trigger apoptosis of various tumor cells 10 and play a role in vascular normalisation processes 11 this protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocytes 12 interactions edit light has been shown to interact with tnfrsf14 13 14 tnfrsf6b 13 14 15 birc2 16 traf2 16 and traf3 16 role in herpes simplex virus edit similar to how cd4 is the primary mediating receptor in hiv infection the hsv glycoprotein gd binds to the hvem receptor which is demanded by tnfsf14 light lowering the ability for light to activate the nfκb pathway nfκb is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting caspase 8 when gd from hsv binds to hvem light is non competitively inhibited from binding encouraging apoptosis in the infected cell 7 references edit 1 2 3 grch38 ensembl release 89 ensg00000125735 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000005824 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine mauri dn ebner r montgomery ri kochel kd cheung tc yu gl et al january 1998 light a new member of the tnf superfamily and lymphotoxin alpha are ligands for herpesvirus entry mediator immunity 8 1 21 30 doi 10 1016 s1074 7613 00 80455 0 pmid 9462508 1 2 entrez gene tnfsf14 tumor necrosis factor ligand superfamily member 14 1 2 ware c 2008 chapter 25 tnf related cytokines in immunity in paul w ed fundamental immunology book 6th ed philadelphia lippincott williams wilkins pp 776 801 isbn 978 0 7817 6519 0 tang h zhu m qiao j fu yx october 2017 lymphotoxin signalling in tertiary lymphoid structures and immunotherapy cellular molecular immunology 14 10 809 818 doi 10 1038 cmi 2017 13 pmc 5649108 pmid 28413217 tamada k shimozaki k chapoval ai zhai y su j chen sf et al april 2000 light a tnf like molecule costimulates t cell proliferation and is required for dendritic cell mediated allogeneic t cell response journal of immunology 164 8 4105 4110 doi 10 4049 jimmunol 164 8 4105 pmid 10754304 s2cid 32066617 rooney ia butrovich kd glass aa borboroglu s benedict ca whitbeck jc et al may 2000 the lymphotoxin beta receptor is necessary and sufficient for light mediated apoptosis of tumor cells the journal of biological chemistry 275 19 14307 14315 doi 10 1074 jbc 275 19 14307 pmid 10799510 he b jabouille a steri v johansson percival a michael ip kotamraju vr et al june 2018 vascular targeting of light normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules the journal of pathology 245 2 209 221 doi 10 1002 path 5080 pmc 6737176 pmid 29603739 matsui h hikichi y tsuji i yamada t shintani y december 2002 light a member of the tumor necrosis factor ligand superfamily prevents tumor necrosis factor alpha mediated human primary hepatocyte apoptosis but not fas mediated apoptosis the journal of biological chemistry 277 51 50054 50061 doi 10 1074 jbc m206562200 pmid 12393901 1 2 zhang j salcedo tw wan x ullrich s hu b gregorio t et al june 2001 modulation of t cell responses to alloantigens by tr6 dcr3 the journal of clinical investigation 107 11 1459 1468 doi 10 1172 jci12159 pmc 209323 pmid 11390428 1 2 yu ky kwon b ni j zhai y ebner r kwon bs may 1999 a newly identified member of tumor necrosis factor receptor superfamily tr6 suppresses light mediated apoptosis the journal of biological chemistry 274 20 13733 13736 doi 10 1074 jbc 274 20 13733 pmid 10318773 hsu tl chang yc chen sj liu yj chiu aw chio cc et al may 2002 modulation of dendritic cell differentiation and maturation by decoy receptor 3 journal of immunology 168 10 4846 4853 doi 10 4049 jimmunol 168 10 4846 pmid 11994433 1 2 3 kuai j nickbarg e wooters j qiu y wang j lin ll april 2003 endogenous association of traf2 traf3 ciap1 and smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis the journal of biological chemistry 278 16 14363 14369 bibcode 2003jbich 27814363k doi 10 1074 jbc m208672200 pmid 12571250 further reading edit yang d zhai y zhang m 2003 light a new member of the tnf superfamily journal of biological regulators and homeostatic agents 16 3 206 210 pmid 12456019 bénichou s benmerah a january 2003 the hiv nef and the kaposi sarcoma associated virus k3 k5 proteins parasites of the endocytosis pathway medecine sciences 19 1 100 106 doi 10 1051 medsci 2003191100 pmid 12836198 anderson jl hope tj april 2004 hiv accessory proteins and surviving the host cell current hiv aids reports 1 1 47 53 doi 10 1007 s11904 004 0007 x pmid 16091223 s2cid 34731265 marsters sa sheridan jp pitti rm brush j goddard a ashkenazi a april 1998 identification of a ligand for the death domain containing receptor apo3 current biology 8 9 525 528 bibcode 1998cbio 8 525m doi 10 1016 s0960 9822 98 70204 0 pmid 9560343 s2cid 14953579 zhai y guo r hsu tl yu gl ni j kwon bs et al september 1998 light a novel ligand for lymphotoxin beta receptor and tr2 hvem induces apoptosis and suppresses in vivo tumor formation via gene transfer the journal of clinical investigation 102 6 1142 1151 doi 10 1172 jci3492 pmc 509097 pmid 9739048 harrop ja mcdonnell pc brigham burke m lyn sd minton j tan kb et al october 1998 herpesvirus entry mediator ligand hvem l a novel ligand for hvem tr2 stimulates proliferation of t cells and inhibits ht29 cell growth the journal of biological chemistry 273 42 27548 27556 doi 10 1074 jbc 273 42 27548 pmid 9765287 yu ky kwon b ni j zhai y ebner r kwon bs may 1999 a newly identified member of tumor necrosis factor receptor superfamily tr6 suppresses light mediated apoptosis the journal of biological chemistry 274 20 13733 13736 doi 10 1074 jbc 274 20 13733 pmid 10318773 rooney ia butrovich kd glass aa borboroglu s benedict ca whitbeck jc et al may 2000 the lymphotoxin beta receptor is necessary and sufficient for light mediated apoptosis of tumor cells the journal of biological chemistry 275 19 14307 14315 doi 10 1074 jbc 275 19 14307 pmid 10799510 lama j ware cf october 2000 human immunodeficiency virus type 1 nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine light on activated t cells journal of virology 74 20 9396 9402 doi 10 1128 jvi 74 20 9396 9402 2000 pmc 112368 pmid 11000208 morel y schiano de colella jm harrop j deen kc holmes sd wattam ta et al october 2000 reciprocal expression of the tnf family receptor herpes virus entry mediator and its ligand light on activated t cells light down regulates its own receptor journal of immunology 165 8 4397 4404 doi 10 4049 jimmunol 165 8 4397 pmid 11035077 zhang j salcedo tw wan x ullrich s hu b gregorio t et al june 2001 modulation of t cell responses to alloantigens by tr6 dcr3 the journal of clinical investigation 107 11 1459 1468 doi 10 1172 jci12159 pmc 209323 pmid 11390428 granger sw butrovich kd houshmand p edwards wr ware cf november 2001 genomic characterization of light reveals linkage to an immune response locus on chromosome 19p13 3 and distinct isoforms generated by alternate splicing or proteolysis journal of immunology 167 9 5122 5128 doi 10 4049 jimmunol 167 9 5122 pmid 11673523 shaikh rb santee s granger sw butrovich k cheung t kronenberg m et al december 2001 constitutive expression of light on t cells leads to lymphocyte activation inflammation and tissue destruction journal of immunology 167 11 6330 6337 doi 10 4049 jimmunol 167 11 6330 pmid 11714797 bobik a kalinina n december 2001 tumor necrosis factor receptor and ligand superfamily family members tnfrsf14 and light new players in human atherogenesis arteriosclerosis thrombosis and vascular biology 21 12 1873 1875 doi 10 1161 atvb 21 12 1873 pmid 11742858 wang j lo jc foster a yu p chen hm wang y et al december 2001 the regulation of t cell homeostasis and autoimmunity by t cell derived light the journal of clinical investigation 108 12 1771 1780 doi 10 1172 jci13827 pmc 209470 pmid 11748260 hsu tl chang yc chen sj liu yj chiu aw chio cc et al may 2002 modulation of dendritic cell differentiation and maturation by decoy receptor 3 journal of immunology 168 10 4846 4853 doi 10 4049 jimmunol 168 10 4846 pmid 11994433 castellano r van lint c peri v veithen e morel y costello r et al november 2002 mechanisms regulating expression of the tumor necrosis factor related light gene role of calcium signaling pathway in the transcriptional control the journal of biological chemistry 277 45 42841 42851 doi 10 1074 jbc m207689200 pmid 12215452 matsui h hikichi y tsuji i yamada t shintani y december 2002 light a member of the tumor necrosis factor ligand superfamily prevents tumor necrosis factor alpha mediated human primary hepatocyte apoptosis but not fas mediated apoptosis the journal of biological chemistry 277 51 50054 50061 doi 10 1074 jbc m206562200 pmid 12393901 external links edit tnfsf14 protein human at the u s national library of medicine medical subject headings mesh this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons v t e cytokine receptor modulators chemokine see here instead csf erythropoietin agonists ara 290 asialo erythropoietin carbamylated erythropoietin cnto 530 darbepoetin alfa epoetin alfa epoetin beta epoetin delta epoetin epsilon epoetin gamma epoetin kappa epoetin omega epoetin theta epoetin zeta erythropoietin epo erythropoietin fc methoxy polyethylene glycol epoetin beta cera mircera peginesatide pegol sihematide epo 018b g csf csf3 agonists filgrastim granulocyte colony stimulating factor lenograstim leridistim lipegfilgrastim nartograstim pegfilgrastim pegnartograstim gm csf csf2 agonists ecogramostim granulocyte macrophage colony stimulating factor milodistim molgramostim regramostim sargramostim antibodies mavrilimumab namilumab otilimab m csf csf1 agonists cilmostim interleukin 34 lanimostim macrophage colony stimulating factor mirimostim kinase inhibitors agerafenib scf c kit see here instead thrombopoietin agonists eltrombopag pegacaristim promegapoietin romiplostim avatrombopag lusutrombopag thrombopoietin thpo mgdf interferon ifnar α β i agonists albinterferon interferon alpha interferon alfa ifn α interferon alfa ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 interferon alfa 2a interferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 interferon beta ifn β ifnb1 ifnb3 interferon beta 1a interferon beta 1b interferon kappa ifn ε κ τ ζ ifnk interferon omega ifn ω ifnw1 peginterferon alfa 2a peginterferon alfa 2b antibodies anifrolumab faralimomab medi 545 rontalizumab sifalimumab decoy receptors bifarcept ifngr γ ii agonists interferon gamma ifn γ interferon gamma 1b antibodies emapalumab fontolizumab ifnlr λ iii see il 28r ifnlr here instead interleukin see here instead tgfβ see here instead tnf see here instead others jak inhibitors jak1 abrocitinib baricitinib deuruxolitinib filgotinib momelotinib oclacitinib peficitinib ruxolitinib tofacitinib tasocitinib upadacitinib jak2 atiprimod azd 1480 baricitinib chz868 cucurbitacin i elatericin b jsi 124 cyt387 deuruxolitinib lestaurtinib nsc 7908 nsc 33994 pacritinib peficitinib ruxolitinib sd 1008 tofacitinib tasocitinib jak3 cercosporamide decernotinib vx 509 peficitinib ritlecitinib tcs 21311 tofacitinib tasocitinib whi p 154 zm 39923 zm 449829 tyk2 deucravacitinib others additional cytokines cardiotrophin 1 ct 1 fms like tyrosine kinase 3 ligand flt3l leukemia leukocyte inhibitory factor lif oncostatin m osm thymic stromal lymphopoietin tslp additional cytokine receptor modulators emfilermin lestaurtinib midostaurin quizartinib sorafenib sunitinib retrieved from https en 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