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ly9 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 interactions 2 references 3 further reading 4 external links toggle the table of contents ly9 4 languages français русский татарча tatarça українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein coding gene in humans ly9 identifiers aliases ly9 cd229 slamf3 hly9 mlymphocyte antigen 9 external ids omim 600684 mgi 96885 genecards ly9 gene location human chr chromosome 1 human 1 band 1q23 3 start 160 796 074 bp 1 end 160 828 261 bp 1 gene location mouse chr chromosome 1 mouse 2 band 1 h3 1 79 54 cm start 171 416 192 bp 2 end 171 434 978 bp 2 rna expression pattern bgee human mouse ortholog top expressed in granulocyte lymph node buccal mucosa cell blood spleen bone marrow cell epithelium of colon superficial temporal artery appendix trabecular bone top expressed in mesenteric lymph nodes stroma of bone marrow thymus spleen granulocyte blood subcutaneous adipose tissue calvaria white adipose tissue right lung lobe more reference expression data biogps more reference expression data gene ontology molecular function molecular function cellular component integral component of membrane cell surface plasma membrane membrane biological process positive regulation of interleukin 17 production innate immune response cell adhesion adaptive immune response t helper 17 cell lineage commitment immune system process sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 4063 17085 ensembl ensg00000122224 ensmusg00000004707 uniprot q9hbg7 q5vyi1 q01965 refseq mrna nm_001033667 nm_001261456 nm_001261457 nm_002348 nm_001277968 nm_008534 refseq protein np_001028839 np_001248385 np_001248386 np_002339 np_001264897 np_032560 location ucsc chr 1 160 8 160 83 mb chr 1 171 42 171 43 mb pubmed search 3 4 wikidata view edit human view edit mouse t lymphocyte surface antigen ly 9 is a protein that in humans is encoded by the ly9 gene 5 6 7 ly9 has also recently been designated cd229 cluster of differentiation 229 interactions edit ly9 has been shown to interact with sh2d1a 8 9 references edit 1 2 3 grch38 ensembl release 89 ensg00000122224 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000004707 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine sandrin ms henning mm lo mf baker e sutherland gr mckenzie if feb 1996 isolation and characterization of cdna clones for humly9 the human homologue of mouse ly9 immunogenetics 43 1 2 13 9 doi 10 1007 bf00186599 pmid 8537117 s2cid 10045488 kingsmore sf souryal ca watson ml patel dd seldin mf aug 1995 physical and genetic linkage of the genes encoding ly 9 and cd48 on mouse and human chromosomes 1 immunogenetics 42 1 59 62 doi 10 1007 bf00164988 pmid 7797269 s2cid 28529549 entrez gene ly9 lymphocyte antigen 9 sayós j martín m chen a simarro m howie d morra m engel p terhorst c jun 2001 cell surface receptors ly 9 and cd84 recruit the x linked lymphoproliferative disease gene product sap blood 97 12 3867 3874 doi 10 1182 blood v97 12 3867 pmid 11389028 morra m simarro grande m martin m chen as lanyi a silander o calpe s davis j pawson t eck mj sumegi j engel p li sc terhorst c sep 2001 characterization of sh2d1a missense mutations identified in x linked lymphoproliferative disease patients pdf j biol chem 276 39 36809 36816 doi 10 1074 jbc m101305200 pmid 11477068 s2cid 39889619 further reading edit andersson b wentland ma ricafrente jy liu w gibbs ra 1996 a double adaptor method for improved shotgun library construction anal biochem 236 1 107 113 doi 10 1006 abio 1996 0138 pmid 8619474 yu w andersson b worley kc muzny dm ding y liu w ricafrente jy wentland ma lennon g gibbs ra 1997 large scale concatenation cdna sequencing genome res 7 4 353 8 doi 10 1101 gr 7 4 353 pmc 139146 pmid 9110174 tovar v de la fuente ma pizcueta p bosch j engel p 2000 gene structure of the mouse leukocyte cell surface molecule ly9 immunogenetics 51 10 788 793 doi 10 1007 s002510000209 pmid 10970093 s2cid 23932012 de la fuente ma tovar v villamor n zapater n pizcueta p campo e bosch j engel p 2001 molecular characterization and expression of a novel human leukocyte cell surface marker homologous to mouse ly 9 blood 97 11 3513 3520 doi 10 1182 blood v97 11 3513 pmid 11369645 sayós j martín m chen a simarro m howie d morra m engel p terhorst c 2001 cell surface receptors ly 9 and cd84 recruit the x linked lymphoproliferative disease gene product sap blood 97 12 3867 3874 doi 10 1182 blood v97 12 3867 pmid 11389028 morra m simarro grande m martin m chen as lanyi a silander o calpe s davis j pawson t eck mj sumegi j engel p li sc terhorst c 2001 characterization of sh2d1a missense mutations identified in x linked lymphoproliferative disease patients j biol chem 276 39 36809 36816 doi 10 1074 jbc m101305200 hdl 2437 230556 pmid 11477068 morra m lu j poy f martin m sayos j calpe s gullo c howie d rietdijk s thompson a coyle aj denny c yaffe mb engel p eck mj terhorst c 2001 structural basis for the interaction of the free sh2 domain eat 2 with slam receptors in hematopoietic cells embo j 20 21 5840 5852 doi 10 1093 emboj 20 21 5840 pmc 125701 pmid 11689425 tovar v del valle j zapater n martin m romero x pizcueta p bosch j terhorst c engel p 2002 mouse novel ly9 a new member of the expanding cd150 slam family of leukocyte cell surface receptors immunogenetics 54 6 394 402 doi 10 1007 s00251 002 0483 3 pmid 12242590 s2cid 38277782 del valle jm engel p martín m 2003 the cell surface expression of sap binding receptor cd229 is regulated via its interaction with clathrin associated adaptor complex 2 ap 2 j biol chem 278 19 17430 17437 doi 10 1074 jbc m301569200 pmid 12621057 martín m del valle jm saborit i engel p 2005 identification of grb2 as a novel binding partner of the signaling lymphocytic activation molecule associated protein binding receptor cd229 j immunol 174 10 5977 86 doi 10 4049 jimmunol 174 10 5977 pmid 15879090 romero x zapater n calvo m kalko sg de la fuente ma tovar v ockeloen c pizcueta p engel p 2005 cd229 ly9 lymphocyte cell surface receptor interacts homophilically through its n terminal domain and relocalizes to the immunological synapse j immunol 174 11 7033 42 doi 10 4049 jimmunol 174 11 7033 pmid 15905546 external links edit ly9 protein human at the u s national library of medicine medical subject headings mesh this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons this membrane protein related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title ly9 oldid 1343018668 categories genes on human chromosome 1 clusters of differentiation membrane protein stubs hidden categories articles with short description short description is different from wikidata wikipedia articles incorporating text from the united states national library of medicine all stub articles this page was last edited on 11 march 2026 at 20 20 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents ly9 4 languages add topic