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brains, been, conjectured, mechanism, high, dose, against, seizures, study, major, metabolites, gives, more, prolonged, therapeutic, effect, after, prodrug, that, derivative, possesses, properties, known, following, brand, mixed, acting, 200, mezapam, ansilan, raporan, bevonium, tranquirax, nobrium, azepamid, skeletal, muscle, relaxant, sedative, anticonvulsant, anxiolytic, verify, key, ylcxgbzizbevpz, uhfffaoysa, c16h15cln2, 11h, 10h2, 1h3, clc1, nccn3c, c3c, smiles, interactive, image, model, jsmol, mol, 270, molar, mass, formula, chemical, physical, 100, 018, 895, dtxsid1048708, epa, comptox, dashboard, chembl28333, chembl, d01292, kegg, p0j3387w3s, unii, 3901, chemspider, none, 4041, cid, pubchem, 2898, cas, number, chloro, phenyl, dihydro, iupac, name, identifiers, biliary, renal, excretion, 150, elimination, hepatic, protein, max, bioavailability, pharmacokinetic, prescription, only, higher, doses, anlage, psychoactive, class, n05ba03, atc, oral, routes, international, com, ahfs, 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languages deutsch فارسی suomi français hrvatski magyar bahasa indonesia italiano 日本語 polski português română русский srpskohrvatski српскохрватски српски srpski svenska türkçe українська tiếng việt 中文 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia benzodiazepine drug pharmaceutical compound medazepam clinical data trade names rudotel others ahfs drugs com international drug names routes of administration oral atc code n05ba03 who legal status legal status br class b1 psychoactive drugs 1 ca schedule iv de prescription only anlage iii for higher doses us schedule iv pharmacokinetic data bioavailability 50 75 с max 1 2 hours protein binding 99 metabolism hepatic elimination half life 2 hours 36 150 hours terminal excretion renal 63 85 biliary 15 37 identifiers iupac name 7 chloro 1 methyl 5 phenyl 2 3 dihydro 1 4 benzodiazepine cas number 2898 12 6 n pubchem cid 4041 drugbank none n chemspider 3901 y unii p0j3387w3s kegg d01292 y chembl chembl28333 y comptox dashboard epa dtxsid1048708 echa infocard 100 018 895 chemical and physical data formula c 16 h 15 cl n 2 molar mass 270 76 g mol 1 3d model jsmol interactive image smiles clc1 cc c c2 cc cc c2 nccn3c c3c c1 inchi inchi 1s c16h15cln2 c1 19 10 9 18 16 12 5 3 2 4 6 12 14 11 13 17 7 8 15 14 19 h2 8 11h 9 10h2 1h3 y key ylcxgbzizbevpz uhfffaoysa n y n y what is this verify medazepam is a drug that is a benzodiazepine derivative it possesses anxiolytic anticonvulsant sedative and skeletal muscle relaxant properties it is known by the following brand names azepamid nobrium tranquirax mixed with bevonium rudotel raporan ansilan and mezapam 2 medazepam is a long acting benzodiazepine drug the half life of medazepam is 36 200 hours 3 pharmacology edit medazepam acts as a prodrug to nordazepam benzodiazepine drugs including medazepam increase the inhibitory processes in the cerebral cortex by allosteric modulation of the gaba receptor 4 benzodiazepines may also act via micromolar benzodiazepine binding sites as ca 2 channel blockers and significantly inhibited depolarization sensitive calcium uptake in experiments with cell components from rat brains this has been conjectured as a mechanism for high dose effects against seizures in a study 5 it has major active benzodiazepine metabolites which gives it a more prolonged therapeutic effect after administration 6 see also edit benzodiazepine dependence benzodiazepine withdrawal syndrome long term effects of benzodiazepines references edit anvisa 2023 03 31 rdc nº 784 listas de substâncias entorpecentes psicotrópicas precursoras e outras sob controle especial collegiate board resolution no 784 lists of narcotic psychotropic precursor and other substances under special control in brazilian portuguese diário oficial da união published 2023 04 04 archived from the original on 2023 08 03 retrieved 2023 08 16 benzodiazepines encyclopedia of drugs ashton h april 2007 benzodiazepine equivalency table benzodiazepines co operation not confrontation bcnc archived from the original on september 28 2007 retrieved september 23 2007 zakusov vv ostrovskaya ru kozhechkin sn markovich vv molodavkin gm voronina ta october 1977 further evidence for gaba ergic mechanisms in the action of benzodiazepines archives internationales de pharmacodynamie et de therapie 229 2 313 26 pmid 23084 taft wc delorenzo rj may 1984 micromolar affinity benzodiazepine receptors regulate voltage sensitive calcium channels in nerve terminal preparations pdf proceedings of the national academy of sciences of the united states of america pdf 81 10 3118 22 bibcode 1984pnas 81 3118t doi 10 1073 pnas 81 10 3118 pmc 345232 pmid 6328498 jochemsen r breimer dd 1984 pharmacokinetics of benzodiazepines metabolic pathways and plasma level profiles current medical research and opinion 8 suppl 4 60 79 doi 10 1185 03007998409109545 pmid 6144464 external links edit inchem medazepam v t e benzodiazepines 1 4 benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam bromazepam bromonordiazepam bms 906024 camazepam carburazepam chlordiazepoxide cinazepam cinolazepam clonazepam cloniprazepam clorazepate cyprazepam delorazepam demoxepam desmethylflunitrazepam devazepide diazepam diclazepam difludiazepam doxefazepam elfazepam ethyl carfluzepate ethyl dirazepate ethyl loflazepate flubromazepam fletazepam fludiazepam flunitrazepam flurazepam flutemazepam flutoprazepam fosazepam gidazepam halazepam iclazepam irazepine kenazepine ketazolam lorazepam lormetazepam lufuradom meclonazepam medazepam menitrazepam metaclazepam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitemazepam nitrazepam nitrazepate nordazepam nortetrazepam oxazepam phenazepam pinazepam pivoxazepam prazepam proflazepam quazepam qh ii 66 reclazepam ro4491533 ro05 4082 ro5 4864 ro07 5220 ro07 9749 ro20 8065 ro20 8552 sh i 048a sulazepam temazepam tetrazepam tifluadom timelotem tolufazepam triflunordazepam tuclazepam uldazepam 1 5 benzodiazepines arfendazam clobazam cp 1414s lofendazam triflubazam 2 3 benzodiazepines girisopam gyki 52466 gyki 52895 nerisopam talampanel tofisopam triazolobenzodiazepines adinazolam alprazolam bromazolam clonazolam estazolam ethylbromazolam fluadinazolam flualprazolam flubromazolam flunitrazolam nitrazolam phenazolam pyrazolam rilmazolam active metabolite of rilmazafone triazolam imidazobenzodiazepines bretazenil climazolam evt 201 fg 8205 flumazenil gl ii 73 imidazenil 123 i iomazenil l 655 708 loprazolam midazolam pwz 029 remimazolam ro15 4513 ro48 6791 ro48 8684 ro4938581 sarmazenil sh 053 r ch3 2 f oxazolobenzodiazepines cloxazolam flutazolam haloxazolam mexazolam oxazolam thienodiazepines bentazepam clotiazepam ro09 9212 thienotriazolodiazepines α hydroxyetizolam apafant brotizolam ciclotizolam clotizolam deschloroclotizolam deschloroetizolam etizolam flubrotizolam fluclotizolam fluetizolam israpafant jq1 metizolam thienobenzodiazepines olanzapine telenzepine pyridodiazepines lopirazepam pyridotriazolodiazepines zapizolam pyrazolodiazepines razobazam ripazepam zolazepam zomebazam zometapine pyrrolodiazepines premazepam tetrahydroisoquinobenzodiazepines clazolam pyrrolobenzodiazepines anthramycin benzodiazepine prodrugs alprazolam triazolobenzophenone avizafone rilmazafone others unsorted ntx 1955 ro 7308480 atypical activity profile not gaba a receptor ligands v t e anxiolytics n05b 5 ht 1a r tooltip 5 ht1a receptor agonists buspirone gepirone tandospirone gaba a r tooltip gabaa receptor pams tooltip positive allosteric modulators benzodiazepines adinazolam alprazolam bromazepam camazepam chlordiazepoxide clobazam clonazepam clorazepate clotiazepam cloxazolam diazepam ethyl loflazepate etizolam fludiazepam halazepam ketazolam lorazepam medazepam nordazepam oxazepam pinazepam prazepam others alpidem barbiturates e g phenobarbital carbamates e g meprobamate carisoprodol chlormezanone ethanol alcohol etifoxine gabapentinoids α 2 δ vdcc blockers gabapentin gabapentin enacarbil phenibut baclofen pregabalin antidepressants ssris tooltip selective serotonin reuptake inhibitors e g escitalopram snris tooltip serotonin norepinephrine reuptake inhibitors e g duloxetine saris tooltip serotonin antagonist and reuptake inhibitors e g trazodone tcas tooltip tricyclic antidepressants e g clomipramine tecas tooltip tetracyclic antidepressants e g mirtazapine maois tooltip monoamine oxidase inhibitors e g phenelzine others agomelatine bupropion tianeptine vilazodone vortioxetine sympatholytics antiadrenergics alpha 1 blockers e g prazosin alpha 2 agonists e g clonidine dexmedetomidine guanfacine beta blockers e g propranolol atenolol betaxolol nadolol oxprenolol pindolol others benzoctamine cycloserine fabomotizole hydroxyzine lorpiprazole mebicar mepiprazole nicotine tobacco opipramol oxaflozane phenaglycodol phenibut picamilon selank tiagabine tofisopam validolum who em withdrawn from market clinical trials phase iii never to phase iii v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valerenic acid valerenol unsorted benzodiazepine site positive modulators α pinene mrk 409 mk 0343 tcs 1105 tcs 1205 see also receptor signaling modulators gaba receptor modulators gaba metabolism transport modulators retrieved from https en wikipedia org w index php title medazepam oldid 1365894372 categories benzodiazepines chloroarene...