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melanotransferrin wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references 2 further reading 3 external links toggle the table of contents melanotransferrin 4 languages 한국어 русский татарча tatarça українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein coding gene in the species homo sapiens meltf identifiers aliases meltf cd228 map97 mtf1 mtf mfi2 melanotransferrin external ids omim 155750 mgi 1353421 genecards meltf gene location human chr chromosome 3 human 1 band 3q29 start 196 980 590 bp 1 end 197 029 835 bp 1 gene location mouse chr chromosome 16 mouse 2 band 16 16 b2 start 31 697 628 bp 2 end 31 717 838 bp 2 rna expression pattern bgee human mouse ortholog top expressed in tibia parotid gland decidua tendon of biceps brachii renal medulla parietal pleura cartilage tissue endothelial cell amniotic fluid germinal epithelium top expressed in vestibular sensory epithelium stria vascularis epithelium of small intestine trachea migratory enteric neural crest cell utricle vestibular membrane of cochlear duct intercostal muscle ankle joint condyle more reference expression data biogps more reference expression data gene ontology molecular function iron ion binding protein binding metal ion binding cellular component cell surface anchored component of plasma membrane anchored component of membrane integral component of plasma membrane extracellular exosome membrane extracellular region extracellular space plasma membrane endoplasmic reticulum lumen biological process positive regulation of extracellular matrix disassembly iron ion homeostasis negative regulation of substrate adhesion dependent cell spreading regulation of cell population proliferation positive regulation of plasminogen activation ion transport regulation of cell growth c terminal protein lipidation post translational protein modification transport iron ion transport sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 4241 30060 ensembl ensg00000163975 ensmusg00000022780 uniprot p08582 q9r0r1 refseq mrna nm_005929 nm_033316 nm_013900 refseq protein np_005920 np_201573 np_038928 location ucsc chr 3 196 98 197 03 mb chr 16 31 7 31 72 mb pubmed search 3 4 wikidata view edit human view edit mouse melanotransferrin is a protein that in humans is encoded by the mfi2 gene mfi2 has also recently been designated cd228 cluster of differentiation 228 the protein encoded by this gene is a cell surface glycoprotein found on melanoma cells the protein shares sequence similarity and iron binding properties with members of the transferrin superfamily the importance of the iron binding function has not yet been identified this gene resides in the same region of chromosome 3 as members of the transferrin superfamily alternative splicing results in two transcript variants 5 it is part of neural crest tissue often present in melanotic neuroectodermal tumor of infancy references edit 1 2 3 grch38 ensembl release 89 ensg00000163975 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000022780 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine entrez gene mfi2 antigen p97 melanoma associated identified by monoclonal antibodies 133 2 and 96 5 further reading edit suryo rahmanto y dunn ll richardson dr 2007 the melanoma tumor antigen melanotransferrin p97 a 25 year hallmark from iron metabolism to tumorigenesis oncogene 26 42 6113 24 doi 10 1038 sj onc 1210442 pmid 17452986 s2cid 35884470 baker en baker hm smith ca et al 1992 human melanotransferrin p97 has only one functional iron binding site febs lett 298 2 3 215 8 bibcode 1992febsl 298 215b doi 10 1016 0014 5793 92 80060 t pmid 1544447 s2cid 21022972 garratt rc jhotí h 1992 a molecular model for the tumour associated antigen p97 suggests a zn binding function febs lett 305 1 55 61 bibcode 1992febsl 305 55g doi 10 1016 0014 5793 92 80654 y pmid 1633859 s2cid 23569786 rose tm plowman gd teplow db et al 1986 primary structure of the human melanoma associated antigen p97 melanotransferrin deduced from the mrna sequence pdf proc natl acad sci u s a 83 5 1261 5 bibcode 1986pnas 83 1261r doi 10 1073 pnas 83 5 1261 pmc 323055 pmid 2419904 furukawa ks furukawa k real fx et al 1989 a unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95 p97 j exp med 169 2 585 90 doi 10 1084 jem 169 2 585 pmc 2189208 pmid 2463331 sciot r de vos r van eyken p et al 1989 in situ localization of melanotransferrin melanoma associated antigen p97 in human liver a light and electronmicroscopic immunohistochemical study liver 9 2 110 9 doi 10 1111 j 1600 0676 1989 tb00387 x pmid 2540389 seligman pa butler cd massey ej et al 1986 the p97 antigen is mapped to the q24 qter region of chromosome 3 the same region as the transferrin receptor am j hum genet 38 4 540 8 pmc 1684788 pmid 3010712 le beau mm diaz mo plowman gd et al 1986 chromosomal sublocalization of the human p97 melanoma antigen hum genet 72 4 294 6 doi 10 1007 bf00290951 pmid 3754536 s2cid 38961040 plowman gd brown jp enns ca et al 1983 assignment of the gene for human melanoma associated antigen p97 to chromosome 3 nature 303 5912 70 2 bibcode 1983natur 303 70p doi 10 1038 303070a0 pmid 6843660 s2cid 4332107 kennard ml richardson dr gabathuler r et al 1995 a novel iron uptake mechanism mediated by gpi anchored human p97 embo j 14 17 4178 86 doi 10 1002 j 1460 2075 1995 tb00091 x pmc 394500 pmid 7556058 food mr rothenberger s gabathuler r et al 1994 transport and expression in human melanomas of a transferrin like glycosylphosphatidylinositol anchored protein j biol chem 269 4 3034 40 doi 10 1016 s0021 9258 17 42043 6 pmid 8300636 rothenberger s food mr gabathuler r et al 1996 coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium brain res 712 1 117 21 doi 10 1016 0006 8993 96 88505 2 pmid 8705293 s2cid 45470799 chi dd merchant re rand r et al 1997 molecular detection of tumor associated antigens shared by human cutaneous melanomas and gliomas am j pathol 150 6 2143 52 pmc 1858329 pmid 9176405 richardson dr 2000 the role of the membrane bound tumour antigen melanotransferrin p97 in iron uptake by the human malignant melanoma cell eur j biochem 267 5 1290 8 doi 10 1046 j 1432 1327 2000 01079 x pmid 10691965 dias neto e correa rg verjovski almeida s et al 2000 shotgun sequencing of the human transcriptome with orf expressed sequence tags proc natl acad sci u s a 97 7 3491 6 bibcode 2000pnas 97 3491d doi 10 1073 pnas 97 7 3491 pmc 16267 pmid 10737800 suzuki y tsunoda t sese j et al 2001 identification and characterization of the potential promoter regions of 1031 kinds of human genes genome res 11 5 677 84 doi 10 1101 gr gr 1640r pmc 311086 pmid 11337467 sekyere e food mr richardson dr 2002 a second melanotransferrin gene mtf2 and a novel protein isoform explanation for the membrane bound and soluble forms of melanotransferrin febs lett 512 1 3 350 2 bibcode 2002febsl 512 350s doi 10 1016 s0014 5793 02 02248 2 pmid 11852110 s2cid 38104056 food mr sekyere eo richardson dr 2002 the soluble form of the membrane bound transferrin homologue melanotransferrin inefficiently donates iron to cells via nonspecific internalization and degradation of the protein eur j biochem 269 18 4435 45 doi 10 1046 j 1432 1033 2002 03140 x pmid 12230555 strausberg rl feingold ea grouse lh et al 2003 generation and initial analysis of more than 15 000 full length human and mouse cdna sequences proc natl acad sci u s a 99 26 16899 903 bibcode 2002pnas 9916899m doi 10 1073 pnas 242603899 pmc 139241 pmid 12477932 guo j wen dr huang rr et al 2003 detection of multiple melanoma associated markers in melanoma cell lines by rt in situ pcr exp mol pathol 74 2 140 7 doi 10 1016 s0014 4800 03 00012 1 pmid 12710945 external links edit mfi2 protein human at the u s national library of medicine medical subject headings mesh this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 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