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account log in personal tools donate create account log in contents move to sidebar hide top 1 chemistry 2 see also 3 references toggle the table of contents minaxolone 4 languages italiano português srpskohrvatski српскохрватски српски srpski edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia chemical compound pharmaceutical compound minaxolone clinical data other names 11α dimethylamino 2β ethoxy 3α hydroxy 5α pregnan 20 one atc code none identifiers iupac name 1 1 s 2 s 4 s 5 s 7 s 10 s 11 s 14 s 15 s 17 r 17 dimethylamino 4 ethoxy 5 hydroxy 2 15 dimethyltetracyclo 8 7 0 0 2 7 0 11 15 heptadecan 14 yl ethan 1 one cas number 62571 87 3 y pubchem cid 71960 iuphar bps 5478 chemspider 64967 n unii 737skc73l0 kegg d05041 y chembl chembl2105209 n comptox dashboard epa dtxsid201024283 chemical and physical data formula c 25 h 43 n o 3 molar mass 405 623 g mol 1 3d model jsmol interactive image smiles cco c h 1c c 2 c h cc c h 3 c h 2 c h c c 4 c h 3cc c h 4c o c c n c c c c h 1o c inchi inchi 1s c25h43no3 c1 7 29 22 14 24 3 16 12 21 22 28 8 9 17 19 11 10 18 15 2 27 25 19 4 13 20 23 17 24 26 5 6 h16 23 28h 7 14h2 1 6h3 t16 17 18 19 20 21 22 23 24 25 m0 s1 n key ncgltzsbtfvvaw knxrzymvsa n n n y what is this verify minaxolone cci 12923 is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long term administration in rats and hence was never marketed 1 2 3 it is a positive allosteric modulator of the gaba a receptor 4 as well as less potently a positive allosteric modulator of the glycine receptor 4 5 chemistry edit see also list of neurosteroids see also edit alfadolone alfaxolone ganaxolone hydroxydione pregnanolone renanolone references edit ganellin cr triggle dj 21 november 1996 dictionary of pharmacological agents crc press pp 1358 isbn 978 0 412 46630 4 bovill jb howie mc eds 1999 clinical pharmacology for anaesthetists w b saunders doi 10 1016 b978 0 323 03707 5 50031 0 isbn 978 0 7020 2167 1 perouansky ma hemmings jr hc 2006 intravenous anesthetic agents in hemmings hc hopkins pm eds foundations of anesthesia basic sciences for clinical practice elsevier health sciences pp 305 isbn 978 0 323 03707 5 1 2 lambert jj harney sc belelli d peters ja 2001 neurosteroid modulation of recombinant and synaptic gabaa receptor in biggio g purdy rh eds neurosteroids and brain function academic press pp 196 isbn 978 0 12 366846 2 weir cj ling at belelli d wildsmith ja peters ja lambert jj may 2004 the interaction of anaesthetic steroids with recombinant glycine and gabaa receptors british journal of anaesthesia 92 5 704 711 citeseerx 10 1 1 519 3591 doi 10 1093 bja aeh125 pmid 15033889 cite journal cite uses deprecated parameter citeseerx help v t e general anesthetics n01a inhalational chloroform cyclopropane desflurane diethyl ether enflurane ethylene fluroxene halothane isoflurane methoxyflurane methoxypropane nitrous oxide sevoflurane trichloroethylene thiomethoxyflurane vinyl ether xenon injection phenols cipepofol ciprofol fospropofol propofol barbiturates amobarbital hexobarbital methohexital narcobarbital thiamylal thiopental thiotetrabarbital benzodiazepines midazolam diazepam lorazepam remimazolam opioids morphine oxycodone anileridine embutramide fentanyl alfentanil phenoperidine remifentanil sufentanil arylcyclohexylamines esketamine ketamine phencyclidine tiletamine neuroactive steroids alfadolone alfaxalone hydroxydione others etomidate propoxate metomidate propanidid who em withdrawn from market clinical trials phase iii never to phase iii v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valerenic acid valerenol unsorted benzodiazepine site positive modulators α pinene mrk 409 mk 0343 tcs 1105 tcs 1205 see also receptor signaling modulators gaba receptor modulators gaba metabolism transport modulators v t e glycine receptor modulators receptor ligands glyr tooltip glycine receptor agonists β alanine β aba baba β aiba caesium d alanine d serine gaba glycine hypotaurine ivermectin l alanine l proline l serine l threonine mdl 27531 milacemide picolinic acid propofol quisqualamine sarcosine taurine positive modulators alcohols e g brometone chlorobutanol chloretone ethanol alcohol tert butanol 2m2p tribromoethanol trichloroethanol trifluoroethanol alkylbenzene sulfonate anandamide barbiturates e g pentobarbital sodium thiopental chlormethiazole d12 116 dihydropyridines e g nicardipine etomidate ginseng constituents e g ginsenosides e g ginsenoside rf glutamic acid glutamate ivermectin ketamine neuroactive steroids e g alfaxolone pregnenolone eltanolone pregnenolone acetate minaxolone org 20599 nitrous oxide penicillin g propofol tamoxifen tetrahydrocannabinol triclofos tropeines e g atropine bemesetron cocaine ly 278584 tropisetron zatosetron volatiles gases e g chloral hydrate chloroform desflurane diethyl ether ether enflurane halothane isoflurane methoxyflurane sevoflurane toluene trichloroethane methyl chloroform trichloroethylene xenon zinc antagonists 2 aminostrychnine 2 nitrostrychnine 4 phenyl 4 formyl n methylpiperidine αembtl bicuculline brucine cacotheline caffeine colchicine colubrine cyanotriphenylborate dendrobine diaboline endocannabinoids e g 2 ag anandamide aea gaboxadol thip gelsemine iso thaz isobutyric acid isonipecotic acid isostrychnine laudanosine n methylbicuculline n methylstrychnine n n dimethylmuscimol nipecotic acid pitrazepin pseudostrychnine quinolines e g 4 hydroxyquinoline 4 hydroxyquinoline 3 carboxylic acid 5 7 ciqa 7 ciq 7 tfq 7 tfqa ru 5135 sinomenine strychnine thaz thiocolchicoside tutin negative modulators amiloride benzodiazepines e g bromazepam clonazepam diazepam flunitrazepam flurazepam corymine cyanotriphenylborate daidzein dihydropyridines e g nicardipine nifedipine nitrendipine furosemide genistein ginkgo constituents e g bilobalide ginkgolides e g ginkgolide a ginkgolide b ginkgolide c ginkgolide j ginkgolide m imipramine nbqx neuroactive steroids e g 3α androsterone sulfate 3β androsterone sulfate deoxycorticosterone dhea sulfate pregnenolone sulfate progesterone opioids e g codeine dextromethorphan dextrorphan levomethadone levorphanol morphine oripavine pethidine thebaine picrotoxin i e picrotin and picrotoxinin pmba riluzole tropeines e g bemesetron ly 278584 tropisetron zatosetron verapamil zinc nmdar tooltip n methyl d aspartate receptor see here instead transporter blockers glyt1 tooltip sodium and chloride dependent glycine transporter 1 acppb alx 5407 nfps asp2535 bitopertin rg1678 ro4917838 cp 802079 ethanol alcohol glycyldodecylamide gsk1018921 iclepertin ly 2365109 mardepodect org 24598 org 25935 sch 900435 pesampator biib 104 pf 04958242 pf 03463275 sarcosine sng 12 synapsinae ssr 103 800 ssr 504 734 tilapertin glyt2 tooltip glycine transporter 2 alx 1393 amoxapine ethanol alcohol nagly opiranserin vvz 149 org 25543 vvz 368 see also receptor signaling modulators gaba receptor modulators gaba a receptor positive modulators ionotropic glutamate receptor modulators this pharmacology article about an anesthetic is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title minaxolone oldid 1371844439 categories drugs not assigned an atc code general anesthetics neurosteroids secondary alcohols ethers dimethylamino compounds ketones gabaa receptor positive allosteric modulators glycine receptor agonists pregnanes ethoxy compounds anesthetic stubs hidden categories articles with short description short description matches wikidata short description is different from wikidata articles with changed chemspider identifier articles with changed ebi identifier articles with changed inchi identifier chemical pages without drugbank identifier drugs with no legal status drugboxes which contain changes to verified fields drugboxes which contain changes to watched fields cs1 errors deprecated parameters all stub articles this page was last edited on 28 august 2026 at 20 47 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the 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