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ncr1 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references 2 further reading 3 external links toggle the table of contents ncr1 5 languages čeština cymraeg deutsch русский українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia mammalian protein found in homo sapiens ncr1 identifiers aliases ncr1 cd335 ly94 nk p46 nkp46 natural cytotoxicity triggering receptor 1 external ids omim 604530 mgi 1336212 genecards ncr1 available structures pdb ortholog search pdbe rcsb list of pdb id codes 1oll 1p6f gene location human chr chromosome 19 human 1 band 19q13 42 start 54 906 148 bp 1 end 54 916 140 bp 1 gene location mouse chr chromosome 7 mouse 2 band 7 7 a1 start 4 340 723 bp 2 end 4 348 163 bp 2 rna expression pattern bgee human mouse ortholog top expressed in granulocyte blood spleen bone marrow cell gonad monocyte placenta liver right lobe of liver lymph node top expressed in blood morula spleen granulocyte gastrula right lung lobe submandibular gland extensor digitorum longus muscle uterus upper arm more reference expression data biogps more reference expression data gene ontology molecular function protein binding cellular component integral component of membrane plasma membrane integral component of plasma membrane swi snf complex membrane biological process cellular defense response natural killer cell activation signal transduction regulation of immune response regulation of natural killer cell mediated cytotoxicity sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 9437 17086 ensembl ensg00000273535 ensg00000277629 ensg00000273916 ensg00000275156 ensg00000277824 ensg00000277334 ensg00000278362 ensg00000275637 ensg00000274053 ensg00000275521 ensg00000275822 ensg00000277442 ensg00000189430 ensg00000284113 ensg00000273506 ensg00000276450 ensg00000278025 ensg00000288651 ensmusg00000062524 uniprot o76036 q8c567 refseq mrna nm_001145457 nm_001145458 nm_001242356 nm_001242357 nm_004829 nm_010746 nm_001368364 refseq protein np_001138929 np_001138930 np_001229285 np_001229286 np_004820 np_034876 np_001355293 location ucsc chr 19 54 91 54 92 mb chr 7 4 34 4 35 mb pubmed search 3 4 wikidata view edit human view edit mouse natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the ncr1 gene 5 6 ncr1 has also been designated as cd335 cluster of differentiation nomenclature nkp46 nkp46 nk p46 and ly94 7 references edit 1 2 3 ensg00000277629 ensg00000273916 ensg00000275156 ensg00000277824 ensg00000277334 ensg00000278362 ensg00000275637 ensg00000274053 ensg00000275521 ensg00000275822 ensg00000277442 ensg00000189430 ensg00000284113 ensg00000273506 ensg00000276450 ensg00000278025 ensg00000288651 grch38 ensembl release 89 ensg00000273535 ensg00000277629 ensg00000273916 ensg00000275156 ensg00000277824 ensg00000277334 ensg00000278362 ensg00000275637 ensg00000274053 ensg00000275521 ensg00000275822 ensg00000277442 ensg00000189430 ensg00000284113 ensg00000273506 ensg00000276450 ensg00000278025 ensg00000288651 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000062524 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine pessino a sivori s bottino c malaspina a morelli l moretta l biassoni r moretta a sep 1998 molecular cloning of nkp46 a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity j exp med 188 5 953 60 doi 10 1084 jem 188 5 953 pmc 3207313 pmid 9730896 entrez gene ncr1 natural cytotoxicity triggering receptor 1 ncr1 natural cytotoxicity triggering receptor 1 homo sapiens human gene ncbi further reading edit biassoni r cantoni c marras d et al 2004 human natural killer cell receptors insights into their molecular function and structure j cell mol med 7 4 376 87 doi 10 1111 j 1582 4934 2003 tb00240 x pmc 6740120 pmid 14754506 sivori s vitale m morelli l et al 1997 p46 a novel natural killer cell specific surface molecule that mediates cell activation j exp med 186 7 1129 36 doi 10 1084 jem 186 7 1129 pmc 2211712 pmid 9314561 vitale m bottino c sivori s et al 1998 nkp44 a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non major histocompatibility complex restricted tumor cell lysis j exp med 187 12 2065 72 doi 10 1084 jem 187 12 2065 pmc 2212362 pmid 9625766 cantoni c bottino c vitale m et al 1999 nkp44 a triggering receptor involved in tumor cell lysis by activated human natural killer cells is a novel member of the immunoglobulin superfamily j exp med 189 5 787 96 doi 10 1084 jem 189 5 787 pmc 2192947 pmid 10049942 vankayalapati r wizel b weis se et al 2002 the nkp46 receptor contributes to nk cell lysis of mononuclear phagocytes infected with an intracellular bacterium j immunol 168 7 3451 7 doi 10 4049 jimmunol 168 7 3451 pmid 11907104 strausberg rl feingold ea grouse lh et al 2003 generation and initial analysis of more than 15 000 full length human and mouse cdna sequences proc natl acad sci u s a 99 26 16899 903 bibcode 2002pnas 9916899m doi 10 1073 pnas 242603899 pmc 139241 pmid 12477932 augugliaro r parolini s castriconi r et al 2003 selective cross talk among natural cytotoxicity receptors in human natural killer cells eur j immunol 33 5 1235 41 doi 10 1002 eji 200323896 pmid 12731048 s2cid 10724743 ponassi m cantoni c biassoni r et al 2003 structure of the human nk cell triggering receptor nkp46 ectodomain biochem biophys res commun 309 2 317 23 bibcode 2003bbrc 309 317p doi 10 1016 j bbrc 2003 08 007 pmid 12951052 foster ce colonna m sun pd 2003 crystal structure of the human natural killer nk cell activating receptor nkp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors j biol chem 278 46 46081 6 doi 10 1074 jbc m308491200 pmid 12960161 arnon ti achdout h lieberman n et al 2004 the mechanisms controlling the recognition of tumor and virus infected cells by nkp46 blood 103 2 664 72 doi 10 1182 blood 2003 05 1716 pmid 14504081 marcenaro e augugliaro r falco m et al 2004 cd59 is physically and functionally associated with natural cytotoxicity receptors and activates human nk cell mediated cytotoxicity eur j immunol 33 12 3367 76 doi 10 1002 eji 200324425 pmid 14635045 s2cid 40345630 carbone e neri p mesuraca m et al 2005 hla class i nkg2d and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells blood 105 1 251 8 doi 10 1182 blood 2004 04 1422 pmid 15328155 gerhard ds wagner l feingold ea et al 2004 the status quality and expansion of the nih full length cdna project the mammalian gene collection mgc genome res 14 10b 2121 7 doi 10 1101 gr 2596504 pmc 528928 pmid 15489334 mavoungou e bouyou akotet mk kremsner pg 2005 effects of prolactin and cortisol on natural killer nk cell surface expression and function of human natural cytotoxicity receptors nkp46 nkp44 and nkp30 clin exp immunol 139 2 287 96 doi 10 1111 j 1365 2249 2004 02686 x pmc 1809301 pmid 15654827 nowbakht p ionescu mc rohner a et al 2005 ligands for natural killer cell activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias blood 105 9 3615 22 doi 10 1182 blood 2004 07 2585 pmid 15657183 poggi a massaro am negrini s et al 2005 tumor induced apoptosis of human il 2 activated nk cells role of natural cytotoxicity receptors j immunol 174 5 2653 60 doi 10 4049 jimmunol 174 5 2653 pmid 15728472 zilka a landau g hershkovitz o et al 2006 characterization of the heparin heparan sulfate binding site of the natural cytotoxicity receptor nkp46 biochemistry 44 44 14477 85 doi 10 1021 bi051241s pmid 16262248 hermann e alonso vega c berthe a et al 2006 human congenital infection with trypanosoma cruzi induces phenotypic and functional modifications of cord blood nk cells pediatr res 60 1 38 43 doi 10 1203 01 pdr 0000220335 05588 ea pmid 16690951 external links edit ncr1 protein human at the u s national library of medicine medical subject headings mesh overview of all the structural information available in the pdb for uniprot o76036 natural cytotoxicity triggering receptor 1 at the pdbe kb v t e pdb gallery 1oll extracellular region of the human receptor nkp46 1p6f structure of the human natural cytotoxicity receptor nkp46 v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons retrieved from https en wikipedia org w index php title ncr1 oldid 1374599479 categories genes on human chromosome 19 clusters of differentiation human proteins cytolytic granules hidden categories articles with short description short description matches wikidata this page was last edited on 13 september 2026 at 01 31 utc page was rendered with parsoid text is available 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