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ns 11394 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references toggle the table of contents ns 11394 2 languages srpskohrvatski српскохрватски српски srpski edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia chemical compound pharmaceutical compound ns 11394 identifiers iupac name 2 3 5 2 hydroxypropan 2 yl benzimidazol 1 yl phenyl benzonitrile cas number 951650 22 9 y pubchem cid 16747643 chemspider 20578861 n unii 1pth9fk74j comptox dashboard epa dtxsid60587781 chemical and physical data formula c 23 h 19 n 3 o molar mass 353 425 g mol 1 3d model jsmol interactive image smiles n cc2ccccc2 c ccc3 cc3 n1cnc c4 c1ccc4c c c o inchi inchi 1s c23h19n3o c1 23 2 27 18 10 11 22 21 13 18 25 15 26 22 19 8 5 7 16 12 19 20 9 4 3 6 17 20 14 24 h3 13 15 27h 1 2h3 n key hlkysqgbiiiqjn uhfffaoysa n n n y what is this verify ns 11394 is a drug which acts as a subtype selective positive allosteric modulator at gaba a receptors with selectivity for the α 3 and α 5 subtypes 1 2 it has been researched as an analgesic for use in chronic or neuropathic pain 3 references edit munro g lopez garcia ja rivera arconada i erichsen hk nielsen eø larsen js ahring pk mirza nr december 2008 comparison of the novel subtype selective gabaa receptor positive allosteric modulator ns11394 3 5 1 hydroxy 1 methyl ethyl benzoimidazol 1 yl biphenyl 2 carbonitrile with diazepam zolpidem bretazenil and gaboxadol in rat models of inflammatory and neuropathic pain the journal of pharmacology and experimental therapeutics 327 3 969 81 doi 10 1124 jpet 108 144568 pmid 18791060 s2cid 36490884 mirza nr larsen js mathiasen c jacobsen ta munro g erichsen hk nielsen an troelsen kb nielsen eø ahring pk december 2008 ns11394 3 5 1 hydroxy 1 methyl ethyl benzoimidazol 1 yl biphenyl 2 carbonitrile a unique subtype selective gabaa receptor positive allosteric modulator in vitro actions pharmacokinetic properties and in vivo anxiolytic efficacy the journal of pharmacology and experimental therapeutics 327 3 954 68 doi 10 1124 jpet 108 138859 pmid 18791063 s2cid 206499795 munro g ahring pk mirza nr september 2009 developing analgesics by enhancing spinal inhibition after injury gabaa receptor subtypes as novel targets trends in pharmacological sciences 30 9 453 9 doi 10 1016 j tips 2009 06 004 pmid 19729210 v t e neuropathic pain and fibromyalgia pharmacotherapies monoaminergics snris tooltip serotonin norepinephrine reuptake inhibitor e g duloxetine milnacipran tcas tooltip tricyclic antidepressants e g amitriptyline nortriptyline dosulepin opioid mris tooltip monoamine reuptake inhibitors e g tapentadol tramadol ion channel blockers anticonvulsants e g gabapentin pregabalin mirogabalin carbamazepine oxcarbazepine lacosamide lamotrigine local anesthetics e g lidocaine mexiletine tcas tooltip tricyclic antidepressants e g amitriptyline nortriptyline desipramine ziconotide others alpha lipoic acid benfotiamine botulinum toxin a bupropion cannabinoids e g cannabis dronabinol nabilone nmda receptor antagonists e g ketamine dextromethorphan methadone opioids e g hydrocodone morphine oxycodone methadone buprenorphine tramadol tapentadol sodium oxybate ghb v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin linarin luteolin rc ome skullcap constituents e g baicalin wogonin imidazoles etomidate metomidate methoxyetomidate propoxate isopropoxate butomidate iso butomidate sec butomidate cf2 etomidate cf3 etomidate cf3 propoxate flutomidate 2 6 dichloro 3 fluoroetomidate kava constituents 10 methoxyyangonin 11 methoxyyangonin 11 hydroxyyangonin desmethoxyyangonin 11 methoxy 12 hydroxydehydrokavain 7 8 dihydroyangonin kavain 5 hydroxykavain 5 6 dihydroyangonin 7 8 dihydrokavain 5 6 7 8 tetrahydroyangonin 5 6 dehydromethysticin methysticin 7 8 dihydromethysticin yangonin monoureides acecarbromal apronal apronalide bromisoval carbromal capuride ectylurea neurosteroids acebrochol allopregnanolone brexanolone alfadolone alfaxalone 3α androstanediol androstenol androsterone certain anabolic androgenic steroids cholesterol cortisol hydrocortisone dhdoc 3α dhp 5α dhp 5β dhp dht etiocholanolone etx 155 ganaxolone hydroxydione lpcn 1154 minaxolone nora 520 org 20599 org 21465 p1 185 posovolone prax 114 pregnanolone eltanolone progesterone renanolone sage 105 sage 324 sage 516 sage 689 sage 872 testosterone thdoc zuranolone nonbenzodiazepines cyclopyrrolones eszopiclone pagoclone pazinaclone suproclone suriclone zopiclone imidazopyridines alpidem ds 1 necopidem saripidem zolpidem pyrazolopyrimidines divaplon fasiplon indiplon lorediplon ocinaplon panadiplon taniplon zaleplon others adipiplon axs 17 baer 101 azd 7325 cgs 8216 cgs 9896 cgs 13767 cgs 20625 cl 218 872 cp 615 003 ctp 354 elb 139 enx 102 tpa 023b gbld 345 imepitoin jm 1232 l 838 417 lirequinil ro41 3696 miltirone rosmariquinone ns 2664 ns 2710 ns 11394 ns 11821 pipequaline rod 188 rwj 51204 sb 205 384 sx 3228 tgsc01aa tp 003 tpa 023 tp 13 u 89843a u 90042 viqualine y 23684 phenols cipepofol fospropofol propofol propofol hemisuccinate thymol piperidinediones glutethimide methyprylon piperidione pyrithyldione pyrazolopyridines cartazolate etazolate ici 190 622 tracazolate quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 volatiles gases acetone acetophenone acetylglycinamide chloral hydrate aliflurane benzene butane butylene centalun chloral chloral betaine chloral hydrate chloroform cryofluorane desflurane dichloralphenazone dichloromethane diethyl ether enflurane ethyl chloride ethylene fluroxene gasoline halopropane halothane isoflurane kerosine methoxyflurane methoxypropane nitric oxide nitrogen nitrous oxide norflurane paraldehyde propane propylene roflurane sevoflurane synthane teflurane toluene trichloroethane methyl chloroform trichloroethylene vinyl ether others unsorted 3 hydroxybutanal α emtbl aa 29504 alogabat avermectins e g ivermectin bromide compounds e g lithium bromide potassium bromide sodium bromide carbamazepine chloralose chlormezanone clomethiazole darigabat deabl deuterated etifoxine dihydroergolines e g dihydroergocryptine dihydroergosine dihydroergotamine ergoloid dihydroergotoxine ds2 efavirenz etazepine etifoxine fenamates e g flufenamic acid mefenamic acid niflumic acid tolfenamic acid fluoxetine flupirtine hopantenic acid krm ii 81 lanthanum lavender oil lignans e g 4 o methylhonokiol honokiol magnolol obovatol loreclezole menthyl isovalerate validolum monastrol nezavist dcuk oet nicotinic acid nicotinamide ntx 1955 ro 7308480 org 25 435 phenytoin propanidid retigabine ezogabine safranal seproxetine stiripentol sulfonylalkanes e g sulfonmethane sulfonal tetronal trional terpenoids e g borneol topiramate valerian constituents e g isovaleric acid isovaleramide valerenic acid valerenol unsorted benzodiazepine site positive modulators α pinene mrk 409 mk 0343 tcs 1105 tcs 1205 see also receptor signaling modulators gaba receptor modulators gaba metabolism transport modulators retrieved from https en wikipedia org w index php title ns 11394 oldid 1120163806 categories analgesics gabaa receptor positive allosteric modulators hidden categories articles with short description short description matches wikidata short description is different from wikidata articles with changed chemspider identifier articles with changed inchi identifier articles without ebi source chemical pages without drugbank identifier articles without kegg source drugs missing an atc code drugs with no legal status drugboxes which contain changes to verified fields this page was last edited on 5 november 2022 at 14 11 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents ns 11394 2 languages add topic