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nissl body wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 staining 2 size and distribution 3 functional role 4 pathology 5 references 6 external links toggle the table of contents nissl body 23 languages العربية বাংলা català čeština deutsch español eesti فارسی français galego עברית italiano 日本語 മലയാളം polski português română русский српски srpski türkçe українська oʻzbekcha ўзбекча 中文 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia rough endoplasmic reticulum structure found in neurons photomicrograph of nissl bodies two are indicated by arrows in the cytoplasm of motor neurons in the anterior horn of the spinal cord cresyl violet stain purple along with a luxol fast blue stain for myelin scale bar 30 microns 0 03mm drawing of a motor neuron from the ventral horn of the medulla spinals of a rabbit the angular and spindle shaped nissl bodies in the cytoplasm are well shown in cellular neuroscience nissl bodies also called nissl granules nissl substance or tigroid substance are discrete granular structures in neurons that consist of rough endoplasmic reticulum a collection of parallel membrane bound cisternae studded with ribosomes on the cytosolic surface of the membranes 1 nissl bodies were named after franz nissl a german neuropathologist who invented the staining method bearing his name nissl staining 2 3 the term nissl bodies generally refers to discrete clumps of rough endoplasmic reticulum and free ribosomes in nerve cells masses of rough endoplasmic reticulum also occur in some non neuronal cells where they are referred to as ergastoplasm basophilic bodies 1 or chromophilic substance 4 while these organelles differ in some ways from nissl bodies in neurons 5 large amounts of rough endoplasmic reticulum are generally linked to the copious production of proteins 1 staining edit nissl stains refers to various basic dyes that selectively label negatively charged molecules such as dna and rna because ribosomes are rich in ribosomal rna they are strongly basophilic base loving the dense accumulation of membrane bound and free ribosomes in nissl bodies results in their intense coloration by nissl stains allowing them to be seen with a light microscope 1 size and distribution edit nissl bodies occur in the somata and dendrites of neurons though not in the axon or axon hillock 6 they vary in size shape and intracellular location they are most conspicuous in the motor neurons of the spinal cord and brainstem where they appear as large blocky assemblies 5 in other neurons they may be smaller and in some such as the granule neurons of the cerebellar cortex very little rough endoplasmic reticulum is present 5 the pattern of coloration with nissl stains once was used to classify neurons 5 for various reasons this practice has largely ceased but specific neuronal types do manifest characteristic types of nissl bodies 5 functional role edit the functions of nissl bodies are thought to be the same as those of the rough endoplasmic reticulum in general primarily the synthesis and segregation of proteins 1 2 similar to the ergastoplasm of glandular cells nissl bodies are the main site of protein synthesis in the neuronal cytoplasm 5 the ultrastructure of nissl bodies suggests they are primarily concerned with the synthesis of proteins for intracellular use 7 pathology edit nissl bodies show changes under various physiological conditions and in pathological conditions such as axonotmesis during which they may dissolve and largely disappear chromatolysis if the neuron is successful in repairing the damage the nissl bodies gradually reappear and return to their characteristic distribution within the cell 5 references edit 1 2 3 4 5 junqueira lc carniero j kelley ro 1995 basic histology appleton lange isbn 0 8385 0567 8 1 2 richard h thompson 29 march 2000 the brain a neuroscience primer macmillan pp 35 isbn 978 0 7167 3226 6 retrieved 4 january 2013 da mota gomes m 2019 franz nissl 1860 1919 noted neuropsychiatrist and neuropathologist staining the neuron but not limiting it dementia neuropsychologia 13 3 352 355 doi 10 1590 1980 57642018dn13 030014 pmc 6753910 fawcett don w 1966 the cell its organelles and inclusions w b saunders company isbn 0 7216 3585 7 1 2 3 4 5 6 7 peters a palay sl webster hd 1991 the fine structure of the nervous system oxford university press isbn 0 19 506571 9 wolfgang kühnel 2003 color atlas of cytology histology and microscopic anatomy thieme pp 182 isbn 978 3 13 562404 4 retrieved 4 january 2013 t herdegen j delgado garcia 25 may 2005 brain damage and repair from molecular research to clinical therapy springer pp 37 isbn 978 1 4020 1892 3 retrieved 4 january 2013 external links edit media related to nissl stain at wikimedia commons nissl bodies at the u s national library of medicine medical subject headings mesh histology image 04103loa histology learning system at boston university nervous tissue and neuromuscular junction spinal cord cell bodies of anterior horn cells histology at anhb uwa edu au tissues containing nissl bodies at harvard edu v t e nervous tissue cns tissue types grey matter white matter projection fiber association fiber commissural fiber lemniscus nerve tract decussation neuropil meninges cell types neuronal pyramidal purkinje granule von economo medium spiny interneuron glial astrocyte ependymal cells tanycyte oligodendrocyte progenitor cell oligodendrocyte microglia pns general dorsal root ganglion ramus ventral root ramus ramus communicans gray white autonomic ganglion preganglionic nerve fibers postganglionic nerve fibers nerve fascicle funiculus connective tissues epineurium perineurium endoneurium neuroglia myelination schwann cell neurilemma myelin incisure node of ranvier internodal segment satellite glial cell neurons nerve fibers parts soma axon hillock axon telodendron axon terminals axoplasm axolemma neurofibril neurofilament dendrite nissl body dendritic spine apical dendrite basal dendrite types bipolar unipolar pseudounipolar multipolar interneuron renshaw afferent nerve fiber sensory neuron gsa gva ssa sva fibers ia or aα ib or golgi or aα ii or aβ and aγ iii or aδ or fast pain iv or c or slow pain efferent nerve fiber motor neuron gse gve sve upper motor neuron lower motor neuron α motorneuron β motorneuron γ motorneuron termination synapse electrical synapse gap junction chemical synapse synaptic vesicle active zone postsynaptic density autapse ribbon synapse neuromuscular junction sensory receptors meissner s corpuscle merkel nerve ending pacinian corpuscle ruffini ending muscle spindle free nerve ending nociceptor olfactory receptor neuron photoreceptor cell hair cell taste receptor retrieved from https en wikipedia org w index php title nissl_body oldid 1377173814 category nervous tissue cells hidden categories articles with short description short description is different from wikidata commons category link is on wikidata this page was last edited on 28 september 2026 at 04 45 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy 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