Meta tags:

Headings (most frequently used words):

partial, least, squares, pls, regression, contents, core, idea, underlying, model, algorithms, extensions, see, also, references, literature, external, links, pls1, opls, 3prf, svd, correlation,

Text of the page (most frequently used words):
the (117), and (68), #regression (65), least (50), squares (48), displaystyle (47), pls (43), #partial (32), doi (27), for (22), model (19), mathrm (19), analysis (18), edit (18), linear (17), matrix (16), are (16), with (15), this (12), journal (12), wold (12), chemometrics (12), variables (12), orth (12), gets (12), vec (12), statistics (11), statistical (11), s2cid (11), data (11), latent (10), covariance (10), correlation (10), algorithm (10), that (10), not (9), 978 (8), 1002 (8), ell (8), wikipedia (7), text (7), models (7), generalized (7), components (7), new (7), between (7), used (7), matrices (7), non (6), orthogonal (6), structure (6), general (6), isbn (6), related (6), pmid (6), algorithms (6), opls (6), input (6), space (6), times (6), may (5), page (5), was (5), errors (5), variable (5), multivariate (5), principal (5), 2010 (5), herman (5), approach (5), effects (5), methods (5), issn (5), 1016 (5), information (5), cem (5), see (5), svd (5), factor (5), when (5), vector (5), will (5), column (5), toggle (4), contents (4), search (4), view (4), from (4), numerical (4), applications (4), response (4), background (4), variance (4), ordinary (4), rank (4), computational (4), links (4), 540 (4), 1994 (4), eds (4), systems (4), 1993 (4), tools (4), abdi (4), 2013 (4), method (4), projections (4), structures (4), projection (4), also (4), two (4), 3prf (4), number (4), same (4), underlying (4), these (4), note (4), pls1 (4), case (4), below (4), hide (4), move (4), sidebar (4), under (3), terms (3), using (3), articles (3), short (3), https (3), portal (3), curve (3), bayesian (3), design (3), theorem (3), mean (3), predicted (3), decomposition (3), logistic (3), normal (3), nonlinear (3), predictor (3), total (3), iteratively (3), history (3), 1990 (3), cross (3), prediction (3), jstor (3), 1111 (3), sciences (3), springer (3), 1007 (3), some (3), hervé (3), pmc (3), bibcode (3), one (3), neuroimaging (3), imaging (3), cite (3), values (3), 2015 (3), many (3), predictors (3), intelligent (3), laboratory (3), improved (3), kernel (3), component (3), has (3), sub (3), groups (3), more (3), singular (3), observations (3), changes (3), extensions (3), deflation (3), form (3), but (3), deflating (3), estimates (3), vectors (3), normalized (3), they (3), loading (3), where (3), scores (3), independent (3), random (3), direction (3), core (3), idea (3), maximum (3), mixed (3), probit (3), main (3), languages (2), table (2), code (2), contact (2), about (2), privacy (2), policy (2), available (2), additional (2), categories (2), pseudocode (2), deprecated (2), description (2), wikidata (2), other (2), national (2), mathematics (2), category (2), chebyshev (2), polynomials (2), approximation (2), theory (2), methodology (2), square (2), error (2), studentized (2), residual (2), goodness (2), fit (2), residuals (2), gauss (2), markov (2), validation (2), selection (2), poisson (2), binomial (2), isotonic (2), quantile (2), robust (2), semiparametric (2), nonparametric (2), standard (2), local (2), segmented (2), growth (2), polynomial (2), weighted (2), simple (2), ridge (2), reweighted (2), its (2), external (2), series (2), wang (2), handbook (2), interpretation (2), 1080 (2), problem (2), 735 (2), svante (2), vol (2), york (2), wiley (2), encyclopedia (2), estimation (2), press (2), scandinavian (2), recent (2), lecture (2), science (2), feature (2), 2005 (2), 1998 (2), henseler (2), jörg (2), path (2), 32827 (2), 109 (2), quantitative (2), literature (2), williams (2), lynne (2), 62703 (2), beggs (2), clive (2), 1932 (2), 6203 (2), 1371 (2), pone (2), plos (2), multicollinearity (2), mcintosh (2), anthony (2), review (2), neuroimage (2), 115 (2), genetics (2), uses (2), help (2), citeseerx (2), kelly (2), bryan (2), pruitt (2), seth (2), market (2), three (2), pass (2), filter (2), high (2), dimensional (2), problems (2), econometrics (2), classification (2), eriksson (2), o2pls (2), visualization (2), www (2), com (2), pdf (2), 2002 (2), 106 (2), 122685021 (2), wics (2), lindgren (2), geladi (2), sets (2), part (2), jong (2), alternative (2), 7439 (2), reduced (2), references (2), sum (2), modeling (2), plsc (2), another (2), been (2), strength (2), relationship (2), into (2), blocks (2), then (2), exist (2), does (2), value (2), version (2), can (2), features (2), called (2), sample (2), improve (2), columns (2), only (2), discriminant (2), discrete (2), step (2), performed (2), estimate (2), ldots (2), scalar (2), widely (2), appropriate (2), orthonormal (2), talk (2), letters (2), score (2), finding (2), output (2), estimating (2), most (2), differ (2), tilde (2), loadings (2), pair (2), length (2), respectively (2), max (2), underbrace (2), cdot (2), term (2), areas (2), find (2), spaces (2), multidimensional (2), regularized (2), ordered (2), logit (2), multinomial (2), appearance (2), upload (2), file (2), read (2), article (2), subsection (2), log (2), create (2), account (2), donate (2), menu (2), add, topic, mobile, cookie, statement, developers, conduct, legal, safety, contacts, disclaimers, apply, site, you, agree, registered, trademark, profit, organization, wikimedia, foundation, inc, use, creative, commons, attribution, sharealike, license, rendered, parsoid, last, edited, july, 2026, utc, hidden, example, prone, spam, november, 2017, cs1, parameters, matches, retrieved, org, index, php, title, partial_least_squares_regression, oldid, 1365854637, yale, lux, israel, united, states, gnd, international, authority, control, databases, topics, outline, moving, system, identification, smoothing, differentiation, calibration, fitting, nodes, gaussian, quadrature, integration, optimal, surface, experiments, frisch, waugh, lovell, minimum, specification, bic, aic, mallows, stepwise, exploration, aov, confounding, kendall, tau, spearman, rho, pearson, product, moment, dependence, video, derivation, prof, harry, asada, introduction, stone, brooks, continuum, validated, sequentially, constructed, embracing, 269, 2345437, 2517, 6161, tb01786, 237, royal, society, 32825, garthwaite, paul, 425, 2291207, 01621459, 10476452, 122, american, association, ruhe, axel, dunn, 1984, collinearity, inverses, 743, 1137, 0905052, siam, scientific, computing, 1985, kotz, samuel, johnson, norman, 591, 581, 1981, amsterdam, north, holland, fix, point, interdependent, 1966, iterative, krishnaiaah, academic, 420, 391, helland, inge, 114, 4616159, rosipal, roman, krämer, nicole, 2006, overview, advances, saunders, craig, grobelnik, marko, gunn, steve, shawe, taylor, john, notes, computer, 34138, 11752790_2, subspace, optimization, perspectives, workshop, slsfs, bohinj, slovenia, february, revised, selected, papers, tenenhaus, michel, régression, théorie, pratique, paris, technip, lingjærde, ole, christian, christophersen, nils, 2000, shrinkage, 473, 121489764, 1467, 9469, 00201, 459, fassott, georg, testing, moderating, illustration, procedures, vinzi, vincenzo, esposito, chin, wynne, huiwen, 8_31, 713, concepts, haenlein, michael, kaplan, andreas, 2004, beginner, guide, 297, 1207, s15328031us0304_4, 283, understanding, frank, ildiko, friedman, jerome, 148, 00401706, 10485033, technometrics, kramer, marcel, dekker, 8247, 0198, chemometric, techniques, reisfeld, brad, mayeno, arthur, 930, humana, 579, 23086857, 058, 059, 5_23, 549, toxicology, weaving, dan, jones, ben, ireton, matt, whitehead, sarah, till, kevin, 2019, connaboy, chris, e0211776, 30763328, 6375576, 0211776, 2019ploso, 1411776w, overcoming, sports, performance, novel, application, magnano, christopher, belov, pavel, krawiecki, jacqueline, ramasamy, deepa, hagemeier, jesper, zivadinov, robert, 2016, castro, fernando, e0153960, 27135831, 4852898, 0153960, 2016ploso, 1153960b, internal, jugular, vein, sectional, area, cerebrospinal, fluid, pulsatility, aqueduct, sylvius, comparative, study, healthy, subjects, multiple, sclerosis, patients, mišić, bratislav, analyses, 525, 22804773, 0066, 4308, 1146, annurev, psych, 113011, 143804, 499, annual, psychology, krishnan, anjali, randal, 2011, tutorial, 475, 8796113, 20656037, 034, 455, lorenzi, marco, altmann, andre, gutman, boris, arber, charles, hibar, derrek, jahanshad, neda, schott, jonathan, alexander, daniel, 2018, 3167, 29511103, 5866534, 0027, 8424, 1073, pnas, 1706100115, 2018pnas, 3162l, 3162, proceedings, academy, susceptibility, brain, atrophy, trib3, alzheimer, disease, evidence, functional, prioritization, wray, selina, parameter, expectations, section, present, 1756, 1540, 6261, jofi, 12060, 498, 5973, 1721, finance, forecasting, 316, jeconom, 011, 294, 186, sæbøa, almøya, flatbergb, aastveita, martens, 2008, lpls, influence, 132, chemolab, 2007, 006, 121, tryg, complex, dynacentrix, telecharg, simcap, trygg, 128, 122699039, 695, 119, höskuldsson, agnar, 1988, 219, 120052390, 1180020306, interdisciplinary, reviews, rannar, fewer, objects, 125, 121613293, 1180080204, 111, simpls, 263, 0169, 85002, 251, dayal, macgregor, 1997, 120753851, sici, 1099, 128x, 199701, aid, cem435, ter, braak, comments, 174, 221549296, 1180080208, 169, 122950427, 1180070104, youtube, watch, px2otk2nz1c, 46s, wires, sjöström, 2001, basic, tool, 130, 11920190, s0169, 00155, schmidli, heinz, march, 642, 50015, activity, relationships, pursuit, machine, learning, extraction, deming, mining, canonical, which, sport, quantify, typically, divides, each, containing, establish, any, amount, shared, might, determine, inertia, consideration, based, provides, memory, efficient, implementation, address, such, relating, millions, genetic, markers, thousands, consumer, grade, hardware, procedure, supposing, large, hence, asymptotically, best, forecast, implied, stock, shown, provide, accurate, out, forecasts, returns, cash, flow, extension, named, shaped, connects, predictability, brief, added, suitable, including, interdependence, published, continuous, separated, predictive, uncorrelated, leads, diagnostics, well, easily, interpreted, however, interpretability, predictivity, similarly, applied, working, biomarker, studies, geometric, require, centering, implicitly, subtraction, necessary, proved, yields, results, user, supplied, limit, factors, equals, yield, initial, return, define, end, loop, break, function, caution, appropriately, expressed, capital, lower, superscripted, scalars, subscripted, target, performing, directions, maximal, composed, repeating, following, steps, variants, them, construct, while, others, deal, whether, final, all, varieties, plsr, thus, chosen, basis, major, difference, pca, orthogonality, imposed, onto, defined, maximized, additionally, zero, neq, decompositions, made, maximise, assumed, identically, distributed, responses, denoted, notation, operatorname, given, first, searches, maximizes, paired, drawn, red, better, visibility, increases, increase, introduced, swedish, statistician, who, developed, his, son, still, dominant, although, original, were, social, today, anthropology, neuroscience, sensometrics, bioinformatics, fundamental, relations, try, explains, particularly, suited, than, there, among, contrast, fail, cases, unless, bears, relation, instead, finds, projecting, because, both, projected, family, known, bilinear, variant, categorical, observable, hyperplanes, spectral, absolute, deviations, negative, equation, angle, fixed, multilevel, binary, choice, free, item, projects, printable, download, print, export, switch, legacy, parser, get, shortened, url, permanent, link, what, here, actions, english, 日本語, français, فارسی, español, deutsch, català, top, personal, special, pages, community, learn, contribute, current, events, navigation, jump, content,

Text of the page (random words):
t events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 core idea 2 underlying model 3 algorithms toggle algorithms subsection 3 1 pls1 4 extensions toggle extensions subsection 4 1 opls 4 2 l pls 4 3 3prf 4 4 partial least squares svd 4 5 pls correlation 5 see also 6 references 7 literature 8 external links toggle the table of contents partial least squares regression 7 languages català deutsch español فارسی français 日本語 中文 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia statistical method part of a series on regression analysis models linear regression simple regression polynomial regression general linear model generalized linear model vector generalized linear model discrete choice binomial regression binary regression logistic regression multinomial logistic regression mixed logit probit multinomial probit ordered logit ordered probit poisson multilevel model fixed effects random effects linear mixed effects model nonlinear mixed effects model nonlinear regression nonparametric semiparametric robust quantile isotonic principal components least angle local segmented errors in variables estimation least squares linear non linear ordinary weighted generalized generalized estimating equation partial total non negative ridge regression regularized least absolute deviations iteratively reweighted bayesian bayesian multivariate least squares spectral analysis background regression validation mean and predicted response errors and residuals goodness of fit studentized residual gauss markov theorem mathematics portal v t e partial least squares pls regression is a statistical method that bears some relation to principal components regression and is a reduced rank regression 1 instead of finding hyperplanes of maximum variance between the response and independent variables it finds a linear regression model by projecting the predicted variables and the observable variables to a new space of maximum covariance see below because both the x and y data are projected to new spaces the pls family of methods are known as bilinear factor models partial least squares discriminant analysis pls da is a variant used when the y is categorical pls is used to find the fundamental relations between two matrices x and y i e a latent variable approach to modeling the covariance structures in these two spaces a pls model will try to find the multidimensional direction in the x space that explains the maximum multidimensional variance direction in the y space pls regression is particularly suited when the matrix of predictors has more variables than observations and when there is multicollinearity among x values by contrast standard regression will fail in these cases unless it is regularized partial least squares was introduced by the swedish statistician herman o a wold who then developed it with his son svante wold an alternative term for pls is projection to latent structures 2 3 but the term partial least squares is still dominant in many areas although the original applications were in the social sciences pls regression is today most widely used in chemometrics and related areas it is also used in bioinformatics sensometrics neuroscience and anthropology core idea edit core idea of pls the loading vectors p 1 q 1 displaystyle vec p _ 1 vec q _ 1 in the input and output space are drawn in red not normalized for better visibility when x 1 displaystyle x_ 1 increases independent of x 2 displaystyle x_ 2 y 1 displaystyle y_ 1 and y 2 displaystyle y_ 2 increase we are given a sample of n displaystyle n paired observations x i y i i 1 n displaystyle vec x _ i vec y _ i i in 1 ldots n in the first step j 1 displaystyle j 1 the partial least squares regression searches for the normalized direction p j displaystyle vec p _ j q j displaystyle vec q _ j that maximizes the covariance 4 max p j q j e p j x t j q j y u j displaystyle max _ vec p _ j vec q _ j operatorname e underbrace vec p _ j cdot vec x _ t_ j underbrace vec q _ j cdot vec y _ u_ j note below the algorithm is denoted in matrix notation underlying model edit the general underlying model of multivariate pls with ℓ displaystyle ell components is x t p t e displaystyle x tp mathrm t e y u q t f displaystyle y uq mathrm t f where x is an n m displaystyle n times m matrix of predictors y is an n p displaystyle n times p matrix of responses t and u are n ℓ displaystyle n times ell matrices that are respectively projections of x the x score component or factor matrix and projections of y the y scores p and q are respectively m ℓ displaystyle m times ell and p ℓ displaystyle p times ell loading matrices and matrices e and f are the error terms assumed to be independent and identically distributed random normal variables the decompositions of x and y are made so as to maximise the covariance between t and u note that this covariance is defined pair by pair the covariance of column i of t length n with the column i of u length n is maximized additionally the covariance of the column i of t with the column j of u with i j displaystyle i neq j is zero in plsr the loadings are thus chosen so that the scores form an orthogonal basis this is a major difference with pca where orthogonality is imposed onto loadings and not the scores algorithms edit a number of variants of pls exist for estimating the factor and loading matrices t u p and q most of them construct estimates of the linear regression between x and y as y x b b 0 displaystyle y x tilde b tilde b _ 0 some pls algorithms are only appropriate for the case where y is a column vector while others deal with the general case of a matrix y algorithms also differ on whether they estimate the factor matrix t as an orthogonal that is orthonormal matrix or not 5 6 7 8 9 10 the final prediction will be the same for all these varieties of pls but the components will differ pls is composed of iteratively repeating the following steps k times for k components finding the directions of maximal covariance in input and output space performing least squares regression on the input score deflating the input x displaystyle x and or target y displaystyle y pls1 edit pls1 is a widely used algorithm appropriate for the vector y case it estimates t as an orthonormal matrix caution the t vectors in the code below may not be normalized appropriately see talk in pseudocode it is expressed below capital letters are matrices lower case letters are vectors if they are superscripted and scalars if they are subscripted 1 function pls1 x y ℓ 2 x 0 x displaystyle x 0 gets x 3 w 0 x t y x t y displaystyle w 0 gets x mathrm t y x mathrm t y an initial estimate of w 4 for k 0 displaystyle k 0 to ℓ 1 displaystyle ell 1 5 t k x k w k displaystyle t k gets x k w k 6 t k t k t t k displaystyle t_ k gets t k mathrm t t k note this is a scalar 7 t k t k t k displaystyle t k gets t k t_ k 8 p k x k t t k displaystyle p k gets x k mathrm t t k 9 q k y t t k displaystyle q_ k gets y mathrm t t k note this is a scalar 10 if q k 0 displaystyle q_ k 0 11 ℓ k displaystyle ell gets k break the for loop 12 if k ℓ 1 displaystyle k ell 1 13 x k 1 x k t k t k p k t displaystyle x k 1 gets x k t_ k t k p k mathrm t 14 w k 1 x k 1 t y displaystyle w k 1 gets x k 1 mathrm t y 15 end for 16 define w to be the matrix with columns w 0 w 1 w ℓ 1 displaystyle w 0 w 1 ldots w ell 1 do the same to form the p matrix and q vector 17 b w p t w 1 q displaystyle b gets w p mathrm t w 1 q 18 b 0 q 0 p 0 t b displaystyle b_ 0 gets q_ 0 p 0 mathrm t b 19 return b b 0 displaystyle b b_ 0 this form of the algorithm does not require centering of the input x and y as this is performed implicitly by the algorithm this algorithm features deflation of the matrix x subtraction of t k t k p k t displaystyle t_ k t k p k mathrm t but deflation of the vector y is not performed as it is not necessary it can be proved that deflating y yields the same results as not deflating 11 the user supplied variable l is the limit on the number of latent factors in the regression if it equals the rank of the matrix x the algorithm will yield the least squares regression estimates for b and b 0 displaystyle b_ 0 geometric interpretation of the deflation step in the input space extensions edit opls edit in 2002 a new method was published called orthogonal projections to latent structures opls in opls continuous variable data is separated into predictive and uncorrelated orthogonal information this leads to improved diagnostics as well as more easily interpreted visualization however these changes only improve the interpretability not the predictivity of the pls models 12 similarly opls da discriminant analysis may be applied when working with discrete variables as in classification and biomarker studies the general underlying model of opls is x t p t t y orth p y orth t e displaystyle x tp mathrm t t_ text y orth p_ text y orth mathrm t e y u q t f displaystyle y uq mathrm t f or in o2 pls 13 x t p t t y orth p y orth t e displaystyle x tp mathrm t t_ text y orth p_ text y orth mathrm t e y u q t u x orth q x orth t f displaystyle y uq mathrm t u_ text x orth q_ text x orth mathrm t f l pls edit another extension of pls regression named l pls for its l shaped matrices connects 3 related data blocks to improve predictability 14 in brief a new z matrix with the same number of columns as the x matrix is added to the pls regression analysis and may be suitable for including additional background information on the interdependence of the predictor variables 3prf edit in 2015 partial least squares was related to a procedure called the three pass regression filter 3prf 15 supposing the number of observations and variables are large the 3prf and hence pls is asymptotically normal for the best forecast implied by a linear latent factor model in stock market data pls has been shown to provide accurate out of sample forecasts of returns and cash flow growth 16 partial least squares svd edit a pls version based on singular value decomposition svd provides a memory efficient implementation that can be used to address high dimensional problems such as relating millions of genetic markers to thousands of imaging features in imaging genetics on consumer grade hardware 17 pls correlation edit pls correlation plsc is another methodology related to pls regression 18 which has been used in neuroimaging 18 19 20 and sport science 21 to quantify the strength of the relationship between data sets typically plsc divides the data into two blocks sub groups each containing one or more variables and then uses singular value decomposition svd to establish the strength of any relationship i e the amount of shared information that might exist between the two component sub groups 22 it does this by using svd to determine the inertia i e the sum of the singular values of the covariance matrix of the sub groups under consideration 22 18 see also edit canonical correlation data mining deming regression feature extraction machine learning partial least squares path modeling principal component analysis regression analysis total sum of squares projection pursuit regression references edit schmidli heinz 13 march 2013 reduced rank regression with applications to quantitative structure activity relationships springer isbn 978 3 642 50015 2 wold s sjöström m eriksson l 2001 pls regression a basic tool of chemometrics chemometrics and intelligent laboratory systems 58 2 109 130 doi 10 1016 s0169 7439 01 00155 1 s2cid 11920190 abdi hervé 2010 partial least squares regression and projection on latent structure regression pls regression wires computational statistics 2 97 106 doi 10 1002 wics 51 s2cid 122685021 see lecture https www youtube com watch v px2otk2nz1c t 46s lindgren f geladi p wold s 1993 the kernel algorithm for pls j chemometrics 7 45 59 doi 10 1002 cem 1180070104 s2cid 122950427 de jong s ter braak c j f 1994 comments on the pls kernel algorithm j chemometrics 8 2 169 174 doi 10 1002 cem 1180080208 s2cid 221549296 dayal b s macgregor j f 1997 improved pls algorithms j chemometrics 11 1 73 85 doi 10 1002 sici 1099 128x 199701 11 1 73 aid cem435 3 0 co 2 s2cid 120753851 de jong s 1993 simpls an alternative approach to partial least squares regression chemometrics and intelligent laboratory systems 18 3 251 263 doi 10 1016 0169 7439 93 85002 x rannar s lindgren f geladi p wold s 1994 a pls kernel algorithm for data sets with many variables and fewer objects part 1 theory and algorithm j chemometrics 8 2 111 125 doi 10 1002 cem 1180080204 s2cid 121613293 abdi h 2010 partial least squares regression and projection on latent structure regression pls regression wiley interdisciplinary reviews computational statistics 2 97 106 doi 10 1002 wics 51 s2cid 122685021 höskuldsson agnar 1988 pls regression methods journal of chemometrics 2 3 219 doi 10 1002 cem 1180020306 s2cid 120052390 trygg j wold s 2002 orthogonal projections to latent structures journal of chemometrics 16 3 119 128 doi 10 1002 cem 695 s2cid 122699039 eriksson s wold and j tryg o2pls for improved analysis and visualization of complex data https www dynacentrix com telecharg simcap o2pls pdf sæbøa s almøya t flatbergb a aastveita a h martens h 2008 lpls regression a method for prediction and classification under the influence of background information on predictor variables chemometrics and intelligent laboratory systems 91 2 121 132 doi 10 1016 j chemolab 2007 10 006 kelly bryan pruitt seth 2015 06 01 the three pass regression filter a new approach to forecasting using many predictors journal of econometrics high dimensional problems in econometrics 186 2 294 316 doi 10 1016 j jeconom 2015 02 011 kelly bryan pruitt seth 2013 10 01 market expectations in the cross section of present values the journal of finance 68 5 1721 1756 citeseerx 10 1 1 498 5973 doi 10 1111 jofi 12060 issn 1540 6261 cite journal cite uses deprecated parameter citeseerx help lorenzi marco altmann andre gutman boris wray selina arber charles hibar derrek p jahanshad neda schott jonathan m alexander daniel c 2018 03 20 susceptibility of brain atrophy to trib3 in alzheimer s disease evidence from functional prioritization in imaging genetics proceedings of the national academy of sciences 115 12 3162 3167 bibcode 2018pnas 115 3162l doi 10 1073 pnas 1706100115 issn 0027 8424 pmc 5866534 pmid 29511103 1 2 3 krishnan anjali williams lynne j mcintosh anthony randal abdi...